MetaADEDB 2.0 @ LMMD
5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride
(GHUUBYQTCDQWRA-UHFFFAOYSA-N)
Structure
SMILES
CCc1ccc(nc1)CCOc1ccc(cc1)CC1SC(=O)NC1=O.Cl
Molecular Formula:
C19H21ClN2O3S
Molecular Weight:
392.900
Log P:
4.2904
Hydrogen Bond Acceptor:
6
Hydrogen Bond Donor:
2
TPSA:
93.59
CAS Number(s):
112529-15-4
Synonym(s)
1.
5-[[4-[2-(5-Ethylpyridin-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;hydron;chloride
2.
Pioglitazone hydrochloride
3.
5-[[4-[2-(5-Ethylpyridin-1-ium-2-yl)ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione;chloride
External Link(s)
PubChem Compound60560
91810984
23137834
ChEBI8229
CHEMBLCHEMBL1715
KEGGdr:D00945
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Myocardial InfarctionFAERS: 7US FAERS
2Blood glucose increasedFAERS: 6US FAERS
3Chest PainFAERS: 4OFFSIDES
US FAERS
4Suicide attemptFAERS: 4US FAERS
5Cerebrovascular accidentFAERS: 3US FAERS
6CholelithiasisFAERS: 3US FAERS
7NauseaFAERS: 3US FAERS
8PainFAERS: 3US FAERS
9SwellingFAERS: 3US FAERS
10Abdominal PainFAERS: 2US FAERS
11Blood glucose fluctuationFAERS: 2US FAERS
12DizzinessFAERS: 2US FAERS
13DyspepsiaFAERS: 2US FAERS
14DysphoniaFAERS: 2US FAERS
15HeadacheFAERS: 2US FAERS
16HypotensionFAERS: 2US FAERS
17Maternal exposure during pregnancyFAERS: 2US FAERS
18Medication ErrorFAERS: 2US FAERS
19Mental status changesFAERS: 2OFFSIDES
US FAERS
20Neck PainFAERS: 2US FAERS
21Pancreatic carcinomaFAERS: 2US FAERS
22PterygiumFAERS: 2US FAERS
23Respiratory FailureFAERS: 2OFFSIDES
US FAERS
24SepsisFAERS: 2US FAERS
25ThrombocytopeniaFAERS: 2US FAERS
26Urinary tract infectionFAERS: 2US FAERS
27Viral upper respiratory tract infectionFAERS: 2OFFSIDES
US FAERS
28AgitationFAERS: 1US FAERS
29Ankle FractureFAERS: 1OFFSIDES
US FAERS
30Anti-thyroid antibody positiveFAERS: 1US FAERS
31AnxietyFAERS: 1US FAERS
32Apparent life threatening eventFAERS: 1US FAERS
33AstheniaFAERS: 1OFFSIDES
US FAERS
34AtelectasisFAERS: 1OFFSIDES
US FAERS
35Atrial FibrillationFAERS: 1US FAERS
36Atrioventricular BlockFAERS: 1OFFSIDES
US FAERS
37Back PainFAERS: 1US FAERS
38Biliary ColicFAERS: 1US FAERS
39Bladder cancer recurrentFAERS: 1US FAERS
40Bladder discomfortFAERS: 1US FAERS
41Bladder transitional cell carcinoma stage IFAERS: 1US FAERS
42Blood albumin increasedFAERS: 1OFFSIDES
US FAERS
43Blood creatine increasedFAERS: 1US FAERS
44Blood creatine phosphokinase increasedFAERS: 1OFFSIDES
US FAERS
45Blood glucose abnormalFAERS: 1US FAERS
46Blood potassium decreasedFAERS: 1US FAERS
47Blood pressure inadequately controlledFAERS: 1US FAERS
48Blood sodium decreasedFAERS: 1US FAERS
49BradycardiaFAERS: 1US FAERS
50Cardiac ArrestFAERS: 1US FAERS
51Cardiac FlutterFAERS: 1US FAERS
52CardiomegalyFAERS: 1US FAERS
53CellulitisFAERS: 1OFFSIDES
US FAERS
54ColectomyFAERS: 1US FAERS
55Compression fractureFAERS: 1US FAERS
56Coronary Artery DiseaseFAERS: 1US FAERS
57DiverticulumFAERS: 1US FAERS
58Drug ineffectiveFAERS: 1OFFSIDES
US FAERS
59DysenteryFAERS: 1US FAERS
60EpistaxisFAERS: 1US FAERS
61ExtravasationFAERS: 1US FAERS
62Failure to ThriveFAERS: 1US FAERS
63FatigueFAERS: 1US FAERS
64FractureFAERS: 1US FAERS
65General physical health deteriorationFAERS: 1US FAERS
66Hepatitis CFAERS: 1US FAERS
67HepatitisFAERS: 1OFFSIDES
US FAERS
68HepatomegalyFAERS: 1US FAERS
69HyperthyroidismFAERS: 1US FAERS
70Incorrect dose administeredFAERS: 1US FAERS
71InfarctionFAERS: 1US FAERS
72InflammationFAERS: 1US FAERS
73Intercostal neuralgiaFAERS: 1US FAERS
74Intermittent ClaudicationFAERS: 1US FAERS
75Lobar PneumoniaFAERS: 1US FAERS
76LymphomaFAERS: 1US FAERS
77Musculoskeletal PainFAERS: 1OFFSIDES
US FAERS
78ObesityFAERS: 1US FAERS
79OverdoseFAERS: 1US FAERS
80PalpitationsFAERS: 1US FAERS
81Pericardial effusionFAERS: 1OFFSIDES
US FAERS
82PneumoniaFAERS: 1US FAERS
83PneumothoraxFAERS: 1US FAERS
84PolyarthritisFAERS: 1US FAERS
85Renal Cell CarcinomaFAERS: 1US FAERS
86Renal cancer recurrentFAERS: 1US FAERS
87SeromaFAERS: 1US FAERS
88SplenomegalyFAERS: 1US FAERS
89Stevens-Johnson SyndromeFAERS: 1US FAERS
90Sudden Cardiac DeathFAERS: 1US FAERS
91Urinary RetentionFAERS: 1US FAERS
92UrticariaFAERS: 1US FAERS
93VertigoFAERS: 1US FAERS
94Visual ImpairmentFAERS: 1US FAERS
95Weight decreasedFAERS: 1US FAERS
96effusionFAERS: 1OFFSIDES
US FAERS
97treatment failureFAERS: 1US FAERS
98AdenocarcinomaOFFSIDES
99AgnosiaOFFSIDES
100Alcohol consumptionOFFSIDES
101AlveolitisOFFSIDES
102Angle Closure GlaucomaOFFSIDES
103Anoxic EncephalopathyOFFSIDES
104Apallic syndromeOFFSIDES
105ArthritisOFFSIDES
106AscitesOFFSIDES
107Aspiration PneumoniaOFFSIDES
108Atrial tachycardiaOFFSIDES
109AuraOFFSIDES
110Basal cell carcinomaOFFSIDES
111Benign Prostatic HyperplasiaOFFSIDES
112Bladder NeoplasmOFFSIDES
113Bladder transitional cell carcinoma stage IIICanada Vigilance: 1Canada Vigilance
114Blood cholesterolOFFSIDES
115Blood iron decreasedOFFSIDES
116Blood lactate dehydrogenase abnormalOFFSIDES
117Blood pH decreasedOFFSIDES
118Blood sodium increasedOFFSIDES
119Bowen's DiseaseOFFSIDES
120BronchopneumoniaOFFSIDES
121Burning sensationOFFSIDES
122Cancer PainOFFSIDES
123Cardiac stress test abnormalOFFSIDES
124Cardiac ventricular disorderOFFSIDES
125Cataract operationOFFSIDES
126Cerebral cystOFFSIDES
127Choking sensationOFFSIDES
128CholangiolitisOFFSIDES
129Chronic left ventricular failureOFFSIDES
130Circumstance or information capable of leading to medication errorOFFSIDES
131CirrhosisOFFSIDES
132Colon adenomaOFFSIDES
133Completed SuicideOFFSIDES
134Congenital tricuspid valve incompetenceOFFSIDES
135CryingOFFSIDES
136CystoceleOFFSIDES
137DependenceOFFSIDES
138Device FailureOFFSIDES
139DiabetesOFFSIDES
140Diabetes mellitus inadequate controlOFFSIDES
141Diabetic RetinopathyOFFSIDES
142Diastolic dysfunctionOFFSIDES
143Disease recurrenceOFFSIDES
144Disseminated Intravascular CoagulationOFFSIDES
145DiverticulosisOFFSIDES
146DrowsinessOFFSIDES
147Drug withdrawal headacheOFFSIDES
148Dysthymic DisorderOFFSIDES
149Ejection Fraction DecreasedOFFSIDES
150Electrocardiogram ST segment abnormalOFFSIDES
151Electrocardiogram ST-T changeOFFSIDES
152Electromechanical dissociationOFFSIDES
153Erosive gastritisOFFSIDES
154ExcoriationOFFSIDES
155Febrile infectionOFFSIDES
156Fluid overloadOFFSIDES
157FormicationOFFSIDES
158Full blood count decreasedOFFSIDES
159GangreneOFFSIDES
160GastroenteritisOFFSIDES
161Gastrointestinal motility disorderOFFSIDES
162Genital rashOFFSIDES
163Glasgow coma scaleOFFSIDES
164GlobulinuriaOFFSIDES
165GoiterOFFSIDES
166GranulocytosisOFFSIDES
167HemiparesisOFFSIDES
168Heparin-induced thrombocytopeniaOFFSIDES
169Hepatic cancer metastaticOFFSIDES
170HyperreflexiaOFFSIDES
171Incision site erythemaOFFSIDES
172IncoherentOFFSIDES
173Infected cystOFFSIDES
174Intentional misuseOFFSIDES
175Intentional self-injuryOFFSIDES
176Intracranial meningioma malignantOFFSIDES
177Intraocular inflammationOFFSIDES
178Jugular vein distensionOFFSIDES
179LeukoencephalopathyOFFSIDES
180Leukopenia neonatalOFFSIDES
181Lymphocyte stimulation test positiveOFFSIDES
182Malignant ascitesOFFSIDES
183Malignant neoplasm progressionOFFSIDES
184Mediastinal massOFFSIDES
185Metabolic acidosisOFFSIDES
186Middle insomniaOFFSIDES
187Multiple drug overdoseOFFSIDES
188Multiple drug overdose intentionalOFFSIDES
189Musculoskeletal stiffnessOFFSIDES
190Nervous tensionOFFSIDES
191Neuroleptic Malignant SyndromeOFFSIDES
192OligohydramniosOFFSIDES
193PCO2 decreasedOFFSIDES
194PO2 decreasedOFFSIDES
195ParanoiaOFFSIDES
196Peripheral arterial occlusive diseaseOFFSIDES
197Pneumocystis jiroveci pneumoniaOFFSIDES
198Post procedural complicationOFFSIDES
199Post procedural painOFFSIDES
200Pregnancy with contraceptive deviceOFFSIDES
201Pulmonary HypertensionOFFSIDES
202PurulenceOFFSIDES
203Pustular psoriasisOFFSIDES
204PyuriaOFFSIDES
205QRS axis abnormalOFFSIDES
206RectoceleOFFSIDES
207Refusal of treatment by relativeOFFSIDES
208Renal cystOFFSIDES
209Renal tubular acidosisOFFSIDES
210Retinal Artery OcclusionOFFSIDES
211Retinal aneurysmOFFSIDES
212Retinal vascular occlusionOFFSIDES
213SarcoidosisOFFSIDES
214SeptoplastyOFFSIDES
215Sick Sinus SyndromeOFFSIDES
216Sinus bradycardiaOFFSIDES
217Skin ErosionOFFSIDES
218Supraventricular tachycardiaOFFSIDES
219Temperature regulation disorderOFFSIDES
220Therapy non-responderOFFSIDES
221Tinea PedisOFFSIDES
222Troponin TOFFSIDES
223Troponin increasedOFFSIDES
224Urge IncontinenceOFFSIDES
225Vascular calcificationOFFSIDES
226Venous InsufficiencyOFFSIDES
227Venous stasisOFFSIDES
228Ventricular hypokinesiaOFFSIDES
229Weight GainOFFSIDES
230keratoacanthomaOFFSIDES
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