MetaADEDB 2.0 @ LMMD
Flecainide
(DJBNUMBKLMJRSA-UHFFFAOYSA-N)
Structure
SMILES
O=C(c1cc(OCC(F)(F)F)ccc1OCC(F)(F)F)NCC1CCCCN1
Type(s)
Approved; Withdrawn
ATC code(s)
C01BC04
Molecular Formula:
C17H20F6N2O3
Molecular Weight:
414.343
Log P:
4.1604
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
2
TPSA:
59.59
CAS Number(s):
54143-55-4
Synonym(s)
1.
Flecainide
2.
Flecainide Acetate
3.
Apocard
4.
Flecadura
5.
Flecainid-Isis
6.
Flecainide Monoacetate
7.
Flecainide Monoacetate, (+-)-Isomer
8.
Flecainide Monoacetate, (R)-Isomer
9.
Flecainide Monoacetate, (S)-Isomer
10.
Flecainide, (R)-Isomer
11.
Flecainide, (S)-Isomer
12.
Flecainide, 5-HO-N-(6-oxo)-Derivative
13.
Flecainide, 5-HO-N-(6-oxo)-Derivative, (+-)-Isomer
14.
Flecatab
15.
Flécaïne
16.
R818
17.
Tambocor
18.
Flecainid Isis
External Link(s)
MeSHD005424
PubChem Compound3356
BindingDB50131434
ChEBI75984
CHEMBLCHEMBL652
DrugBankDB01195
DrugCentral1176
IUPHAR/BPS Guide to PHARMACOLOGY2560
KEGGcpd:C07001
dr:D07962
Therapeutic Target DatabaseD03DAP
D0N5FI
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Toxicity to various agentsFAERS: 80
Canada Vigilance: 1		Canada Vigilance
US FAERS
2TachycardiaFAERS: 28

View details

1898629
2480856
3117552
10793448
15638992
19298558
 		CTD
SIDER
US FAERS
3HypotensionFAERS: 261975861
20736205		CTD
SIDER
US FAERS
4Cardiac ArrestFAERS: 25SIDER
US FAERS
5Drug ineffectiveFAERS: 24
Canada Vigilance: 2		Canada Vigilance
US FAERS
6BradycardiaFAERS: 2011932086
22744888		CTD
OFFSIDES
SIDER
US FAERS
7OverdoseFAERS: 20US FAERS
8Product quality issueFAERS: 18US FAERS
9Atrial FibrillationFAERS: 16

View details

1509993
1510001
1514492
1898998
1899432
2513143
3127189
3149084
8074041
8607392
8607395
9290572
15312873
16805213
18376118
19531695
20736205
 		CTD
US FAERS
10Atrial FlutterFAERS: 16

View details

1577021
8407013
9124022
10729843
15312873
15546305
15683478
18286943
20219811
 		CTD
OFFSIDES
US FAERS
11DizzinessFAERS: 15
Canada Vigilance: 1		8077075
8607395
19298558		CTD
OFFSIDES
SIDER
Canada Vigilance
US FAERS
12SyncopeFAERS: 1512930510
17452686
19140927		CTD
SIDER
US FAERS
13Accidental overdoseFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
14Drug level increasedFAERS: 11
Canada Vigilance: 1		Canada Vigilance
US FAERS
15Acute kidney injuryFAERS: 109798462CTD
US FAERS
16Electrocardiogram abnormalFAERS: 10US FAERS
17Incorrect dose administeredFAERS: 8US FAERS
18AstheniaFAERS: 7OFFSIDES
SIDER
US FAERS
19CardiotoxicityFAERS: 7US FAERS
20NauseaFAERS: 7SIDER
US FAERS
21PalpitationsFAERS: 7SIDER
US FAERS
22HeadacheFAERS: 68607395CTD
SIDER
US FAERS
23LethargyFAERS: 6US FAERS
24Suicide attemptFAERS: 6US FAERS
25Supraventricular tachycardiaFAERS: 6US FAERS
26Electrolyte imbalanceFAERS: 5US FAERS
27Medication ErrorFAERS: 5US FAERS
28Mental status changesFAERS: 5US FAERS
29Metabolic acidosisFAERS: 5US FAERS
30Product substitution issueFAERS: 5
Canada Vigilance: 2		Canada Vigilance
US FAERS
31TremorFAERS: 5
Canada Vigilance: 1		Canada Vigilance
SIDER
US FAERS
32Ventricular FibrillationFAERS: 5

View details

2510412
3950909
8364947
8913906
12687841
12975443
18599870
19897501
 		CTD
SIDER
US FAERS
33Accidental exposure to productFAERS: 4US FAERS
34Atrial tachycardiaFAERS: 4US FAERS
35Bifascicular blockFAERS: 4US FAERS
36Completed SuicideFAERS: 4
Canada Vigilance: 1		Canada Vigilance
US FAERS
37FatigueFAERS: 4
Canada Vigilance: 1		17452686CTD
SIDER
Canada Vigilance
US FAERS
38PresyncopeFAERS: 4SIDER
US FAERS
39SomnolenceFAERS: 4SIDER
US FAERS
40Adrenocortical insufficiency chronicFAERS: 3US FAERS
41Cardiac dysfunctionFAERS: 3
Canada Vigilance: 2		Canada Vigilance
US FAERS
42Chest discomfortFAERS: 3US FAERS
43CyanosisFAERS: 3US FAERS
44Epigastric discomfortFAERS: 3US FAERS
45ErythemaFAERS: 3US FAERS
46MalaiseFAERS: 3SIDER
US FAERS
47Maternal exposure during pregnancyFAERS: 3US FAERS
48Muscle RigidityFAERS: 3US FAERS
49PoisoningFAERS: 3US FAERS
50Product dispensing errorFAERS: 3US FAERS
51Respiratory FailureFAERS: 3US FAERS
52TachyarrhythmiaFAERS: 3US FAERS
53Unmasking of previously unidentified diseaseFAERS: 3US FAERS
54Unresponsive to stimuliFAERS: 3US FAERS
55UrticariaFAERS: 3SIDER
US FAERS
56Visual ImpairmentFAERS: 3SIDER
US FAERS
57AgitationFAERS: 2US FAERS
58ArthralgiaFAERS: 2SIDER
US FAERS
59AtaxiaFAERS: 2SIDER
US FAERS
60Autonomic neuropathyFAERS: 2US FAERS
61BlindnessFAERS: 2US FAERS
62Cerebrovascular accidentFAERS: 2US FAERS
63ChokingFAERS: 2US FAERS
64Device malfunctionFAERS: 2US FAERS
65DiplopiaFAERS: 2OFFSIDES
SIDER
US FAERS
66Drug dispensing errorFAERS: 2US FAERS
67DysarthriaFAERS: 23099275CTD
US FAERS
68DysphoniaFAERS: 2OFFSIDES
SIDER
US FAERS
69Exposure via ingestionFAERS: 2US FAERS
70Feeling abnormalFAERS: 2SIDER
US FAERS
71Foreign body in respiratory tractFAERS: 2US FAERS
72HypersensitivityFAERS: 2US FAERS
73HypoperfusionFAERS: 2US FAERS
74HypophagiaFAERS: 2OFFSIDES
US FAERS
75Pharmaceutical product complaintFAERS: 2US FAERS
76Post-anoxic myoclonusFAERS: 2US FAERS
77Product preparation errorFAERS: 2US FAERS
78ShockFAERS: 2SIDER
US FAERS
79Sinus TachycardiaFAERS: 2US FAERS
80Sinus bradycardiaFAERS: 2SIDER
US FAERS
81Slow response to stimuliFAERS: 2US FAERS
82Systolic dysfunctionFAERS: 2US FAERS
83Throat irritationFAERS: 2US FAERS
84Ventricular DysfunctionFAERS: 2US FAERS
85VomitingFAERS: 2SIDER
US FAERS
86treatment failureFAERS: 2US FAERS
87Abdominal PainFAERS: 1SIDER
US FAERS
88Abdominal discomfortFAERS: 1US FAERS
89Accidental exposure to product by childFAERS: 1US FAERS
90Adverse eventFAERS: 1US FAERS
91AngerFAERS: 1US FAERS
92Anticoagulation drug level below therapeuticFAERS: 1US FAERS
93Antiphospholipid SyndromeFAERS: 1US FAERS
94ArteriosclerosisFAERS: 1US FAERS
95Atrioventricular conduction time shortenedFAERS: 1US FAERS
96Blood creatinine increasedFAERS: 1US FAERS
97Blood potassium decreasedFAERS: 1OFFSIDES
US FAERS
98Blood pressure fluctuationFAERS: 1US FAERS
99Cardiac ablationFAERS: 1US FAERS
100Cardioactive drug level above therapeuticFAERS: 1US FAERS
101Chest PainFAERS: 17811145CTD
SIDER
US FAERS
102ChillsFAERS: 1US FAERS
103Cold sweatFAERS: 1US FAERS
104CryingFAERS: 1US FAERS
105DehydrationFAERS: 1OFFSIDES
US FAERS
106Depressed moodFAERS: 1US FAERS
107Device pacing issueFAERS: 1US FAERS
108DiverticulumFAERS: 1US FAERS
109Drug level above therapeuticFAERS: 1US FAERS
110Drug level below therapeuticFAERS: 1US FAERS
111Drug level decreasedFAERS: 1US FAERS
112Drug prescribing errorFAERS: 1US FAERS
113Drug screen positiveFAERS: 1US FAERS
114Dry skinFAERS: 1OFFSIDES
US FAERS
115DysgeusiaFAERS: 1OFFSIDES
SIDER
US FAERS
116DyspepsiaFAERS: 1OFFSIDES
SIDER
US FAERS
117Ejection Fraction DecreasedFAERS: 1OFFSIDES
US FAERS
118Ejection fraction abnormalFAERS: 1US FAERS
119EnteritisFAERS: 1US FAERS
120Feeding disorder neonatalFAERS: 1US FAERS
121Feeling ColdFAERS: 1US FAERS
122FormicationFAERS: 1US FAERS
123Gastrointestinal inflammationFAERS: 1US FAERS
124HypokinesiaFAERS: 1US FAERS
125HypoxiaFAERS: 1US FAERS
126Impaired driving abilityFAERS: 1US FAERS
127Impaired work abilityFAERS: 1US FAERS
128Joint swellingFAERS: 1US FAERS
129Memory impairmentFAERS: 1US FAERS
130MetamorphopsiaFAERS: 1US FAERS
131Muscle tightnessFAERS: 1US FAERS
132Musculoskeletal PainFAERS: 1US FAERS
133Myocardial necrosisFAERS: 1US FAERS
134MyoclonusFAERS: 17526455
18376118		CTD
US FAERS
135Neck PainFAERS: 1US FAERS
136Negative cardiac inotropic effectFAERS: 1US FAERS
137NervousnessFAERS: 1SIDER
US FAERS
138NeutropeniaFAERS: 1US FAERS
139Oropharyngeal blisteringFAERS: 1US FAERS
140PainFAERS: 1SIDER
US FAERS
141PolyneuropathyFAERS: 1US FAERS
142Poor feeding infantFAERS: 1US FAERS
143Product administration errorFAERS: 1US FAERS
144Product contamination physicalFAERS: 1US FAERS
145PruritusFAERS: 1SIDER
US FAERS
146Pulmonary congestionFAERS: 1US FAERS
147Pulmonary toxicityFAERS: 1US FAERS
148StomatitisFAERS: 1US FAERS
149Therapeutic response unexpected with drug substitutionFAERS: 1US FAERS
150Unevaluable eventFAERS: 1US FAERS
151Ventricular arrhythmiaFAERS: 1US FAERS
152Vitreous DetachmentFAERS: 1US FAERS
153Weight decreasedFAERS: 1US FAERS
154WheezingFAERS: 1US FAERS
155AbasiaOFFSIDES
156AcidosisOFFSIDES
157Activities of daily living impairedOFFSIDES
158Affective Disorders, Psychotic3127189CTD
159AgeusiaSIDER
160AgranulocytosisSIDER
161AgraphiaOFFSIDES
162Alkaline phosphatase serum increasedSIDER
163AlopeciaSIDER
164AmnesiaSIDER
165Angina PectorisSIDER
166AngioedemaOFFSIDES
167Anorectal discomfortOFFSIDES
168AnorexiaSIDER
169Anxiety Disorders7526455CTD
170AnxietyCanada Vigilance: 1Canada Vigilance
SIDER
171ApathySIDER
172Arteritis obliteransOFFSIDES
173ArthropathyOFFSIDES
174AscitesOFFSIDES
175Atrioventricular BlockOFFSIDES
SIDER
176AzoospermiaOFFSIDES
177Blood GlucoseOFFSIDES
178Blood alkaline phosphatase increasedOFFSIDES
SIDER
179Blood creatine phosphokinase decreasedOFFSIDES
180Blood fibrinogen increasedOFFSIDES
181Blood sodiumOFFSIDES
182Blurred visionOFFSIDES
183Body TemperatureOFFSIDES
184BotulismOFFSIDES
185BronchitisOFFSIDES
186BronchospasmSIDER
187Bundle-Branch Block7811145
10793448
12687841		CTD
188Cataract operationOFFSIDES
189CataractOFFSIDES
190CholestasisSIDER
191Clostridium colitisOFFSIDES
192Confusion20736205CTD
193ConstipationSIDER
194Cytolytic hepatitisOFFSIDES
195DeafnessSIDER
196Delirium19531695CTD
197Delusional disorder, persecutory typeOFFSIDES
198Depressed Level of ConsciousnessSIDER
199DermatitisSIDER
200DiarrheaOFFSIDES
201DiscomfortSIDER
202Disturbance in sexual arousalSIDER
203DyslexiaOFFSIDES
204Dyspnea8077075CTD
205DysuriaSIDER
206Ear discomfortOFFSIDES
207Electrocardiogram ST segment abnormalOFFSIDES
208Erectile dysfunctionCanada Vigilance: 1Canada Vigilance
SIDER
209Euphoric moodSIDER
210Eye painOFFSIDES
SIDER
211Flat affectSIDER
212FlatulenceSIDER
213FlushingSIDER
214Gastric ulcerOFFSIDES
215Gastrointestinal PainSIDER
216General physical health deteriorationOFFSIDES
217Hallucinations3099275
7526455		CTD
218Heart Block3136088
3717029		CTD
219Heart failure8607395CTD
220HemiparesisOFFSIDES
SIDER
221Hepatitis3149084CTD
OFFSIDES
222HiccoughOFFSIDES
223HypertrichosisSIDER
224Hypoaesthesia facialOFFSIDES
225Hypokalemia17452686CTD
226Hyponatremia17452686
19298558		CTD
227ImmobileOFFSIDES
228InfertilityOFFSIDES
229Intention tremorOFFSIDES
230Intestinal ObstructionOFFSIDES
231Intraocular inflammationOFFSIDES
232LaryngospasmSIDER
233LeukoencephalopathyOFFSIDES
234LeukopeniaSIDER
235LightheadednessSIDER
236Lip swellingSIDER
237Long QT Syndrome17056139
24052561		CTD
238LymphedemaOFFSIDES
239MassageOFFSIDES
240MegacolonOFFSIDES
241Morbid dreamsSIDER
242Motor retardationOFFSIDES
243Musculoskeletal discomfortSIDER
244MyalgiaSIDER
245Myocardial Infarction3105568CTD
246Neuromuscular Diseases2105626CTD
247NeuropathySIDER
248Nipple painOFFSIDES
249Non-cardiac chest painOFFSIDES
250NystagmusSIDER
251ParanoiaSIDER
252Paranoid reactionSIDER
253ParesisSIDER
254Paresthesia1330141CTD
255Performance status decreasedOFFSIDES
256Peripheral Nervous System Diseases1330141
16076915		CTD
257PhotophobiaSIDER
258PlasmacytomaOFFSIDES
259PneumoniaSIDER
260PolyuriaCanada Vigilance: 1Canada Vigilance
SIDER
261Progesterone receptor assayOFFSIDES
262Pulmonary FibrosisSIDER
263PyeloplastyOFFSIDES
264Renal cystOFFSIDES
265Saliva alteredOFFSIDES
266ScotomaSIDER
267Seizures2513205CTD
268Shock, Cardiogenic1354292
3141115
11373489		CTD
269Sick Sinus Syndrome1898629
19018229		CTD
OFFSIDES
270Sinus Arrest, Cardiac1514492
8364947
8607395		CTD
271Sinus polypOFFSIDES
272SnoringOFFSIDES
273Spots before eyesSIDER
274StridorOFFSIDES
275StuporSIDER
276Tachycardia, Paroxysmal1509993
1899432
8607395		CTD
277Tachycardia, Reciprocating1721165CTD
278Tachycardia, Ventricular

View details

1975861
2500880
2510412
3113836
3136716
3717029
3950909
7064795
7648679
7755819
7850964
8077075
8364947
12687841
16715868
18599870
19897501
21743453
 		CTD
279Tension HeadacheOFFSIDES
280TensionSIDER
281Therapeutic product effect incompleteCanada Vigilance: 1Canada Vigilance
282ThrombocytopeniaSIDER
283TinnitusSIDER
284Torsades de Pointes

View details

2120306
3146965
11227957
12930510
17056139
17467628
 		CTD
285Urinary Retention2106405CTD
SIDER
286Urine output increasedSIDER
287VertigoSIDER
288Vision Disorders1514492
8607395		CTD
289Visual disturbanceSIDER
290Wolff-Parkinson-White Syndrome3830711CTD
291jaundiceSIDER
292nervous system disorderSIDER
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