MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Ertapenem

(JUZNIMUFDBIJCM-ANEDZVCMSA-N)

Structure

SMILES: O=C([C@H]1NC[C@H](C1)SC1=C(C(=O)O)N2[C@H]([C@H]1C)[C@H](C2=O)[C@H](O)C)Nc1cccc(c1)C(=O)O
Type(s): Approved; Investigational
ATC code(s): J01DH03
Molecular Formula:: C22H25N3O7S
Molecular Weight:: 475.515
Log P:: 1.2804
Hydrogen Bond Acceptor:: 11
Hydrogen Bond Donor:: 5
TPSA:: 181.57
CAS Number(s):: 153832-46-3

Synonym(s)

Ertapenem

Ertapenem Sodium

Invanoz

Invanz

External Link(s)

MeSH	D000077727
PubChem Compound	150610
ChEBI	404903
CHEMBL	CHEMBL1359
DrugBank	DB00303
DrugCentral	1046
KEGG	dr:D07908
Therapeutic Target Database	D0Q1MS
ZINC	3918453

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Mental status changes	FAERS: 14		OFFSIDES SIDER US FAERS
2	Pruritus	FAERS: 7		SIDER US FAERS
3	Urticaria	FAERS: 6		SIDER US FAERS
4	Agitation	FAERS: 5		SIDER US FAERS
5	Abdominal Pain	FAERS: 4		OFFSIDES SIDER US FAERS
6	Delirium	FAERS: 3		SIDER US FAERS
7	Unresponsive to stimuli	FAERS: 3		US FAERS
8	Angioedema	FAERS: 2		US FAERS
9	Asthenia	FAERS: 2		OFFSIDES SIDER US FAERS
10	Bradycardia	FAERS: 2		SIDER US FAERS
11	Erythema Multiforme	FAERS: 2		US FAERS
12	Hypotension	FAERS: 2		SIDER US FAERS
13	Myoclonus	FAERS: 2		SIDER US FAERS
14	Status Epilepticus	FAERS: 2		OFFSIDES US FAERS
15	Stevens-Johnson Syndrome	FAERS: 2		US FAERS
16	Tardive Dyskinesia	FAERS: 2		US FAERS
17	Therapy cessation	FAERS: 2		US FAERS
18	Therapy change	FAERS: 2		US FAERS
19	Tremor	FAERS: 2		SIDER US FAERS
20	Abasia	FAERS: 1		OFFSIDES US FAERS
21	Abdominal tenderness	FAERS: 1		US FAERS
22	Anticonvulsant drug level decreased	FAERS: 1		OFFSIDES US FAERS
23	Aphasia	FAERS: 1		US FAERS
24	Arthralgia	FAERS: 1		SIDER US FAERS
25	Arthritis	FAERS: 1		US FAERS
26	Ataxia	FAERS: 1		US FAERS
27	Atrial Fibrillation	FAERS: 1		SIDER US FAERS
28	Blood potassium abnormal	FAERS: 1		US FAERS
29	Clostridium difficile infection	FAERS: 1		US FAERS
30	Dermatitis	FAERS: 1		SIDER US FAERS
31	Drug ineffective	FAERS: 1		US FAERS
32	Drug level increased	FAERS: 1		US FAERS
33	Dysarthria	FAERS: 1		US FAERS
34	Feeling abnormal	FAERS: 1		SIDER US FAERS
35	General physical health deterioration	FAERS: 1		US FAERS
36	Hallucinations, mixed	FAERS: 1		US FAERS
37	Hemiparesis	FAERS: 1		US FAERS
38	Hypersensitivity	FAERS: 1		SIDER US FAERS
39	Lethargy	FAERS: 1		OFFSIDES US FAERS
40	Leukocytosis	FAERS: 1		US FAERS
41	Medication Error	FAERS: 1		US FAERS
42	Myoclonic Epilepsy	FAERS: 1		OFFSIDES US FAERS
43	Nausea	FAERS: 1		SIDER US FAERS
44	Neck Pain	FAERS: 1		US FAERS
45	Peripheral swelling	FAERS: 1		US FAERS
46	Rash erythematous	FAERS: 1		SIDER US FAERS
47	Screaming	FAERS: 1		US FAERS
48	Seizure like phenomena	FAERS: 1		US FAERS
49	Serum Sickness	FAERS: 1		US FAERS
50	Sluggishness	FAERS: 1		US FAERS
51	Somnolence	FAERS: 1		SIDER US FAERS
52	Staring	FAERS: 1		US FAERS
53	Tonic clonic movements	FAERS: 1		US FAERS
54	Wheezing	FAERS: 1		SIDER US FAERS
55	jaundice	FAERS: 1		SIDER US FAERS
56	nervous system disorder	FAERS: 1		SIDER US FAERS
57	Abdominal Abscess			OFFSIDES SIDER
58	Abdominal discomfort			OFFSIDES
59	Abscess			OFFSIDES
60	Accidental exposure			OFFSIDES
61	Acid reflux			OFFSIDES
62	Actinomycosis			OFFSIDES
63	Acute psychosis			OFFSIDES
64	Adenocarcinoma			OFFSIDES
65	Administration site infection			OFFSIDES
66	Adverse event			OFFSIDES
67	Alanine Aminotransferase Increased			OFFSIDES SIDER
68	Alopecia			OFFSIDES
69	Altered state of consciousness			SIDER
70	Alveoloplasty			OFFSIDES
71	Anaphylactic shock			SIDER
72	Anaphylactoid Reaction			SIDER
73	Anastomotic Leak			SIDER
74	Anorexia			SIDER
75	Antidepressant drug clearance decreased			OFFSIDES
76	Antiphospholipid Antibodies			OFFSIDES
77	Anuria			SIDER
78	Anxiety			OFFSIDES SIDER
79	Aphagia			OFFSIDES
80	Appendectomy			OFFSIDES
81	Appendicitis			OFFSIDES
82	Aspartate Aminotransferase Increased			SIDER
83	Asthma			OFFSIDES SIDER
84	Atelectasis			OFFSIDES SIDER
85	Aura			OFFSIDES
86	Automatism			OFFSIDES
87	Belligerence			OFFSIDES
88	Bladder dysfunction			SIDER
89	Blood Glucose			OFFSIDES
90	Blood albumin decreased			SIDER
91	Blood alkaline phosphatase increased			SIDER
92	Blood amylase increased			OFFSIDES
93	Blood and lymphatic system disorders			SIDER
94	Blood cholesterol			OFFSIDES
95	Blood creatinine increased			SIDER
96	Blood glucose abnormal			OFFSIDES
97	Blood glucose increased			SIDER
98	Blood lactate dehydrogenase increased			OFFSIDES
99	Blood potassium decreased			SIDER
100	Blood potassium increased			SIDER
101	Blood potassium			OFFSIDES
102	Blood urine present			SIDER
103	Bone erosion			OFFSIDES
104	Bone fragmentation			OFFSIDES
105	Bone lesion			OFFSIDES
106	Bone pain			OFFSIDES
107	Bone swelling			OFFSIDES
108	Brain Abscess			OFFSIDES
109	Breast cancer recurrent			OFFSIDES
110	Bronchoconstriction			SIDER
111	Bronchopneumonia			OFFSIDES
112	Bronchospasm			SIDER
113	Bursitis			OFFSIDES
114	Butterfly rash			OFFSIDES
115	CREST Syndrome			OFFSIDES
116	Cardiac Arrest			SIDER
117	Cardioactive drug level			OFFSIDES
118	Carotid bruit			OFFSIDES
119	Cartilage atrophy			OFFSIDES
120	Cataract operation			OFFSIDES
121	Cataract			OFFSIDES
122	Catheter sepsis			OFFSIDES
123	Catheter site infection			OFFSIDES
124	Cellulitis			OFFSIDES SIDER
125	Cerebrovascular accident			SIDER
126	Cervical myelopathy			OFFSIDES
127	Chest Pain			OFFSIDES SIDER
128	Chills			SIDER
129	Cholecystitis			SIDER
130	Cholelithiasis			SIDER
131	Chronic ulcerative colitis			OFFSIDES
132	Circumstance or information capable of leading to medication error			OFFSIDES
133	Citrobacter sepsis			OFFSIDES
134	Clostridium colitis			SIDER
135	Clostridium difficile toxin test positive			OFFSIDES
136	Colectomy			OFFSIDES
137	Colitis			SIDER
138	Complex partial seizures			OFFSIDES
139	Confabulation			OFFSIDES
140	Congenital tricuspid valve incompetence			OFFSIDES
141	Constipation			SIDER
142	Corneal Ulcer			OFFSIDES
143	Debridement			OFFSIDES
144	Dehydration			SIDER
145	Dental abscess			OFFSIDES
146	Dental caries			OFFSIDES
147	Depressed Level of Consciousness			SIDER
148	Depressed mood			OFFSIDES
149	Device Failure			OFFSIDES
150	Diabetes Mellitus			SIDER
151	Diabetic foot infection			OFFSIDES
152	Diabetic			SIDER
153	Diarrhea			OFFSIDES
154	Discomfort			SIDER
155	Disorientation			SIDER
156	Diverticulum			OFFSIDES
157	Dizziness			SIDER
158	Drowsiness			OFFSIDES
159	Drug resistance			OFFSIDES
160	Duodenitis			SIDER
161	Dysgeusia			SIDER
162	Dyspepsia			SIDER
163	Dysphonia			SIDER
164	Dysuria			SIDER
165	Emotional distress			OFFSIDES
166	Encephalitis			OFFSIDES
167	Endocarditis			OFFSIDES
168	Endodontic procedure			OFFSIDES
169	Enteritis			OFFSIDES SIDER
170	Enterobacter pneumonia			OFFSIDES
171	Enterococcal infection			OFFSIDES
172	Eosinophilia			SIDER
173	Epilepsy			OFFSIDES
174	Epistaxis			SIDER
175	Epithelial cells urine			SIDER
176	Erythema			SIDER
177	Escherichia coli Infections		20805395	CTD
178	Escherichia infection			OFFSIDES
179	Extravasation			SIDER
180	Eye laser surgery			OFFSIDES
181	Facial Neuralgia			OFFSIDES
182	Fatigue			OFFSIDES SIDER
183	Femoral artery occlusion			OFFSIDES
184	Fistula discharge			OFFSIDES
185	Fistula repair			OFFSIDES
186	Flank Pain			SIDER
187	Flat affect			OFFSIDES
188	Flatulence			SIDER
189	Flushing			SIDER
190	Formication			OFFSIDES
191	Fungal rash			SIDER
192	Gangrene			OFFSIDES
193	Gastric ulcer			SIDER
194	Gastritis			SIDER
195	Gastroduodenitis			OFFSIDES
196	Gastrointestinal Pain			SIDER
197	Gastrointestinal stoma complication			SIDER
198	Gaze palsy			OFFSIDES
199	General symptom			OFFSIDES
200	Genital infection fungal			OFFSIDES
201	Genital rash			SIDER
202	Gliosis			OFFSIDES
203	Glomerulonephritis			OFFSIDES
204	Glucose increased			SIDER
205	Gout			SIDER
206	Granuloma			OFFSIDES
207	Headache			SIDER
208	Hepatic Infarction			OFFSIDES
209	Hiccough			OFFSIDES
210	Hydronephrosis			OFFSIDES
211	Hypoaesthesia facial			OFFSIDES
212	Hypophagia			OFFSIDES
213	Hypoxemia			SIDER
214	Hypoxia			OFFSIDES SIDER
215	Ileus			SIDER
216	Immobile			OFFSIDES
217	Impatience			OFFSIDES
218	Incision site complication			SIDER
219	Induration			OFFSIDES SIDER
220	Infection			OFFSIDES SIDER
221	Infestation			SIDER
222	Infusion site burning			SIDER
223	Infusion site erythema			SIDER
224	Infusion site induration			SIDER
225	Infusion site pain			SIDER
226	Infusion site phlebitis			SIDER
227	Infusion site pruritus			SIDER
228	Infusion site reaction			SIDER
229	Infusion site swelling			SIDER
230	Infusion site warmth			SIDER
231	Injection site dermatitis			OFFSIDES
232	Injection site erythema			SIDER
233	Injection site pain			SIDER
234	Injection site stinging			SIDER
235	Intervertebral Disc Degeneration			OFFSIDES
236	Intestinal stoma complication			SIDER
237	Kidney Failure			OFFSIDES
238	Leukoencephalopathy			OFFSIDES
239	Lipase			OFFSIDES
240	Liver Abscess			OFFSIDES
241	Lupus Nephritis			OFFSIDES
242	Lymphangiosis carcinomatosa			OFFSIDES
243	Malaise			SIDER
244	Malignant neoplasm progression			OFFSIDES
245	Malnutrition			SIDER
246	Malocclusion			OFFSIDES
247	Mental disorder due to a general medical condition			OFFSIDES
248	Mental impairment			OFFSIDES
249	Metastatic Neoplasm			OFFSIDES
250	Metatarsalgia			OFFSIDES
251	Mixed Connective Tissue Disease			OFFSIDES
252	Molluscum Contagiosum			OFFSIDES
253	Mononeuritis			OFFSIDES
254	Muscle Weakness			OFFSIDES
255	Muscle necrosis			OFFSIDES
256	Muscle tightness			OFFSIDES
257	Musculoskeletal Pain			SIDER
258	Musculoskeletal discomfort			SIDER
259	Nasopharyngitis			SIDER
260	Necrosis			SIDER
261	Nervousness			SIDER
262	Neutropenia			SIDER
263	Neutrophil count decreased			SIDER
264	Oliguria			OFFSIDES SIDER
265	Oral candidiasis			SIDER
266	Osteitis Deformans			OFFSIDES
267	Osteolysis			OFFSIDES
268	Osteomyelitis			OFFSIDES
269	Osteopenia			OFFSIDES
270	Osteoporosis			OFFSIDES
271	Osteoradionecrosis			OFFSIDES
272	Osteosclerosis			OFFSIDES
273	Pain in elbow			SIDER
274	Pain			OFFSIDES SIDER
275	Palmar erythema			OFFSIDES
276	Pancreatitis			OFFSIDES SIDER
277	Paranasal sinus mucosal hypertrophy			OFFSIDES
278	Parotidectomy			OFFSIDES
279	Parotitis			OFFSIDES
280	Pathogen resistance			OFFSIDES
281	Pelvic abscess			SIDER
282	Pelvic peritonitis			SIDER
283	Periodontitis			OFFSIDES
284	Peritonitis			SIDER
285	Petechiae			SIDER
286	Pharyngitis			SIDER
287	Phlebitis			SIDER
288	Physical disability			OFFSIDES
289	Plasmacytoma			OFFSIDES
290	Pleuritic pain			SIDER
291	Pneumonia			SIDER
292	Pneumothorax			SIDER
293	Poor dental condition			OFFSIDES
294	Post procedural infection			SIDER
295	Postoperative infection			SIDER
296	Pregnancy			SIDER
297	Protein urine present			SIDER
298	Proteinuria			SIDER
299	Pseudomonal sepsis			OFFSIDES
300	Pulmonary Embolism			SIDER
301	Pulmonary congestion			SIDER
302	Purulent discharge			OFFSIDES
303	Pyloric Stenosis			SIDER
304	Radiation mucositis			OFFSIDES
305	Rales			SIDER
306	Regurgitation			SIDER
307	Renal abscess			OFFSIDES
308	Renal cyst			OFFSIDES
309	Renal tubular necrosis			OFFSIDES
310	Respiratory Failure			OFFSIDES
311	Respiratory distress			SIDER
312	Respiratory tract congestion			SIDER
313	Restless Legs Syndrome			SIDER
314	Rhinitis			SIDER
315	Rhinorrhea			OFFSIDES
316	Rhonchi			SIDER
317	Risus sardonicus			OFFSIDES
318	Sacroiliitis			OFFSIDES
319	Scab			OFFSIDES
320	Scan bone marrow abnormal			OFFSIDES
321	Scleroderma			OFFSIDES
322	Sepsis			SIDER
323	Septic Shock			SIDER
324	Septicemia			SIDER
325	Sequestrectomy			OFFSIDES
326	Seroma			SIDER
327	Serum bilirubin increased			SIDER
328	Serum potassium decreased			SIDER
329	Serum potassium increased			SIDER
330	Shock			SIDER
331	Shoulder Pain			SIDER
332	Sinus bradycardia			OFFSIDES SIDER
333	Sinusitis			OFFSIDES
334	Sjogren's Syndrome			OFFSIDES
335	Skin Wrinkling			OFFSIDES
336	Skin laceration			OFFSIDES
337	Skin lesion			SIDER
338	Spinal column stenosis			OFFSIDES
339	Splenic Infarction			OFFSIDES
340	Splenic abscess			OFFSIDES
341	Stomatitis			SIDER
342	Stridor			OFFSIDES
343	Stupor			SIDER
344	Sweating			SIDER
345	Swelling			SIDER
346	Syncope			SIDER
347	Tachycardia			SIDER
348	Tension			SIDER
349	Thirst			SIDER
350	Thrombocytopenia			SIDER
351	Thrombocytosis			SIDER
352	Thrombophlebitis			SIDER
353	Tooth Erosion			OFFSIDES
354	Tooth Extraction			OFFSIDES
355	Tooth Loss			OFFSIDES
356	Toothache			SIDER
357	Transaminases increased			OFFSIDES
358	Urinary Retention			SIDER
359	Urinary sediment present			SIDER
360	Urinary tract infection			SIDER
361	Vaginal dryness			SIDER
362	Vasculitis			SIDER
363	Venoocclusive disease			OFFSIDES
364	Vertebroplasty			OFFSIDES
365	Vertigo			SIDER
366	Viral pharyngitis			SIDER
367	Vitreous Detachment			OFFSIDES
368	Voice Disturbance			SIDER
369	Vomiting			SIDER
370	Vulvovaginal dryness			SIDER
371	Vulvovaginal mycotic infection			OFFSIDES SIDER
372	Vulvovaginal pruritus			SIDER
373	Vulvovaginitis			SIDER
374	Weight decreased			SIDER
375	White blood cell count decreased			SIDER
376	Wound Complication			OFFSIDES SIDER
377	Wound Infection			SIDER
378	Wound dehiscence			SIDER
379	Wound infection staphylococcal			OFFSIDES
380	pseudomembranous colitis			SIDER
381	rhinoplasty			OFFSIDES
382	treatment failure			OFFSIDES

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