MetaADEDB 2.0 @ LMMD
Buprenorphine
(UAIXRPCCYXNJMQ-RZIPZOSSSA-N)
Structure
SMILES
CO[C@]12CC[C@]3(C[C@@H]1[C@@](C(C)(C)C)(O)C)[C@@]14[C@H]2Oc2c4c(C[C@H]3N(CC1)CC1CC1)ccc2O.Cl
Molecular Formula:
C29H42ClNO4
Molecular Weight:
504.101
Log P:
5.1537
Hydrogen Bond Acceptor:
5
Hydrogen Bond Donor:
3
TPSA:
62.16
CAS Number(s):
52485-79-7; 53152-21-9
Synonym(s)
1.
Buprenorphine
2.
6029-M
3.
Buprenex
4.
Buprenorphine Hydrochloride
5.
Buprex
6.
Prefin
7.
RX-6029-M
8.
Subutex
9.
Temgesic
10.
Temgésic
11.
6029 M
12.
6029M
13.
Hydrochloride, Buprenorphine
14.
RX 6029 M
15.
RX6029M
External Link(s)
MeSHD002047
PubChem Compound3033050
45265653
ChEBI652822
KEGGdr:D00836
Adverse Drug Event(s)
NameNumber of ReportsReference(s)Data Source
1Drug ineffectiveFAERS: 87
Canada Vigilance: 14
Canada Vigilance
US FAERS
2Drug exposure during pregnancyFAERS: 79US FAERS
3Intentional misuseFAERS: 70US FAERS
4Intentional drug misuseFAERS: 65US FAERS
5NauseaFAERS: 51US FAERS
6Product quality issueFAERS: 50US FAERS
7HeadacheFAERS: 41US FAERS
8Weight decreasedFAERS: 34US FAERS
9VomitingFAERS: 30
Canada Vigilance: 1
Canada Vigilance
US FAERS
10PainFAERS: 27US FAERS
11InflammationFAERS: 26US FAERS
12SomnolenceFAERS: 25US FAERS
13Drug withdrawal syndromeFAERS: 23
Canada Vigilance: 2
Canada Vigilance
US FAERS
14Medication ErrorFAERS: 23US FAERS
15EndocarditisFAERS: 19US FAERS
16MalaiseFAERS: 19US FAERS
17PregnancyFAERS: 19US FAERS
18Completed SuicideFAERS: 18US FAERS
19DizzinessFAERS: 18US FAERS
20AstheniaFAERS: 17US FAERS
21OverdoseFAERS: 17US FAERS
22Product taste abnormalFAERS: 17US FAERS
23DeliriumFAERS: 16US FAERS
24Feeling abnormalFAERS: 16US FAERS
25SepsisFAERS: 16US FAERS
26Wrong technique in product usage processFAERS: 16US FAERS
27CyanosisFAERS: 15US FAERS
28EndophthalmitisFAERS: 15US FAERS
29AnxietyFAERS: 14US FAERS
30Drug DependenceFAERS: 14US FAERS
31Drug abuserFAERS: 14US FAERS
32NecrosisFAERS: 14US FAERS
33PneumoniaFAERS: 14US FAERS
34Wrong technique in drug usage processFAERS: 14US FAERS
35Drug toxicityFAERS: 13US FAERS
36PneumothoraxFAERS: 13US FAERS
37AbscessFAERS: 12US FAERS
38LymphadenopathyFAERS: 12US FAERS
39Product adhesion issueFAERS: 12
Canada Vigilance: 6
Canada Vigilance
US FAERS
40PruritusFAERS: 12US FAERS
41AnorexiaFAERS: 11US FAERS
42Drug abuseFAERS: 11US FAERS
43FatigueFAERS: 11US FAERS
44General physical health deteriorationFAERS: 11US FAERS
45Incorrect route of drug administrationFAERS: 11US FAERS
46Toxicity to various agentsFAERS: 10US FAERS
47Accidental overdoseFAERS: 9US FAERS
48CandidiasisFAERS: 9US FAERS
49Chest PainFAERS: 9US FAERS
50Drug screen positiveFAERS: 9US FAERS
51Hepatitis CFAERS: 9US FAERS
52Product solubility abnormalFAERS: 9
Canada Vigilance: 1
Canada Vigilance
US FAERS
53Product substitution issueFAERS: 9US FAERS
54RestlessnessFAERS: 9US FAERS
55Abdominal PainFAERS: 8US FAERS
56GranulocytosisFAERS: 8US FAERS
57RhabdomyolysisFAERS: 8US FAERS
58StomatitisFAERS: 8US FAERS
59AscitesFAERS: 7US FAERS
60Cytolytic hepatitisFAERS: 7US FAERS
61GangreneFAERS: 7US FAERS
62Respiratory DepressionFAERS: 7US FAERS
63SwellingFAERS: 7US FAERS
64Injection site painFAERS: 6US FAERS
65Intentional product misuseFAERS: 6US FAERS
66Intentional product use issueFAERS: 6US FAERS
67LeukocytosisFAERS: 6US FAERS
68Maternal exposure during pregnancyFAERS: 6US FAERS
69PalpitationsFAERS: 6US FAERS
70Pulmonary EmbolismFAERS: 6US FAERS
71Subcutaneous AbscessFAERS: 6US FAERS
72Suicide attemptFAERS: 6US FAERS
73TremorFAERS: 6US FAERS
74AlopeciaFAERS: 5US FAERS
75ArthritisFAERS: 5US FAERS
76Back PainFAERS: 5US FAERS
77Cardiac ArrestFAERS: 5US FAERS
78Chest discomfortFAERS: 5US FAERS
79Deep Vein ThrombosisFAERS: 5US FAERS
80Depressed moodFAERS: 5
Canada Vigilance: 1
Canada Vigilance
US FAERS
81Drug screen negativeFAERS: 5US FAERS
82Epidermal necrosisFAERS: 5US FAERS
83EpilepsyFAERS: 5US FAERS
84Inappropriate schedule of drug administrationFAERS: 5US FAERS
85LymphopeniaFAERS: 5US FAERS
86Oral candidiasisFAERS: 5US FAERS
87PancreatitisFAERS: 5US FAERS
88Pulmonary sepsisFAERS: 5US FAERS
89PurpuraFAERS: 5US FAERS
90Septic ShockFAERS: 5US FAERS
91Skin necrosisFAERS: 5US FAERS
92StillbirthFAERS: 5US FAERS
93Abnormal palmar/plantar creasesFAERS: 4US FAERS
94Activities of daily living impairedFAERS: 4US FAERS
95AgitationFAERS: 4US FAERS
96Alanine Aminotransferase IncreasedFAERS: 4US FAERS
97Application site erythemaFAERS: 4US FAERS
98Aspartate Aminotransferase IncreasedFAERS: 4US FAERS
99Cerebrovascular accidentFAERS: 4US FAERS
100ChillsFAERS: 4US FAERS
101ConstipationFAERS: 4US FAERS
102Drug dispensing errorFAERS: 4US FAERS
103EclampsiaFAERS: 4US FAERS
104ErysipelasFAERS: 4US FAERS
105FractureFAERS: 4US FAERS
106Hepatitis C positiveFAERS: 4US FAERS
107Inadequate analgesiaFAERS: 4US FAERS
108Incorrect dose administeredFAERS: 4US FAERS
109Intentional self-injuryFAERS: 4US FAERS
110LividityFAERS: 4US FAERS
111Metabolic acidosisFAERS: 4US FAERS
112MyositisFAERS: 4US FAERS
113Nephrotic SyndromeFAERS: 4US FAERS
114Product use issueFAERS: 4US FAERS
115ShockFAERS: 4US FAERS
116Skin noduleFAERS: 4US FAERS
117Unevaluable eventFAERS: 4US FAERS
118Urinary RetentionFAERS: 4US FAERS
119Abdominal discomfortFAERS: 3US FAERS
120Accidental drug intake by childFAERS: 3US FAERS
121Accidental exposure to productFAERS: 3US FAERS
122Acute myocardial infarctionFAERS: 3US FAERS
123Aortic AneurysmFAERS: 3US FAERS
124Application site pruritusFAERS: 3US FAERS
125Application site swellingFAERS: 3US FAERS
126AsphyxiaFAERS: 3US FAERS
127Atrial FibrillationFAERS: 3US FAERS
128Blood amylase increasedFAERS: 3US FAERS
129Bone infarctionFAERS: 3US FAERS
130Breakthrough PainFAERS: 3US FAERS
131Cholestasis of pregnancyFAERS: 3US FAERS
132CholestasisFAERS: 3US FAERS
133DementiaFAERS: 3US FAERS
134Depressed Level of ConsciousnessFAERS: 3US FAERS
135DisorientationFAERS: 3US FAERS
136Drug ineffective for unapproved indicationFAERS: 3US FAERS
137DysarthriaFAERS: 3US FAERS
138DysgeusiaFAERS: 3US FAERS
139DyspepsiaFAERS: 3US FAERS
140Euphoric moodFAERS: 3US FAERS
141GastroschisisFAERS: 3US FAERS
142Hallucinations, mixedFAERS: 3US FAERS
143HepatomegalyFAERS: 3US FAERS
144HypersensitivityFAERS: 3US FAERS
145Impaired gastric emptyingFAERS: 3US FAERS
146Inappropriate schedule of product administrationFAERS: 3US FAERS
147Injection Site ReactionFAERS: 3US FAERS
148Injection site abscessFAERS: 3US FAERS
149LethargyFAERS: 3US FAERS
150LeukoencephalopathyFAERS: 3US FAERS
151Lipase increasedFAERS: 3US FAERS
152LymphadenitisFAERS: 3US FAERS
153MicrocephalyFAERS: 3US FAERS
154MyalgiaFAERS: 3US FAERS
155NervousnessFAERS: 3US FAERS
156OliguriaFAERS: 3US FAERS
157Pre-EclampsiaFAERS: 3US FAERS
158Product formulation issueFAERS: 3US FAERS
159PyopneumothoraxFAERS: 3US FAERS
160Rash erythematousFAERS: 3US FAERS
161Respiratory distressFAERS: 3US FAERS
162Septic embolusFAERS: 3US FAERS
163Squamous cell carcinomaFAERS: 3US FAERS
164Toxicologic test abnormalFAERS: 3US FAERS
165UrticariaFAERS: 3US FAERS
166AmnesiaFAERS: 2US FAERS
167AneurysmFAERS: 2US FAERS
168AngerFAERS: 2US FAERS
169Application site irritationFAERS: 2US FAERS
170ArthropathyFAERS: 2US FAERS
171Burning sensationFAERS: 2US FAERS
172CachexiaFAERS: 2US FAERS
173Cardiac valve vegetationFAERS: 2US FAERS
174CellulitisFAERS: 2US FAERS
175Cerebral InfarctionFAERS: 2US FAERS
176ChorioamnionitisFAERS: 2US FAERS
177Cold sweatFAERS: 2US FAERS
178Complications of maternal exposure to therapeutic drugsFAERS: 2US FAERS
179Congenital intestinal malformationFAERS: 2US FAERS
180Denervation atrophyFAERS: 2US FAERS
181Dental cariesFAERS: 2US FAERS
182DependenceFAERS: 2US FAERS
183DermatitisFAERS: 2US FAERS
184DiscomfortFAERS: 2US FAERS
185Drug administered at inappropriate siteFAERS: 2US FAERS
186Drug administered to patient of inappropriate ageFAERS: 2US FAERS
187Drug effect incompleteFAERS: 2US FAERS
188Drug level increasedFAERS: 2US FAERS
189Drug resistanceFAERS: 2US FAERS
190Dry gangreneFAERS: 2US FAERS
191DysmorphismFAERS: 2US FAERS
192DysphoniaFAERS: 2US FAERS
193DysuriaFAERS: 2US FAERS
194Embolic strokeFAERS: 2US FAERS
195EmbolismFAERS: 2US FAERS
196Enamel anomalyFAERS: 2US FAERS
197ErythrocyanosisFAERS: 2US FAERS
198Escherichia urinary tract infectionFAERS: 2US FAERS
199Feeling ColdFAERS: 2US FAERS
200Gastrointestinal candidiasisFAERS: 2US FAERS
201HepatitisFAERS: 2US FAERS
202HepatotoxicityFAERS: 2US FAERS
203HyperreflexiaFAERS: 2US FAERS
204Incorrect drug administration durationFAERS: 2US FAERS
205Injection site necrosisFAERS: 2US FAERS
206Intercepted drug dispensing errorFAERS: 2US FAERS
207LymphomaFAERS: 2US FAERS
208Memory impairmentFAERS: 2US FAERS
209Mood swingsFAERS: 2US FAERS
210Muscle tightnessFAERS: 2US FAERS
211Myocardial InfarctionFAERS: 2US FAERS
212MyoclonusFAERS: 2US FAERS
213Neonatal aspirationFAERS: 2US FAERS
214NeuralgiaFAERS: 2US FAERS
215Opiates positiveFAERS: 2US FAERS
216Oral pruritusFAERS: 2US FAERS
217Oropharyngeal blisteringFAERS: 2US FAERS
218Oropharyngeal painFAERS: 2US FAERS
219Pancreatic carcinomaFAERS: 2US FAERS
220PanniculitisFAERS: 2US FAERS
221PneumoperitoneumFAERS: 2US FAERS
222PoisoningFAERS: 2US FAERS
223Poor sucking reflexFAERS: 2US FAERS
224Product dispensing errorFAERS: 2US FAERS
225Product use in unapproved indicationFAERS: 2US FAERS
226Pulmonary congestionFAERS: 2US FAERS
227Respiratory FailureFAERS: 2US FAERS
228Retinal DetachmentFAERS: 2US FAERS
229SacroiliitisFAERS: 2US FAERS
230Skin UlcerFAERS: 2US FAERS
231Therapeutic response unexpectedFAERS: 2US FAERS
232ThrombophlebitisFAERS: 2US FAERS
233ThrombosisFAERS: 2US FAERS
234Thyroid NeoplasmFAERS: 2US FAERS
235Tooth LossFAERS: 2US FAERS
236ToothacheFAERS: 2US FAERS
237Transcription medication errorFAERS: 2US FAERS
238Unresponsive to stimuliFAERS: 2US FAERS
239Unwanted pregnancyFAERS: 2US FAERS
240Vascular stenosisFAERS: 2US FAERS
241VitritisFAERS: 2US FAERS
242Accidental exposureFAERS: 1US FAERS
243Acute psychosisFAERS: 1US FAERS
244Administration site irritationFAERS: 1US FAERS
245Altered state of consciousnessFAERS: 1US FAERS
246Amino acid level increasedFAERS: 1US FAERS
247AnuriaFAERS: 1US FAERS
248ApathyFAERS: 1US FAERS
249Application site dischargeFAERS: 1US FAERS
250Application site erosionFAERS: 1US FAERS
251Application site hypersensitivityFAERS: 1US FAERS
252Application site painFAERS: 1US FAERS
253Application site rashFAERS: 1US FAERS
254Application site reactionFAERS: 1US FAERS
255Application site scarFAERS: 1US FAERS
256Application site woundFAERS: 1US FAERS
257ArthralgiaFAERS: 1US FAERS
258AsthmaFAERS: 1US FAERS
259AtaxiaFAERS: 1US FAERS
260AuraFAERS: 1US FAERS
261Bacillus infectionFAERS: 1US FAERS
262BedriddenFAERS: 1US FAERS
263Bladder painFAERS: 1US FAERS
264Blood alkaline phosphatase increasedFAERS: 1US FAERS
265Blood culture negativeFAERS: 1US FAERS
266Blood folate decreasedFAERS: 1US FAERS
267Blood glucose decreasedFAERS: 1US FAERS
268BradycardiaFAERS: 1US FAERS
269Brain ContusionFAERS: 1US FAERS
270Breast FeedingFAERS: 1US FAERS
271BronchiolitisFAERS: 1US FAERS
272BruxismFAERS: 1US FAERS
273Cardiac TamponadeFAERS: 1US FAERS
274Cardiac ablationFAERS: 1US FAERS
275Carotid artery occlusionFAERS: 1US FAERS
276Choking sensationFAERS: 1US FAERS
277CholecystitisFAERS: 1US FAERS
278Congenital cystic kidney diseaseFAERS: 1US FAERS
279Coronary Artery DiseaseFAERS: 1US FAERS
280Culture positiveFAERS: 1US FAERS
281CystFAERS: 1US FAERS
282DeafnessFAERS: 1US FAERS
283DehydrationFAERS: 1US FAERS
284Delusional disorder, persecutory typeFAERS: 1US FAERS
285Disease recurrenceFAERS: 1US FAERS
286DrowningFAERS: 1US FAERS
287Drug dose omissionFAERS: 1US FAERS
288Drug effect delayedFAERS: 1US FAERS
289Drug effect variableFAERS: 1US FAERS
290Drug level above therapeuticFAERS: 1US FAERS
291Drug prescribing errorFAERS: 1US FAERS
292Drug screen false positiveFAERS: 1US FAERS
293DyscheziaFAERS: 1US FAERS
294Enterobacter test positiveFAERS: 1US FAERS
295Enterococcal sepsisFAERS: 1US FAERS
296Enzyme level increasedFAERS: 1US FAERS
297EpistaxisFAERS: 1US FAERS
298Erectile dysfunctionFAERS: 1US FAERS
299ErythemaFAERS: 1US FAERS
300Exposure during breast feedingFAERS: 1US FAERS
301Extremity necrosisFAERS: 1US FAERS
302Eye irritationFAERS: 1US FAERS
303FlushingFAERS: 1US FAERS
304FolliculitisFAERS: 1US FAERS
305Fundoscopy abnormalFAERS: 1US FAERS
306General physical condition abnormalFAERS: 1US FAERS
307GlaucomaFAERS: 1US FAERS
308Graft infectionFAERS: 1US FAERS
309Hepatic EncephalopathyFAERS: 1US FAERS
310Hepatic necrosisFAERS: 1US FAERS
311Hepatitis C antibody positiveFAERS: 1US FAERS
312HoarsenessFAERS: 1US FAERS
313HypervigilanceFAERS: 1US FAERS
314HypotensionFAERS: 1US FAERS
315HypoxiaFAERS: 1US FAERS
316Impaired driving abilityFAERS: 1US FAERS
317Impaired work abilityFAERS: 1US FAERS
318IncoherentFAERS: 1US FAERS
319InfectionFAERS: 1US FAERS
320Intentional dose omissionFAERS: 1US FAERS
321Intercepted medication errorFAERS: 1US FAERS
322Intercepted product dispensing errorFAERS: 1US FAERS
323Joint swellingFAERS: 1US FAERS
324LacerationFAERS: 1US FAERS
325LaryngitisFAERS: 1US FAERS
326Livedo ReticularisFAERS: 1US FAERS
327Loss of personal independence in daily activitiesFAERS: 1US FAERS
328Lung adenocarcinoma recurrentFAERS: 1US FAERS
329Malignant neoplasm progressionFAERS: 1US FAERS
330MarasmusFAERS: 1US FAERS
331Medication residueFAERS: 1US FAERS
332Medication residue presentFAERS: 1US FAERS
333Mental status changesFAERS: 1US FAERS
334MicropenisFAERS: 1US FAERS
335Migration of implanted drugFAERS: 1US FAERS
336Miscarriage of partnerFAERS: 1US FAERS
337MonoplegiaFAERS: 1US FAERS
338Motion SicknessFAERS: 1US FAERS
339Mouth swellingFAERS: 1US FAERS
340Multi-organ disorderFAERS: 1US FAERS
341MyocarditisFAERS: 1US FAERS
342Nasal mucosal disorderFAERS: 1US FAERS
343NasopharyngitisFAERS: 1US FAERS
344Neonatal disorderFAERS: 1US FAERS
345Neuropsychiatric syndromeFAERS: 1US FAERS
346No adverse effectFAERS: 1US FAERS
347No adverse eventFAERS: 1US FAERS
348NystagmusFAERS: 1US FAERS
349Obsessive thoughtsFAERS: 1US FAERS
350Oral mucosal eruptionFAERS: 1US FAERS
351OsteitisFAERS: 1US FAERS
352OsteomyelitisFAERS: 1US FAERS
353PO2 decreasedFAERS: 1US FAERS
354Pancreas lipomatosisFAERS: 1US FAERS
355ParanoiaFAERS: 1US FAERS
356Pelvic abscessFAERS: 1US FAERS
357Penile necrosisFAERS: 1US FAERS
358PericarditisFAERS: 1US FAERS
359PetechiaeFAERS: 1US FAERS
360PharyngitisFAERS: 1US FAERS
361PiloerectionFAERS: 1US FAERS
362PlagiocephalyFAERS: 1US FAERS
363PneumoconiosisFAERS: 1US FAERS
364PneumonitisFAERS: 1US FAERS
365PolyneuropathyFAERS: 1US FAERS
366PriapismFAERS: 1US FAERS
367Product administered at inappropriate siteFAERS: 1US FAERS
368Product dosage form issueFAERS: 1US FAERS
369Product friableFAERS: 1US FAERS
370Product label confusionFAERS: 1US FAERS
371Product physical issueFAERS: 1US FAERS
372Product size issueFAERS: 1US FAERS
373Pulmonary HypertensionFAERS: 1US FAERS
374Pulmonary vascular disorderFAERS: 1US FAERS
375PyelonephritisFAERS: 1US FAERS
376QuadriplegiaFAERS: 1US FAERS
377Quality of life decreasedFAERS: 1US FAERS
378Radiation injuryFAERS: 1US FAERS
379Respiratory arrestFAERS: 1US FAERS
380ScotomaFAERS: 1US FAERS
381Sinus TachycardiaFAERS: 1US FAERS
382Skin lesionFAERS: 1US FAERS
383SluggishnessFAERS: 1US FAERS
384SneezingFAERS: 1US FAERS
385SpondylitisFAERS: 1US FAERS
386Staphylococcal abscessFAERS: 1US FAERS
387StaringFAERS: 1US FAERS
388Stasis dermatitisFAERS: 1US FAERS
389StrabismusFAERS: 1US FAERS
390Streptococcal abscessFAERS: 1US FAERS
391Sudden deathFAERS: 1US FAERS
392SuperinfectionFAERS: 1US FAERS
393SyncopeFAERS: 1US FAERS
394SyndactylyFAERS: 1US FAERS
395Systemic Inflammatory Response SyndromeFAERS: 1US FAERS
396Tablet physical issueFAERS: 1US FAERS
397TensionFAERS: 1US FAERS
398TheftFAERS: 1US FAERS
399Therapeutic product effect incompleteFAERS: 1US FAERS
400Therapeutic product ineffective for unapproved indicationFAERS: 1US FAERS
401Therapy cessationFAERS: 1US FAERS
402Therapy naiveFAERS: 1US FAERS
403ThirstFAERS: 1US FAERS
404Transaminases increasedFAERS: 1US FAERS
405Transmission of drug via semenFAERS: 1US FAERS
406TuberculosisFAERS: 1US FAERS
407UlcerFAERS: 1US FAERS
408UrethritisFAERS: 1US FAERS
409Urinary tract infectionFAERS: 1US FAERS
410VasculitisFAERS: 1US FAERS
411Venous thrombosis limbFAERS: 1US FAERS
412Visceral congestionFAERS: 1US FAERS
413Vitreous floatersFAERS: 1US FAERS
414furuncleFAERS: 1US FAERS
415Oral administration complicationCanada Vigilance: 1Canada Vigilance
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