MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Idarubicin

(XDXDZDZNSLXDNA-TZNDIEGXSA-N)

Structure

SMILES: O[C@H]1[C@@H](N)C[C@@H](O[C@H]1C)O[C@H]1C[C@@](O)(Cc2c1c(O)c1c(c2O)C(=O)c2c(C1=O)cccc2)C(=O)C
Type(s): Approved
ATC code(s): L01DB06
Molecular Formula:: C26H27NO9
Molecular Weight:: 497.494
Log P:: 1.7206
Hydrogen Bond Acceptor:: 10
Hydrogen Bond Donor:: 5
TPSA:: 176.61
CAS Number(s):: 57852-57-0; 58957-92-9

Synonym(s)

Idarubicin

4-Demethoxydaunorubicin

4-Desmethoxydaunorubicin

IMI-30

Idarubicin Hydrochloride

NSC-256439

4 Demethoxydaunorubicin

4 Desmethoxydaunorubicin

Hydrochloride, Idarubicin

10.

IMI 30

11.

IMI30

12.

NSC 256439

13.

NSC256439

External Link(s)

MeSH	D015255
PubChem Compound	42890
BindingDB	58490
ChEBI	42068
CHEMBL	CHEMBL1117
DrugBank	DB01177
DrugCentral	1414
IUPHAR/BPS Guide to PHARMACOLOGY	7083
KEGG	dr:D08062
Therapeutic Target Database	D01XDL
ZINC	3920266

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Ejection Fraction Decreased	FAERS: 2		US FAERS
2	Neutropenia	FAERS: 2	20060166	CTD SIDER US FAERS
3	Neutropenic colitis	FAERS: 2		SIDER US FAERS
4	Pneumatosis intestinalis	FAERS: 2		US FAERS
5	Sepsis	FAERS: 2	12497211	CTD SIDER US FAERS
6	Ventricular Dysfunction	FAERS: 2		US FAERS
7	Ventricular hypokinesia	FAERS: 2		US FAERS
8	Cardiac Arrest	FAERS: 1		US FAERS
9	Enterococcal infection	FAERS: 1		US FAERS
10	Escherichia infection	FAERS: 1		US FAERS
11	Febrile Neutropenia	FAERS: 1		OFFSIDES SIDER US FAERS
12	Hypotension	FAERS: 1		US FAERS
13	Hypoxia	FAERS: 1		OFFSIDES US FAERS
14	Nutritional condition abnormal	FAERS: 1		US FAERS
15	Respiratory distress	FAERS: 1		US FAERS
16	Abdominal Cramps			SIDER
17	Abdominal Pain			SIDER
18	Acral erythema			SIDER
19	Acute Coronary Syndrome			SIDER
20	Acute kidney injury		7858489	CTD
21	Alopecia reversible			SIDER
22	Alopecia		3162625 3162850	CTD SIDER
23	Anaphylactic shock			SIDER
24	Anorexia		1617662	CTD SIDER
25	Aspergilloma			OFFSIDES
26	Atrial Fibrillation			SIDER
27	Atrioventricular Block			SIDER
28	Autonomic nervous system imbalance			SIDER
29	Blood and lymphatic system disorders			SIDER
30	Blood bilirubin unconjugated increased			OFFSIDES
31	Blood chloride increased			OFFSIDES
32	Blood creatine phosphokinase BB increased			OFFSIDES
33	Blood creatine phosphokinase increased			OFFSIDES
34	Blood lactate dehydrogenase increased			OFFSIDES
35	Blood sodium increased			OFFSIDES
36	Blood uric acid decreased			OFFSIDES
37	Bone marrow depression			OFFSIDES SIDER
38	Burning sensation			SIDER
39	Cardiomyopathies		7595745 9768820	CTD
40	Cardiomyopathy, Dilated		12144690	CTD
41	Cardiotoxicity		28973540	CTD SIDER
42	Central Nervous System Infection			OFFSIDES
43	Chemical phlebitis			SIDER
44	Chest Pain		20060166	CTD SIDER
45	Chills			SIDER
46	Cholangiolitis			OFFSIDES
47	Colitis			SIDER
48	Cystitis		8603442	CTD
49	Dehydration			SIDER
50	Dermatitis			SIDER
51	Diarrhea		View details 3162625 7858489 12161355 12497211	CTD
52	Drug exposure during pregnancy			OFFSIDES
53	Edema		16473794	CTD
54	Embolism			SIDER
55	Endocarditis			OFFSIDES
56	Engraftment syndrome			OFFSIDES
57	Enterocolitis			SIDER
58	Extravasation			SIDER
59	Fatty Liver			OFFSIDES
60	Fever		9436936 20060166	CTD
61	Fluid overload			SIDER
62	Flushing			SIDER
63	Gastrointestinal Pain			SIDER
64	Gastrointestinal toxicity			SIDER
65	Headache			SIDER
66	Heart Diseases		View details 1352605 1617662 3162850 3403095	CTD
67	Heart Failure, Diastolic		16151589 16473794	CTD
68	Heart failure		7595745	CTD
69	Hemorrhage		15045822	CTD
70	Hepaplastin decreased			OFFSIDES
71	Hepatic Veno-Occlusive Disease		12497211	CTD
72	Hepatic necrosis			OFFSIDES
73	Histiocytosis haematophagic			OFFSIDES
74	Hypersensitivity			SIDER
75	Incorrect dose administered			OFFSIDES
76	Infection			OFFSIDES SIDER
77	Infusion site infection			OFFSIDES
78	Injection site urticaria			SIDER
79	Instability vasomotor			SIDER
80	Kidney Diseases		17922055	CTD
81	Leukemia, Radiation-Induced		7858489	CTD
82	Leukoencephalopathy			OFFSIDES
83	Leukopenia		3162625	CTD SIDER
84	Liver diseases		7858489	CTD
85	Local reaction			SIDER
86	Long QT Syndrome		24052561	CTD
87	Lymphoma, Non-Hodgkin		1617662	CTD
88	Lymphoma		3162850	CTD SIDER
89	MYELODYSPLASTIC SYNDROME			SIDER
90	Malnutrition			SIDER
91	Mechanical ventilation			OFFSIDES
92	Mitochondrial Diseases		6929617	CTD
93	Mucormycosis			OFFSIDES
94	Multiple Myeloma		9436936 9436937	CTD
95	Myelodysplasia			OFFSIDES
96	Myelosuppression			SIDER
97	Myocardial Infarction			SIDER
98	Myocarditis		17619879 20060166	CTD SIDER
99	Nausea		View details 1617662 3162625 3162850 7858489	CTD SIDER
100	Necrosis		7729748	CTD SIDER
101	Neoplasms, Second Primary		28973540	CTD
102	Neoplasms		2920759 11867198	CTD
103	Pain			OFFSIDES
104	Pancytopenia			SIDER
105	Papilledema		15045822	CTD
106	Pericarditis			SIDER
107	Phlebitis			SIDER
108	Platelet Transfusion			OFFSIDES
109	Pseudotumor Cerebri		15045822	CTD
110	Radiation injury			SIDER
111	Recall phenomenon			SIDER
112	Recurrence		11279639 17207701	CTD
113	Renal tubular necrosis			OFFSIDES
114	Respiratory Failure			OFFSIDES
115	Septic Shock			SIDER
116	Septicemia			SIDER
117	Shock			SIDER
118	Sick Sinus Syndrome		8431564	CTD
119	Sinus Tachycardia			SIDER
120	Sinus Thrombosis, Intracranial		18832917	CTD
121	Stomatitis			SIDER
122	Subcutaneous Emphysema			OFFSIDES
123	Tachyarrhythmia			SIDER
124	Thrombocytopenia			SIDER
125	Thromboembolism			SIDER
126	Thrombophlebitis			SIDER
127	Thrombosis		16932337 18832917	CTD
128	Ulcer			SIDER
129	Urticaria			SIDER
130	Ventricular Dysfunction, Left		16151589	CTD
131	Vomiting		View details 1617662 3162625 3162850 7858489	CTD SIDER
132	Vulvitis		7729748	CTD
133	leukemia		1831987 28973540	CTD

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