MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Clobazam

(CXOXHMZGEKVPMT-UHFFFAOYSA-N)

Structure

SMILES: Clc1ccc2c(c1)N(C(=O)CC(=O)N2C)c1ccccc1
Type(s): Approved; Illicit
ATC code(s): N05BA09
Molecular Formula:: C16H13ClN2O2
Molecular Weight:: 300.740
Log P:: 3.5012
Hydrogen Bond Acceptor:: 3
Hydrogen Bond Donor:: 0
TPSA:: 40.62
CAS Number(s):: 22316-47-8

Synonym(s)

Clobazam

1-Phenyl-5-methyl-8-chloro-1,2,4,5- tetrahydro-2,4-diketo-3H-1,5-benzodiazepine

Frisium

HR 376

LM-2717

Onfi

Urbanyl

LM 2717

LM2717

External Link(s)

MeSH	D000078306
PubChem Compound	2789
BindingDB	50247888
ChEBI	31413
CHEMBL	CHEMBL70418
DrugBank	DB00349
DrugCentral	682
IUPHAR/BPS Guide to PHARMACOLOGY	7149
KEGG	dr:D01253
Therapeutic Target Database	D0P0KF
ZINC	1175

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fatigue	FAERS: 26		SIDER US FAERS
2	Somnolence	FAERS: 16 Canada Vigilance: 2		Canada Vigilance SIDER US FAERS
3	Product substitution issue	FAERS: 9 Canada Vigilance: 7		Canada Vigilance US FAERS
4	Drug ineffective	FAERS: 8 Canada Vigilance: 5		Canada Vigilance US FAERS
5	Headache	FAERS: 5		SIDER US FAERS
6	Malaise	FAERS: 5		US FAERS
7	Epilepsy	FAERS: 4		OFFSIDES US FAERS
8	Agitation	FAERS: 3 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
9	Drug Dependence	FAERS: 3		SIDER US FAERS
10	Abdominal Pain	FAERS: 2		OFFSIDES US FAERS
11	Accidental death	FAERS: 2		US FAERS
12	Alanine Aminotransferase Increased	FAERS: 2		US FAERS
13	Anxiety	FAERS: 2		SIDER US FAERS
14	Aspartate Aminotransferase Increased	FAERS: 2		US FAERS
15	Dizziness	FAERS: 2		SIDER US FAERS
16	Drug withdrawal convulsions	FAERS: 2 Canada Vigilance: 2		Canada Vigilance US FAERS
17	Dysuria	FAERS: 2		OFFSIDES US FAERS
18	Intentional product misuse	FAERS: 2		US FAERS
19	Lethargy	FAERS: 2		SIDER US FAERS
20	Status Epilepticus	FAERS: 2 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
21	Toxicity to various agents	FAERS: 2		US FAERS
22	Tremor	FAERS: 2 Canada Vigilance: 1		Canada Vigilance SIDER US FAERS
23	Weight decreased	FAERS: 2		US FAERS
24	Asthenia	FAERS: 1		SIDER US FAERS
25	CYP2C19 polymorphism	FAERS: 1		US FAERS
26	Complex partial seizures	FAERS: 1		OFFSIDES US FAERS
27	Crying	FAERS: 1 Canada Vigilance: 1		Canada Vigilance OFFSIDES US FAERS
28	Cystic Fibrosis	FAERS: 1		US FAERS
29	Dependence	FAERS: 1		SIDER US FAERS
30	Depressed Level of Consciousness	FAERS: 1		OFFSIDES US FAERS
31	Disorientation	FAERS: 1		SIDER US FAERS
32	Diverticulitis	FAERS: 1		US FAERS
33	Drooling	FAERS: 1		SIDER US FAERS
34	Drug level increased	FAERS: 1		US FAERS
35	Drug prescribing error	FAERS: 1		US FAERS
36	Drug resistance	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
37	Drug withdrawal syndrome	FAERS: 1		SIDER US FAERS
38	Dyspepsia	FAERS: 1		US FAERS
39	Expired product administered	FAERS: 1		US FAERS
40	Exposure via breast milk	FAERS: 1		US FAERS
41	Feeling abnormal	FAERS: 1		SIDER US FAERS
42	Focal dyscognitive seizures	FAERS: 1		US FAERS
43	Gamma-Glutamyltransferase Increased	FAERS: 1		OFFSIDES US FAERS
44	General physical health deterioration	FAERS: 1		OFFSIDES US FAERS
45	Hypophagia	FAERS: 1		US FAERS
46	Impaired quality of life	FAERS: 1		US FAERS
47	Initial insomnia	FAERS: 1		US FAERS
48	Intracranial mass	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
49	Laceration	FAERS: 1		US FAERS
50	Mental impairment	FAERS: 1		US FAERS
51	Mood swings	FAERS: 1		US FAERS
52	Obsessive-Compulsive Disorder	FAERS: 1		US FAERS
53	Overdose	FAERS: 1		US FAERS
54	Paranoia	FAERS: 1		US FAERS
55	Pharmaceutical product complaint	FAERS: 1		US FAERS
56	Pneumonia	FAERS: 1		SIDER US FAERS
57	Polyuria	FAERS: 1		US FAERS
58	Product physical consistency issue	FAERS: 1		US FAERS
59	Psychogenic seizure	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
60	Respiratory Depression	FAERS: 1		SIDER US FAERS
61	Respiratory Failure	FAERS: 1		SIDER US FAERS
62	Restlessness	FAERS: 1		US FAERS
63	Skin reaction	FAERS: 1		US FAERS
64	Suicide attempt	FAERS: 1		US FAERS
65	Therapeutic response changed	FAERS: 1		US FAERS
66	Therapeutic response unexpected	FAERS: 1		US FAERS
67	Tinnitus	FAERS: 1		US FAERS
68	Urinary hesitation	FAERS: 1		US FAERS
69	Urinary tract infection	FAERS: 1		SIDER US FAERS
70	Vertigo	FAERS: 1		US FAERS
71	Vomiting	FAERS: 1		SIDER US FAERS
72	Wheelchair user	FAERS: 1		US FAERS
73	Wrong technique in product usage process	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
74	nervous system disorder	FAERS: 1		SIDER US FAERS
75	Abasia			OFFSIDES
76	Abdominal discomfort	Canada Vigilance: 1		Canada Vigilance
77	Abdominal tenderness			OFFSIDES
78	Abdominal wall cyst			OFFSIDES
79	Abnormal vision			OFFSIDES
80	Abortion induced complete			OFFSIDES
81	Accidental exposure to product	Canada Vigilance: 1		Canada Vigilance
82	Acne			OFFSIDES
83	Acute bronchitis			OFFSIDES
84	Adenitis			OFFSIDES
85	Adenoma			OFFSIDES
86	Agraphia			OFFSIDES
87	Akinesia			OFFSIDES
88	Alopecia totalis			OFFSIDES
89	Altered state of consciousness			OFFSIDES
90	Amimia			OFFSIDES
91	Ammonia increased			OFFSIDES
92	Amnesia			OFFSIDES SIDER
93	Angioedema			OFFSIDES
94	Anhidrosis			OFFSIDES
95	Anorexia			SIDER
96	Anticonvulsant drug level above therapeutic			OFFSIDES
97	Anticonvulsant drug level decreased			OFFSIDES
98	Anticonvulsant drug level increased			OFFSIDES
99	Antiendomysial antibody positive			OFFSIDES
100	Antiviral drug level above therapeutic			OFFSIDES
101	Anxiety Disorders		6135690 10901839	CTD
102	Apathy			OFFSIDES SIDER
103	Arachnoiditis			OFFSIDES
104	Aspiration Pneumonia			OFFSIDES
105	Asterixis			OFFSIDES
106	Asthma			SIDER
107	Ataxia	Canada Vigilance: 2	2917546	CTD OFFSIDES SIDER Canada Vigilance
108	Atrioventricular Block			OFFSIDES
109	Aura			OFFSIDES
110	Automatism			OFFSIDES
111	Base excess decreased			OFFSIDES
112	Bedridden			OFFSIDES
113	Belligerence			OFFSIDES
114	Beta 2 microglobulin increased			OFFSIDES
115	Biopsy intestine abnormal			OFFSIDES
116	Biopsy liver abnormal			OFFSIDES
117	Blood albumin decreased			OFFSIDES
118	Blood albumin increased			OFFSIDES
119	Blood alkaline phosphatase increased			OFFSIDES
120	Blood beta-D-glucan increased			OFFSIDES
121	Blood cholinesterase decreased			OFFSIDES
122	Blood lactate dehydrogenase increased			OFFSIDES
123	Blood pH decreased			OFFSIDES
124	Blood phosphorus decreased			OFFSIDES
125	Blood pressure immeasurable			OFFSIDES
126	Blood sodium			OFFSIDES
127	Blood testosterone decreased			OFFSIDES
128	Body Temperature			OFFSIDES
129	Brain stem syndrome			OFFSIDES
130	Breast Cyst			OFFSIDES
131	Bronchitis			SIDER
132	C-reactive protein abnormal			OFFSIDES
133	Cardioactive drug level			OFFSIDES
134	Carnitine deficiency			OFFSIDES
135	Cerebral atrophy			OFFSIDES
136	Cerebral ventricle dilatation			OFFSIDES
137	Cheilitis			OFFSIDES
138	Chemotherapeutic drug level increased			OFFSIDES
139	Cholestasis of pregnancy			OFFSIDES
140	Cholestatic liver injury			OFFSIDES
141	Chronic ulcerative colitis			OFFSIDES
142	Cleft Palate			OFFSIDES
143	Clonus			OFFSIDES
144	Confabulation			OFFSIDES
145	Congenital heart disease			OFFSIDES
146	Congenital hydronephrosis			OFFSIDES
147	Congenital hyperextension of spine			OFFSIDES
148	Congenital renal cyst			OFFSIDES
149	Congenital torticollis			OFFSIDES
150	Conjunctival deposit			OFFSIDES
151	Constipation			SIDER
152	Continuous Positive Airway Pressure			OFFSIDES
153	Corneal Ulcer			OFFSIDES
154	Cyanosis			OFFSIDES
155	Cytolytic hepatitis			OFFSIDES
156	Delirium			SIDER
157	Depressed mood			OFFSIDES
158	Dermatitis			SIDER
159	Device related infection			OFFSIDES
160	Diet refusal			OFFSIDES
161	Difficult to wean from ventilator			OFFSIDES
162	Diplopia			OFFSIDES SIDER
163	Disorders of Excessive Somnolence		10901839	CTD
164	Disturbance in sexual arousal			SIDER
165	Drowning			OFFSIDES
166	Drowsiness			OFFSIDES SIDER
167	Drug addict			OFFSIDES
168	Drug dispensing error			OFFSIDES
169	Drug exposure during pregnancy			OFFSIDES
170	Drug level below therapeutic			OFFSIDES
171	Drug toxicity			OFFSIDES
172	Dysarthria			SIDER
173	Dyschezia			OFFSIDES
174	Dysmorphism			OFFSIDES
175	Dystonia			OFFSIDES
176	Echolalia			OFFSIDES
177	Ecthyma			OFFSIDES
178	Eczema			OFFSIDES
179	Encephalitis			OFFSIDES
180	Enterococcal infection			OFFSIDES
181	Eosinophilia			SIDER
182	Epilepsy, Rolandic		19921623	CTD
183	Epileptic aura			OFFSIDES
184	Erythema Multiforme			SIDER
185	Erythema			OFFSIDES
186	Euphoric mood			SIDER
187	Exfoliative rash			OFFSIDES
188	Extra dose administered	Canada Vigilance: 1		Canada Vigilance
189	Eye Infection			OFFSIDES
190	Fanconi Syndrome		7624000	CTD OFFSIDES
191	Flat affect			SIDER
192	Gastric ulcer			OFFSIDES
193	Gastrostomy			OFFSIDES
194	Gaze palsy			OFFSIDES
195	Genital erosion			OFFSIDES
196	Gingival Hypertrophy			OFFSIDES
197	Glioblastoma			OFFSIDES
198	Glioma			OFFSIDES
199	Glycosuria		7624000	CTD
200	Graft infection			OFFSIDES
201	Granulocytosis			OFFSIDES
202	Grip strength			OFFSIDES
203	Hernia			OFFSIDES
204	Hip Dysplasia			OFFSIDES
205	Histiocytosis haematophagic			OFFSIDES
206	Hostility			SIDER
207	Hydronephrosis			OFFSIDES
208	Hydrothorax			OFFSIDES
209	Hypercapnia			OFFSIDES
210	Hypereosinophilic syndrome			OFFSIDES
211	Hyperventilation	Canada Vigilance: 1		Canada Vigilance
212	Hypokinesia			OFFSIDES
213	Hypomania			OFFSIDES
214	Hypophosphatemia		7624000	CTD
215	Hypospadias			OFFSIDES
216	Hypotension			SIDER
217	Hypothyroidism		22982618	CTD
218	Impaired insulin secretion			OFFSIDES
219	Inappropriate affect			OFFSIDES
220	Incontinence	Canada Vigilance: 1		Canada Vigilance
221	Infection			OFFSIDES SIDER
222	Infestation			SIDER
223	Intention tremor			OFFSIDES
224	Intentional self-injury			OFFSIDES
225	Intestinal villi atrophy			OFFSIDES
226	Joint injury			OFFSIDES
227	Leukoencephalopathy			OFFSIDES
228	Leukopenia			SIDER
229	Lichenification			OFFSIDES
230	Live Birth			OFFSIDES
231	Low set ears			OFFSIDES
232	Lupus-like syndrome			OFFSIDES
233	Lymphocytosis			OFFSIDES
234	Lymphoid tissue hyperplasia			OFFSIDES
235	Malignant Glioma			OFFSIDES
236	Malignant Hypertension			OFFSIDES
237	Malnutrition			SIDER
238	Mastication disorder	Canada Vigilance: 1		Canada Vigilance
239	Meningocele			OFFSIDES
240	Metamorphopsia			OFFSIDES
241	Moaning			OFFSIDES
242	Morose			OFFSIDES
243	Motor retardation			OFFSIDES
244	Mucosal erosion			OFFSIDES
245	Muscle necrosis			OFFSIDES
246	Musculoskeletal discomfort			SIDER
247	Musculoskeletal stiffness			SIDER
248	Mutism			OFFSIDES
249	Myalgia			SIDER
250	Myoclonic Epilepsy			OFFSIDES
251	Myoclonus		98317	CTD
252	Nail Infection			OFFSIDES
253	Nausea			SIDER
254	Negativism			OFFSIDES
255	Nervous tension			OFFSIDES
256	Nervousness			SIDER
257	Neurobehavioral Manifestations		1904374	CTD
258	Neutrophil Pelger-Huet anomaly present			OFFSIDES
259	Nutritional condition abnormal			OFFSIDES
260	Nystagmus			OFFSIDES SIDER
261	Obsessive thoughts			OFFSIDES
262	Oculogyric crisis			OFFSIDES
263	Open wound			OFFSIDES
264	Optic Neuropathy			OFFSIDES
265	Oral mucosal erythema			OFFSIDES
266	Oxygen supplementation			OFFSIDES
267	PROTHROMBIN TIME			OFFSIDES
268	Pain of skin			OFFSIDES
269	Pallor			OFFSIDES
270	Pancreatic Pseudocyst			OFFSIDES
271	Pancreatitis			OFFSIDES
272	Paresis		16376047	CTD
273	Personality Change			OFFSIDES
274	Pharyngolaryngeal Pain			OFFSIDES
275	Pharyngotonsillitis			OFFSIDES
276	Phimosis			OFFSIDES
277	Pilonidal cyst congenital			OFFSIDES
278	Placental Insufficiency			OFFSIDES
279	Plagiocephaly			OFFSIDES
280	Poor peripheral circulation			OFFSIDES
281	Postural Orthostatic Tachycardia Syndrome			OFFSIDES
282	Potentiating drug interaction			OFFSIDES
283	Pregnancy with implant contraceptive			OFFSIDES
284	Proctitis			OFFSIDES
285	Product complaint	Canada Vigilance: 1		Canada Vigilance
286	Proteinuria		7624000	CTD
287	Prothrombin level decreased			OFFSIDES
288	Pruritus			SIDER
289	Pseudocyst			OFFSIDES
290	Pulmonary congestion			OFFSIDES
291	Pulmonary function test decreased			SIDER
292	Pyelonephritis			OFFSIDES
293	Pyloric Stenosis			OFFSIDES
294	Renal tubular disorder			OFFSIDES
295	Respiratory Insufficiency			SIDER
296	Respiratory syncytial virus bronchiolitis			OFFSIDES
297	Respiratory tract congestion			OFFSIDES
298	Retrognathia			OFFSIDES
299	Rhinitis			OFFSIDES
300	Rickets			OFFSIDES
301	Schizophrenia			OFFSIDES
302	Scotoma			OFFSIDES
303	Seizures		View details 98317 2917546 3208226 6807671 7475702 10783916 14636342 16180713 16938433	CTD
304	Skin lesion			OFFSIDES
305	Skin toxicity			OFFSIDES
306	Slurred speech			SIDER
307	Somnambulism	Canada Vigilance: 1		Canada Vigilance
308	Sopor			OFFSIDES
309	Spina Bifida			OFFSIDES
310	Stevens-Johnson Syndrome		25811541	CTD OFFSIDES SIDER
311	Stiffness			SIDER
312	Stress at work			OFFSIDES
313	Subileus			OFFSIDES
314	Substance Withdrawal Syndrome		9579909	CTD
315	Sudden death			OFFSIDES
316	Surfactant protein increased			OFFSIDES
317	Sweating			SIDER
318	Syndactyly			OFFSIDES
319	Talipes			OFFSIDES
320	Tension			SIDER
321	Therapeutic product effect incomplete	Canada Vigilance: 1		Canada Vigilance
322	Thrombocytopenia			SIDER
323	Tonic clonic movements			OFFSIDES
324	Toxic Epidermal Necrolysis			SIDER
325	Tracheobronchitis			OFFSIDES
326	Transaminases increased			OFFSIDES
327	Trisomy 21			OFFSIDES
328	Unresponsive to stimuli			OFFSIDES
329	Urinary sediment abnormal			OFFSIDES
330	Urticaria			SIDER
331	Vasospasm, Intracranial		16376047	CTD
332	Visual Impairment			SIDER
333	Vitamin B 12 Deficiency			OFFSIDES
334	Vitamin K Deficiency			OFFSIDES
335	Walking aid user			OFFSIDES
336	Wrong drug administered			OFFSIDES
337	jejunitis			OFFSIDES

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