MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

fludarabine

(HBUBKKRHXORPQB-FJFJXFQQSA-N)

Structure

SMILES: OC[C@H]1O[C@H]([C@H]([C@@H]1O)O)n1cnc2c1nc(F)nc2N
Type(s): Approved
ATC code(s): L01BB05
Molecular Formula:: C10H12FN5O4
Molecular Weight:: 285.232
Log P:: -1.2597
Hydrogen Bond Acceptor:: 9
Hydrogen Bond Donor:: 4
TPSA:: 139.54
CAS Number(s):: 21679-14-1

Synonym(s)

fludarabine

2-fluoroadenine arabinoside

9-beta-D-arabinofuranosyl-2-fluoroadenine

F-ara-A

External Link(s)

MeSH	C024352
PubChem Compound	657237
BindingDB	68391
ChEBI	94701
CHEMBL	CHEMBL1568
DrugBank	DB01073
IUPHAR/BPS Guide to PHARMACOLOGY	4802
KEGG	cpd:C21550 dr:D01907 dr:D07966
Therapeutic Target Database	D0F2XQ
ZINC	4216238

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Leukoencephalopathy	FAERS: 8		US FAERS
2	Sepsis	FAERS: 5 Canada Vigilance: 1		Canada Vigilance US FAERS
3	Delirium	FAERS: 4 Canada Vigilance: 1		Canada Vigilance US FAERS
4	Agitation	FAERS: 3		SIDER US FAERS
5	Asthenia	FAERS: 3		SIDER US FAERS
6	Blindness	FAERS: 3		SIDER US FAERS
7	Chest discomfort	FAERS: 3		US FAERS
8	Fatigue	FAERS: 3		SIDER US FAERS
9	Febrile Neutropenia	FAERS: 3		OFFSIDES US FAERS
10	Hepatitis	FAERS: 3		OFFSIDES US FAERS
11	Ileus	FAERS: 3		US FAERS
12	Nausea	FAERS: 3		SIDER US FAERS
13	Pancreatitis	FAERS: 3		US FAERS
14	Pneumonia	FAERS: 3		SIDER US FAERS
15	Anxiety	FAERS: 2		US FAERS
16	Bronchiolitis	FAERS: 2		US FAERS
17	Chills	FAERS: 2		SIDER US FAERS
18	Cytokine Release Syndrome	FAERS: 2		OFFSIDES US FAERS
19	Demyelination	FAERS: 2		OFFSIDES US FAERS
20	Disorientation	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
21	Drug ineffective	FAERS: 2		US FAERS
22	General physical health deterioration	FAERS: 2		OFFSIDES US FAERS
23	Immune thrombocytopenic purpura	FAERS: 2		US FAERS
24	Leukopenia	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
25	Mycosis Fungoides	FAERS: 2		US FAERS
26	Ocular Toxicity	FAERS: 2		OFFSIDES US FAERS
27	Optic Atrophy	FAERS: 2		OFFSIDES US FAERS
28	Pancytopenia	FAERS: 2		SIDER US FAERS
29	Paraneoplastic pemphigus	FAERS: 2		OFFSIDES US FAERS
30	Pneumonitis	FAERS: 2		US FAERS
31	Product use in unapproved indication	FAERS: 2		US FAERS
32	Rash erythematous	FAERS: 2		US FAERS
33	Somnolence	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
34	Toxicity to various agents	FAERS: 2		US FAERS
35	Visual Impairment	FAERS: 2		SIDER US FAERS
36	Weight decreased	FAERS: 2		SIDER US FAERS
37	Absence of immediate treatment response	FAERS: 1		US FAERS
38	Acantholysis	FAERS: 1		US FAERS
39	Apallic syndrome	FAERS: 1		US FAERS
40	Ascites	FAERS: 1		OFFSIDES US FAERS
41	Autonomic nervous system imbalance	FAERS: 1		US FAERS
42	Basal cell carcinoma	FAERS: 1		US FAERS
43	Blood lactate dehydrogenase increased	FAERS: 1		OFFSIDES SIDER US FAERS
44	Clonus	FAERS: 1		US FAERS
45	Coombs test positive	FAERS: 1		US FAERS
46	Deep Vein Thrombosis	FAERS: 1		SIDER US FAERS
47	Dermatitis	FAERS: 1		SIDER US FAERS
48	Diplopia	FAERS: 1		US FAERS
49	Electrolyte depletion	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
50	Encephalomalacia	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
51	Epilepsy	FAERS: 1		US FAERS
52	Epistaxis	FAERS: 1		SIDER US FAERS
53	Erythema	FAERS: 1		US FAERS
54	Evans syndrome	FAERS: 1		OFFSIDES SIDER US FAERS
55	Gastroenteritis astroviral	FAERS: 1		US FAERS
56	Hepatitis B	FAERS: 1	19008178	CTD OFFSIDES US FAERS
57	Histiocytosis haematophagic	FAERS: 1		OFFSIDES US FAERS
58	Hydrocephalus	FAERS: 1		US FAERS
59	Hyperreflexia	FAERS: 1		OFFSIDES US FAERS
60	Hypokinesia	FAERS: 1		US FAERS
61	Infection	FAERS: 1 Canada Vigilance: 1	15501959	CTD OFFSIDES SIDER Canada Vigilance US FAERS
62	Inflammation	FAERS: 1		US FAERS
63	Lymphadenopathy	FAERS: 1		US FAERS
64	Meningitis	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
65	Mental status changes	FAERS: 1		OFFSIDES US FAERS
66	Musculoskeletal Pain	FAERS: 1		US FAERS
67	Myalgia	FAERS: 1		SIDER US FAERS
68	Neuralgia	FAERS: 1		US FAERS
69	Neutrophil count decreased	FAERS: 1		OFFSIDES SIDER US FAERS
70	Pain	FAERS: 1		SIDER US FAERS
71	Petechiae	FAERS: 1		US FAERS
72	Prescribed overdose	FAERS: 1		US FAERS
73	Product prescribing error	FAERS: 1		US FAERS
74	Protein total increased	FAERS: 1 Canada Vigilance: 1		Canada Vigilance US FAERS
75	Pseudomonal sepsis	FAERS: 1		OFFSIDES US FAERS
76	Pulmonary Hypertension	FAERS: 1		US FAERS
77	Respiratory Failure	FAERS: 1		OFFSIDES SIDER US FAERS
78	Respiratory distress	FAERS: 1		SIDER US FAERS
79	Septic Shock	FAERS: 1		OFFSIDES US FAERS
80	Squamous cell carcinoma	FAERS: 1		US FAERS
81	T-Cell Lymphoma	FAERS: 1		US FAERS
82	Tremor	FAERS: 1		US FAERS
83	Urticaria	FAERS: 1		US FAERS
84	Visual disturbance	FAERS: 1		SIDER US FAERS
85	Vomiting	FAERS: 1		SIDER US FAERS
86	White blood cell count decreased	FAERS: 1		US FAERS
87	Abdominal Pain			SIDER
88	Abdominal mass			OFFSIDES
89	Abdominal tenderness			OFFSIDES
90	Abnormal clotting factor			OFFSIDES
91	Absolute neutrophil count decreased			SIDER
92	Acid fast bacilli infection			OFFSIDES
93	Acquired pyloric stenosis			OFFSIDES
94	Acute Coronary Syndrome			SIDER
95	Acute bronchitis			OFFSIDES
96	Acute graft versus host disease in intestine			OFFSIDES
97	Acute graft versus host disease in liver			OFFSIDES
98	Acute kidney injury		16313266	CTD
99	Acute respiratory failure			OFFSIDES
100	Acute sinusitis			OFFSIDES
101	Adenocarcinoma			OFFSIDES
102	Adenoviral hepatitis			OFFSIDES
103	Aldolase increased			OFFSIDES
104	Alopecia			SIDER
105	Altered state of consciousness			OFFSIDES
106	Alveolitis			OFFSIDES
107	Amyloidosis			OFFSIDES
108	Anal Fistula			OFFSIDES
109	Anaphylactic shock			SIDER
110	Aneurysm			SIDER
111	Angina Pectoris			SIDER
112	Angiotensin converting enzyme decreased			OFFSIDES
113	Anorexia			OFFSIDES SIDER
114	Anti-GAD antibody			OFFSIDES
115	Anti-GAD antibody positive			OFFSIDES
116	Anti-erythrocyte antibody positive			OFFSIDES
117	Anti-platelet antibody positive			OFFSIDES
118	Antinuclear antibody increased			OFFSIDES
119	Antithrombin III decreased			OFFSIDES
120	Aortic valve calcification			OFFSIDES
121	Apathy			OFFSIDES
122	Aphthous Stomatitis			OFFSIDES
123	Apoptosis			OFFSIDES
124	Arthralgia			SIDER
125	Aspergilloma			OFFSIDES
126	Aspergillosis			OFFSIDES
127	Astigmatism			OFFSIDES
128	Atrial Flutter			OFFSIDES
129	Autoimmune neutropenia			OFFSIDES
130	Autoimmune thrombocytopenia			OFFSIDES SIDER
131	Autoimmune thyroiditis			OFFSIDES
132	Autologous bone marrow transplantation therapy			OFFSIDES
133	Automatism			OFFSIDES
134	Axonal neuropathy			OFFSIDES
135	B-cell lymphoma recurrent			OFFSIDES
136	B-cell unclassifiable lymphoma high grade			OFFSIDES
137	BK virus infection			OFFSIDES
138	Bacillus infection			OFFSIDES
139	Back Pain			SIDER
140	Bacteria blood identified			OFFSIDES
141	Bacterial sepsis			OFFSIDES
142	Bacterial test positive			OFFSIDES
143	Basilar artery thrombosis			OFFSIDES
144	Beta 2 microglobulin decreased			OFFSIDES
145	Beta 2 microglobulin increased			OFFSIDES
146	Biopsy bone marrow abnormal			OFFSIDES
147	Bladder spasm			OFFSIDES
148	Blast cells present			OFFSIDES
149	Blood bilirubin unconjugated increased			OFFSIDES
150	Blood blister			OFFSIDES
151	Blood fibrinogen			OFFSIDES
152	Blood immunoglobulin M			OFFSIDES
153	Blood immunoglobulin M decreased			OFFSIDES
154	Blood osmolarity decreased			OFFSIDES
155	Blood product transfusion dependent			OFFSIDES
156	Blood stem cell transplant failure			OFFSIDES
157	Blood uric acid decreased			OFFSIDES
158	Blood uric acid			OFFSIDES
159	Body temperature fluctuation			OFFSIDES
160	Bone Marrow Neoplasms		20026017	CTD
161	Bone marrow depression			OFFSIDES SIDER
162	Bone marrow toxicity			OFFSIDES
163	Bone marrow transplant rejection			OFFSIDES
164	Brain Abscess			OFFSIDES
165	Brain natriuretic peptide increased			OFFSIDES
166	Bronchiectasis			OFFSIDES
167	Bronchitis			SIDER
168	Bronchoalveolar Lavage			OFFSIDES
169	Bronchoalveolar lavage abnormal			OFFSIDES
170	Bronchopneumonia			OFFSIDES
171	Bronchoscopy abnormal			OFFSIDES
172	Brown-Sequard Syndrome			OFFSIDES
173	Brucellosis			OFFSIDES
174	Butterfly rash			OFFSIDES
175	CD4 Lymphocytes Decreased			OFFSIDES
176	CYTOMEGALOVIRUS ANTIGEN			OFFSIDES
177	Candida sepsis			OFFSIDES
178	Candida serology positive			OFFSIDES
179	Capillary Leak Syndrome			OFFSIDES
180	Cardiac Tamponade			OFFSIDES
181	Cardiac infection			OFFSIDES
182	Cardiac neoplasm unspecified			OFFSIDES
183	Cardiotoxicity			OFFSIDES
184	Cardiovascular insufficiency			OFFSIDES
185	Carotid Artery Thrombosis			OFFSIDES
186	Catheter related complication			OFFSIDES
187	Catheter related infection			OFFSIDES
188	Catheter site erythema			OFFSIDES
189	Central line infection			OFFSIDES
190	Central nervous system lesion			OFFSIDES
191	Cerebral disorder			OFFSIDES
192	Cerebral ventricle dilatation			OFFSIDES
193	Cerebrovascular accident			SIDER
194	Cervical laser therapy			OFFSIDES
195	Chest Pain			SIDER
196	Chimerism			OFFSIDES
197	Cholelithiasis			SIDER
198	Chronic ulcerative colitis			OFFSIDES
199	Chylothorax			OFFSIDES
200	Citrobacter sepsis			OFFSIDES
201	Clostridium difficile colitis			OFFSIDES
202	Complex partial seizures			OFFSIDES
203	Complications of bone marrow transplant			OFFSIDES
204	Complications of transplant surgery			OFFSIDES
205	Constipation			SIDER
206	Cord blood transplant therapy			OFFSIDES
207	Corneal epithelium defect			OFFSIDES
208	Coronary artery dilatation			OFFSIDES
209	Coronary artery insufficiency			OFFSIDES
210	Cryptosporidiosis			OFFSIDES
211	Crystalluria			SIDER
212	Culture positive			OFFSIDES
213	Cutaneous Candidiasis			OFFSIDES
214	Cystitis viral			OFFSIDES
215	Cytogenetic analysis abnormal			OFFSIDES
216	Cytomegalovirus antibody positive			OFFSIDES
217	Cytomegalovirus chorioretinitis			OFFSIDES
218	Cytomegalovirus enterocolitis			OFFSIDES
219	Cytomegalovirus gastroenteritis			OFFSIDES
220	Cytomegalovirus gastrointestinal infection			OFFSIDES
221	Cytomegalovirus test positive			OFFSIDES
222	Cytomegalovirus test			OFFSIDES
223	Cytopenia			SIDER
224	Dacryostenosis acquired			OFFSIDES
225	Deafness			SIDER
226	Dehydration			SIDER
227	Delayed engraftment			OFFSIDES
228	Device ineffective			OFFSIDES
229	Device related infection			OFFSIDES
230	Diaphragmatic Hernia			OFFSIDES
231	Diarrhea			OFFSIDES
232	Diffuse Large B-Cell Lymphoma			OFFSIDES
233	Diffuse alveolar damage			OFFSIDES
234	Diffuse large B-cell lymphoma recurrent			OFFSIDES
235	Discomfort			SIDER
236	Disease Progression			OFFSIDES
237	Disease complication			OFFSIDES
238	Disease recurrence			OFFSIDES
239	Disease susceptibility		20026017	CTD
240	Disseminated Intravascular Coagulation			OFFSIDES
241	Drug exposure before pregnancy			OFFSIDES
242	Drug toxicity			OFFSIDES
243	Dyspepsia			SIDER
244	Dysuria			SIDER
245	Ejection Fraction Decreased			OFFSIDES
246	Electrocardiogram T wave biphasic			OFFSIDES
247	Encephalitis			OFFSIDES
248	Endothelial dysfunction			OFFSIDES
249	Engraft failure			OFFSIDES
250	Engraftment syndrome			OFFSIDES
251	Enterobacter sepsis			OFFSIDES
252	Enterococcal infection			OFFSIDES
253	Enterococcal sepsis			OFFSIDES
254	Enterocolitis viral			OFFSIDES
255	Eosinophilic myocarditis			OFFSIDES
256	Epidural Abscess			OFFSIDES
257	Epstein-Barr virus antibody positive			OFFSIDES
258	Epstein-Barr virus antigen positive			OFFSIDES
259	Epstein-Barr virus associated lymphoproliferative disorder			OFFSIDES
260	Epstein-Barr virus serology positive			OFFSIDES
261	Erysipelas			OFFSIDES
262	Erythema Infectiosum			OFFSIDES
263	Erythema Multiforme			SIDER
264	Exfoliative rash			OFFSIDES
265	Eye laser surgery			OFFSIDES
266	Eyelid margin crusting			OFFSIDES
267	False negative laboratory result			OFFSIDES
268	Febrile bone marrow aplasia			OFFSIDES
269	Febrile infection			OFFSIDES
270	Feeling abnormal			SIDER
271	Femur Head Necrosis		30506661	CTD
272	Fibrosis			SIDER
273	Flank Pain			SIDER
274	Fluid imbalance			OFFSIDES
275	Fluid overload			OFFSIDES
276	Focal Nodular Hyperplasia			OFFSIDES
277	Folliculitis			OFFSIDES
278	Full blood count decreased			OFFSIDES
279	Fungal rhinitis			OFFSIDES
280	Fungal test positive			OFFSIDES
281	Fungus serology test positive			OFFSIDES
282	Fungus stool identified			OFFSIDES
283	Gallop rhythm present			OFFSIDES
284	Gastroenteritis norovirus			OFFSIDES
285	Gastrointestinal Pain			SIDER
286	Gastrointestinal hypermotility			OFFSIDES
287	Gastrointestinal infection			OFFSIDES
288	Gastrointestinal toxicity			OFFSIDES
289	Gliosis			OFFSIDES
290	Graft versus host disease in intestine			OFFSIDES
291	Graft versus host disease in liver			OFFSIDES
292	Graft versus host disease in lung			OFFSIDES
293	Granulocytes abnormal			OFFSIDES
294	Granulocytes maturation arrest			OFFSIDES
295	Granulomatous liver disease			OFFSIDES
296	Granuloma			OFFSIDES
297	Haematotoxicity			OFFSIDES
298	Haptoglobin Decreased			OFFSIDES
299	Headache			SIDER
300	Hematologic Neoplasms		18626885	CTD
301	Hemothorax			OFFSIDES
302	Hepaplastin decreased			OFFSIDES
303	Hepatic infection bacterial			OFFSIDES
304	Hepatic infection fungal			OFFSIDES
305	Hepatic vein occlusion			OFFSIDES
306	Hepatitis B positive			OFFSIDES
307	Hepatitis C RNA			OFFSIDES
308	Hepatitis C virus test			OFFSIDES
309	Hepatosplenomegaly			OFFSIDES
310	Hepatotoxicity			OFFSIDES
311	Hidradenitis			OFFSIDES
312	Human herpes virus 6 serology positive			OFFSIDES
313	Human polyomavirus infection			OFFSIDES
314	Hypersensitivity			SIDER
315	Hypoxia			OFFSIDES SIDER
316	Idiopathic pneumonia syndrome			OFFSIDES
317	Idiosyncratic drug reaction			OFFSIDES
318	Immune agglutinins			OFFSIDES
319	Immunodeficiency congenital			OFFSIDES
320	Immunology test abnormal			OFFSIDES
321	Immunosuppression			OFFSIDES
322	Induration			OFFSIDES
323	Infection in an immunocompromised host			OFFSIDES
324	Influenza			SIDER
325	Intervertebral disc disorder			OFFSIDES
326	Intestinal adenocarcinoma			OFFSIDES
327	Intracranial Hypotension			OFFSIDES
328	Intravascular papillary endothelial hyperplasia			OFFSIDES
329	Intubation			OFFSIDES
330	Iridocyclitis			OFFSIDES
331	JC virus infection			OFFSIDES
332	Kidney Failure			OFFSIDES
333	Kidney Neoplasm			OFFSIDES
334	Klebsiella sepsis			OFFSIDES
335	Labile blood pressure			OFFSIDES
336	Lactic dehydrogenase activity increased			SIDER
337	Large cell carcinoma of the respiratory tract stage unspecified			OFFSIDES
338	Legionella			OFFSIDES
339	Leriche Syndrome			OFFSIDES
340	Leukaemic infiltration brain			OFFSIDES
341	Leukopenia neonatal			OFFSIDES
342	Lichenification			OFFSIDES
343	Liver Failure, Acute		19008178	CTD
344	Liver palpable subcostal			OFFSIDES
345	Lower respiratory tract infection viral			OFFSIDES
346	Lung consolidation			OFFSIDES
347	Lung hyperinflation			OFFSIDES
348	Lung infection pseudomonal			OFFSIDES
349	Lymphadenitis viral			OFFSIDES
350	Lymphocyte count decreased			OFFSIDES
351	Lymphocytic infiltration			OFFSIDES
352	Lymphocytosis			OFFSIDES
353	Lymphohistiocytosis			OFFSIDES
354	Lymphoma			OFFSIDES
355	MYELODYSPLASTIC SYNDROME			SIDER
356	Malaise			SIDER
357	Malignant melanoma stage II			OFFSIDES
358	Malignant neoplasm progression			OFFSIDES
359	Mantle cell lymphoma			OFFSIDES
360	Mechanical ventilation			OFFSIDES
361	Megakaryocytes increased			OFFSIDES
362	Meningeal disorder			OFFSIDES
363	Meningitis enterococcal			OFFSIDES
364	Metabolic acidosis			OFFSIDES SIDER
365	Metaplasia			OFFSIDES
366	Microsporum infection			OFFSIDES
367	Miller Fisher Syndrome			OFFSIDES
368	Molluscum Contagiosum			OFFSIDES
369	Monocyte percentage increased			OFFSIDES
370	Mononeuritis			OFFSIDES
371	Mucormycosis			OFFSIDES
372	Mucosal erosion			OFFSIDES
373	Multiple Myeloma			OFFSIDES
374	Musculoskeletal discomfort			SIDER
375	Myasthenia Gravis			OFFSIDES
376	Mycobacterium chelonei infection			OFFSIDES
377	Myelitis			OFFSIDES
378	Myelodysplasia			OFFSIDES
379	Myelodysplastic syndrome transformation			OFFSIDES
380	Myeloma recurrence			OFFSIDES
381	Myelosuppression			SIDER
382	Myocardial Infarction			SIDER
383	Nail Infection			OFFSIDES
384	Neoplasms, Second Primary		20026017	CTD
385	Neuroblastoma recurrent			OFFSIDES
386	Neuroblastoma			OFFSIDES
387	Neurocysticercosis			OFFSIDES
388	Neurological decompensation			OFFSIDES
389	Neutropenia			SIDER
390	Neutropenic sepsis			OFFSIDES
391	Nodular regenerative hyperplasia			OFFSIDES
392	Nutritional condition abnormal			OFFSIDES
393	Ophthalmoplegia			OFFSIDES
394	Optic Disc Edema			OFFSIDES
395	Optic Neuritis			OFFSIDES SIDER
396	Oral mucosal exfoliation			OFFSIDES
397	Oropharyngeal pain			OFFSIDES
398	Osteoporosis			SIDER
399	Oxygen consumption increased			OFFSIDES
400	PROTHROMBIN TIME			OFFSIDES
401	Paraparesis			OFFSIDES
402	Parenteral Nutrition			OFFSIDES
403	Parotitis			OFFSIDES
404	Parvovirus B19 serology positive			OFFSIDES
405	Pathogen resistance			OFFSIDES
406	Pemphigus			OFFSIDES SIDER
407	Pericardial effusion			OFFSIDES SIDER
408	Pericarditis			OFFSIDES
409	Peripheral Nervous System Diseases		8394169 8445943 15279668	CTD
410	Pharyngitis			SIDER
411	Phlebitis			SIDER
412	Placental Insufficiency			OFFSIDES
413	Plasmacytoma			OFFSIDES
414	Platelet Transfusion			OFFSIDES
415	Platelet count abnormal			OFFSIDES
416	Pneumococcal sepsis			OFFSIDES
417	Pneumocystis jiroveci pneumonia			OFFSIDES
418	Pneumonia herpes viral			OFFSIDES
419	Pneumothorax			OFFSIDES
420	Post procedural sepsis			OFFSIDES
421	Post transplant distal limb syndrome			OFFSIDES
422	Presbyopia			OFFSIDES
423	Prostate cancer recurrent			OFFSIDES
424	Protein urine present			SIDER
425	Proteinuria			SIDER
426	Pruritus			SIDER
427	Psychiatric symptom			OFFSIDES
428	Pulmonary Fibrosis			SIDER
429	Pulmonary arterial hypertension			OFFSIDES
430	Pulmonary sepsis			OFFSIDES
431	Pulmonary toxicity			OFFSIDES SIDER
432	Quadriparesis			OFFSIDES
433	Quadriplegia			OFFSIDES
434	Radial nerve palsy			SIDER
435	Radicular pain			OFFSIDES
436	Rales			OFFSIDES
437	Recurrence		17207701	CTD
438	Red blood cell schistocytes present			OFFSIDES
439	Refractory cytopenia with multilineage dysplasia			OFFSIDES
440	Relapsing Fever			OFFSIDES
441	Renal abscess			OFFSIDES
442	Reticulocyte count decreased			OFFSIDES
443	Reticulocytopenia			OFFSIDES
444	Reticulocytosis			OFFSIDES
445	Retrograde portal vein flow			OFFSIDES
446	Rhinitis			SIDER
447	Rhinovirus infection			OFFSIDES
448	Right ventricular systolic pressure increased			OFFSIDES
449	Sarcoidosis			OFFSIDES
450	Secretion discharge			OFFSIDES
451	Septic embolus			OFFSIDES
452	Serum Sickness			OFFSIDES
453	Sigmoiditis			OFFSIDES
454	Sinus headache			OFFSIDES
455	Sinusitis aspergillus			OFFSIDES
456	Sinusitis			OFFSIDES SIDER
457	Skin lesion			OFFSIDES
458	Skin neoplasm excision			OFFSIDES
459	Skin toxicity			OFFSIDES SIDER
460	Soft tissue necrosis			OFFSIDES
461	Splenic Infarction			OFFSIDES
462	Splenic abscess			OFFSIDES
463	Sputum culture positive			OFFSIDES
464	Squamous cell carcinoma of skin			OFFSIDES
465	Staphylococcal Scalded Skin Syndrome			OFFSIDES
466	Stem cell transplant			OFFSIDES
467	Stenotrophomonas infection			OFFSIDES
468	Stenotrophomonas sepsis			OFFSIDES
469	Steroid withdrawal syndrome			OFFSIDES
470	Stevens-Johnson Syndrome		25811541	CTD SIDER
471	Stomatitis			SIDER
472	Subacute hepatic failure			OFFSIDES
473	Subcutaneous Abscess			OFFSIDES
474	Sudden death			OFFSIDES
475	Superficial spreading melanoma stage I			OFFSIDES
476	Supraventricular tachycardia			SIDER
477	Systemic mycosis			OFFSIDES
478	Therapeutic product ineffective			OFFSIDES
479	Therapy non-responder			OFFSIDES
480	Thoracic cavity drainage			OFFSIDES
481	Thrombocytopenia		15501959	CTD SIDER
482	Thrombocytopenic purpura			SIDER
483	Thrombotic stroke			OFFSIDES
484	Thyroiditis			OFFSIDES
485	Tonsillitis			OFFSIDES
486	Toxic Epidermal Necrolysis			SIDER
487	Toxoplasmosis			OFFSIDES
488	Transaminases increased			OFFSIDES
489	Transfusion Reaction			OFFSIDES
490	Treatment related secondary malignancy			OFFSIDES
491	Trichosporon infection			OFFSIDES
492	Trigeminal Nerve Disorder			OFFSIDES
493	Tuberculosis test positive			OFFSIDES
494	Tumor Lysis Syndrome		16313266	CTD
495	Type III immune complex mediated reaction			OFFSIDES
496	Unresponsive to verbal stimuli			OFFSIDES
497	Upper respiratory tract infection bacterial			OFFSIDES
498	Upper respiratory tract inflammation			OFFSIDES
499	Urinary hesitation			SIDER
500	Urinary tract infection pseudomonal			OFFSIDES
501	Urinary tract infection			SIDER
502	Vaccination failure			OFFSIDES
503	Vasoplegia syndrome			OFFSIDES
504	Venoocclusive disease			OFFSIDES
505	Venous Insufficiency			OFFSIDES
506	Ventricular Dysfunction, Left		11498753	CTD
507	Viral DNA test positive			OFFSIDES
508	Viral upper respiratory tract infection			OFFSIDES
509	Viral vasculitis			OFFSIDES
510	Virus serology test positive			OFFSIDES
511	Virus urine test positive			OFFSIDES
512	Vitamin B 12 Deficiency			OFFSIDES
513	Vulval cancer recurrent			OFFSIDES
514	Waldenstrom Macroglobulinemia		10721776 18347188	CTD
515	Weight Gain			OFFSIDES
516	West Nile viral infection			OFFSIDES
517	bone marrow fibrosis			OFFSIDES
518	leukemia		15501959 18852132	CTD
519	nervous system disorder			SIDER
520	treatment failure			OFFSIDES

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