MetaADEDB: Drug

MetaADEDB 2.0 @ LMMD

Midodrine

(PTKSEFOSCHHMPD-UHFFFAOYSA-N)

Structure

SMILES: COc1ccc(cc1C(CNC(=O)CN)O)OC
Type(s): Approved
ATC code(s): C01CA17
Molecular Formula:: C12H18N2O4
Molecular Weight:: 254.282
Log P:: 0.9033
Hydrogen Bond Acceptor:: 6
Hydrogen Bond Donor:: 3
TPSA:: 93.81
CAS Number(s):: 42794-76-3; 97476-58-9

Synonym(s)

Midodrine

Amatine

Gutron

Midodrin

Midodrine Hydrochloride

Midodrine Monohydrochloride

Midon

ProAmatine

ST-1085

10.

Monohydrochloride, Midodrine

11.

ST 1085

12.

ST1085

External Link(s)

MeSH	D008879
PubChem Compound	4195
ChEBI	6933
CHEMBL	CHEMBL1201212
DrugBank	DB00211
DrugCentral	1803
IUPHAR/BPS Guide to PHARMACOLOGY	7240
KEGG	cpd:C07890 dr:D08220
Therapeutic Target Database	D02XJY

Adverse Drug Event(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Toxicity to various agents	FAERS: 5		US FAERS
2	Bradycardia	FAERS: 4	7507712	CTD SIDER US FAERS
3	Drug ineffective	FAERS: 3		US FAERS
4	Metabolic acidosis	FAERS: 3		US FAERS
5	Posterior reversible encephalopathy syndrome	FAERS: 3		US FAERS
6	Syncope	FAERS: 3	14727996 17530320	CTD US FAERS
7	Anxiety	FAERS: 2		OFFSIDES SIDER US FAERS
8	Headache	FAERS: 2	9745973	CTD SIDER US FAERS
9	Troponin increased	FAERS: 2		US FAERS
10	Vomiting	FAERS: 2		US FAERS
11	Abdominal Pain	FAERS: 1		OFFSIDES SIDER US FAERS
12	Abdominal discomfort	FAERS: 1		OFFSIDES SIDER US FAERS
13	Akinesia	FAERS: 1		US FAERS
14	Angina Pectoris	FAERS: 1		US FAERS
15	Aphonia	FAERS: 1		US FAERS
16	Apparent life threatening event	FAERS: 1		US FAERS
17	Cerebral hypoperfusion	FAERS: 1		US FAERS
18	Chest Pain	FAERS: 1		OFFSIDES US FAERS
19	Constipation	FAERS: 1		US FAERS
20	Depressed Level of Consciousness	FAERS: 1		OFFSIDES US FAERS
21	Diplopia	FAERS: 1		US FAERS
22	Drug dispensing error	FAERS: 1		US FAERS
23	Drug effect incomplete	FAERS: 1		US FAERS
24	Drug half-life reduced	FAERS: 1		US FAERS
25	Dysphonia	FAERS: 1		US FAERS
26	Epilepsy	FAERS: 1		US FAERS
27	Fatigue	FAERS: 1	9398120	CTD OFFSIDES US FAERS
28	Hypotension	FAERS: 1	9398120 19522958	CTD US FAERS
29	Ileus	FAERS: 1		US FAERS
30	Intestinal Obstruction	FAERS: 1		US FAERS
31	Malaise	FAERS: 1		US FAERS
32	Memory impairment	FAERS: 1		US FAERS
33	Multi-organ disorder	FAERS: 1		US FAERS
34	Nausea	FAERS: 1		OFFSIDES SIDER US FAERS
35	Overdose	FAERS: 1		US FAERS
36	Pain	FAERS: 1		OFFSIDES SIDER US FAERS
37	Palpitations	FAERS: 1		US FAERS
38	Paranoia	FAERS: 1		US FAERS
39	Poor quality sleep	FAERS: 1		US FAERS
40	Product quality issue	FAERS: 1		US FAERS
41	Product substitution issue	FAERS: 1		US FAERS
42	Pruritus	FAERS: 1	15466905	CTD SIDER US FAERS
43	Pulmonary Fibrosis	FAERS: 1		US FAERS
44	Tachycardia	FAERS: 1		SIDER US FAERS
45	Urinary Retention	FAERS: 1	17901021	CTD SIDER US FAERS
46	Visual Impairment	FAERS: 1		US FAERS
47	Weight decreased	FAERS: 1		US FAERS
48	Abasia			OFFSIDES
49	Abnormal vision			OFFSIDES
50	Abscess			OFFSIDES
51	Abuse			OFFSIDES
52	Acid reflux			OFFSIDES
53	Activities of daily living impaired			OFFSIDES
54	Acute respiratory failure			OFFSIDES
55	Adrenal mass			OFFSIDES
56	Adverse event			OFFSIDES
57	Ageusia			OFFSIDES
58	Agitation			SIDER
59	Alcoholic Intoxication			OFFSIDES
60	Altered state of consciousness			OFFSIDES
61	Amenorrhea			OFFSIDES
62	Amnesia			OFFSIDES
63	Anal sphincter atony			OFFSIDES
64	Angioplasty			OFFSIDES
65	Anhedonia			OFFSIDES
66	Anhidrosis			OFFSIDES
67	Ankle Fracture			OFFSIDES
68	Anorexia			OFFSIDES
69	Anosmia			OFFSIDES
70	Anoxia			OFFSIDES
71	Antidepressant drug clearance decreased			OFFSIDES
72	Aortic valve calcification			OFFSIDES
73	Apathy			OFFSIDES
74	Aphthous Stomatitis			SIDER
75	Apnea			OFFSIDES
76	Arterial insufficiency			OFFSIDES
77	Arteriosclerosis			OFFSIDES
78	Arteriovenous fistula occlusion			OFFSIDES
79	Arteriovenous fistula thrombosis			OFFSIDES
80	Arteriovenous graft thrombosis			OFFSIDES
81	Arthritis			OFFSIDES
82	Arthropathy			OFFSIDES
83	Aspiration Pneumonia			OFFSIDES
84	Asterixis			OFFSIDES
85	Asthenia			OFFSIDES SIDER
86	Ataxia		17901021	CTD OFFSIDES
87	Atelectasis			OFFSIDES
88	Atrial thrombosis			OFFSIDES
89	Aura			OFFSIDES
90	Autonomic neuropathy			OFFSIDES
91	Axonal neuropathy			OFFSIDES
92	Back Pain			SIDER
93	Back disorder			OFFSIDES
94	Bacterial sepsis			OFFSIDES
95	Beta 2 microglobulin increased			OFFSIDES
96	Biopsy bone abnormal			OFFSIDES
97	Blepharitis			OFFSIDES
98	Blood cholesterol			OFFSIDES
99	Blood creatine phosphokinase increased			OFFSIDES
100	Blood glucose decreased			OFFSIDES
101	Blood glucose fluctuation			OFFSIDES
102	Blood pressure fluctuation			OFFSIDES
103	Blood pressure orthostatic decreased			OFFSIDES
104	Blood sodium			OFFSIDES
105	Blood testosterone decreased			OFFSIDES
106	Blood urea increased			OFFSIDES
107	Bone pain			OFFSIDES
108	Bone swelling			OFFSIDES
109	Brain Contusion			OFFSIDES
110	Bronchiectasis			OFFSIDES
111	Bronchitis			OFFSIDES
112	Bronchopneumonia			OFFSIDES
113	Burning sensation			OFFSIDES
114	Bursitis			OFFSIDES
115	Calciphylaxis			OFFSIDES
116	Cardiac discomfort			OFFSIDES
117	Cartilage injury			OFFSIDES
118	Cataract operation			OFFSIDES
119	Cataract			OFFSIDES
120	Catheter related infection			OFFSIDES
121	Catheter sepsis			OFFSIDES
122	Catheter site erythema			OFFSIDES
123	Catheter site infection			OFFSIDES
124	Cellulitis			OFFSIDES
125	Central retinal vein occlusion			SIDER
126	Cerebellar Hypoplasia			OFFSIDES
127	Cerebral artery stenosis			OFFSIDES
128	Cerebral atrophy			OFFSIDES
129	Chills			SIDER
130	Choking sensation			OFFSIDES
131	Cholecystitis			OFFSIDES
132	Chromaturia			OFFSIDES
133	Chronic Obstructive Airway Disease			OFFSIDES
134	Chronic sinusitis			OFFSIDES
135	Circumstance or information capable of leading to medication error			OFFSIDES
136	Clostridium difficile colitis			OFFSIDES
137	Colon adenoma			OFFSIDES
138	Confabulation			OFFSIDES
139	Congenital cystic kidney disease			OFFSIDES
140	Congenital tricuspid valve incompetence			OFFSIDES
141	Contracture			OFFSIDES
142	Cramps of lower extremities			SIDER
143	Deafness			OFFSIDES
144	Debridement			OFFSIDES
145	Dehydration			OFFSIDES
146	Demyelination			OFFSIDES
147	Dental abscess			OFFSIDES
148	Dental alveolar anomaly			OFFSIDES
149	Dental examination			OFFSIDES
150	Dermatitis			SIDER
151	Device related infection			OFFSIDES
152	Diarrhea			OFFSIDES
153	Diastolic dysfunction			OFFSIDES
154	Distress gastrointestinal			SIDER
155	Diverticular perforation			OFFSIDES
156	Diverticulosis			OFFSIDES
157	Diverticulum			OFFSIDES
158	Dizziness		9398120 9745973	CTD OFFSIDES SIDER
159	Drowsiness			OFFSIDES
160	Drug toxicity			OFFSIDES
161	Drug withdrawal headache			OFFSIDES
162	Dry gangrene			OFFSIDES
163	Dry skin			OFFSIDES SIDER
164	Dyspepsia			OFFSIDES SIDER
165	Dysthymic Disorder			OFFSIDES
166	Dystonia		11001613 18344053	CTD OFFSIDES
167	Dysuria			SIDER
168	Economic problem			OFFSIDES
169	Ejection Fraction Decreased			OFFSIDES
170	Emotional distress			OFFSIDES
171	Encephalitis			OFFSIDES
172	Endodontic procedure			OFFSIDES
173	Enteritis			OFFSIDES
174	Enterococcal infection			OFFSIDES
175	Epistaxis			OFFSIDES
176	Epstein-Barr virus associated lymphoproliferative disorder			OFFSIDES
177	Erectile dysfunction			OFFSIDES
178	Erythema Multiforme			SIDER
179	Erythema			OFFSIDES
180	Excitability			SIDER
181	Excoriation			OFFSIDES
182	Extremity contracture			OFFSIDES
183	Extremity necrosis			OFFSIDES
184	Failure to Thrive			OFFSIDES
185	Fanconi Syndrome			OFFSIDES
186	Fatty Liver			OFFSIDES
187	Feeling abnormal			SIDER
188	Flatulence			SIDER
189	Fluid overload			OFFSIDES
190	Flushing			SIDER
191	Focal glomerulosclerosis			OFFSIDES
192	Formication			OFFSIDES
193	Gangrene			OFFSIDES
194	Gastrointestinal Pain			SIDER
195	Gastrointestinal arteriovenous malformation			OFFSIDES
196	General physical health deterioration			OFFSIDES
197	Glaucoma			OFFSIDES
198	Globulinuria			OFFSIDES
199	Gout			OFFSIDES
200	Granulocytosis			OFFSIDES
201	Heart failure		19522958	CTD
202	Heartburn			SIDER
203	Heparin-induced thrombocytopenia			OFFSIDES
204	Hepatitis C			OFFSIDES
205	Hepatitis			OFFSIDES
206	High frequency ablation			OFFSIDES
207	Hydrocephalus			OFFSIDES
208	Hydronephrosis		17901021	CTD OFFSIDES
209	Hyperkeratosis			OFFSIDES
210	Hyperparathyroidism			OFFSIDES
211	Hyperpigmentation			OFFSIDES
212	Hypersensation skin			SIDER
213	Hypocoagulable state			OFFSIDES
214	Hypophagia			OFFSIDES
215	Hyporeflexia			OFFSIDES
216	Hypotension, Orthostatic		View details 2480881 7507712 7690382 11145175 11761508 12401592 14727996 15198285 15466905 16520351 17530320 17901021 18344053 19944906	CTD
217	Impetigo			OFFSIDES
218	Incontinence			OFFSIDES
219	Induration			OFFSIDES
220	Infection			OFFSIDES
221	Infusion site mobility decreased			OFFSIDES
222	Intention tremor			OFFSIDES
223	Intentional drug misuse			OFFSIDES
224	Intermittent Claudication			OFFSIDES
225	Intervertebral Disc Degeneration			OFFSIDES
226	Intestinal infarction			OFFSIDES
227	Joint Range of Motion Decreased			OFFSIDES
228	Joint stiffness			OFFSIDES
229	Kidney Failure			OFFSIDES
230	Large intestine perforation			OFFSIDES
231	Lethargy			OFFSIDES
232	Leukoencephalopathy			OFFSIDES
233	Limb injury			OFFSIDES
234	Limb operation			OFFSIDES
235	Livedo Reticularis			OFFSIDES
236	Liver transplant rejection			OFFSIDES
237	Lymphedema			OFFSIDES
238	Malocclusion			OFFSIDES
239	Mastication disorder			OFFSIDES
240	Mechanical ventilation			OFFSIDES
241	Medical device complication			OFFSIDES
242	Medication residue			OFFSIDES
243	Mental status changes			OFFSIDES
244	Metastatic Neoplasm			OFFSIDES
245	Multiple Myeloma			OFFSIDES
246	Multiple drug overdose intentional			OFFSIDES
247	Muscle Cramp		9398120	CTD
248	Muscle Weakness		9398120	CTD OFFSIDES
249	Muscle tightness			OFFSIDES
250	Musculoskeletal Pain			OFFSIDES
251	Musculoskeletal chest pain			OFFSIDES
252	Musculoskeletal discomfort			OFFSIDES
253	Musculoskeletal stiffness			OFFSIDES
254	Myelodysplasia			OFFSIDES
255	Myeloma recurrence			OFFSIDES
256	Myosclerosis			OFFSIDES
257	Necrosis		21983523	CTD
258	Nephrogenic Fibrosing Dermopathy			OFFSIDES
259	Nervousness			SIDER
260	Neuralgia			OFFSIDES
261	Neutrophil count decreased			OFFSIDES
262	Nipple pain			OFFSIDES
263	Nodule on extremity			OFFSIDES
264	Ocular icterus			OFFSIDES
265	Olfaction Disorders		15466905	CTD
266	Osteolysis			OFFSIDES
267	Osteomyelitis			OFFSIDES
268	Osteopenia			OFFSIDES
269	Osteoporosis			OFFSIDES
270	Osteosclerosis			OFFSIDES
271	Pain of skin			OFFSIDES
272	Pancreatitis			OFFSIDES
273	Panic Disorder			OFFSIDES
274	Paresthesia of scalp			SIDER
275	Paresthesia		9398120	CTD
276	Peripheral arterial occlusive disease			OFFSIDES
277	Perirectal abscess			OFFSIDES
278	Peritoneal Dialysis			OFFSIDES
279	Peritoneal Infection			OFFSIDES
280	Peritonitis			OFFSIDES
281	Pharmaceutical product complaint			OFFSIDES
282	Physical disability			OFFSIDES
283	Piloerection			OFFSIDES SIDER
284	Polymyalgia Rheumatica			OFFSIDES
285	Portal Hypertension			OFFSIDES
286	Portal hypertensive gastropathy			OFFSIDES
287	Potentiating drug interaction			OFFSIDES
288	Procedural hypotension			OFFSIDES
289	Proctitis			OFFSIDES
290	Prostate cancer recurrent			OFFSIDES
291	Protein total decreased			OFFSIDES
292	Proteinuria		16520351	CTD
293	Pulmonary Hypertension			OFFSIDES
294	Pulmonary congestion			OFFSIDES
295	Pulmonary function test decreased			OFFSIDES
296	Purulent discharge			OFFSIDES
297	Pyelonephritis			OFFSIDES
298	Quadriplegia			OFFSIDES
299	Reflex bradycardia			SIDER
300	Renal cyst			OFFSIDES
301	Retinal Vein Occlusion			SIDER
302	Retinal vascular thrombosis			OFFSIDES
303	Retroperitoneal lymphadenopathy			OFFSIDES
304	Rhabdomyolysis			OFFSIDES
305	Scab			OFFSIDES
306	Sclerodactylia			OFFSIDES
307	Scotoma			SIDER
308	Septic Shock			OFFSIDES
309	Sigmoiditis			OFFSIDES
310	Sinusitis			OFFSIDES
311	Sjogren's Syndrome			OFFSIDES
312	Skin Erosion			OFFSIDES
313	Skin Induration			OFFSIDES
314	Skin hypertrophy			OFFSIDES
315	Skin laceration			OFFSIDES
316	Skin tightness			OFFSIDES
317	Somnolence			SIDER
318	Spinal column stenosis			OFFSIDES
319	Spinal fusion surgery			OFFSIDES
320	Spondylitis			OFFSIDES
321	Stasis dermatitis			OFFSIDES
322	Stent occlusion			OFFSIDES
323	Stevens-Johnson Syndrome			SIDER
324	Stomatitis			SIDER
325	Sudden Cardiac Death			OFFSIDES
326	Taste Disorders		15466905	CTD
327	Temporal Arteritis			OFFSIDES
328	Tension			SIDER
329	Therapeutic response unexpected with drug substitution			OFFSIDES
330	Thrombectomy			OFFSIDES
331	Thrombophlebitis			OFFSIDES
332	Thrombosis in device			OFFSIDES
333	Tooth Extraction			OFFSIDES
334	Transaminases increased			OFFSIDES
335	Ulcer			OFFSIDES
336	Unresponsive to stimuli			OFFSIDES
337	Ureteral Diseases		17901021	CTD
338	Urge Incontinence			OFFSIDES
339	Vasodilation procedure			SIDER
340	Vasodilation			SIDER
341	Venous Insufficiency			OFFSIDES
342	Venous stasis			OFFSIDES
343	Venous stenosis			OFFSIDES
344	Venous thrombosis limb			OFFSIDES
345	Vitreous Detachment			OFFSIDES
346	Weight Gain			OFFSIDES
347	Wound dehiscence			OFFSIDES
348	muscle injury			OFFSIDES
349	nervous system disorder			SIDER

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