MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

leukemia

(UMLS:C0023418)

Definition:: A progressive, malignant disease of the blood-forming organs, characterized by distorted proliferation and development of leukocytes and their precursors in the blood and bone marrow. Leukemias were originally termed acute or chronic based on life expectancy but now are classified according to cellular maturity. Acute leukemias consist of predominately immature cells; chronic leukemias are composed of more mature cells. (From The Merck Manual, 2006)
UMLS ID:: C0023418
MeSH ID:: D007938

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.337

Synonym(s)

leukemia

Blood (Leukemia)

LEUKEMIA

LEUKEMIA, MALIGNANT

Leukaemia

Leukaemia NOS

Leukaemia morphology

Leukaemia, NOS

Leukaemia, NOS, without mention of remission

10.

Leukaemia, unspecified

11.

Leukaemia, unspecified, without mention of remission

12.

Leukemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,3-butadiene	16155477 26070419 26343807	CTD
2	2,2-bis(bromomethyl)-1,3-propanediol	12594523	CTD
3	2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one	12970779	CTD
4	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	10755388	CTD
5	2-desamino-2-methylaminopterin	1313737	CTD
6	2-formylpyridine thiosemicarbazone	25130544	CTD
7	2-nitrotoluene	12087420	CTD
8	28-deoxonimbolide	21381696	CTD
9	4'-deoxy-4'-iododoxorubicin	3607745	CTD
10	5,7,3'-trihydroxy-3,4'-dimethoxyflavone	21229608	CTD
11	5-iminodaunorubicin	423181	CTD
12	Amlodipine	16684125	CTD
13	Amsacrine	3681383 9295513	CTD
14	Azacitidine	2408741 19148494	CTD
15	Azathioprine	19229528 23958494	CTD
16	BEP protocol	1713639	CTD
17	Benzene	View details 1868253 2676498 3311642 9118896 14694614 15935818 17119257 18335105 19029204 19162166 20026016 20083130 22411970 30567741	CTD
18	Bortezomib	15039284 16481037	CTD
19	C.I. Acid Red 114	12621513	CTD
20	Calcitriol	7837819 10470102 16886663	CTD
21	Carboplatin	7630183 15501959	CTD
22	Carmustine	6354414 11960597	CTD
23	Chlorambucil	118440	CTD
24	Chloramphenicol	1211407 8834551 18559535	CTD
25	Cyclophosphamide	572348 10602166 18034189	CTD
26	Cytarabine	View details 1068643 1545440 1661126 2011096 2411382 2554727 2778484 3470173 3481363 3585447 3655707 3681383 3874431 3885116 3925559 3971396 4033929 4521468 6223674 6594185 6651239 7306918 8504443 8909309 10561356 11902300 15135655	CTD
27	Dasatinib	28243904	CTD
28	Daunorubicin	5293526 17204177	CTD
29	Decitabine	9180389 18980019 19235587	CTD
30	Diazinon	16236997	CTD
31	Doxorubicin	View details 1617512 1831987 6213212 7287901 9768830 12969434 23220514 26915917	CTD
32	Ethylnitrosourea	3476793 11773516 11773517	CTD
33	Fenretinide	2523991	CTD
34	Genistein	17468513 18980019	CTD
35	Heptachlor	17096337	CTD
36	Hydrocortisone	11902300	CTD
37	Hydroxyurea	4883783 11317962 17686055	CTD
38	Idarubicin	1831987 28973540	CTD
39	Ifosfamide	7596151	CTD
40	Imatinib Mesylate	24240679	CTD
41	LAQ824	16275999 18852132	CTD
42	Lignans	20932957	CTD
43	Mercaptopurine	581272 22688000 23358152	CTD
44	Methotrexate	View details 581272 766954 1058923 1062350 1313737 1758061 1838364 2854471 4125793 4504035 5171437 7797145 10458822 11800653 11902300 11992760 16166815	CTD
45	Mitoxantrone	View details 3481363 8262731 15623667 16503747	CTD
46	NSC 680410	16481037	CTD
47	Nelfinavir	20105315	CTD
48	Niacin	19372544	CTD
49	Nitrates	16291529	CTD
50	POMP protocol	5038956	CTD
51	Paclitaxel	7904060	CTD
52	Permethrin	12937054	CTD
53	Polychlorinated Dibenzodioxins	18192277	CTD
54	Polyvinyl Chloride	14651027	CTD
55	Prednisone	3875694 4166870	CTD
56	Quercetin	17468513	CTD
57	Roscovitine	16275999	CTD
58	Rutin	26091902	CTD
59	Silymarin	20932957	CTD
60	Sorafenib	17205056 20105315	CTD
61	Temozolomide	15360003 17500047	CTD
62	Thioguanine	1068643	CTD
63	Topotecan	15501959 16684125	CTD
64	Tretinoin	17143497 17290005	CTD
65	Uracil Mustard	3369437	CTD
66	Vincristine	View details 581272 630255 3875694 4163141 5286047 5660206 6149015	CTD
67	Vindesine	6268296 7193278	CTD
68	acteoside	20932957	CTD
69	alachlor	14769641	CTD
70	alvocidib	15039284	CTD
71	azadiradione	21381696	CTD
72	beta-lapachone	21830773	CTD
73	bryostatin 1	15070760	CTD
74	cordiaquinone J	19962971	CTD
75	fludarabine	15501959 18852132	CTD
76	gedunin	21381696	CTD
77	geraniol	10082788	CTD
78	kaempferol	17468513	CTD
79	linalool	23220514	CTD
80	lomeguatrib	17500047	CTD
81	mancozeb	12562632	CTD
82	paricalcitol	12618899	CTD
83	pregna-4,17-diene-3,16-dione	17475222	CTD
84	propylnitrosourea	3476793	CTD
85	pterostilbene	23921149	CTD
86	riddelliine	12844193 12927348	CTD
87	salinomycin	22215106	CTD
88	thiophenfurin	17143497	CTD
89	tiazofurin	2200759 9042306	CTD
90	turmeric extract	18462866 20932957	CTD
91	wogonin	23872129	CTD
92	zorubicin	270389 4507740	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplasms, Germ Cell and Embryonal	42.9%
2	Neoplasms, Glandular and Epithelial	42.9%
3	Germ Cell Cancer	42.9%
4	Neuroectodermal Tumors	40.9%
5	Neoplasms, Neuroepithelial	40%
6	Gliomatosis cerebri	40%
7	melanoma	37.2%
8	Carcinosarcoma	37.1%
9	Hemangiosarcoma	37.1%
10	lymphangiosarcoma	37.1%
11	Medulloblastoma	35.8%
12	Adenoma, Acidophil	34.4%
13	Ganglioneuroma	34.4%
14	Glioma	34.4%
15	Malignant Glioma	34.4%
16	Basal cell carcinoma	33.3%
17	Carcinoma, Papillary	33.3%
18	Squamous cell carcinoma	33.3%
19	Chondrosarcoma	33.3%
20	Craniopharyngioma	33.3%
21	Cystadenoma	33.3%
22	leiomyosarcoma	33.3%
23	liposarcoma	33.3%
24	Mesothelioma	33.3%
25	synovial sarcoma	33.3%
26	Neuroectodermal Tumor, Melanotic	33.3%
27	Angiomyolipoma	33.3%
28	Clear Cell Sarcoma of Soft Tissue	33.3%
29	Alveolar Soft Part Sarcoma	33.3%
30	Neuroendocrine Tumors	33.3%
31	Carcinoma, Basal Cell	33.3%
32	Carcinoid Tumor	33.1%
33	Neurilemmoma	33.1%
34	Hutchinson's Melanotic Freckle	33.1%
35	Melanoma, Amelanotic	33.1%
36	Astrocytoma	31.7%
37	Ependymoma	31.7%
38	oligodendroglioma	31.7%
39	Ganglioglioma	31.7%
40	gliosarcoma	31.7%
41	Anaplastic astrocytoma	31.7%
42	Anaplastic Oligodendroglioma	31.7%
43	Cystadenocarcinoma	31.5%
44	Fibrosarcoma	31.5%
45	Osteosarcoma	31.5%
46	Mucoepidermoid Carcinoma	31.5%
47	Adenoma	31%
48	Ameloblastoma	31%
49	Angiokeratoma	31%
50	Carcinoma	31%
51	Chordoma	31%
52	Hemangioma	31%
53	hemangiopericytoma	31%
54	Lymphangioma	31%
55	Malignant Carcinoid Syndrome	31%
56	Mesenchymoma	31%
57	Nevus	31%
58	Teratoma	31%
59	Hepatoblastoma	31%
60	Mixed Tumor, Mullerian	31%
61	Germinoma	31%
62	Teratocarcinoma	31%
63	Angiofibroma	31%
64	Sarcoma	31%
65	Epithelioma	31%
66	Carcinoma 256, Walker	30.8%
67	Adenofibroma	30.6%
68	Fibroadenoma	30.6%
69	Malignant Fibrous Histiocytoma	30.6%
70	Glioblastoma	30.4%
71	Neuroblastoma	30.4%
72	Glioblastoma Multiforme	30.4%
73	Ganglioneuroblastoma	29.7%
74	Bowen's Disease	29.7%
75	Paraganglioma	29.7%
76	Rhabdomyosarcoma	29.7%
77	Giant Cell Tumor of Bone	29.7%
78	Dermatofibrosarcoma	28.8%
79	Dermatofibrosarcoma Protuberans	28.8%
80	Histiocytic Disorders, Malignant	27.9%
81	Pheochromocytoma	27.9%
82	Alveolar rhabdomyosarcoma	27.9%
83	Meningioma	26.9%
84	Melanoma, Experimental	26.7%
85	Carcinoma, Ehrlich Tumor	26.4%
86	Dermoid Cyst	26.4%
87	Carcinoma, Lewis Lung	26.4%
88	Adenocarcinoma	25.4%
89	Carcinoma in Situ	25.4%
90	Carcinoma, Transitional Cell	25.4%
91	Phyllodes Tumor	25.4%
92	Dysgerminoma	25.4%
93	Hemangioendothelioma	25.4%
94	Lipoma	25.4%
95	Myoma	25.4%
96	Myxoma	25.4%
97	Neuroma	25.4%
98	Papilloma	25.4%
99	Pseudomyxoma Peritonei	25.4%
100	Seminoma	25.4%
101	Papillomatosis	25.4%
102	Angiolipoma	25.4%
103	Myelolipoma	25.4%
104	Neoplasms, Bone Tissue	25.4%
105	Neoplasms, Fibrous Tissue	25.4%
106	Smooth Muscle Tumor	25.4%
107	Adenomatosis, Pulmonary	25.4%
108	Adenomatous Polyps	25.4%
109	Carcinoma, Large Cell	25.4%
110	Carcinoma, Small Cell	25.4%
111	Desmoplastic Small Round Cell Tumor	25.4%
112	Chondroma	25.4%
113	Enchondroma	25.4%
114	Carcinoid Heart Disease	24.5%
115	Composite Lymphoma	24%
116	Acanthoma	23.6%
117	Hamartoma	23.1%
118	Neoplasms, Hormone-Dependent	23.1%
119	Neoplasms, Multiple Primary	23.1%
120	Paraneoplastic Syndromes	23.1%
121	Precancerous Conditions	23.1%
122	Neoplasms, Second Primary	23.1%
123	Choriocarcinoma	22.8%
124	Carcinoma, Lobular	22.8%
125	Adenoid Cystic Carcinoma	22.7%
126	fibroma	22.7%
127	Fibromatosis	22.7%
128	Osteoblastoma	22.7%
129	Osteoma	22.7%
130	Rhabdomyoma	22.7%
131	Chondromatosis	22.7%
132	Adenocarcinoma, Clear Cell	22.7%
133	Cholangiocarcinoma	22.7%
134	Cervical Intraepithelial Neoplasia	22.7%
135	Hemangioblastoma	22.7%
136	Lymphoma, Extranodal NK-T-Cell	22.7%
137	Trophoblastic Neoplasms	22.4%
138	Sarcoma 180	21.8%
139	Neurofibrosarcoma	21.4%
140	Fibromatosis, Aggressive	21.3%
141	Fibromatosis, Abdominal	21.3%
142	Klatskin Tumor	21.3%
143	Lymphoma	20.7%
144	Endometrial Stromal Sarcoma	20.6%
145	Plasmacytoma	20.5%
146	Malignant histiocytosis	20.2%
147	Histiocytic sarcoma	20.2%
148	Lymphangioleiomyomatosis	19.7%
149	Retinoblastoma	19.5%
150	Sarcoma, Experimental	19.5%
151	Thymoma	19.3%
152	Sarcoma, Myeloid	16.7%
153	Acoustic Neuroma	15.7%
154	Hydatidiform Mole	15.2%
155	Mastocytoma	15.1%
156	Cyst	15%
157	Hodgkin Disease	15%
158	Lymphoma, Non-Hodgkin	15%
159	Neoplastic Processes	15%
160	Neoplastic Syndromes, Hereditary	15%
161	Pregnancy Complications, Neoplastic	15%
162	Mastocytosis, Systemic	14.9%
163	Carcinoma, Pancreatic Ductal	14.9%
164	Neoplasms, Experimental	14.6%
165	Abdominal Neoplasms	14.3%
166	Erythroplasia	14.3%
167	Follicular cyst	14.3%
168	Head and Neck Neoplasms	14.3%
169	Mucocele	14.3%
170	Pilonidal Cyst	14.3%
171	Soft Tissue Neoplasms	14.3%
172	Thoracic Neoplasms	14.3%
173	Thyroglossal Cyst	14.3%
174	Synovial Cyst	14.3%
175	Aberrant Crypt Foci	14.3%
176	Lymphomatoid Granulomatosis	14.2%
177	Optic Nerve Glioma	14%
178	Vipoma	13.9%
179	Hepatocellular Adenoma	13.3%
180	Basal Cell Nevus Syndrome	13.1%
181	Mastocytosis	12.8%
182	Sturge-Weber Syndrome	12.8%
183	Multiple Endocrine Neoplasia	12.8%
184	Gastrointestinal Stromal Tumors	12.6%
185	Hemangioma, Cavernous	12.5%
186	Leukemia, Plasma Cell	12.5%
187	neurofibroma	12.3%
188	Lymphoma, Follicular	12.3%
189	T-Cell Lymphoma	12.3%
190	Mantle cell lymphoma	12.3%
191	Paraneoplastic Encephalomyelitis	12.3%
192	Primary amyloidosis	12.1%
193	Mammary Neoplasms, Experimental	12%
194	Nephroblastoma	11.2%
195	Prolactinoma	11%
196	Growth Hormone-Secreting Pituitary Adenoma	11%
197	Lymphoma, T-Cell, Cutaneous	11%
198	Lymphoma, AIDS-Related	11%
199	Enteropathy-Associated T-Cell Lymphoma	11%
200	Primary Effusion Lymphoma	11%
201	Dupuytren Contracture	10.8%
202	Neoplasms, Radiation-Induced	10.8%
203	Urticaria Pigmentosa	10.6%
204	Mesoblastic Nephroma	10.5%
205	insulinoma	10.4%
206	Retroperitoneal Neoplasms	10.3%
207	Mycosis Fungoides	10.3%
208	Lymphomatoid Papulosis	10.3%
209	Plasmablastic lymphoma	10.3%
210	Gastrinoma	10.1%
211	Glucagonoma	10.1%
212	Digestive System Neoplasms	10%
213	Endocrine Gland Neoplasms	10%
214	Eye Neoplasms	10%
215	Nervous System Neoplasms	10%
216	Adrenocortical carcinoma	9.8%
217	Bone neoplasms	9.5%
218	Leukoplakia	9.5%
219	Lymphocele	9.5%
220	Pancreatic Cyst	9.5%
221	Skin Neoplasms	9.5%
222	Hematologic Neoplasms	9.5%
223	Multiple Endocrine Neoplasia Type 1	9.4%
224	granulosa cell tumor	9.3%
225	Carcinoma, Ovarian Epithelial	9.3%
226	Barrett Esophagus	9.3%
227	Breast Cyst	9.3%
228	Actinic keratosis	9.3%
229	Mediastinal Cyst	9.3%
230	Neoplasm Invasiveness	9.3%
231	Neoplasm Metastasis	9.3%
232	Neoplasm Recurrence, Local	9.3%
233	Parovarian Cyst	9.3%
234	Pericardial Cyst	9.3%
235	Splenic Neoplasms	9.3%
236	Thymic Cyst	9.3%
237	Carcinogenesis	9.3%
238	Myxoid cyst	9.3%
239	Metastasis	9.3%
240	Leydig Cell Tumor	9%
241	Waldenstrom Macroglobulinemia	8.6%
242	Multiple Myeloma	8.6%
243	Adenomatous Polyposis Coli	8.4%
244	Renal Cell Carcinoma	8.3%
245	Parathyroid Neoplasms	8.3%
246	Peritoneal Neoplasms	8.3%
247	Thyroid Neoplasm	8.3%
248	Thyroid carcinoma	8.3%
249	Papillary Renal Cell Carcinoma	8.3%
250	Tuberous Sclerosis	8.2%
251	Carcinoma, Endometrioid	8.2%
252	Nasopharyngeal carcinoma	7.8%
253	Tracheal Neoplasms	7.6%
254	Leukoplakia, Oral	7.4%
255	Burkitt Lymphoma	7.3%
256	Paraneoplastic Cerebellar Degeneration	7.3%
257	Liver Neoplasms, Experimental	7.3%
258	Mouth Neoplasms	7%
259	Pancreatic Neoplasm	7%
260	Central Nervous System Neoplasms	7%
261	Vascular Neoplasms	7%
262	Thymus Neoplasms	7%
263	Sezary Syndrome	6.9%
264	Leukemia, Experimental	6.8%
265	Genital Neoplasms, Female	6.8%
266	Pancreatic Pseudocyst	6.8%
267	Corpus Luteum Cyst	6.8%
268	Ovarian Cysts	6.8%
269	Leukemia L1210	6.7%
270	Leukemia P388	6.7%
271	Lymphatic Metastasis	6.7%
272	Neoplasms, Unknown Primary	6.7%
273	Leukemic Infiltration	6.7%
274	Breast Neoplasms, Male	6.7%
275	Neoplasm Micrometastasis	6.7%
276	Triple Negative Breast Neoplasms	6.7%
277	Thyroid Nodule	6.7%
278	Denys-Drash Syndrome	6.3%
279	Esophageal Neoplasms	6.1%
280	Limbic Encephalitis	6.1%
281	Meningeal Neoplasms	5.6%
282	Choledochal Cyst	5.6%
283	Leukemia, Radiation-Induced	5.5%
284	Peutz-Jeghers Syndrome	5.4%
285	Lambert-Eaton Myasthenic Syndrome	5.3%
286	Testicular Neoplasms	5.3%
287	Adrenal Gland Neoplasms	5.3%
288	Gastrointestinal Neoplasms	5.3%
289	Genital Neoplasms, Male	5.3%
290	Liver neoplasms	5.3%
291	Uveal Neoplasms	5.3%
292	Urologic Neoplasms	5.2%
293	Sebaceous Gland Neoplasms	5.1%
294	Spinal Neoplasms	5.1%
295	Bone Marrow Neoplasms	5.1%
296	Meningeal Carcinomatosis	5%
297	Polycystic Ovary Syndrome	5%
298	Opsoclonus-Myoclonus Syndrome	4.6%
299	Palatal Neoplasms	4.5%
300	Ear Neoplasms	4.3%
301	Eyelid Neoplasms	4.3%
302	Lung Neoplasms	4.3%
303	Pleural Neoplasms	4.3%
304	Nose Neoplasms	4.3%
305	Cell Transformation, Viral	4.2%
306	Brain Neoplasms	4.2%
307	Salivary Gland Neoplasms	4.2%
308	Spinal Cord Neoplasms	4.2%
309	Tongue Neoplasms	4.2%
310	Uterine Neoplasms	4.1%
311	Vaginal Neoplasms	4.1%
312	Vulvar Neoplasms	4.1%
313	Uterine Cancer	4.1%
314	Fallopian Tube Neoplasms	4.1%
315	Myelitis, Transverse	4%
316	Bronchial Neoplasms	3.8%
317	Multiple Pulmonary Nodules	3.8%
318	Pituitary Adenoma	3.7%
319	Pituitary Neoplasms	3.7%
320	Supratentorial Neoplasms	3.7%
321	Endometrial Neoplasms	3.7%
322	Pharyngeal Neoplasms	3.5%
323	Brain Stem Neoplasms	3.5%
324	Central Nervous System Cysts	3.4%
325	ovarian neoplasm	3.4%
326	Bile Duct Neoplasms	3.4%
327	gallbladder neoplasm	3.4%
328	Intestinal Neoplasms	3.4%
329	Penile Neoplasms	3.4%
330	Prostatic Neoplasms	3.4%
331	Stomach Neoplasms	3.4%
332	Choroid Plexus Papilloma	3.3%
333	Polycythemia Vera	3.3%
334	Hypopharyngeal Neoplasms	3%
335	Pleural Effusion, Malignant	3%
336	Hypopharyngeal Cancer	3%
337	Xeroderma Pigmentosum	3%
338	Parotid Neoplasms	3%
339	Prostatic Neoplasms, Castration-Resistant	3%
340	Nelson Syndrome	2.9%
341	Laryngeal neoplasm	2.9%
342	Tonsillar Neoplasms	2.8%
343	Cerebellar Neoplasms	2.8%
344	Bladder Neoplasm	2.8%
345	Kidney Neoplasm	2.8%
346	Ureteral Neoplasms	2.8%
347	Urethral Neoplasms	2.8%
348	Zollinger-Ellison syndrome	2.5%
349	Cecal Neoplasms	2.5%
350	Duodenal Neoplasms	2.5%
351	Radicular Cyst	2.3%
352	Appendiceal Neoplasms	2.3%
353	Colonic Neoplasms	2.3%
354	Rectal Neoplasms	2.3%
355	Nasopharyngeal Neoplasms	2.1%
356	Colorectal Neoplasms	2.1%
357	Anus Neoplasms	1.9%
358	Sigmoid Neoplasms	1.9%
359	Paranasal Sinus Neoplasms	1.9%
360	Maxillary Sinus Neoplasms	1.7%

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