MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Parakeratosis

(UMLS:C0030436)

Definition:: Persistence of the nuclei of the keratinocytes into the stratum corneum of the skin. This is a normal state only in the epithelium of true mucous membranes in the mouth and vagina. (Dorland, 27th ed)
UMLS ID:: C0030436
MeSH ID:: D010241

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.428.736

Synonym(s)

Parakeratosis

Parakeratosis, NOS

parakeratosis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methotrexate	FAERS: 6		US FAERS
2	Clozapine	FAERS: 5		US FAERS
3	Imatinib Mesylate	FAERS: 5		US FAERS
4	Fingolimod Hydrochloride	FAERS: 4		US FAERS
5	Alendronate	FAERS: 3		US FAERS
6	Carbamazepine	FAERS: 3		US FAERS
7	Imatinib Mesylate	FAERS: 3		US FAERS
8	Ondansetron	FAERS: 3		US FAERS
9	Simvastatin	FAERS: 3		US FAERS
10	Furosemide	FAERS: 2		US FAERS
11	Lisinopril	FAERS: 2		US FAERS
12	NuvaRing	FAERS: 2		OFFSIDES US FAERS
13	2-(Tert-butylamino)-1-(3-chlorophenyl)propan-1-one;hydron;chloride	FAERS: 1		US FAERS
14	Amoxicillin-Potassium Clavulanate Combination	FAERS: 1		US FAERS
15	Bupropion	FAERS: 1		US FAERS
16	Enalapril	FAERS: 1		US FAERS
17	Everolimus	FAERS: 1		US FAERS
18	Hydrochlorothiazide	FAERS: 1		US FAERS
19	Imiquimod	FAERS: 1		US FAERS
20	Ketotifen	FAERS: 1		US FAERS
21	Lenalidomide	FAERS: 1		US FAERS
22	Letrozole	FAERS: 1		OFFSIDES US FAERS
23	Leuprolide	FAERS: 1		US FAERS
24	Leuprolide	FAERS: 1		US FAERS
25	Orlistat	FAERS: 1		US FAERS
26	Pamidronate	FAERS: 1		US FAERS
27	Prednisolone	FAERS: 1		US FAERS
28	Sorafenib	FAERS: 1		US FAERS
29	Tacrolimus	FAERS: 1		US FAERS
30	Valproic Acid	FAERS: 1		US FAERS
31	Valproic Acid	FAERS: 1		US FAERS
32	Zoledronic Acid	FAERS: 1		OFFSIDES US FAERS
33	bosutinib	FAERS: 1		US FAERS
34	dabrafenib	FAERS: 1		US FAERS
35	liposomal doxorubicin	FAERS: 1		US FAERS
36	pazopanib	FAERS: 1		US FAERS
37	Dobutamine			OFFSIDES
38	Fulvestrant			OFFSIDES
39	Mupirocin			OFFSIDES
40	Polychlorinated Dibenzodioxins		24161567	CTD
41	Raloxifene Hydrochloride			OFFSIDES
42	Sevelamer			OFFSIDES
43	Sevelamer			OFFSIDES
44	Sodium ferric gluconate complex			OFFSIDES
45	Terbinafine			OFFSIDES
46	acetaminophen, dextropropoxyphene, drug combination			OFFSIDES
47	alpha-naphthoflavone		24161567	CTD
48	beta-Naphthoflavone		24161567	CTD
49	betamethasone-17,21-dipropionate			OFFSIDES
50	calcium acetate			OFFSIDES
51	cevimeline			OFFSIDES
52	ebastine			OFFSIDES
53	hydrocortisone-17-butyrate			OFFSIDES
54	quazepam			OFFSIDES
55	repaglinide			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Cholesteatoma	46.7%
2	Porokeratosis	33.3%
3	Keratoderma, Palmoplantar	33.3%
4	Actinic keratosis	31.8%
5	Breast Diseases	31%
6	Dermatitis	31%
7	Exanthema	31%
8	Facial Dermatoses	31%
9	Hair Diseases	31%
10	Hand Dermatoses	31%
11	keratoacanthoma	31%
12	Nail Diseases	31%
13	Photosensitivity Disorders	31%
14	Prurigo	31%
15	Pyoderma	31%
16	Rosacea	31%
17	Sebaceous Gland Diseases	31%
18	Skin Diseases, Vesiculobullous	31%
19	Skin Ulcer	31%
20	Sweat Gland Diseases	31%
21	Skin Diseases, Papulosquamous	31%
22	Skin Diseases, Vascular	31%
23	Acneiform Eruptions	31%
24	Ocular Rosacea	31%
25	Subcorneal pustular dermatosis	31%
26	Erythematotelangiectatic Rosacea	31%
27	Papulopustular Rosacea	31%
28	Chronic Actinic Dermatitis	31%
29	Pyoderma Gangrenosum	30%
30	Lupus Erythematosus, Cutaneous	27.9%
31	Panniculitis	27.9%
32	Systemic Scleroderma	27.9%
33	Morphea	27.9%
34	Xeroderma	27%
35	Acne Vulgaris	26.7%
36	Contact Dermatitis	26.7%
37	Eczema	26.7%
38	Erythema Multiforme	26.7%
39	Intertrigo	26.7%
40	Neurodermatitis	26.7%
41	Rhinophyma	26.7%
42	Perioral Dermatitis	26.7%
43	Acne	26.7%
44	Papillon-Lefevre Disease	24.4%
45	Foot Ulcer	23.1%
46	Foot Diseases	22%
47	Dermatitis, Phototoxic	22%
48	Pityriasis Lichenoides et Varioliformis Acuta	22%
49	Pityriasis Lichenoides	22%
50	Phototoxicity	22%
51	Skin Abnormalities	20.9%
52	Skin Diseases, Infectious	20.9%
53	Skin Neoplasms	20.9%
54	Pigmentation Disorders	20.9%
55	Lipomatosis	20.5%
56	Pruritus	20.5%
57	Erythema	20.5%
58	Necrolytic Migratory Erythema	20.5%
59	Cutaneous Fistula	20.5%
60	Nephrogenic Fibrosing Dermopathy	20.5%
61	Nephrogenic Systemic Fibrosis	20.5%
62	Dermatitis Herpetiformis	20.3%
63	Acrodermatitis	20%
64	Anhidrosis	20%
65	Pressure Ulcer	20%
66	Dermatitis, Atopic	20%
67	Epidermolysis Bullosa	20%
68	Folliculitis	20%
69	Foot Dermatoses	20%
70	Gynecomastia	20%
71	Hypertrichosis	20%
72	Hypohidrosis	20%
73	Hypotrichosis	20%
74	Leg Ulcer	20%
75	Miliaria	20%
76	Parapsoriasis	20%
77	Pityriasis	20%
78	Psoriasis	20%
79	Sebaceous Gland Neoplasms	20%
80	Sweet Syndrome	20%
81	Hidradenitis	20%
82	Onycholysis	20%
83	Miliaria Rubra	20%
84	Hyperpigmentation	20%
85	Lichenoid Eruptions	20%
86	Gianotti-Crosti Syndrome	20%
87	Chloracne	20%
88	Dermatitis, Irritant	19.6%
89	Acne Conglobata	19.6%
90	Connective Tissue Diseases	18.5%
91	Panniculitis, Lupus Erythematosus	18.4%
92	Xeroderma Pigmentosum	17.9%
93	Necrobiosis Lipoidica Diabeticorum	17.9%
94	Lupus Erythematosus, Discoid	17.8%
95	Scleroderma, Limited	17.8%
96	Dermatitis, Photoallergic	17.5%
97	Urticaria Pigmentosa	17.1%
98	Dermatomyositis	16.2%
99	Diaper Rash	16.1%
100	Hyperkeratosis, Epidermolytic	15.6%
101	Dermatitis, Occupational	15.5%
102	Cutis Laxa	15.3%
103	Mastocytosis	15.1%
104	Lichen Planus	14.8%
105	Melanosis	14.8%
106	Chloasma	14.8%
107	Pityriasis Rosea	14.8%
108	Pityriasis Rubra Pilaris	14.8%
109	Vitiligo	14.8%
110	Dermatitis, Allergic Contact	14.8%
111	Lichen Nitidus	14.8%
112	Erythema Induratum	14.4%
113	Erythema Infectiosum	14.1%
114	Exanthema Subitum	14%
115	Ichthyosis, X-Linked	13.8%
116	Erythema Nodosum	13.7%
117	Sjogren-Larsson Syndrome	13.7%
118	Acantholysis	13.6%
119	Breast Cyst	13.6%
120	Pemphigoid, Benign Mucous Membrane	13.6%
121	Pemphigus	13.6%
122	Piedra	13.6%
123	Sunburn	13.6%
124	Argyria	13.3%
125	Ectodermal Dysplasia	13.3%
126	Hirsutism	13.3%
127	Lactation Disorder	13.3%
128	Mastitis	13.3%
129	Urticaria	13.3%
130	Aplasia Cutis Congenita	13.3%
131	Adiposis Dolorosa	13.2%
132	Pruritus Vulvae	13.2%
133	Mastocytoma	13.1%
134	Pruritus Ani	13.1%
135	Tinea Capitis	12.7%
136	Onychomycosis	12.7%
137	Toxic Epidermal Necrolysis	12.6%
138	Stevens-Johnson Syndrome	12.6%
139	Pseudoxanthoma Elasticum	12.6%
140	Granuloma Annulare	12.4%
141	Acanthosis Nigricans	12.2%
142	Alopecia Areata	12.2%
143	Lentigo	12.2%
144	Ecthyma	11.5%
145	Collagen Diseases	10.3%
146	Mixed Connective Tissue Disease	10.3%
147	Mucinoses	10.3%
148	Dermatomycoses	10.2%
149	Mucocutaneous Lymph Node Syndrome	10.2%
150	Skin Diseases, Bacterial	10.2%
151	Alopecia	10.1%
152	Sweating, Gustatory	10.1%
153	Androgenetic Alopecia	10.1%
154	Auriculotemporal Syndrome	10.1%
155	Drug Eruptions	10%
156	Lipodystrophy	10%
157	Livedo Reticularis	10%
158	Malignant Atrophic Papulosis	10%
159	Behcet Syndrome	10%
160	Lice Infestations	9.9%
161	Varicose Ulcer	9.9%
162	Breast Neoplasms, Male	9.9%
163	Triple Negative Breast Neoplasms	9.9%
164	Polyarteritis Nodosa	9.8%
165	Takayasu Arteritis	9.8%
166	Hidradenitis Suppurativa	9.8%
167	Galactorrhea	9.8%
168	Tinea Pedis	8.9%
169	Albinism	8.7%
170	Erythema Chronicum Migrans	8.5%
171	Lichen Planus, Oral	8.4%
172	Nail-Patella Syndrome	8.2%
173	Porphyrias, Hepatic	8.1%
174	Larva Migrans	7.6%
175	Leishmaniasis	7.6%
176	Molluscum Contagiosum	7.6%
177	Angioedema	7.5%
178	Onchocerciasis	7.5%
179	Chromoblastomycosis	7.4%
180	Dermatophytosis	7.4%
181	Sporotrichosis	7.4%
182	Tinea	7.4%
183	Tinea Versicolor	7.4%
184	Trichophytosis	7.4%
185	Hyalohyphomycosis	7.4%
186	Mycetoma	7.3%
187	Cartilage Diseases	7.3%
188	Rheumatism	7.3%
189	Chondromalacia	7.3%
190	Acute Generalized Exanthematous Pustulosis	7.3%
191	Lupus Erythematosus, Systemic	7%
192	Overlap syndrome	7%
193	Scleromyxedema	6.7%
194	Leishmaniasis, Cutaneous	6.1%
195	Eczema Herpeticum	6.1%
196	Warts	6.1%
197	Fusariosis	6%
198	Candidiasis, Chronic Mucocutaneous	5.9%
199	Cutaneous Candidiasis	5.9%
200	Erysipelas	5.9%
201	Serum Sickness	5.9%
202	Staphylococcal Skin Infections	5.9%
203	Variegate Porphyria	5.9%
204	Acute intermittent porphyria	5.9%
205	Porphyria Cutanea Tarda	5.9%
206	Erythrasma	5.9%
207	Carcinoma, Lobular	5.9%
208	Arthritis, Psoriatic	5.8%
209	CREST Syndrome	5.6%
210	Hereditary Angioedema Type III	5.4%
211	Hereditary Angioedema Types I and II	5.4%
212	Dupuytren Contracture	5%
213	Angioedemas, Hereditary	5%
214	Epidermodysplasia Verruciformis	4.9%
215	Herpes Labialis	4.9%
216	Giant Cell Arteritis	4.9%
217	Temporal Arteritis	4.9%
218	Diabetic Foot	4.9%
219	Staphylococcal Scalded Skin Syndrome	4.8%
220	Mesenteric Panniculitis	4.5%
221	Panniculitis, Peritoneal	4.5%
222	Tietze's Syndrome	4.5%
223	Orbital Cellulitis	4.5%
224	Myxoid cyst	4.5%
225	Peutz-Jeghers Syndrome	4.5%
226	Myxedema	4.4%
227	carbuncle	4.3%
228	Blastomycosis	4.2%
229	HIV-Associated Lipodystrophy Syndrome	4.2%
230	Condylomata Acuminata	4.1%
231	Furunculosis	4.1%
232	furuncle	4.1%
233	Cellulitis	4%
234	Impetigo	4%
235	Rhinoscleroma	3.8%
236	Menkes Kinky Hair Syndrome	3.5%
237	Osteochondritis	3.4%
238	Polymyalgia Rheumatica	3.4%
239	Osteogenesis Imperfecta	3.4%
240	Keloid	3.3%
241	Noonan Syndrome	2.9%
242	Rheumatoid Arthritis	2.7%
243	Juvenile arthritis	2.7%
244	Lupus Nephritis	2.6%
245	Marfan Syndrome	2.5%
246	Rheumatoid Nodule	2.5%
247	Homocystinuria	2.4%
248	Laryngomalacia	2.3%
249	Pectus carinatum	2.3%
250	Felty Syndrome	2%
251	Bronchomalacia	2%
252	Tracheomalacia	2%
253	Rheumatoid Vasculitis	1.6%
254	Mucopolysaccharidosis III	1.6%
255	Sicca Syndrome	1.4%
256	Sjogren's Syndrome	1.4%
257	Lupus Vasculitis, Central Nervous System	1.1%
258	Mucopolysaccharidosis II	1.1%

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