MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Scleroderma, Limited

(UMLS:C0748540)

Definition:: The least progressive form of SYSTEMIC SCLERODERMA with skin thickening restricted to the face, neck and areas distal to the elbows and/or knees, sparing the trunk. The CREST SYNDROME is a form of limited scleroderma.
UMLS ID:: C0748540
MeSH ID:: D045745

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.799.801|C17.800.784.801

Synonym(s)

Scleroderma, Limited

Limited cutaneous systemic sclerosis

Limited scleroderma

Limited systemic sclerosis

SCLERODERMA LIMITED

Systemic sclerosis with limited cutaneous involvement

Systemic sclerosis, limited

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Fluorouracil		19917437	CTD
2	Pentazocine		8915318 9282692	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lupus Erythematosus, Cutaneous	41.4%
2	Panniculitis	41.4%
3	Morphea	41.4%
4	Pyoderma Gangrenosum	32%
5	Panniculitis, Lupus Erythematosus	30.8%
6	Breast Diseases	27.3%
7	Collagen Diseases	27.3%
8	Dermatitis	27.3%
9	Exanthema	27.3%
10	Facial Dermatoses	27.3%
11	Hair Diseases	27.3%
12	Hand Dermatoses	27.3%
13	keratoacanthoma	27.3%
14	Keratosis	27.3%
15	Mixed Connective Tissue Disease	27.3%
16	Nail Diseases	27.3%
17	Photosensitivity Disorders	27.3%
18	Prurigo	27.3%
19	Pyoderma	27.3%
20	Rosacea	27.3%
21	Sebaceous Gland Diseases	27.3%
22	Skin Diseases, Vesiculobullous	27.3%
23	Skin Ulcer	27.3%
24	Sweat Gland Diseases	27.3%
25	Skin Diseases, Papulosquamous	27.3%
26	Skin Diseases, Vascular	27.3%
27	Mucinoses	27.3%
28	Acneiform Eruptions	27.3%
29	Ocular Rosacea	27.3%
30	Subcorneal pustular dermatosis	27.3%
31	Erythematotelangiectatic Rosacea	27.3%
32	Papulopustular Rosacea	27.3%
33	Chronic Actinic Dermatitis	27.3%
34	Cutis Laxa	27%
35	Dermatomyositis	26.9%
36	Acne Vulgaris	26.7%
37	Contact Dermatitis	26.7%
38	Eczema	26.7%
39	Erythema Multiforme	26.7%
40	Intertrigo	26.7%
41	Lupus Erythematosus, Discoid	26.7%
42	Neurodermatitis	26.7%
43	Rhinophyma	26.7%
44	Perioral Dermatitis	26.7%
45	Acne	26.7%
46	Necrobiosis Lipoidica Diabeticorum	24.3%
47	Dermatitis, Phototoxic	23.5%
48	Pityriasis Lichenoides et Varioliformis Acuta	23.5%
49	Pityriasis Lichenoides	23.5%
50	Phototoxicity	23.5%
51	Foot Ulcer	23.1%
52	Dermatitis, Atopic	22.9%
53	Epidermolysis Bullosa	22.9%
54	Dermatitis Herpetiformis	21.6%
55	Xeroderma Pigmentosum	21.5%
56	Cartilage Diseases	21.4%
57	Foot Diseases	21.4%
58	Rheumatism	21.4%
59	Chondromalacia	21.4%
60	Acrodermatitis	21.3%
61	Sebaceous Gland Neoplasms	21.3%
62	Porokeratosis	21.3%
63	Gianotti-Crosti Syndrome	21.3%
64	Keratoderma, Palmoplantar	21.3%
65	Erythema Induratum	21%
66	Pseudoxanthoma Elasticum	20.8%
67	Lupus Erythematosus, Systemic	20.7%
68	Skin Abnormalities	20.7%
69	Skin Diseases, Infectious	20.7%
70	Skin Neoplasms	20.7%
71	Overlap syndrome	20.7%
72	Pigmentation Disorders	20.7%
73	Lipomatosis	20.3%
74	Pruritus	20.3%
75	Erythema	20.3%
76	Necrolytic Migratory Erythema	20.3%
77	Cutaneous Fistula	20.3%
78	Nephrogenic Fibrosing Dermopathy	20.3%
79	Nephrogenic Systemic Fibrosis	20.3%
80	Dermatitis, Irritant	19.7%
81	Acne Conglobata	19.7%
82	Dermatitis, Photoallergic	19.6%
83	Granuloma Annulare	18.5%
84	Urticaria Pigmentosa	18.3%
85	Xeroderma	18%
86	Anhidrosis	17.8%
87	Cholesteatoma	17.8%
88	Pressure Ulcer	17.8%
89	Folliculitis	17.8%
90	Foot Dermatoses	17.8%
91	Gynecomastia	17.8%
92	Hypertrichosis	17.8%
93	Hypohidrosis	17.8%
94	Hypotrichosis	17.8%
95	Leg Ulcer	17.8%
96	Miliaria	17.8%
97	Parakeratosis	17.8%
98	Parapsoriasis	17.8%
99	Pityriasis	17.8%
100	Psoriasis	17.8%
101	Sweet Syndrome	17.8%
102	Hidradenitis	17.8%
103	Onycholysis	17.8%
104	Miliaria Rubra	17.8%
105	Hyperpigmentation	17.8%
106	Lichenoid Eruptions	17.8%
107	Scleromyxedema	17.8%
108	Chloracne	17.8%
109	Dermatitis, Occupational	16.4%
110	Diaper Rash	16.3%
111	Mastocytosis	16.1%
112	Dupuytren Contracture	16%
113	Dermatitis, Allergic Contact	15.8%
114	Papillon-Lefevre Disease	15.7%
115	Erythema Infectiosum	15.6%
116	Exanthema Subitum	15.6%
117	Erythema Nodosum	15.3%
118	Ectodermal Dysplasia	15.2%
119	Aplasia Cutis Congenita	15.2%
120	Toxic Epidermal Necrolysis	14.7%
121	Stevens-Johnson Syndrome	14.7%
122	Tinea Capitis	14.1%
123	Onychomycosis	14.1%
124	Acantholysis	13.6%
125	Breast Cyst	13.6%
126	Actinic keratosis	13.6%
127	Mesenteric Panniculitis	13.6%
128	Panniculitis, Peritoneal	13.6%
129	Pemphigoid, Benign Mucous Membrane	13.6%
130	Pemphigus	13.6%
131	Piedra	13.6%
132	Sunburn	13.6%
133	Tietze's Syndrome	13.6%
134	Orbital Cellulitis	13.6%
135	Myxoid cyst	13.6%
136	Cellulitis	13.4%
137	Argyria	13.3%
138	Hirsutism	13.3%
139	Lactation Disorder	13.3%
140	Mastitis	13.3%
141	Myxedema	13.3%
142	Urticaria	13.3%
143	Adiposis Dolorosa	13.2%
144	Pruritus Vulvae	13.2%
145	Lichen Planus	13.2%
146	Melanosis	13.2%
147	Chloasma	13.2%
148	Pityriasis Rosea	13.2%
149	Pityriasis Rubra Pilaris	13.2%
150	Vitiligo	13.2%
151	Lichen Nitidus	13.2%
152	Mastocytoma	13.2%
153	Pruritus Ani	13.2%
154	Ecthyma	13.1%
155	Hyperkeratosis, Epidermolytic	12.9%
156	Ichthyosis, X-Linked	11.9%
157	Connective Tissue Diseases	11.9%
158	Sjogren-Larsson Syndrome	11.9%
159	Behcet Syndrome	11.6%
160	Hidradenitis Suppurativa	11.3%
161	Osteochondritis	11%
162	Polymyalgia Rheumatica	11%
163	Acanthosis Nigricans	10.9%
164	Alopecia Areata	10.9%
165	Lentigo	10.9%
166	Dermatomycoses	10.8%
167	Mucocutaneous Lymph Node Syndrome	10.8%
168	Skin Diseases, Bacterial	10.8%
169	Osteogenesis Imperfecta	10.7%
170	Drug Eruptions	10.7%
171	Lipodystrophy	10.7%
172	Livedo Reticularis	10.7%
173	Malignant Atrophic Papulosis	10.7%
174	Keloid	10.5%
175	Polyarteritis Nodosa	10.5%
176	Takayasu Arteritis	10.5%
177	Systemic Scleroderma	10.3%
178	Albinism	10.3%
179	Tinea Pedis	10.2%
180	Erythema Chronicum Migrans	10.1%
181	Alopecia	10.1%
182	Sweating, Gustatory	10.1%
183	Androgenetic Alopecia	10.1%
184	Auriculotemporal Syndrome	10.1%
185	Noonan Syndrome	10%
186	Lice Infestations	9.9%
187	Varicose Ulcer	9.9%
188	Breast Neoplasms, Male	9.9%
189	Triple Negative Breast Neoplasms	9.9%
190	Galactorrhea	9.8%
191	Rheumatoid Arthritis	9.1%
192	Nail-Patella Syndrome	9.1%
193	Juvenile arthritis	9.1%
194	Marfan Syndrome	9%
195	Porphyrias, Hepatic	9%
196	Lupus Nephritis	8.7%
197	Homocystinuria	8.7%
198	Mycetoma	8.7%
199	Lichen Planus, Oral	8.4%
200	Larva Migrans	8.1%
201	Leishmaniasis	8.1%
202	Molluscum Contagiosum	8.1%
203	Angioedema	8%
204	Onchocerciasis	8%
205	Chromoblastomycosis	7.9%
206	Dermatophytosis	7.9%
207	Rheumatoid Nodule	7.9%
208	Sporotrichosis	7.9%
209	Tinea	7.9%
210	Tinea Versicolor	7.9%
211	Trichophytosis	7.9%
212	Hyalohyphomycosis	7.9%
213	Laryngomalacia	7.8%
214	Acute Generalized Exanthematous Pustulosis	7.8%
215	Pectus carinatum	7.8%
216	Warts	6.8%
217	Scleroderma, Limited	6.7%
218	Candidiasis, Chronic Mucocutaneous	6.6%
219	Cutaneous Candidiasis	6.6%
220	Felty Syndrome	6.6%
221	Bronchomalacia	6.6%
222	Tracheomalacia	6.6%
223	Erysipelas	6.6%
224	Leishmaniasis, Cutaneous	6.6%
225	Serum Sickness	6.6%
226	Staphylococcal Skin Infections	6.6%
227	Variegate Porphyria	6.6%
228	Acute intermittent porphyria	6.6%
229	Porphyria Cutanea Tarda	6.6%
230	Eczema Herpeticum	6.6%
231	Erythrasma	6.5%
232	Carcinoma, Lobular	6.5%
233	Arthritis, Psoriatic	6.5%
234	Fusariosis	6.5%
235	Hereditary Angioedema Type III	5.8%
236	Hereditary Angioedema Types I and II	5.8%
237	Giant Cell Arteritis	5.8%
238	Temporal Arteritis	5.8%
239	Rheumatoid Vasculitis	5.6%
240	Mucopolysaccharidosis III	5.5%
241	Angioedemas, Hereditary	5.5%
242	Epidermodysplasia Verruciformis	5.5%
243	Herpes Labialis	5.5%
244	Diabetic Foot	5.4%
245	Staphylococcal Scalded Skin Syndrome	5.4%
246	Peutz-Jeghers Syndrome	5%
247	Blastomycosis	5%
248	Sicca Syndrome	4.9%
249	Sjogren's Syndrome	4.9%
250	HIV-Associated Lipodystrophy Syndrome	4.9%
251	carbuncle	4.8%
252	Condylomata Acuminata	4.7%
253	Furunculosis	4.7%
254	furuncle	4.7%
255	Impetigo	4.6%
256	Rhinoscleroma	4.5%
257	Menkes Kinky Hair Syndrome	4.3%
258	Lupus Vasculitis, Central Nervous System	4%
259	Mucopolysaccharidosis II	3.9%
260	CREST Syndrome	2.4%

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