MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Onycholysis

(UMLS:C0085661)

Definition:: Separation of nail plate from the underlying nail bed. It can be a sign of skin disease, infection (such as ONYCHOMYCOSIS) or tissue injury.
UMLS ID:: C0085661
MeSH ID:: D054039

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.529.478

Synonym(s)

Onycholysis

Detachment of nail

Detachment of nail plate

ONYCHOLYSIS

Oncholysis

Separation of nail plate

nail detachment

nail plate separation

nails onycholysis

10.

onycholysis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Paclitaxel	FAERS: 32	12582404	CTD SIDER US FAERS
2	Docetaxel	FAERS: 15		SIDER US FAERS
3	Valproic Acid	FAERS: 10		US FAERS
4	Doxycycline	FAERS: 8 Canada Vigilance: 2		Canada Vigilance US FAERS
5	Everolimus	FAERS: 8		US FAERS
6	Capecitabine	FAERS: 7		OFFSIDES SIDER US FAERS
7	Erlotinib Hydrochloride	FAERS: 7		US FAERS
8	apremilast	FAERS: 6		US FAERS
9	tavaborole	FAERS: 6		US FAERS
10	tofacitinib	FAERS: 5		US FAERS
11	Lapatinib	FAERS: 4		US FAERS
12	rofecoxib	FAERS: 4		US FAERS
13	Imatinib Mesylate	FAERS: 3		US FAERS
14	Pregabalin	FAERS: 3		US FAERS
15	Valproic Acid	FAERS: 3		US FAERS
16	Varenicline	FAERS: 3		US FAERS
17	cabazitaxel	FAERS: 3		US FAERS
18	palbociclib	FAERS: 3		US FAERS
19	5-(4-ethylpiperazin-1-ylmethyl)pyridin-2-yl)-(5-fluoro-4-(7-fluoro-3-isopropyl-2-methyl-3H-benzimidazol-5-yl)pyrimidin-2-yl)amine	FAERS: 2		US FAERS
20	Alendronate	FAERS: 2		US FAERS
21	Atorvastatin	FAERS: 2		US FAERS
22	Ciclopirox	FAERS: 2		US FAERS
23	Ibandronic Acid	FAERS: 2		US FAERS
24	Ramipril	FAERS: 2		SIDER US FAERS
25	Voriconazole	FAERS: 2		US FAERS
26	efinaconazole	FAERS: 2 Canada Vigilance: 1		Canada Vigilance US FAERS
27	regorafenib	FAERS: 2		US FAERS
28	4-Aminopyridine	FAERS: 1		US FAERS
29	Afatinib	FAERS: 1		US FAERS
30	Allopurinol	FAERS: 1		SIDER US FAERS
31	Azathioprine	FAERS: 1		US FAERS
32	Azithromycin	FAERS: 1		US FAERS
33	Cinacalcet	FAERS: 1		US FAERS
34	Cyclophosphamide	FAERS: 1		US FAERS
35	Diltiazem	FAERS: 1		US FAERS
36	Doxorubicin	FAERS: 1		SIDER US FAERS
37	Doxycycline	FAERS: 1		US FAERS
38	Dronedarone	FAERS: 1		US FAERS
39	Goserelin	FAERS: 1		US FAERS
40	Hydrochlorothiazide	FAERS: 1		US FAERS
41	Hydroxychloroquine	FAERS: 1		US FAERS
42	Hydroxyurea	FAERS: 1		US FAERS
43	Ibuprofen	FAERS: 1		US FAERS
44	Isotretinoin	FAERS: 1		US FAERS
45	Ivabradine	FAERS: 1		US FAERS
46	Lamotrigine	FAERS: 1		US FAERS
47	Latanoprost	FAERS: 1		US FAERS
48	MDV 3100	FAERS: 1		US FAERS
49	Metformin	FAERS: 1		US FAERS
50	Metformin	FAERS: 1		US FAERS
51	Methotrexate	FAERS: 1		US FAERS
52	Methylene Blue	FAERS: 1		US FAERS
53	Methylphenidate	FAERS: 1		US FAERS
54	Metoprolol	FAERS: 1		US FAERS
55	Nebivolol	FAERS: 1		US FAERS
56	Oxytetracycline	FAERS: 1		US FAERS
57	PCI 32765	FAERS: 1		US FAERS
58	Pamidronate	FAERS: 1		US FAERS
59	Risperidone	FAERS: 1		US FAERS
60	Sitagliptin Phosphate	FAERS: 1		US FAERS
61	Sulfamethoxazole	FAERS: 1		US FAERS
62	Sunitinib	FAERS: 1		US FAERS
63	Valproic Acid	FAERS: 1		US FAERS
64	Varenicline	FAERS: 1		US FAERS
65	liposomal doxorubicin	FAERS: 1		US FAERS
66	niraparib	FAERS: 1		US FAERS
67	rucaparib	FAERS: 1		US FAERS
68	telavancin	FAERS: 1		US FAERS
69	temsirolimus	FAERS: 1		US FAERS
70	4-toluenesulfonamide-formaldehyde resin		7053232	CTD
71	Acetazolamide			OFFSIDES
72	Amiodarone			SIDER
73	Cefotaxime			OFFSIDES
74	Cephalexin			OFFSIDES
75	Clorazepate Dipotassium			OFFSIDES
76	Dapsone			OFFSIDES
77	Estramustine			OFFSIDES
78	Estrogens, Conjugated (USP)			OFFSIDES
79	Famciclovir			OFFSIDES
80	Gentamicins			OFFSIDES
81	Irinotecan			OFFSIDES
82	Isosorbide			OFFSIDES
83	Ketoprofen			SIDER
84	Ketotifen	Canada Vigilance: 1		Canada Vigilance
85	Linezolid			OFFSIDES
86	Meperidine			OFFSIDES
87	Minocycline			SIDER
88	Mitoxantrone			SIDER
89	Nitrofurantoin			OFFSIDES
90	Pamidronate			OFFSIDES
91	Piroxicam			SIDER
92	Tenofovir			OFFSIDES
93	Tetracycline			SIDER
94	Theophylline			OFFSIDES
95	benoxaprofen		6407402 6993665 7084281	CTD
96	lacidipine			OFFSIDES
97	ramiprilat			SIDER
98	strontium ranelate			OFFSIDES
99	tizanidine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Breast Diseases	31%
2	Dermatitis	31%
3	Exanthema	31%
4	Facial Dermatoses	31%
5	Hair Diseases	31%
6	Hand Dermatoses	31%
7	keratoacanthoma	31%
8	Keratosis	31%
9	Photosensitivity Disorders	31%
10	Prurigo	31%
11	Pyoderma	31%
12	Rosacea	31%
13	Sebaceous Gland Diseases	31%
14	Skin Diseases, Vesiculobullous	31%
15	Skin Ulcer	31%
16	Sweat Gland Diseases	31%
17	Skin Diseases, Papulosquamous	31%
18	Skin Diseases, Vascular	31%
19	Acneiform Eruptions	31%
20	Ocular Rosacea	31%
21	Subcorneal pustular dermatosis	31%
22	Erythematotelangiectatic Rosacea	31%
23	Papulopustular Rosacea	31%
24	Chronic Actinic Dermatitis	31%
25	Pyoderma Gangrenosum	30%
26	Lupus Erythematosus, Cutaneous	27.9%
27	Panniculitis	27.9%
28	Systemic Scleroderma	27.9%
29	Morphea	27.9%
30	Acne Vulgaris	26.7%
31	Contact Dermatitis	26.7%
32	Eczema	26.7%
33	Erythema Multiforme	26.7%
34	Intertrigo	26.7%
35	Neurodermatitis	26.7%
36	Rhinophyma	26.7%
37	Perioral Dermatitis	26.7%
38	Acne	26.7%
39	Foot Ulcer	23.1%
40	Onychomycosis	23.1%
41	Foot Diseases	22%
42	Dermatitis, Phototoxic	22%
43	Pityriasis Lichenoides et Varioliformis Acuta	22%
44	Pityriasis Lichenoides	22%
45	Phototoxicity	22%
46	Skin Abnormalities	20.9%
47	Skin Diseases, Infectious	20.9%
48	Skin Neoplasms	20.9%
49	Pigmentation Disorders	20.9%
50	Lipomatosis	20.5%
51	Pruritus	20.5%
52	Erythema	20.5%
53	Necrolytic Migratory Erythema	20.5%
54	Cutaneous Fistula	20.5%
55	Nephrogenic Fibrosing Dermopathy	20.5%
56	Nephrogenic Systemic Fibrosis	20.5%
57	Dermatitis Herpetiformis	20.3%
58	Acrodermatitis	20%
59	Anhidrosis	20%
60	Cholesteatoma	20%
61	Pressure Ulcer	20%
62	Dermatitis, Atopic	20%
63	Epidermolysis Bullosa	20%
64	Folliculitis	20%
65	Foot Dermatoses	20%
66	Gynecomastia	20%
67	Hypertrichosis	20%
68	Hypohidrosis	20%
69	Hypotrichosis	20%
70	Leg Ulcer	20%
71	Miliaria	20%
72	Parakeratosis	20%
73	Parapsoriasis	20%
74	Pityriasis	20%
75	Psoriasis	20%
76	Sebaceous Gland Neoplasms	20%
77	Sweet Syndrome	20%
78	Hidradenitis	20%
79	Miliaria Rubra	20%
80	Hyperpigmentation	20%
81	Porokeratosis	20%
82	Lichenoid Eruptions	20%
83	Gianotti-Crosti Syndrome	20%
84	Chloracne	20%
85	Keratoderma, Palmoplantar	20%
86	Dermatitis, Irritant	19.6%
87	Acne Conglobata	19.6%
88	Nail-Patella Syndrome	19.2%
89	Connective Tissue Diseases	18.5%
90	Panniculitis, Lupus Erythematosus	18.4%
91	Xeroderma Pigmentosum	17.9%
92	Necrobiosis Lipoidica Diabeticorum	17.9%
93	Lupus Erythematosus, Discoid	17.8%
94	Scleroderma, Limited	17.8%
95	Dermatitis, Photoallergic	17.5%
96	Urticaria Pigmentosa	17.1%
97	Xeroderma	16.2%
98	Dermatomyositis	16.2%
99	Diaper Rash	16.1%
100	Dermatitis, Occupational	15.5%
101	Cutis Laxa	15.3%
102	Mastocytosis	15.1%
103	Lichen Planus	14.8%
104	Melanosis	14.8%
105	Chloasma	14.8%
106	Pityriasis Rosea	14.8%
107	Pityriasis Rubra Pilaris	14.8%
108	Vitiligo	14.8%
109	Dermatitis, Allergic Contact	14.8%
110	Lichen Nitidus	14.8%
111	Papillon-Lefevre Disease	14.6%
112	Erythema Induratum	14.4%
113	Erythema Infectiosum	14.1%
114	Exanthema Subitum	14%
115	Erythema Nodosum	13.7%
116	Acantholysis	13.6%
117	Breast Cyst	13.6%
118	Actinic keratosis	13.6%
119	Pemphigoid, Benign Mucous Membrane	13.6%
120	Pemphigus	13.6%
121	Piedra	13.6%
122	Sunburn	13.6%
123	Argyria	13.3%
124	Ectodermal Dysplasia	13.3%
125	Hirsutism	13.3%
126	Lactation Disorder	13.3%
127	Mastitis	13.3%
128	Urticaria	13.3%
129	Aplasia Cutis Congenita	13.3%
130	Adiposis Dolorosa	13.2%
131	Pruritus Vulvae	13.2%
132	Mastocytoma	13.1%
133	Pruritus Ani	13.1%
134	Tinea Capitis	12.7%
135	Toxic Epidermal Necrolysis	12.6%
136	Stevens-Johnson Syndrome	12.6%
137	Pseudoxanthoma Elasticum	12.6%
138	Granuloma Annulare	12.4%
139	Acanthosis Nigricans	12.2%
140	Alopecia Areata	12.2%
141	Lentigo	12.2%
142	Ecthyma	11.5%
143	Hyperkeratosis, Epidermolytic	11%
144	Collagen Diseases	10.3%
145	Mixed Connective Tissue Disease	10.3%
146	Mucinoses	10.3%
147	Dermatomycoses	10.2%
148	Mucocutaneous Lymph Node Syndrome	10.2%
149	Skin Diseases, Bacterial	10.2%
150	Alopecia	10.1%
151	Sweating, Gustatory	10.1%
152	Androgenetic Alopecia	10.1%
153	Auriculotemporal Syndrome	10.1%
154	Drug Eruptions	10%
155	Lipodystrophy	10%
156	Livedo Reticularis	10%
157	Malignant Atrophic Papulosis	10%
158	Behcet Syndrome	10%
159	Lice Infestations	9.9%
160	Varicose Ulcer	9.9%
161	Breast Neoplasms, Male	9.9%
162	Triple Negative Breast Neoplasms	9.9%
163	Polyarteritis Nodosa	9.8%
164	Takayasu Arteritis	9.8%
165	Ichthyosis, X-Linked	9.8%
166	Hidradenitis Suppurativa	9.8%
167	Galactorrhea	9.8%
168	Sjogren-Larsson Syndrome	9.8%
169	Tinea Pedis	8.9%
170	Albinism	8.7%
171	Erythema Chronicum Migrans	8.5%
172	Lichen Planus, Oral	8.4%
173	Porphyrias, Hepatic	8.1%
174	Larva Migrans	7.6%
175	Leishmaniasis	7.6%
176	Molluscum Contagiosum	7.6%
177	Angioedema	7.5%
178	Onchocerciasis	7.5%
179	Chromoblastomycosis	7.4%
180	Dermatophytosis	7.4%
181	Sporotrichosis	7.4%
182	Tinea	7.4%
183	Tinea Versicolor	7.4%
184	Trichophytosis	7.4%
185	Hyalohyphomycosis	7.4%
186	Mycetoma	7.3%
187	Cartilage Diseases	7.3%
188	Rheumatism	7.3%
189	Chondromalacia	7.3%
190	Acute Generalized Exanthematous Pustulosis	7.3%
191	Lupus Erythematosus, Systemic	7%
192	Overlap syndrome	7%
193	Scleromyxedema	6.7%
194	Leishmaniasis, Cutaneous	6.1%
195	Eczema Herpeticum	6.1%
196	Warts	6.1%
197	Fusariosis	6%
198	Candidiasis, Chronic Mucocutaneous	5.9%
199	Cutaneous Candidiasis	5.9%
200	Erysipelas	5.9%
201	Serum Sickness	5.9%
202	Staphylococcal Skin Infections	5.9%
203	Variegate Porphyria	5.9%
204	Acute intermittent porphyria	5.9%
205	Porphyria Cutanea Tarda	5.9%
206	Erythrasma	5.9%
207	Carcinoma, Lobular	5.9%
208	Arthritis, Psoriatic	5.8%
209	CREST Syndrome	5.6%
210	Hereditary Angioedema Type III	5.4%
211	Hereditary Angioedema Types I and II	5.4%
212	Dupuytren Contracture	5%
213	Angioedemas, Hereditary	5%
214	Epidermodysplasia Verruciformis	4.9%
215	Herpes Labialis	4.9%
216	Giant Cell Arteritis	4.9%
217	Temporal Arteritis	4.9%
218	Diabetic Foot	4.9%
219	Staphylococcal Scalded Skin Syndrome	4.8%
220	Mesenteric Panniculitis	4.5%
221	Panniculitis, Peritoneal	4.5%
222	Tietze's Syndrome	4.5%
223	Orbital Cellulitis	4.5%
224	Myxoid cyst	4.5%
225	Peutz-Jeghers Syndrome	4.5%
226	Myxedema	4.4%
227	carbuncle	4.3%
228	Blastomycosis	4.2%
229	HIV-Associated Lipodystrophy Syndrome	4.2%
230	Condylomata Acuminata	4.1%
231	Furunculosis	4.1%
232	furuncle	4.1%
233	Cellulitis	4%
234	Impetigo	4%
235	Rhinoscleroma	3.8%
236	Menkes Kinky Hair Syndrome	3.5%
237	Osteochondritis	3.4%
238	Polymyalgia Rheumatica	3.4%
239	Osteogenesis Imperfecta	3.4%
240	Keloid	3.3%
241	Noonan Syndrome	2.9%
242	Rheumatoid Arthritis	2.7%
243	Juvenile arthritis	2.7%
244	Lupus Nephritis	2.6%
245	Marfan Syndrome	2.5%
246	Rheumatoid Nodule	2.5%
247	Homocystinuria	2.4%
248	Laryngomalacia	2.3%
249	Pectus carinatum	2.3%
250	Felty Syndrome	2%
251	Bronchomalacia	2%
252	Tracheomalacia	2%
253	Rheumatoid Vasculitis	1.6%
254	Mucopolysaccharidosis III	1.6%
255	Sicca Syndrome	1.4%
256	Sjogren's Syndrome	1.4%
257	Lupus Vasculitis, Central Nervous System	1.1%
258	Mucopolysaccharidosis II	1.1%

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