MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hemangioblastoma

(UMLS:C0206734)

Definition:: A benign tumor of the nervous system that may occur sporadically or in association with VON HIPPEL-LINDAU DISEASE. It accounts for approximately 2% of intracranial tumors, arising most frequently in the cerebellar hemispheres and vermis. Histologically, the tumors are composed of multiple capillary and sinusoidal channels lined with endothelial cells and clusters of lipid-laden pseudoxanthoma cells. Usually solitary, these tumors can be multiple and may also occur in the brain stem, spinal cord, retina, and supratentorial compartment. Cerebellar hemangioblastomas usually present in the third decade with INTRACRANIAL HYPERTENSION, and ataxia. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2071-2)
UMLS ID:: C0206734
MeSH ID:: D018325

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.645.375.380.370

Synonym(s)

Hemangioblastoma

Angioblastoma

Capillary Hemangioblastoma

HEMANGIOBLASTOMA

Haemangioblastoma

angioblastoma

haemangioblastoma

hemangioblastoma

hemangioblastomas

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Methotrexate	3359561	CTD
2	Procarbazine	3359561	CTD
3	Vincristine	3359561	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hemangioendothelioma	36%
2	Angiokeratoma	28.5%
3	hemangiopericytoma	28.5%
4	Angiofibroma	28.5%
5	Hemangiosarcoma	23.8%
6	leukemia	22.7%
7	Neoplasms, Germ Cell and Embryonal	22.7%
8	Neoplasms, Glandular and Epithelial	22.7%
9	Germ Cell Cancer	22.7%
10	Sturge-Weber Syndrome	18.7%
11	Hemangioma, Cavernous	18.2%
12	Meningioma	16.9%
13	Neuroectodermal Tumors	16.4%
14	Hamartoma	15.3%
15	Neoplasms, Hormone-Dependent	15.3%
16	Neoplasms, Multiple Primary	15.3%
17	Paraneoplastic Syndromes	15.3%
18	Precancerous Conditions	15.3%
19	Neoplasms, Second Primary	15.3%
20	Histiocytic Disorders, Malignant	15.1%
21	Neoplasms, Neuroepithelial	13.4%
22	Gliomatosis cerebri	13.4%
23	Carcinosarcoma	13%
24	lymphangiosarcoma	13%
25	Adenoma	12.2%
26	Ameloblastoma	12.2%
27	Carcinoma	12.2%
28	Chordoma	12.2%
29	Lymphangioma	12.2%
30	Mesenchymoma	12.2%
31	Nevus	12.2%
32	Teratoma	12.2%
33	Hepatoblastoma	12.2%
34	Mixed Tumor, Mullerian	12.2%
35	Germinoma	12.2%
36	Teratocarcinoma	12.2%
37	Sarcoma	12.2%
38	Epithelioma	12.2%
39	Lymphoma	11.3%
40	melanoma	10.8%
41	Cyst	10.2%
42	Neoplastic Processes	10.2%
43	Neoplastic Syndromes, Hereditary	10.2%
44	Pregnancy Complications, Neoplastic	10.2%
45	Trophoblastic Neoplasms	10%
46	Leukemia, Experimental	10%
47	Carcinoma, Ehrlich Tumor	9.9%
48	Dermoid Cyst	9.9%
49	Carcinoma, Lewis Lung	9.9%
50	Neoplasms, Experimental	9.9%
51	Carcinoma 256, Walker	9.8%
52	Composite Lymphoma	9.8%
53	Leukemia, Plasma Cell	9.7%
54	Basal cell carcinoma	9.6%
55	Carcinoma, Papillary	9.6%
56	Squamous cell carcinoma	9.6%
57	Chondrosarcoma	9.6%
58	Craniopharyngioma	9.6%
59	Cystadenoma	9.6%
60	leiomyosarcoma	9.6%
61	liposarcoma	9.6%
62	Mesothelioma	9.6%
63	synovial sarcoma	9.6%
64	Neuroectodermal Tumor, Melanotic	9.6%
65	Angiomyolipoma	9.6%
66	Clear Cell Sarcoma of Soft Tissue	9.6%
67	Alveolar Soft Part Sarcoma	9.6%
68	Neuroendocrine Tumors	9.6%
69	Sarcoma, Myeloid	9.6%
70	Carcinoma, Basal Cell	9.6%
71	Adenoma, Acidophil	8.4%
72	Ganglioneuroma	8.4%
73	Glioma	8.4%
74	Malignant Glioma	8.4%
75	Plasmacytoma	8.2%
76	Malignant histiocytosis	8.1%
77	Histiocytic sarcoma	8.1%
78	Leukemia, Radiation-Induced	8.1%
79	Cystadenocarcinoma	8%
80	Fibrosarcoma	8%
81	Osteosarcoma	8%
82	Mucoepidermoid Carcinoma	8%
83	Leukemia L1210	7.6%
84	Leukemia P388	7.6%
85	Acanthoma	7.6%
86	Abdominal Neoplasms	7.6%
87	Erythroplasia	7.6%
88	Follicular cyst	7.6%
89	Head and Neck Neoplasms	7.6%
90	Mucocele	7.6%
91	Pilonidal Cyst	7.6%
92	Soft Tissue Neoplasms	7.6%
93	Thoracic Neoplasms	7.6%
94	Thyroglossal Cyst	7.6%
95	Synovial Cyst	7.6%
96	Aberrant Crypt Foci	7.6%
97	Neoplasms, Radiation-Induced	7.4%
98	Sarcoma, Experimental	7.4%
99	Thymoma	7.3%
100	Melanoma, Experimental	7.3%
101	Adenocarcinoma	7.2%
102	Carcinoma in Situ	7.2%
103	Carcinoma, Transitional Cell	7.2%
104	Phyllodes Tumor	7.2%
105	Dysgerminoma	7.2%
106	Lipoma	7.2%
107	Myoma	7.2%
108	Myxoma	7.2%
109	Neuroma	7.2%
110	Papilloma	7.2%
111	Pseudomyxoma Peritonei	7.2%
112	Seminoma	7.2%
113	Papillomatosis	7.2%
114	Angiolipoma	7.2%
115	Myelolipoma	7.2%
116	Neoplasms, Bone Tissue	7.2%
117	Neoplasms, Fibrous Tissue	7.2%
118	Smooth Muscle Tumor	7.2%
119	Adenomatosis, Pulmonary	7.2%
120	Adenomatous Polyps	7.2%
121	Carcinoma, Large Cell	7.2%
122	Carcinoma, Small Cell	7.2%
123	Desmoplastic Small Round Cell Tumor	7.2%
124	Chondroma	7.2%
125	Enchondroma	7.2%
126	Adenofibroma	7.2%
127	Fibroadenoma	7.2%
128	Malignant Fibrous Histiocytoma	7.2%
129	Carcinoid Tumor	7.1%
130	Neurilemmoma	7.1%
131	Hutchinson's Melanotic Freckle	7.1%
132	Melanoma, Amelanotic	7.1%
133	Medulloblastoma	6.8%
134	Endometrial Stromal Sarcoma	6.7%
135	Multiple Endocrine Neoplasia	6.6%
136	Choriocarcinoma	6.5%
137	Carcinoma, Lobular	6.5%
138	Bowen's Disease	6.3%
139	Paraganglioma	6.3%
140	Rhabdomyosarcoma	6.3%
141	Giant Cell Tumor of Bone	6.3%
142	Hodgkin Disease	6.1%
143	Lymphoma, Non-Hodgkin	6.1%
144	Paraneoplastic Encephalomyelitis	6%
145	Astrocytoma	5.9%
146	Ependymoma	5.9%
147	oligodendroglioma	5.9%
148	Ganglioglioma	5.9%
149	gliosarcoma	5.9%
150	Anaplastic astrocytoma	5.9%
151	Anaplastic Oligodendroglioma	5.9%
152	Sarcoma 180	5.9%
153	Mammary Neoplasms, Experimental	5.8%
154	Lymphangioleiomyomatosis	5.8%
155	Dermatofibrosarcoma	5.5%
156	Dermatofibrosarcoma Protuberans	5.5%
157	Digestive System Neoplasms	5.4%
158	Endocrine Gland Neoplasms	5.4%
159	Eye Neoplasms	5.4%
160	Nervous System Neoplasms	5.4%
161	Malignant Carcinoid Syndrome	5.3%
162	Bone neoplasms	5.1%
163	Leukoplakia	5.1%
164	Lymphocele	5.1%
165	Pancreatic Cyst	5.1%
166	Skin Neoplasms	5.1%
167	Hematologic Neoplasms	5.1%
168	Barrett Esophagus	5%
169	Breast Cyst	5%
170	Actinic keratosis	5%
171	Mediastinal Cyst	5%
172	Neoplasm Invasiveness	5%
173	Neoplasm Metastasis	5%
174	Neoplasm Recurrence, Local	5%
175	Parovarian Cyst	5%
176	Pericardial Cyst	5%
177	Splenic Neoplasms	5%
178	Thymic Cyst	5%
179	Carcinogenesis	5%
180	Myxoid cyst	5%
181	Metastasis	5%
182	Primary amyloidosis	4.9%
183	Retinoblastoma	4.9%
184	Lymphomatoid Granulomatosis	4.9%
185	Leukemia, Myelomonocytic, Chronic	4.8%
186	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4.8%
187	Adenoid Cystic Carcinoma	4.8%
188	fibroma	4.8%
189	Fibromatosis	4.8%
190	Osteoblastoma	4.8%
191	Osteoma	4.8%
192	Rhabdomyoma	4.8%
193	Chondromatosis	4.8%
194	Adenocarcinoma, Clear Cell	4.8%
195	Cholangiocarcinoma	4.8%
196	Cervical Intraepithelial Neoplasia	4.8%
197	Lymphoma, Extranodal NK-T-Cell	4.8%
198	Pheochromocytoma	4.7%
199	Alveolar rhabdomyosarcoma	4.7%
200	Glioblastoma	4.7%
201	Neuroblastoma	4.7%
202	Glioblastoma Multiforme	4.7%
203	Nephroblastoma	4.7%
204	Tuberous Sclerosis	4.6%
205	Neurofibrosarcoma	4.4%
206	Ganglioneuroblastoma	4.1%
207	Retroperitoneal Neoplasms	4.1%
208	Hepatocellular Adenoma	3.9%
209	Mesoblastic Nephroma	3.9%
210	Basal Cell Nevus Syndrome	3.8%
211	Mastocytosis	3.7%
212	Corpus Luteum Cyst	3.7%
213	Ovarian Cysts	3.7%
214	Gastrointestinal Stromal Tumors	3.7%
215	Carcinoid Heart Disease	3.6%
216	Leukemia, T-Cell	3.6%
217	Leukemia, B-Cell	3.6%
218	neurofibroma	3.6%
219	Hydatidiform Mole	3.6%
220	Lymphoma, Follicular	3.6%
221	T-Cell Lymphoma	3.6%
222	Mantle cell lymphoma	3.6%
223	Fibromatosis, Aggressive	3.6%
224	Fibromatosis, Abdominal	3.6%
225	Klatskin Tumor	3.6%
226	Multiple Endocrine Neoplasia Type 1	3.5%
227	Waldenstrom Macroglobulinemia	3.5%
228	Multiple Myeloma	3.5%
229	Parathyroid Neoplasms	3.4%
230	Peritoneal Neoplasms	3.4%
231	Thyroid Neoplasm	3.4%
232	Thyroid carcinoma	3.4%
233	Carcinoma, Pancreatic Ductal	3.3%
234	Liver Neoplasms, Experimental	3.3%
235	Prolactinoma	3.2%
236	Growth Hormone-Secreting Pituitary Adenoma	3.2%
237	Mastocytoma	3.2%
238	Mastocytosis, Systemic	3.2%
239	Leukemia, Myeloid, Chronic-Phase	3.2%
240	Choledochal Cyst	3.1%
241	Acoustic Neuroma	3%
242	Peutz-Jeghers Syndrome	3%
243	Pancreatic Neoplasm	2.8%
244	Mouth Neoplasms	2.8%
245	Central Nervous System Neoplasms	2.8%
246	Vascular Neoplasms	2.8%
247	Thymus Neoplasms	2.8%
248	granulosa cell tumor	2.8%
249	Carcinoma, Ovarian Epithelial	2.8%
250	Genital Neoplasms, Female	2.7%
251	Pancreatic Pseudocyst	2.7%
252	Lymphatic Metastasis	2.7%
253	Neoplasms, Unknown Primary	2.7%
254	Leukemic Infiltration	2.7%
255	Breast Neoplasms, Male	2.7%
256	Neoplasm Micrometastasis	2.7%
257	Triple Negative Breast Neoplasms	2.7%
258	Tracheal Neoplasms	2.7%
259	Optic Nerve Glioma	2.7%
260	Adenomatous Polyposis Coli	2.7%
261	Leukoplakia, Oral	2.6%
262	Paraneoplastic Cerebellar Degeneration	2.6%
263	Vipoma	2.6%
264	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
265	Leukemia, Large Granular Lymphocytic	2.4%
266	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.4%
267	Lymphoma, T-Cell, Cutaneous	2.4%
268	Lymphoma, AIDS-Related	2.4%
269	Enteropathy-Associated T-Cell Lymphoma	2.4%
270	Primary Effusion Lymphoma	2.4%
271	insulinoma	2.3%
272	Esophageal Neoplasms	2.2%
273	Limbic Encephalitis	2.2%
274	Adrenocortical carcinoma	2.1%
275	Adrenal Gland Neoplasms	2.1%
276	Gastrointestinal Neoplasms	2.1%
277	Genital Neoplasms, Male	2.1%
278	Liver neoplasms	2.1%
279	Uveal Neoplasms	2.1%
280	Nasopharyngeal carcinoma	2.1%
281	Urologic Neoplasms	2.1%
282	Sebaceous Gland Neoplasms	2.1%
283	Spinal Neoplasms	2.1%
284	Bone Marrow Neoplasms	2.1%
285	Polycystic Ovary Syndrome	2%
286	Thyroid Nodule	2%
287	Gastrinoma	1.9%
288	Glucagonoma	1.9%
289	Denys-Drash Syndrome	1.9%
290	Lambert-Eaton Myasthenic Syndrome	1.9%
291	Testicular Neoplasms	1.9%
292	Leydig Cell Tumor	1.9%
293	Dupuytren Contracture	1.9%
294	Renal Cell Carcinoma	1.8%
295	Papillary Renal Cell Carcinoma	1.8%
296	Urticaria Pigmentosa	1.8%
297	Mycosis Fungoides	1.8%
298	Lymphomatoid Papulosis	1.8%
299	Plasmablastic lymphoma	1.8%
300	Carcinoma, Endometrioid	1.7%
301	Xeroderma Pigmentosum	1.7%
302	Opsoclonus-Myoclonus Syndrome	1.7%
303	Meningeal Neoplasms	1.6%
304	Burkitt Lymphoma	1.6%
305	Myelitis, Transverse	1.5%
306	ovarian neoplasm	1.4%
307	Nose Neoplasms	1.3%
308	Ear Neoplasms	1.3%
309	Eyelid Neoplasms	1.3%
310	Lung Neoplasms	1.3%
311	Pleural Neoplasms	1.3%
312	Cell Transformation, Viral	1.2%
313	Brain Neoplasms	1.2%
314	Salivary Gland Neoplasms	1.2%
315	Spinal Cord Neoplasms	1.2%
316	Tongue Neoplasms	1.2%
317	Uterine Neoplasms	1.2%
318	Vaginal Neoplasms	1.2%
319	Vulvar Neoplasms	1.2%
320	Uterine Cancer	1.2%
321	Sezary Syndrome	1.2%
322	Fallopian Tube Neoplasms	1.2%
323	Palatal Neoplasms	1.2%
324	Pituitary Adenoma	1.1%
325	Pituitary Neoplasms	1.1%
326	Meningeal Carcinomatosis	1.1%
327	Zollinger-Ellison syndrome	1%
328	Pharyngeal Neoplasms	1%
329	Central Nervous System Cysts	1%
330	Bile Duct Neoplasms	1%
331	gallbladder neoplasm	1%
332	Intestinal Neoplasms	1%
333	Penile Neoplasms	1%
334	Prostatic Neoplasms	1%
335	Stomach Neoplasms	1%
336	Polycythemia Vera	1%
337	Laryngeal neoplasm	0.9%
338	Bronchial Neoplasms	0.8%
339	Bladder Neoplasm	0.8%
340	Kidney Neoplasm	0.8%
341	Ureteral Neoplasms	0.8%
342	Urethral Neoplasms	0.8%
343	Multiple Pulmonary Nodules	0.8%
344	Supratentorial Neoplasms	0.8%
345	Endometrial Neoplasms	0.8%
346	Hypopharyngeal Neoplasms	0.7%
347	Pleural Effusion, Malignant	0.7%
348	Hypopharyngeal Cancer	0.7%
349	Parotid Neoplasms	0.6%
350	Prostatic Neoplasms, Castration-Resistant	0.6%
351	Nelson Syndrome	0.6%
352	Brain Stem Neoplasms	0.6%
353	Cecal Neoplasms	0.5%
354	Duodenal Neoplasms	0.5%
355	Choroid Plexus Papilloma	0.5%
356	Tonsillar Neoplasms	0.5%
357	Cerebellar Neoplasms	0.5%
358	Nasopharyngeal Neoplasms	0.5%
359	Colorectal Neoplasms	0.5%
360	Paranasal Sinus Neoplasms	0.4%
361	Radicular Cyst	0.4%
362	Appendiceal Neoplasms	0.4%
363	Colonic Neoplasms	0.4%
364	Rectal Neoplasms	0.4%
365	Maxillary Sinus Neoplasms	0.3%
366	Anus Neoplasms	0.3%
367	Sigmoid Neoplasms	0.3%

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