MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Mastocytosis, Systemic

(UMLS:C0221013)

Definition:: A group of disorders caused by the abnormal proliferation of MAST CELLS in a variety of extracutaneous tissues including bone marrow, liver, spleen, lymph nodes, and gastrointestinal tract. Systemic mastocytosis is commonly seen in adults. These diseases are categorized on the basis of clinical features, pathologic findings, and prognosis.
UMLS ID:: C0221013
MeSH ID:: D034721

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.565.465.750

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.543.520.350.750

Synonym(s)

Mastocytosis, Systemic

MAST CELL DISEASE, SYSTEMIC

SMCD - systemic mast cell disease

Systemic Mastocytosis

Systemic Tissue Mast Cell Disease

Systemic mast cell disease

Systemic mastocytosis

Systemic mastocytosis, NOS

Systemic tissue mast cell disease

10.

Urticaria pigmentosa, systemic

11.

disease (or disorder); systemic tissue, mast cell

12.

mastocytosis systemic

13.

neoplasm uncert behavior of histiocytic & mast cells systemic mastocytosis

14.

systemic mast cell disease

15.

systemic mast-cell disease

16.

systemic mastocytosis

17.

systemic tissue mast cell disease

18.

systemic urticaria pigmentosa

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Aspirin	2880686	CTD
2	Cimetidine	420338 18951251	CTD
3	midostaurin	17420286	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrosarcoma	26.5%
2	synovial sarcoma	26.5%
3	Clear Cell Sarcoma of Soft Tissue	26.5%
4	Mastocytoma	25%
5	Myxoma	24.1%
6	Neoplasms, Bone Tissue	24.1%
7	Neoplasms, Fibrous Tissue	24.1%
8	Chondroma	24.1%
9	Enchondroma	24.1%
10	Giant Cell Tumor of Bone	23.9%
11	Fibrosarcoma	20.4%
12	Osteosarcoma	20.4%
13	Sarcoma	18.9%
14	Malignant Fibrous Histiocytoma	17.4%
15	Vasculitis, Leukocytoclastic, Cutaneous	17.1%
16	leiomyosarcoma	16.9%
17	liposarcoma	16.9%
18	Angiomyolipoma	16.9%
19	Alveolar Soft Part Sarcoma	16.9%
20	Latex allergy	16.6%
21	fibroma	16%
22	Fibromatosis	16%
23	Osteoblastoma	16%
24	Osteoma	16%
25	Chondromatosis	16%
26	Urticaria Pigmentosa	15%
27	leukemia	14.9%
28	Neoplasms, Germ Cell and Embryonal	14.9%
29	Neoplasms, Glandular and Epithelial	14.9%
30	Germ Cell Cancer	14.9%
31	Gastrointestinal Stromal Tumors	14.7%
32	Carcinosarcoma	14.6%
33	Hemangiosarcoma	14.6%
34	lymphangiosarcoma	14.6%
35	Serum Sickness	14.6%
36	Dermatofibrosarcoma	14.5%
37	Dermatofibrosarcoma Protuberans	14.5%
38	Environmental Illness	13.1%
39	Adenofibroma	12.6%
40	Fibroadenoma	12.6%
41	Neuroectodermal Tumors	12.2%
42	Sarcoma, Myeloid	12%
43	Fibromatosis, Aggressive	11.9%
44	Fibromatosis, Abdominal	11.9%
45	Phyllodes Tumor	11.2%
46	Lipoma	11.2%
47	Myoma	11.2%
48	Angiolipoma	11.2%
49	Myelolipoma	11.2%
50	Smooth Muscle Tumor	11.2%
51	Desmoplastic Small Round Cell Tumor	11.2%
52	Histiocytic Disorders, Malignant	11.2%
53	Rhabdomyosarcoma	11.2%
54	Lymphoma	11%
55	Neoplasms, Neuroepithelial	10.7%
56	Gliomatosis cerebri	10.7%
57	Carcinoma 256, Walker	10.5%
58	Autoimmune Diseases	10.4%
59	Immunologic Deficiency Syndromes	10.4%
60	Immunoproliferative Disorders	10.4%
61	Immune reconstitution syndrome	10.4%
62	Immune Reconstitution Inflammatory Syndrome	10.4%
63	Kounis Syndrome	10%
64	Sarcoma, Experimental	9.8%
65	Hamartoma	9.8%
66	Neoplasms, Hormone-Dependent	9.8%
67	Neoplasms, Multiple Primary	9.8%
68	Paraneoplastic Syndromes	9.8%
69	Precancerous Conditions	9.8%
70	Neoplasms, Second Primary	9.8%
71	anaphylaxis	9.7%
72	Food Allergy	9.7%
73	Anaphylactic shock	9.7%
74	Neurofibrosarcoma	9.6%
75	Composite Lymphoma	9.2%
76	Lymphangioleiomyomatosis	9.1%
77	Leukemia, Plasma Cell	9.1%
78	melanoma	8.7%
79	Meningioma	8.6%
80	Plasmacytoma	8.6%
81	Asthma, Aspirin-Induced	8.5%
82	Alveolar rhabdomyosarcoma	8.3%
83	Adenoma	8.1%
84	Ameloblastoma	8.1%
85	Angiokeratoma	8.1%
86	Carcinoma	8.1%
87	Chordoma	8.1%
88	Hemangioma	8.1%
89	hemangiopericytoma	8.1%
90	Lymphangioma	8.1%
91	Mesenchymoma	8.1%
92	Nevus	8.1%
93	Teratoma	8.1%
94	Hepatoblastoma	8.1%
95	Mixed Tumor, Mullerian	8.1%
96	Germinoma	8.1%
97	Teratocarcinoma	8.1%
98	Angiofibroma	8.1%
99	Epithelioma	8.1%
100	Trophoblastic Neoplasms	8%
101	Leukemia, Experimental	7.9%
102	Transfusion Reaction	7.9%
103	Hypotensive Transfusion Reaction	7.9%
104	Respiratory Hypersensitivity	7.7%
105	Endometrial Stromal Sarcoma	7.7%
106	Sarcoma 180	7.7%
107	Sick Building Syndrome	7.5%
108	Multiple Chemical Sensitivity	7.5%
109	Rhabdomyoma	7.4%
110	Cyst	7.4%
111	Neoplastic Processes	7.4%
112	Neoplastic Syndromes, Hereditary	7.4%
113	Pregnancy Complications, Neoplastic	7.4%
114	Carcinoma, Ehrlich Tumor	7.4%
115	Dermoid Cyst	7.4%
116	Carcinoma, Lewis Lung	7.4%
117	Dupuytren Contracture	7.4%
118	Primary amyloidosis	7.4%
119	Urticaria	7.3%
120	Neoplasms, Experimental	7.3%
121	Basal cell carcinoma	7.2%
122	Carcinoma, Papillary	7.2%
123	Squamous cell carcinoma	7.2%
124	Craniopharyngioma	7.2%
125	Cystadenoma	7.2%
126	Mesothelioma	7.2%
127	Neuroectodermal Tumor, Melanotic	7.2%
128	Neuroendocrine Tumors	7.2%
129	Carcinoma, Basal Cell	7.2%
130	Adenoma, Acidophil	6.7%
131	Ganglioneuroma	6.7%
132	Glioma	6.7%
133	Malignant Glioma	6.7%
134	Leukemia, Radiation-Induced	6.7%
135	Milk Allergy	6.4%
136	Wheat Hypersensitivity	6.4%
137	Melanoma, Experimental	6.2%
138	Hodgkin Disease	6.1%
139	Lymphoma, Non-Hodgkin	6.1%
140	Malignant histiocytosis	6.1%
141	Histiocytic sarcoma	6.1%
142	Glomerulonephritis, Membranoproliferative	6%
143	Cystadenocarcinoma	6%
144	Mucoepidermoid Carcinoma	6%
145	Medulloblastoma	5.9%
146	Drug Eruptions	5.9%
147	Thymoma	5.9%
148	Neoplasms, Radiation-Induced	5.8%
149	Dermatitis, Allergic Contact	5.8%
150	Carcinoid Tumor	5.7%
151	Neurilemmoma	5.7%
152	Hutchinson's Melanotic Freckle	5.7%
153	Melanoma, Amelanotic	5.7%
154	Leukemia L1210	5.7%
155	Leukemia P388	5.7%
156	Acanthoma	5.7%
157	Multiple Endocrine Neoplasia	5.6%
158	Antiphospholipid Syndrome	5.5%
159	Multiple Myeloma	5.5%
160	Choriocarcinoma	5.4%
161	Carcinoma, Lobular	5.4%
162	Abdominal Neoplasms	5%
163	Erythroplasia	5%
164	Follicular cyst	5%
165	Head and Neck Neoplasms	5%
166	Mucocele	5%
167	Pilonidal Cyst	5%
168	Soft Tissue Neoplasms	5%
169	Thoracic Neoplasms	5%
170	Thyroglossal Cyst	5%
171	Synovial Cyst	5%
172	Aberrant Crypt Foci	5%
173	Adenocarcinoma	4.8%
174	Carcinoma in Situ	4.8%
175	Carcinoma, Transitional Cell	4.8%
176	Dysgerminoma	4.8%
177	Hemangioendothelioma	4.8%
178	Neuroma	4.8%
179	Papilloma	4.8%
180	Pseudomyxoma Peritonei	4.8%
181	Seminoma	4.8%
182	Papillomatosis	4.8%
183	Adenomatosis, Pulmonary	4.8%
184	Adenomatous Polyps	4.8%
185	Carcinoma, Large Cell	4.8%
186	Carcinoma, Small Cell	4.8%
187	Bowen's Disease	4.8%
188	Paraganglioma	4.8%
189	Astrocytoma	4.8%
190	Ependymoma	4.8%
191	oligodendroglioma	4.8%
192	Ganglioglioma	4.8%
193	gliosarcoma	4.8%
194	Anaplastic astrocytoma	4.8%
195	Anaplastic Oligodendroglioma	4.8%
196	Lymphomatoid Granulomatosis	4.7%
197	Paraneoplastic Encephalomyelitis	4.7%
198	Mammary Neoplasms, Experimental	4.6%
199	Autoimmune Lymphoproliferative Syndrome	4.5%
200	Retinoblastoma	4.4%
201	Waldenstrom Macroglobulinemia	4.3%
202	Malignant Carcinoid Syndrome	4.3%
203	Thrombocytopenic purpura	4.3%
204	Dermatitis, Atopic	4.2%
205	Nephroblastoma	4.2%
206	Lupus Erythematosus, Systemic	4.2%
207	Lymphoproliferative Disorders	4.2%
208	Overlap syndrome	4.2%
209	Leukemia, T-Cell	4.2%
210	Leukemia, B-Cell	4.2%
211	Addison Disease	4.1%
212	Paraproteinemias	4.1%
213	Pemphigus	4.1%
214	Autoimmune thyroiditis	4.1%
215	Primary Adrenal Insufficiency	4.1%
216	Tuberous Sclerosis	4.1%
217	Lymphopenia	4.1%
218	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	4.1%
219	Autoimmune hepatitis	4.1%
220	Angioedema	3.9%
221	Digestive System Neoplasms	3.9%
222	Endocrine Gland Neoplasms	3.9%
223	Eye Neoplasms	3.9%
224	Nervous System Neoplasms	3.9%
225	Acute Generalized Exanthematous Pustulosis	3.9%
226	Lymphoma, Follicular	3.8%
227	T-Cell Lymphoma	3.8%
228	Mantle cell lymphoma	3.8%
229	Bone neoplasms	3.8%
230	Glioblastoma	3.8%
231	Leukoplakia	3.8%
232	Lymphocele	3.8%
233	Neuroblastoma	3.8%
234	Pancreatic Cyst	3.8%
235	Skin Neoplasms	3.8%
236	Hematologic Neoplasms	3.8%
237	Glioblastoma Multiforme	3.8%
238	Barrett Esophagus	3.7%
239	Breast Cyst	3.7%
240	Actinic keratosis	3.7%
241	Mediastinal Cyst	3.7%
242	Neoplasm Invasiveness	3.7%
243	Neoplasm Metastasis	3.7%
244	Neoplasm Recurrence, Local	3.7%
245	Parovarian Cyst	3.7%
246	Pericardial Cyst	3.7%
247	Splenic Neoplasms	3.7%
248	Thymic Cyst	3.7%
249	Carcinogenesis	3.7%
250	Myxoid cyst	3.7%
251	Metastasis	3.7%
252	Autoimmune thrombocytopenia	3.6%
253	Immune thrombocytopenic purpura	3.6%
254	Leukemia, Myelomonocytic, Chronic	3.6%
255	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	3.6%
256	Pheochromocytoma	3.6%
257	Mesoblastic Nephroma	3.4%
258	Basal Cell Nevus Syndrome	3.4%
259	Hypergammaglobulinemia	3.4%
260	Latent Autoimmune Diabetes in Adults	3.3%
261	Asthma	3.3%
262	Agammaglobulinemia	3.3%
263	Dermatitis Herpetiformis	3.3%
264	Ganglioneuroblastoma	3.3%
265	HIV Infections	3.3%
266	Transfusion-Related Acute Lung Injury	3.3%
267	Monoclonal Gammopathy of Undetermined Significance	3.3%
268	Hepatocellular Adenoma	3.3%
269	Erythema Nodosum	3.2%
270	Dermatitis, Photoallergic	3.2%
271	Adenoid Cystic Carcinoma	3.2%
272	Adenocarcinoma, Clear Cell	3.2%
273	Cholangiocarcinoma	3.2%
274	Cervical Intraepithelial Neoplasia	3.2%
275	Hemangioblastoma	3.2%
276	Lymphoma, Extranodal NK-T-Cell	3.2%
277	Multiple Endocrine Neoplasia Type 1	3%
278	Carcinoid Heart Disease	3%
279	Sturge-Weber Syndrome	3%
280	Carcinoma, Pancreatic Ductal	3%
281	Corpus Luteum Cyst	3%
282	Ovarian Cysts	3%
283	Sezary Syndrome	2.9%
284	Asthma, Exercise-Induced	2.9%
285	Status Asthmaticus	2.9%
286	Hemangioma, Cavernous	2.9%
287	Lambert-Eaton Myasthenic Syndrome	2.9%
288	neurofibroma	2.9%
289	Hydatidiform Mole	2.9%
290	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.9%
291	Leukemia, Large Granular Lymphocytic	2.9%
292	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.9%
293	Liver Neoplasms, Experimental	2.8%
294	Aspergillosis, Allergic Bronchopulmonary	2.8%
295	Rheumatoid Arthritis	2.8%
296	Parathyroid Neoplasms	2.8%
297	Peritoneal Neoplasms	2.8%
298	Thyroid Neoplasm	2.8%
299	Thyroid carcinoma	2.8%
300	Juvenile arthritis	2.8%
301	Prolactinoma	2.8%
302	Growth Hormone-Secreting Pituitary Adenoma	2.8%
303	Graves Disease	2.8%
304	Acoustic Neuroma	2.7%
305	Anti-Glomerular Basement Membrane Disease	2.7%
306	Retroperitoneal Neoplasms	2.7%
307	Lymphoma, T-Cell, Cutaneous	2.7%
308	Lymphoma, AIDS-Related	2.7%
309	Enteropathy-Associated T-Cell Lymphoma	2.7%
310	Primary Effusion Lymphoma	2.7%
311	Asthma, Occupational	2.5%
312	Choledochal Cyst	2.5%
313	Optic Nerve Glioma	2.5%
314	Farmer's Lung	2.5%
315	Peutz-Jeghers Syndrome	2.5%
316	Angioedemas, Hereditary	2.5%
317	Tumor Lysis Syndrome	2.4%
318	HTLV-I Infections	2.4%
319	Job Syndrome	2.4%
320	Toxic Epidermal Necrolysis	2.4%
321	Stevens-Johnson Syndrome	2.4%
322	Pancreatic Neoplasm	2.4%
323	Adenomatous Polyposis Coli	2.4%
324	Hay fever	2.4%
325	Rhinitis, Allergic, Perennial	2.4%
326	granulosa cell tumor	2.4%
327	Carcinoma, Ovarian Epithelial	2.4%
328	Leukemia, Myeloid, Chronic-Phase	2.4%
329	Hereditary Angioedema Type III	2.4%
330	Hereditary Angioedema Types I and II	2.4%
331	Klatskin Tumor	2.4%
332	Vipoma	2.3%
333	Tracheal Neoplasms	2.2%
334	Leukoplakia, Oral	2.2%
335	Paraneoplastic Cerebellar Degeneration	2.2%
336	Schnitzler Syndrome	2.1%
337	Mycosis Fungoides	2.1%
338	Lymphomatoid Papulosis	2.1%
339	Plasmablastic lymphoma	2.1%
340	Mouth Neoplasms	2.1%
341	Central Nervous System Neoplasms	2.1%
342	Vascular Neoplasms	2.1%
343	Thymus Neoplasms	2.1%
344	Kernicterus	2.1%
345	Genital Neoplasms, Female	2%
346	Pancreatic Pseudocyst	2%
347	Lymphatic Metastasis	2%
348	Neoplasms, Unknown Primary	2%
349	Leukemic Infiltration	2%
350	Breast Neoplasms, Male	2%
351	Neoplasm Micrometastasis	2%
352	Triple Negative Breast Neoplasms	2%
353	insulinoma	2%
354	Myasthenia Gravis	2%
355	Uveomeningoencephalitic Syndrome	2%
356	Myelitis, Transverse	2%
357	Chronic granulomatous disease	2%
358	Heavy Chain Disease	2%
359	Granulomatosis with polyangiitis	1.9%
360	Burkitt Lymphoma	1.9%
361	HIV Seropositivity	1.9%
362	Esophageal Neoplasms	1.9%
363	Nasopharyngeal carcinoma	1.9%
364	Limbic Encephalitis	1.9%
365	Ataxia Telangiectasia	1.9%
366	Adrenocortical carcinoma	1.8%
367	Hydrops Fetalis	1.8%
368	Denys-Drash Syndrome	1.8%
369	Gastrinoma	1.7%
370	Glucagonoma	1.7%
371	Adrenal Gland Neoplasms	1.7%
372	Gastrointestinal Neoplasms	1.7%
373	Genital Neoplasms, Male	1.7%
374	Liver neoplasms	1.7%
375	Uveal Neoplasms	1.7%
376	Stiff-Person Syndrome	1.7%
377	Leydig Cell Tumor	1.7%
378	Polyradiculoneuropathy	1.7%
379	Polyradiculoneuritis	1.7%
380	Urologic Neoplasms	1.7%
381	Testicular Neoplasms	1.7%
382	Acquired Immunodeficiency Syndrome	1.6%
383	AIDS related complex	1.6%
384	Sebaceous Gland Neoplasms	1.6%
385	Spinal Neoplasms	1.6%
386	Bone Marrow Neoplasms	1.6%
387	Infectious Mononucleosis	1.6%
388	Cryoglobulinemia	1.6%
389	Felty Syndrome	1.6%
390	Thyroid Nodule	1.6%
391	POEMS Syndrome	1.6%
392	Myasthenia Gravis, Autoimmune, Experimental	1.6%
393	Lupus Nephritis	1.6%
394	Polycystic Ovary Syndrome	1.6%
395	Renal Cell Carcinoma	1.6%
396	Papillary Renal Cell Carcinoma	1.6%
397	Xeroderma Pigmentosum	1.5%
398	Carcinoma, Endometrioid	1.5%
399	Opsoclonus-Myoclonus Syndrome	1.5%
400	AIDS-Related Opportunistic Infections	1.4%
401	Vasculitis, Central Nervous System	1.4%
402	HIV Wasting Syndrome	1.4%
403	Rheumatoid Vasculitis	1.4%
404	AIDS Dementia Complex	1.4%
405	AIDS-Associated Nephropathy	1.4%
406	Multiple Sclerosis	1.3%
407	Lupus Vasculitis, Central Nervous System	1.2%
408	Wiskott-Aldrich Syndrome	1.2%
409	Sicca Syndrome	1.2%
410	Sjogren's Syndrome	1.2%
411	Meningeal Neoplasms	1.2%
412	HIV-Associated Lipodystrophy Syndrome	1.2%
413	ovarian neoplasm	1.2%
414	Neuromyelitis Optica	1.1%
415	Leukoencephalitis, Acute Hemorrhagic	1.1%
416	Nose Neoplasms	1.1%
417	Encephalomyelitis, Acute Disseminated	1.1%
418	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	1.1%
419	Neuritis, Autoimmune, Experimental	1.1%
420	Pituitary Adenoma	1%
421	Pituitary Neoplasms	1%
422	Palatal Neoplasms	1%
423	Ear Neoplasms	1%
424	Eyelid Neoplasms	1%
425	Lung Neoplasms	1%
426	Pleural Neoplasms	1%
427	Cell Transformation, Viral	1%
428	Brain Neoplasms	1%
429	Salivary Gland Neoplasms	1%
430	Spinal Cord Neoplasms	1%
431	Tongue Neoplasms	1%
432	Uterine Neoplasms	1%
433	Vaginal Neoplasms	1%
434	Vulvar Neoplasms	1%
435	Uterine Cancer	1%
436	Fallopian Tube Neoplasms	1%
437	Multiple Sclerosis, Chronic Progressive	1%
438	Multiple Sclerosis, Relapsing-Remitting	1%
439	Guillain-Barre Syndrome	0.9%
440	Zollinger-Ellison syndrome	0.9%
441	Pharyngeal Neoplasms	0.8%
442	Central Nervous System Cysts	0.8%
443	Bile Duct Neoplasms	0.8%
444	gallbladder neoplasm	0.8%
445	Intestinal Neoplasms	0.8%
446	Penile Neoplasms	0.8%
447	Prostatic Neoplasms	0.8%
448	Stomach Neoplasms	0.8%
449	Polycythemia Vera	0.8%
450	Meningeal Carcinomatosis	0.8%
451	Laryngeal neoplasm	0.7%
452	Giant Cell Arteritis	0.7%
453	Temporal Arteritis	0.7%
454	Bladder Neoplasm	0.7%
455	Kidney Neoplasm	0.7%
456	Ureteral Neoplasms	0.7%
457	Urethral Neoplasms	0.7%
458	Bronchial Neoplasms	0.7%
459	Multiple Pulmonary Nodules	0.6%
460	Supratentorial Neoplasms	0.6%
461	Endometrial Neoplasms	0.6%
462	Hypopharyngeal Neoplasms	0.5%
463	Pleural Effusion, Malignant	0.5%
464	Hypopharyngeal Cancer	0.5%
465	Parotid Neoplasms	0.5%
466	Prostatic Neoplasms, Castration-Resistant	0.5%
467	Nelson Syndrome	0.5%
468	Miller Fisher Syndrome	0.5%
469	Brain Stem Neoplasms	0.5%
470	Cecal Neoplasms	0.5%
471	Duodenal Neoplasms	0.5%
472	Nasopharyngeal Neoplasms	0.4%
473	Colorectal Neoplasms	0.4%
474	Tonsillar Neoplasms	0.4%
475	Cerebellar Neoplasms	0.4%
476	Choroid Plexus Papilloma	0.4%
477	Paranasal Sinus Neoplasms	0.4%
478	Radicular Cyst	0.3%
479	Appendiceal Neoplasms	0.3%
480	Colonic Neoplasms	0.3%
481	Rectal Neoplasms	0.3%
482	Maxillary Sinus Neoplasms	0.3%
483	Anus Neoplasms	0.2%
484	Sigmoid Neoplasms	0.2%

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