MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Lupus Erythematosus, Systemic

(UMLS:C0024141)

Definition:: A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.
UMLS ID:: C0024141
MeSH ID:: D008180

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.480

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.111.590

Synonym(s)

Lupus Erythematosus, Systemic

Disseminated lupus erythematosus

LE SYNDROME

LUPUS

LUPUS ERYTHEMATOSUS SYSTEMIC

LUPUS ERYTHEMATOSUS, DISSEMINATED

LUPUS, ERYTHEMATOSUS, SYSTEMIC

Lupus erythematosus, Systemic

Lupus erythematosus, disseminated

10.

Lupus erythematosus, systemic

11.

SLE

12.

SLE - Lupus Erythematosus, Systemic

13.

SLE - Systemic lupus erythematosus

14.

SYSTEMIC LUPUS ERYTHEMATOSIS

Associated Drug(s)

	Name	Reference(s)	Data Source
1	8-oxo-7-hydrodeoxyguanosine	24345202	CTD
2	Amiodarone	10577372 11926860	CTD
3	Aspirin	420719 4022693	CTD
4	Azathioprine	View details 95811 577907 2985516 4700007 6689657 10582204 12739036 16038116 16396707 18250137 19129747	CTD
5	Carbamazepine	View details 1747706 10669712 16283138 16628512	CTD
6	Celecoxib	17761345	CTD
7	Chlorambucil	4700007	CTD
8	Chlordecone	17578864	CTD
9	Chloroquine	View details 1828574 4076494 7873836 9922366 11245140 11966675 12361838 12739036 14740170 15846170 17590456 18692276	CTD
10	Chlorpromazine	68769 2245719	CTD
11	Cocaine	19966204	CTD
12	Cyclophosphamide	View details 901598 4700007 5120183 9149702 12739036 19078457 20398172	CTD
13	Diatomaceous Earth	16373255	CTD
14	Diclofenac	1930326	CTD
15	Estradiol	17578864	CTD
16	Ethosuximide	9776542	CTD
17	Folic Acid	9758264 17718048	CTD
18	Griseofulvin	7577414	CTD
19	Homocysteine	18348424	CTD
20	Hydralazine	View details 19187 68769 288303 2940667 15286391	CTD
21	Hydroxychloroquine	View details 5120183 8895146 9051865 9712114 10219755 10229401 11495297 15079764 16153529 16615675 18061791 19208570	CTD
22	Ibuprofen	View details 420719 3600902 6844855 7180901	CTD
23	Indomethacin	3600902 6694957	CTD
24	Isoniazid	68769 19995658	CTD
25	Mefenamic Acid	6694957	CTD
26	Melatonin	16373423	CTD
27	Methotrexate	17400583	CTD
28	Methyldopa	68769 8586931	CTD
29	Methylprednisolone	View details 2084249 3152997 3752071 6860385 11441330 19995658	CTD
30	Metoprolol	1747706	CTD
31	Minocycline	View details 68769 10406406 10555598 11254246 17542873 18983308	CTD
32	Mycophenolic Acid	18238994	CTD
33	Nitrofurantoin	1079107	CTD
34	Penicillamine	View details 159020 1604135 2082056 2940667 3752071 6216862 6658398 6723128 6939878 7213433 7370063 8592607	CTD
35	Phenylbutazone	577907	CTD
36	Prednisolone	View details 1550394 5475847 7443604 8174575 9712114 10566758 11491499 16130515 16260053 20398172	CTD
37	Prednisone	View details 95811 577907 2985516 3944744 4061472 5120183 7247116 14740170 16153529 16425441 17634902 19208570	CTD
38	Procainamide	View details 19187 68769 95811 617255 921427 2940667 4517705 4781063 5015024 5031767 6155782 6159783 6261406 6858967 7015825 15286391	CTD
39	Propylthiouracil	2484903 16425441 16887463	CTD
40	Quinacrine	7873836 18170732	CTD
41	Quinidine	68769	CTD
42	Ranitidine	10598151	CTD
43	Rifampin	11422169	CTD
44	SC-11800 EE	7458971	CTD
45	Sulfadiazine	68769	CTD
46	Sulfasalazine	2894766 6124962 9374926	CTD
47	Tacrolimus	9462174	CTD
48	Thalidomide	2985516 10918274 12072099	CTD
49	Valproic Acid	9003978	CTD
50	Vincristine	1696192	CTD
51	Vitamin B 12	17718048	CTD
52	chloroquine diphosphate	638620 2957973	CTD
53	roquinimex	21195814	CTD
54	tofacitinib	27429362	CTD
55	triptolide	23639586	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Overlap syndrome	42.9%
2	Collagen Diseases	28.6%
3	Lupus Erythematosus, Cutaneous	28.6%
4	Mixed Connective Tissue Disease	28.6%
5	Panniculitis	28.6%
6	Systemic Scleroderma	28.6%
7	Antiphospholipid Syndrome	28.6%
8	Mucinoses	28.6%
9	Morphea	28.6%
10	Pemphigus	26.3%
11	Dermatitis Herpetiformis	25%
12	Panniculitis, Lupus Erythematosus	24.7%
13	Rheumatoid Arthritis	24.4%
14	Juvenile arthritis	24.4%
15	Cartilage Diseases	22.2%
16	Rheumatism	22.2%
17	Chondromalacia	22.2%
18	Addison Disease	21.1%
19	Autoimmune thyroiditis	21.1%
20	Primary Adrenal Insufficiency	21.1%
21	Scleromyxedema	20.9%
22	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	20.9%
23	Autoimmune hepatitis	20.9%
24	Cutis Laxa	20.8%
25	Lupus Erythematosus, Discoid	20.7%
26	Scleroderma, Limited	20.7%
27	Felty Syndrome	18.5%
28	Dermatomyositis	18.3%
29	Autoimmune Lymphoproliferative Syndrome	17.4%
30	Latent Autoimmune Diabetes in Adults	16.8%
31	Dupuytren Contracture	16.5%
32	Mesenteric Panniculitis	15.8%
33	Panniculitis, Peritoneal	15.8%
34	Tietze's Syndrome	15.8%
35	Orbital Cellulitis	15.8%
36	Rheumatoid Vasculitis	15.8%
37	Myxoid cyst	15.8%
38	Myxedema	15.5%
39	Necrobiosis Lipoidica Diabeticorum	15.3%
40	Hypersensitivity	15%
41	Immunologic Deficiency Syndromes	15%
42	Immunoproliferative Disorders	15%
43	Immune reconstitution syndrome	15%
44	Immune Reconstitution Inflammatory Syndrome	15%
45	Granuloma Annulare	14.3%
46	Sicca Syndrome	13.8%
47	Sjogren's Syndrome	13.8%
48	Graves Disease	13.8%
49	Cellulitis	13.7%
50	Pseudoxanthoma Elasticum	13.6%
51	Anti-Glomerular Basement Membrane Disease	13.5%
52	Erythema Induratum	12.7%
53	Osteochondritis	12.7%
54	Polymyalgia Rheumatica	12.7%
55	Myasthenia Gravis	12.5%
56	Uveomeningoencephalitic Syndrome	12.5%
57	Myasthenia Gravis, Autoimmune, Experimental	12.5%
58	Osteogenesis Imperfecta	12.4%
59	Pyoderma Gangrenosum	12.3%
60	Granulomatosis with polyangiitis	12.2%
61	Keloid	12.2%
62	Autoimmune thrombocytopenia	11.9%
63	Immune thrombocytopenic purpura	11.9%
64	Dermatitis, Atopic	11.7%
65	Dermatitis, Photoallergic	11.1%
66	Transfusion Reaction	11.1%
67	Hypotensive Transfusion Reaction	11.1%
68	Dermatitis, Allergic Contact	10.8%
69	Stiff-Person Syndrome	10.5%
70	Polyradiculoneuropathy	10.4%
71	Polyradiculoneuritis	10.4%
72	Acne Vulgaris	10.3%
73	Contact Dermatitis	10.3%
74	Eczema	10.3%
75	Erythema Multiforme	10.3%
76	Intertrigo	10.3%
77	Neurodermatitis	10.3%
78	Rhinophyma	10.3%
79	Urticaria	10.3%
80	Perioral Dermatitis	10.3%
81	Acne	10.3%
82	Multiple Sclerosis	10.2%
83	Noonan Syndrome	10.2%
84	Rheumatoid Nodule	10.1%
85	Dermatitis, Phototoxic	10.1%
86	Pityriasis Lichenoides et Varioliformis Acuta	10.1%
87	Pityriasis Lichenoides	10.1%
88	Phototoxicity	10.1%
89	Mastocytosis	9.7%
90	Breast Diseases	9.5%
91	Dermatitis	9.5%
92	Exanthema	9.5%
93	Facial Dermatoses	9.5%
94	Hair Diseases	9.5%
95	Hand Dermatoses	9.5%
96	Immune Complex Diseases	9.5%
97	keratoacanthoma	9.5%
98	Keratosis	9.5%
99	Nail Diseases	9.5%
100	Photosensitivity Disorders	9.5%
101	Prurigo	9.5%
102	Pyoderma	9.5%
103	Rosacea	9.5%
104	Sebaceous Gland Diseases	9.5%
105	Skin Diseases, Vesiculobullous	9.5%
106	Skin Ulcer	9.5%
107	Sweat Gland Diseases	9.5%
108	Skin Diseases, Papulosquamous	9.5%
109	Skin Diseases, Vascular	9.5%
110	Acneiform Eruptions	9.5%
111	Ocular Rosacea	9.5%
112	Latex allergy	9.5%
113	Subcorneal pustular dermatosis	9.5%
114	Erythematotelangiectatic Rosacea	9.5%
115	Papulopustular Rosacea	9.5%
116	Chronic Actinic Dermatitis	9.5%
117	Neuromyelitis Optica	9.5%
118	Foot Ulcer	9.4%
119	Leukoencephalitis, Acute Hemorrhagic	9.4%
120	Marfan Syndrome	9.1%
121	Multiple Sclerosis, Chronic Progressive	9%
122	Multiple Sclerosis, Relapsing-Remitting	9%
123	Laryngomalacia	9%
124	Erythema Nodosum	8.9%
125	Serum Sickness	8.9%
126	Pectus carinatum	8.9%
127	Homocystinuria	8.8%
128	Vasculitis, Central Nervous System	8.8%
129	Epidermolysis Bullosa	8.7%
130	Dermatitis, Irritant	8.5%
131	Acne Conglobata	8.5%
132	Bronchomalacia	8.4%
133	Tracheomalacia	8.4%
134	Encephalomyelitis, Acute Disseminated	8.4%
135	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	8.4%
136	Neuritis, Autoimmune, Experimental	8.4%
137	Glomerulonephritis, Membranoproliferative	8.4%
138	Toxic Epidermal Necrolysis	8.3%
139	Stevens-Johnson Syndrome	8.3%
140	CREST Syndrome	8.3%
141	Acrodermatitis	8.2%
142	Drug Eruptions	8.2%
143	Sebaceous Gland Neoplasms	8.2%
144	Porokeratosis	8.2%
145	Gianotti-Crosti Syndrome	8.2%
146	Keratoderma, Palmoplantar	8.2%
147	Xeroderma Pigmentosum	8.2%
148	Giant Cell Arteritis	7.7%
149	Temporal Arteritis	7.7%
150	Lambert-Eaton Myasthenic Syndrome	7.7%
151	Diaper Rash	7.6%
152	Foot Diseases	7.4%
153	Environmental Illness	7.4%
154	Urticaria Pigmentosa	7.4%
155	Guillain-Barre Syndrome	7.2%
156	Lymphoproliferative Disorders	7.1%
157	Skin Abnormalities	7.1%
158	Skin Diseases, Infectious	7.1%
159	Skin Neoplasms	7.1%
160	Pigmentation Disorders	7.1%
161	Mucopolysaccharidosis III	7%
162	Dermatitis, Occupational	7%
163	Lipomatosis	7%
164	Paraproteinemias	7%
165	Pruritus	7%
166	Erythema	7%
167	Necrolytic Migratory Erythema	7%
168	Cutaneous Fistula	7%
169	Nephrogenic Fibrosing Dermopathy	7%
170	Nephrogenic Systemic Fibrosis	7%
171	anaphylaxis	7%
172	Anhidrosis	7%
173	Cholesteatoma	7%
174	Pressure Ulcer	7%
175	Folliculitis	7%
176	Food Allergy	7%
177	Foot Dermatoses	7%
178	Gynecomastia	7%
179	Hypertrichosis	7%
180	Hypohidrosis	7%
181	Hypotrichosis	7%
182	Leg Ulcer	7%
183	Miliaria	7%
184	Parakeratosis	7%
185	Parapsoriasis	7%
186	Pityriasis	7%
187	Psoriasis	7%
188	Sweet Syndrome	7%
189	Hidradenitis	7%
190	Onycholysis	7%
191	Miliaria Rubra	7%
192	Hyperpigmentation	7%
193	Lichenoid Eruptions	7%
194	Chloracne	7%
195	Anaphylactic shock	7%
196	Lymphopenia	7%
197	Xeroderma	6.9%
198	Angioedema	6.8%
199	Primary amyloidosis	6.8%
200	Monoclonal Gammopathy of Undetermined Significance	6.7%
201	Papillon-Lefevre Disease	6.7%
202	Acute Generalized Exanthematous Pustulosis	6.7%
203	Erythema Infectiosum	6.3%
204	Exanthema Subitum	6.2%
205	Thrombocytopenic purpura	5.9%
206	Tinea Capitis	5.8%
207	Onychomycosis	5.8%
208	Ectodermal Dysplasia	5.8%
209	Aplasia Cutis Congenita	5.8%
210	Asthma, Aspirin-Induced	5.8%
211	Hyperkeratosis, Epidermolytic	5.7%
212	Lichen Planus	5.7%
213	Melanosis	5.7%
214	Chloasma	5.7%
215	Pityriasis Rosea	5.7%
216	Pityriasis Rubra Pilaris	5.7%
217	Vitiligo	5.7%
218	Milk Allergy	5.7%
219	Lichen Nitidus	5.7%
220	Schnitzler Syndrome	5.7%
221	Wheat Hypersensitivity	5.7%
222	Hereditary Angioedema Type III	5.6%
223	Hereditary Angioedema Types I and II	5.6%
224	Hypergammaglobulinemia	5.6%
225	Agammaglobulinemia	5.6%
226	Kounis Syndrome	5.6%
227	HIV Infections	5.5%
228	Transfusion-Related Acute Lung Injury	5.5%
229	Respiratory Hypersensitivity	5.5%
230	Acantholysis	5.3%
231	Breast Cyst	5.3%
232	Ecthyma	5.3%
233	Actinic keratosis	5.3%
234	Pemphigoid, Benign Mucous Membrane	5.3%
235	Piedra	5.3%
236	Sick Building Syndrome	5.3%
237	Sunburn	5.3%
238	Multiple Chemical Sensitivity	5.3%
239	Argyria	5.2%
240	Hirsutism	5.2%
241	Lactation Disorder	5.2%
242	Mastitis	5.2%
243	Plasmacytoma	5.2%
244	Tumor Lysis Syndrome	5.2%
245	Vasculitis, Leukocytoclastic, Cutaneous	5.2%
246	Acanthosis Nigricans	5.1%
247	Alopecia Areata	5.1%
248	Lentigo	5.1%
249	Adiposis Dolorosa	5.1%
250	HTLV-I Infections	5.1%
251	Pruritus Vulvae	5.1%
252	Job Syndrome	5.1%
253	Mastocytoma	5.1%
254	Pruritus Ani	5.1%
255	Angioedemas, Hereditary	5.1%
256	Multiple Myeloma	5%
257	Myelitis, Transverse	5%
258	Mucopolysaccharidosis II	4.9%
259	Ichthyosis, X-Linked	4.8%
260	Sjogren-Larsson Syndrome	4.8%
261	Sezary Syndrome	4.8%
262	Hidradenitis Suppurativa	4.8%
263	Behcet Syndrome	4.7%
264	HIV-Associated Lipodystrophy Syndrome	4.6%
265	Miller Fisher Syndrome	4.5%
266	Tinea Pedis	4.5%
267	Alopecia	4.3%
268	Sweating, Gustatory	4.3%
269	Androgenetic Alopecia	4.3%
270	Auriculotemporal Syndrome	4.3%
271	Lice Infestations	4.3%
272	Varicose Ulcer	4.3%
273	Breast Neoplasms, Male	4.3%
274	Triple Negative Breast Neoplasms	4.3%
275	Galactorrhea	4.2%
276	Mastocytosis, Systemic	4.2%
277	Dermatomycoses	4.2%
278	Lymphoma	4.2%
279	Mucocutaneous Lymph Node Syndrome	4.2%
280	Skin Diseases, Bacterial	4.2%
281	Albinism	4.1%
282	Lipodystrophy	4.1%
283	Livedo Reticularis	4.1%
284	Malignant Atrophic Papulosis	4.1%
285	Chronic granulomatous disease	4.1%
286	Heavy Chain Disease	4.1%
287	Polyarteritis Nodosa	4.1%
288	Takayasu Arteritis	4.1%
289	HIV Seropositivity	4%
290	Erythema Chronicum Migrans	4%
291	Lichen Planus, Oral	3.9%
292	Lupus Vasculitis, Central Nervous System	3.8%
293	Mycetoma	3.7%
294	Nail-Patella Syndrome	3.5%
295	Larva Migrans	3.4%
296	Leishmaniasis	3.4%
297	Molluscum Contagiosum	3.4%
298	Porphyrias, Hepatic	3.4%
299	Onchocerciasis	3.4%
300	Kernicterus	3.4%
301	Acquired Immunodeficiency Syndrome	3.4%
302	AIDS related complex	3.4%
303	Infectious Mononucleosis	3.4%
304	Chromoblastomycosis	3.4%
305	Dermatophytosis	3.4%
306	Hodgkin Disease	3.4%
307	Leukemia, Plasma Cell	3.4%
308	Lymphoma, Non-Hodgkin	3.4%
309	Sporotrichosis	3.4%
310	Tinea	3.4%
311	Tinea Versicolor	3.4%
312	Trichophytosis	3.4%
313	Hyalohyphomycosis	3.4%
314	Cryoglobulinemia	3.4%
315	POEMS Syndrome	3.4%
316	Leukemia, T-Cell	3.4%
317	Leukemia, B-Cell	3.4%
318	Asthma, Exercise-Induced	3.1%
319	Status Asthmaticus	3.1%
320	Ataxia Telangiectasia	3%
321	Leishmaniasis, Cutaneous	3%
322	Eczema Herpeticum	3%
323	Lymphoma, Follicular	3%
324	T-Cell Lymphoma	3%
325	Fusariosis	3%
326	Mantle cell lymphoma	3%
327	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3%
328	Leukemia, Large Granular Lymphocytic	3%
329	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3%
330	Hydrops Fetalis	3%
331	AIDS-Related Opportunistic Infections	2.9%
332	Asthma	2.9%
333	Warts	2.9%
334	HIV Wasting Syndrome	2.9%
335	AIDS Dementia Complex	2.9%
336	AIDS-Associated Nephropathy	2.9%
337	Lymphoma, T-Cell, Cutaneous	2.8%
338	Lymphoma, AIDS-Related	2.8%
339	Enteropathy-Associated T-Cell Lymphoma	2.8%
340	Primary Effusion Lymphoma	2.8%
341	Candidiasis, Chronic Mucocutaneous	2.8%
342	Cutaneous Candidiasis	2.8%
343	Composite Lymphoma	2.8%
344	Erysipelas	2.8%
345	Staphylococcal Skin Infections	2.8%
346	Variegate Porphyria	2.8%
347	Acute intermittent porphyria	2.8%
348	Porphyria Cutanea Tarda	2.8%
349	Erythrasma	2.8%
350	Carcinoma, Lobular	2.8%
351	Lymphangioleiomyomatosis	2.8%
352	Arthritis, Psoriatic	2.8%
353	Mycosis Fungoides	2.7%
354	Lymphomatoid Papulosis	2.7%
355	Plasmablastic lymphoma	2.7%
356	Asthma, Occupational	2.6%
357	Farmer's Lung	2.5%
358	Epidermodysplasia Verruciformis	2.5%
359	Herpes Labialis	2.5%
360	Waldenstrom Macroglobulinemia	2.5%
361	Wiskott-Aldrich Syndrome	2.5%
362	Hay fever	2.5%
363	Rhinitis, Allergic, Perennial	2.5%
364	Diabetic Foot	2.5%
365	Staphylococcal Scalded Skin Syndrome	2.5%
366	Aspergillosis, Allergic Bronchopulmonary	2.4%
367	Peutz-Jeghers Syndrome	2.4%
368	Lymphomatoid Granulomatosis	2.4%
369	carbuncle	2.3%
370	Condylomata Acuminata	2.2%
371	Furunculosis	2.1%
372	furuncle	2.1%
373	Impetigo	2.1%
374	Blastomycosis	2.1%
375	Burkitt Lymphoma	2%
376	Rhinoscleroma	1.9%
377	Menkes Kinky Hair Syndrome	1.6%

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