MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pruritus Vulvae

(UMLS:C0033778)

Definition:: Intense itching of the external female genitals.
UMLS ID:: C0033778
MeSH ID:: D011539

Classification 1:

Name:

Female Urogenital Diseases and Pregnancy Complications
MeSH Tree Number(s):: C13.351.500.944.626

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.685.710

Synonym(s)

Pruritus Vulvae

Itching of vulva

Itching;vulva

Pruritus of vulva

Pruritus vulvae

Pruritus;vulva

Vulval itching

itch; vulva

pruritus vulvae

10.

pruritus; vulvae

11.

vulva itch

12.

vulva; itch

13.

vulva; pruritus

14.

vulvae; pruritus

15.

vulval itching

16.

vulvar itching

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Azithromycin	10879639	CTD
2	Cefazolin		SIDER
3	Cefuroxime		SIDER
4	Floxacillin		SIDER
5	Medroxyprogesterone		SIDER
6	Tamoxifen		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Vulvitis	32.6%
2	Vulvodynia	32.6%
3	Vulvovaginitis	26.6%
4	Pyoderma Gangrenosum	23.8%
5	Vulvar Neoplasms	23.4%
6	Endometriosis	23.1%
7	Uterine Diseases	23.1%
8	Vaginal Diseases	23.1%
9	Endometrioma	23.1%
10	Pruritus Ani	22.9%
11	Lupus Erythematosus, Cutaneous	20.5%
12	Panniculitis	20.5%
13	Systemic Scleroderma	20.5%
14	Morphea	20.5%
15	Breast Diseases	20.2%
16	Dermatitis	20.2%
17	Exanthema	20.2%
18	Facial Dermatoses	20.2%
19	Hair Diseases	20.2%
20	Hand Dermatoses	20.2%
21	keratoacanthoma	20.2%
22	Keratosis	20.2%
23	Nail Diseases	20.2%
24	Photosensitivity Disorders	20.2%
25	Prurigo	20.2%
26	Pyoderma	20.2%
27	Rosacea	20.2%
28	Sebaceous Gland Diseases	20.2%
29	Skin Diseases, Vesiculobullous	20.2%
30	Skin Ulcer	20.2%
31	Sweat Gland Diseases	20.2%
32	Skin Diseases, Papulosquamous	20.2%
33	Skin Diseases, Vascular	20.2%
34	Acneiform Eruptions	20.2%
35	Ocular Rosacea	20.2%
36	Subcorneal pustular dermatosis	20.2%
37	Erythematotelangiectatic Rosacea	20.2%
38	Papulopustular Rosacea	20.2%
39	Chronic Actinic Dermatitis	20.2%
40	Endometritis	19.8%
41	Acne Vulgaris	19.8%
42	Contact Dermatitis	19.8%
43	Eczema	19.8%
44	Erythema Multiforme	19.8%
45	Intertrigo	19.8%
46	Neurodermatitis	19.8%
47	Rhinophyma	19.8%
48	Perioral Dermatitis	19.8%
49	Acne	19.8%
50	Candidiasis, Vulvovaginal	17.8%
51	Infertility	17.6%
52	Dermatitis, Phototoxic	17.5%
53	Pityriasis Lichenoides et Varioliformis Acuta	17.5%
54	Pityriasis Lichenoides	17.5%
55	Phototoxicity	17.5%
56	Foot Ulcer	17.2%
57	Dermatitis, Atopic	17.1%
58	Epidermolysis Bullosa	17.1%
59	Salpingitis	16.9%
60	Dermatitis Herpetiformis	16.1%
61	Xeroderma Pigmentosum	16.1%
62	Foot Diseases	15.9%
63	Acrodermatitis	15.9%
64	Sebaceous Gland Neoplasms	15.9%
65	Porokeratosis	15.9%
66	Gianotti-Crosti Syndrome	15.9%
67	Keratoderma, Palmoplantar	15.9%
68	Skin Abnormalities	15.4%
69	Skin Diseases, Infectious	15.4%
70	Skin Neoplasms	15.4%
71	Pigmentation Disorders	15.4%
72	Panniculitis, Lupus Erythematosus	15.3%
73	Endometrial Hyperplasia	15.2%
74	Pyometra	15.2%
75	Vaginitis	15.2%
76	Vaginal Discharge	15.2%
77	Lipomatosis	15.1%
78	Erythema	15.1%
79	Necrolytic Migratory Erythema	15.1%
80	Cutaneous Fistula	15.1%
81	Nephrogenic Fibrosing Dermopathy	15.1%
82	Nephrogenic Systemic Fibrosis	15.1%
83	Necrobiosis Lipoidica Diabeticorum	14.8%
84	Dermatitis, Irritant	14.6%
85	Acne Conglobata	14.6%
86	Dermatitis, Photoallergic	14.6%
87	Uterine Inversion	13.9%
88	Urticaria Pigmentosa	13.7%
89	Oophoritis	13.6%
90	Xeroderma	13.4%
91	Dermatomyositis	13.4%
92	Urologic Diseases	13.3%
93	Lupus Erythematosus, Discoid	13.2%
94	Scleroderma, Limited	13.2%
95	Anhidrosis	13.2%
96	Cholesteatoma	13.2%
97	Pressure Ulcer	13.2%
98	Folliculitis	13.2%
99	Foot Dermatoses	13.2%
100	Gynecomastia	13.2%
101	Hypertrichosis	13.2%
102	Hypohidrosis	13.2%
103	Hypotrichosis	13.2%
104	Leg Ulcer	13.2%
105	Miliaria	13.2%
106	Parakeratosis	13.2%
107	Parapsoriasis	13.2%
108	Pityriasis	13.2%
109	Psoriasis	13.2%
110	Sweet Syndrome	13.2%
111	Hidradenitis	13.2%
112	Onycholysis	13.2%
113	Miliaria Rubra	13.2%
114	Hyperpigmentation	13.2%
115	Lichenoid Eruptions	13.2%
116	Chloracne	13.2%
117	Uterine Neoplasms	13%
118	Vaginal Neoplasms	13%
119	Uterine Cancer	13%
120	Erythema Induratum	12.8%
121	Lactation Disorder	12.4%
122	Mastitis	12.4%
123	Sexually Transmitted Diseases	12.3%
124	Dermatitis, Occupational	12.2%
125	Diaper Rash	12.1%
126	Cutis Laxa	12.1%
127	Mastocytosis	12%
128	Connective Tissue Diseases	11.8%
129	Dermatitis, Allergic Contact	11.8%
130	Papillon-Lefevre Disease	11.7%
131	Genital Herpes	11.7%
132	Ovarian Diseases	11.7%
133	Erythema Infectiosum	11.7%
134	Exanthema Subitum	11.6%
135	Adnexitis	11.5%
136	Uterine hemorrhage	11.5%
137	Vaginal Fistula	11.5%
138	Pelvic Inflammatory Disease	11.5%
139	Erythema Nodosum	11.4%
140	Uterine Prolapse	11.4%
141	Vaginal Prolapse	11.4%
142	Ectodermal Dysplasia	11.4%
143	Aplasia Cutis Congenita	11.4%
144	Uterine Cervicitis	11.4%
145	Leukorrhea	11.4%
146	Parametritis	11.4%
147	Uterine Rupture	11.3%
148	Pseudoxanthoma Elasticum	11.1%
149	Toxic Epidermal Necrolysis	11%
150	Stevens-Johnson Syndrome	11%
151	Fallopian Tube Neoplasms	10.7%
152	Urogenital Abnormalities	10.6%
153	Pregnancy Complications	10.6%
154	Tinea Capitis	10.5%
155	Onychomycosis	10.5%
156	Uterine Cervical Incompetence	10.1%
157	Acantholysis	10.1%
158	Breast Cyst	10.1%
159	Actinic keratosis	10.1%
160	Pemphigoid, Benign Mucous Membrane	10.1%
161	Pemphigus	10.1%
162	Piedra	10.1%
163	Sunburn	10.1%
164	Argyria	9.9%
165	Hirsutism	9.9%
166	Urticaria	9.9%
167	Granuloma Annulare	9.9%
168	Adiposis Dolorosa	9.8%
169	Ecthyma	9.8%
170	Mastocytoma	9.8%
171	Lichen Planus	9.8%
172	Melanosis	9.8%
173	Chloasma	9.8%
174	Pityriasis Rosea	9.8%
175	Pityriasis Rubra Pilaris	9.8%
176	Vitiligo	9.8%
177	Lichen Nitidus	9.8%
178	Hyperkeratosis, Epidermolytic	9.7%
179	Endometrial Neoplasms	9.6%
180	Dyspareunia	9.3%
181	Vesicovaginal Fistula	8.9%
182	Galactorrhea	8.9%
183	Ichthyosis, X-Linked	8.9%
184	Sjogren-Larsson Syndrome	8.9%
185	Bacterial Vaginosis	8.7%
186	Behcet Syndrome	8.7%
187	Trichomonas Vaginitis	8.6%
188	Uterine Perforation	8.6%
189	Ovarian Hyperstimulation Syndrome	8.6%
190	Metrorrhagia	8.5%
191	Hidradenitis Suppurativa	8.4%
192	Acanthosis Nigricans	8.1%
193	Alopecia Areata	8.1%
194	Lentigo	8.1%
195	Dermatomycoses	8.1%
196	Mucocutaneous Lymph Node Syndrome	8.1%
197	Skin Diseases, Bacterial	8.1%
198	Drug Eruptions	7.9%
199	Lipodystrophy	7.9%
200	Livedo Reticularis	7.9%
201	Malignant Atrophic Papulosis	7.9%
202	Polyarteritis Nodosa	7.8%
203	Takayasu Arteritis	7.8%
204	ovarian neoplasm	7.8%
205	Albinism	7.7%
206	Tinea Pedis	7.6%
207	Erythema Chronicum Migrans	7.6%
208	Urinary Bladder Diseases	7.6%
209	Kidney Diseases	7.6%
210	Ureteral Diseases	7.6%
211	Urethral Diseases	7.6%
212	Urination Disorders	7.6%
213	Urolithiasis	7.6%
214	Alopecia	7.5%
215	Sweating, Gustatory	7.5%
216	Androgenetic Alopecia	7.5%
217	Auriculotemporal Syndrome	7.5%
218	Genital Neoplasms, Female	7.4%
219	Lice Infestations	7.4%
220	Varicose Ulcer	7.4%
221	Breast Neoplasms, Male	7.4%
222	Triple Negative Breast Neoplasms	7.4%
223	Bladder Exstrophy	7.1%
224	Epispadias	7.1%
225	Tuberculosis, Renal	7.1%
226	Corpus Luteum Cyst	7%
227	Ovarian Cysts	7%
228	Anovulation	6.8%
229	Menorrhagia	6.8%
230	Carcinoma, Endometrioid	6.8%
231	Nail-Patella Syndrome	6.8%
232	Premature Menopause	6.8%
233	Collagen Diseases	6.7%
234	Mixed Connective Tissue Disease	6.7%
235	Mucinoses	6.7%
236	Porphyrias, Hepatic	6.7%
237	Anuria	6.6%
238	Ureterolithiasis	6.6%
239	Nephrolithiasis	6.6%
240	Mycetoma	6.5%
241	Multicystic Dysplastic Kidney	6.4%
242	Lichen Planus, Oral	6.2%
243	Urinary tract infection	6.1%
244	Urologic Neoplasms	6%
245	Endometrial Stromal Sarcoma	6%
246	Horseshoe Kidney	6%
247	Larva Migrans	6%
248	Leishmaniasis	6%
249	Molluscum Contagiosum	6%
250	Angioedema	6%
251	Onchocerciasis	5.9%
252	Chromoblastomycosis	5.9%
253	Dermatophytosis	5.9%
254	Sporotrichosis	5.9%
255	Tinea	5.9%
256	Tinea Versicolor	5.9%
257	Trichophytosis	5.9%
258	Hyalohyphomycosis	5.9%
259	Acute Generalized Exanthematous Pustulosis	5.8%
260	Bladder neck obstruction	5.7%
261	Polycystic Ovary Syndrome	5.7%
262	Polyhydramnios	5.6%
263	Obstetric Labor Complications	5.6%
264	Ectopic Pregnancy	5.6%
265	Pregnancy, Prolonged	5.6%
266	Puerperal Disorders	5.6%
267	Oligohydramnios	5.6%
268	Prenatal Injuries	5.6%
269	Urinary Bladder Fistula	5.6%
270	Bladder Neoplasm	5.6%
271	Kidney Neoplasm	5.6%
272	Ureteral Neoplasms	5.6%
273	Urethral Neoplasms	5.6%
274	granulosa cell tumor	5.4%
275	Carcinoma, Ovarian Epithelial	5.4%
276	Cartilage Diseases	5.3%
277	Rheumatism	5.3%
278	Chondromalacia	5.3%
279	Lupus Erythematosus, Systemic	5.1%
280	Overlap syndrome	5.1%
281	Hermaphroditism	5.1%
282	Disorders of Sex Development	5.1%
283	Warts	5.1%
284	Hypospadias	5%
285	Abruptio Placentae	5%
286	Placenta Accreta	5%
287	Candidiasis, Chronic Mucocutaneous	4.9%
288	Cutaneous Candidiasis	4.9%
289	Cystitis	4.9%
290	Hydronephrosis	4.9%
291	Hyperoxaluria	4.9%
292	Kidney Cortex Necrosis	4.9%
293	Kidney Papillary Necrosis	4.9%
294	Nephritis	4.9%
295	Nephrosclerosis	4.9%
296	Nephrosis	4.9%
297	Perinephritis	4.9%
298	Kidney Failure	4.9%
299	Uremia	4.9%
300	Ureteral obstruction	4.9%
301	Ureterocele	4.9%
302	Urethral Obstruction	4.9%
303	Urethritis	4.9%
304	Vesico-Ureteral Reflux	4.9%
305	Urinary Retention	4.9%
306	Oxalosis	4.9%
307	Renal Insufficiency	4.9%
308	Erysipelas	4.9%
309	Serum Sickness	4.9%
310	Staphylococcal Skin Infections	4.9%
311	Variegate Porphyria	4.9%
312	Acute intermittent porphyria	4.9%
313	Porphyria Cutanea Tarda	4.9%
314	Leishmaniasis, Cutaneous	4.9%
315	Eczema Herpeticum	4.9%
316	Erythrasma	4.9%
317	Carcinoma, Lobular	4.9%
318	Chlamydia Infections	4.9%
319	Gonorrhea	4.9%
320	CREST Syndrome	4.9%
321	Arthritis, Psoriatic	4.9%
322	Fusariosis	4.8%
323	Kidney Calculi	4.8%
324	Ureteral Calculi	4.8%
325	Chorioamnionitis	4.4%
326	Fetal Diseases	4.4%
327	Pregnancy Complications, Cardiovascular	4.4%
328	Pregnancy Complications, Neoplastic	4.4%
329	Pyelocystitis	4.4%
330	Scleromyxedema	4.4%
331	Hereditary Angioedema Type III	4.3%
332	Hereditary Angioedema Types I and II	4.3%
333	Giant Cell Arteritis	4.3%
334	Temporal Arteritis	4.3%
335	Pregnancy Complications, Hematologic	4.3%
336	Pregnancy Complications, Infectious	4.3%
337	Syphilis	4.3%
338	Lupus Nephritis	4.2%
339	Fetal Death	4.2%
340	Perinatal death	4.2%
341	Morning Sickness	4.2%
342	Angioedemas, Hereditary	4.1%
343	Epidermodysplasia Verruciformis	4.1%
344	Herpes Labialis	4.1%
345	Diabetic Foot	4.1%
346	Staphylococcal Scalded Skin Syndrome	4%
347	Lymphogranuloma Venereum	4%
348	Diabetes Insipidus	4%
349	Hepatorenal Syndrome	4%
350	Pyelonephritis	4%
351	Dupuytren Contracture	4%
352	Puerperal Infection	4%
353	Bacteriuria	3.9%
354	Diabetic Nephropathy	3.9%
355	Glycosuria	3.9%
356	Hematuria	3.9%
357	Renal hypertension	3.9%
358	Oliguria	3.9%
359	Polyuria	3.9%
360	Postpartum Hemorrhage	3.9%
361	Proteinuria	3.9%
362	Pyuria	3.9%
363	Renal Artery Obstruction	3.9%
364	Renal Artery Stenosis	3.9%
365	Urinary Calculi	3.9%
366	Cystocele	3.9%
367	Nephrocalcinosis	3.9%
368	Urinary Incontinence	3.9%
369	Peutz-Jeghers Syndrome	3.7%
370	Blastomycosis	3.7%
371	HIV-Associated Lipodystrophy Syndrome	3.7%
372	Glomerulonephritis	3.6%
373	Nephritis, Interstitial	3.6%
374	Lipoid nephrosis	3.6%
375	Nephrotic Syndrome	3.6%
376	Pyelitis	3.6%
377	Pyonephrosis	3.6%
378	Urethral Stenosis	3.6%
379	Nephrogenic Diabetes Insipidus	3.6%
380	Congenital Nephrogenic Diabetes Insipidus	3.6%
381	Acute kidney injury	3.6%
382	Urethral stricture	3.6%
383	Mesoblastic Nephroma	3.6%
384	Renal Cell Carcinoma	3.6%
385	Papillary Renal Cell Carcinoma	3.6%
386	carbuncle	3.6%
387	Condylomata Acuminata	3.5%
388	Furunculosis	3.5%
389	furuncle	3.5%
390	Impetigo	3.4%
391	Gestational Diabetes	3.4%
392	Mesenteric Panniculitis	3.4%
393	Panniculitis, Peritoneal	3.4%
394	Tietze's Syndrome	3.4%
395	Orbital Cellulitis	3.4%
396	Myxoid cyst	3.4%
397	Rhinoscleroma	3.4%
398	Cellulitis	3.3%
399	Enuresis	3.3%
400	Myxedema	3.3%
401	Abortion, Habitual	3.3%
402	Dystocia	3.3%
403	Eclampsia	3.3%
404	Fetal Membranes, Premature Rupture	3.3%
405	Placental Insufficiency	3.3%
406	Pre-Eclampsia	3.3%
407	Prenatal Exposure Delayed Effects	3.3%
408	HELLP Syndrome	3.3%
409	Placenta, Retained	3.3%
410	Gonadal Dysgenesis	3.3%
411	Adrenogenital Syndrome	3.3%
412	Ovotesticular Disorders of Sex Development	3.3%
413	Menkes Kinky Hair Syndrome	3.2%
414	Glycosuria, Renal	3.2%
415	Balkan Nephropathy	3%
416	Focal glomerulosclerosis	3%
417	Kidney Failure, Chronic	3%
418	Azotemia	3%
419	Nephroblastoma	2.9%
420	Albuminuria	2.9%
421	Hemoglobinuria	2.9%
422	Hypertension, Renovascular	2.9%
423	Urge Incontinence	2.9%
424	Hyperandrogenism	2.9%
425	AIDS-Associated Nephropathy	2.8%
426	Denys-Drash Syndrome	2.8%
427	Osteochondritis	2.7%
428	Polymyalgia Rheumatica	2.7%
429	Osteogenesis Imperfecta	2.7%
430	Keloid	2.6%
431	Abortion, Veterinary	2.6%
432	Pregnancy Complications, Parasitic	2.6%
433	Glomerulonephritis, Membranoproliferative	2.5%
434	Noonan Syndrome	2.5%
435	Depression, Postpartum	2.5%
436	Embryo Loss	2.5%
437	Fetal Resorption	2.5%
438	Polycystic Kidney Diseases	2.5%
439	Hyperemesis Gravidarum	2.4%
440	Diurnal Enuresis	2.4%
441	Renal Aminoacidurias	2.4%
442	Fanconi Syndrome	2.4%
443	Pseudohypoaldosteronism	2.4%
444	Liddle Syndrome	2.4%
445	Hemolytic-Uremic Syndrome	2.4%
446	Rheumatoid Arthritis	2.3%
447	Juvenile arthritis	2.3%
448	Marfan Syndrome	2.2%
449	Premature Birth	2.2%
450	Homocystinuria	2.2%
451	Renal Osteodystrophy	2.2%
452	Renal rickets	2.2%
453	Renal tubular acidosis	2.1%
454	Anti-Glomerular Basement Membrane Disease	2.1%
455	Fetal Growth Retardation	2%
456	Trophoblastic Neoplasms	2%
457	Polycystic Kidney, Autosomal Dominant	2%
458	Cystinuria	2%
459	Embolism, Amniotic Fluid	2%
460	Fetal Hypoxia	2%
461	Atypical Hemolytic Uremic Syndrome	2%
462	Fetal Alcohol Spectrum Disorders	2%
463	Breech Presentation	2%
464	Rheumatoid Nodule	2%
465	Stillbirth	2%
466	Laryngomalacia	2%
467	Turner Syndrome	1.9%
468	Pectus carinatum	1.9%
469	Kallmann Syndrome	1.8%
470	Felty Syndrome	1.6%
471	Bronchomalacia	1.6%
472	Tracheomalacia	1.6%
473	Zellweger Syndrome	1.6%
474	Hyperphosphaturia	1.6%
475	Klinefelter Syndrome	1.6%
476	Meconium Aspiration Syndrome	1.5%
477	Rheumatoid Vasculitis	1.4%
478	Mucopolysaccharidosis III	1.4%
479	Sicca Syndrome	1.2%
480	Sjogren's Syndrome	1.2%
481	Choriocarcinoma	1.1%
482	Lupus Vasculitis, Central Nervous System	1%
483	Hydatidiform Mole	1%
484	Mucopolysaccharidosis II	1%
485	Familial Hypophosphatemic Rickets	0.9%
486	Hydrops Fetalis	0.7%

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