MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Germinoma

(UMLS:C0206660)

Definition:: A malignant neoplasm of the germinal tissue of the GONADS; MEDIASTINUM; or pineal region. Germinomas are uniform in appearance, consisting of large, round cells with vesicular nuclei and clear or finely granular eosinophilic-staining cytoplasm. (Stedman, 265th ed; from DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1642-3)
UMLS ID:: C0206660
MeSH ID:: D018237

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.330

Synonym(s)

Germinoma

germinoma

germinomas

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	gemcitabine		16991134	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Chordoma	46.7%
2	Teratoma	46.7%
3	Teratocarcinoma	46.7%
4	Neuroectodermal Tumors	44.4%
5	Neoplasms, Neuroepithelial	34.4%
6	Gliomatosis cerebri	34.4%
7	Craniopharyngioma	32.6%
8	Neuroectodermal Tumor, Melanotic	32.6%
9	Neuroendocrine Tumors	32.6%
10	leukemia	31%
11	Neoplasms, Glandular and Epithelial	31%
12	Dermoid Cyst	30.3%
13	melanoma	30.1%
14	Trophoblastic Neoplasms	28.8%
15	Adenoma, Acidophil	27.4%
16	Ganglioneuroma	27.4%
17	Glioma	27.4%
18	Malignant Glioma	27.4%
19	Medulloblastoma	27.3%
20	Paraganglioma	26.9%
21	Carcinoid Tumor	26.1%
22	Neurilemmoma	26.1%
23	Hutchinson's Melanotic Freckle	25.3%
24	Melanoma, Amelanotic	25.3%
25	Pheochromocytoma	24.1%
26	Astrocytoma	24%
27	Ependymoma	24%
28	oligodendroglioma	24%
29	Ganglioglioma	24%
30	gliosarcoma	24%
31	Anaplastic astrocytoma	24%
32	Anaplastic Oligodendroglioma	24%
33	Malignant Carcinoid Syndrome	23.4%
34	Carcinosarcoma	23.1%
35	Hemangiosarcoma	23.1%
36	lymphangiosarcoma	23.1%
37	Glioblastoma	22.3%
38	Neuroblastoma	22.3%
39	Glioblastoma Multiforme	22.3%
40	Ganglioneuroblastoma	21.5%
41	Choriocarcinoma	21.2%
42	Histiocytic Disorders, Malignant	20.5%
43	Melanoma, Experimental	20.4%
44	Adenoma	20%
45	Ameloblastoma	20%
46	Angiokeratoma	20%
47	Carcinoma	20%
48	Hemangioma	20%
49	hemangiopericytoma	20%
50	Lymphangioma	20%
51	Mesenchymoma	20%
52	Nevus	20%
53	Hepatoblastoma	20%
54	Mixed Tumor, Mullerian	20%
55	Angiofibroma	20%
56	Sarcoma	20%
57	Epithelioma	20%
58	Basal cell carcinoma	19.6%
59	Carcinoma, Papillary	19.6%
60	Squamous cell carcinoma	19.6%
61	Chondrosarcoma	19.6%
62	Cystadenoma	19.6%
63	leiomyosarcoma	19.6%
64	liposarcoma	19.6%
65	Mesothelioma	19.6%
66	synovial sarcoma	19.6%
67	Angiomyolipoma	19.6%
68	Clear Cell Sarcoma of Soft Tissue	19.6%
69	Alveolar Soft Part Sarcoma	19.6%
70	Sarcoma, Myeloid	19.6%
71	Carcinoma, Basal Cell	19.6%
72	Carcinoma 256, Walker	18.7%
73	Hamartoma	18.5%
74	Neoplasms, Hormone-Dependent	18.5%
75	Neoplasms, Multiple Primary	18.5%
76	Paraneoplastic Syndromes	18.5%
77	Precancerous Conditions	18.5%
78	Neoplasms, Second Primary	18.5%
79	Carcinoid Heart Disease	18%
80	Cystadenocarcinoma	17.8%
81	Fibrosarcoma	17.8%
82	Osteosarcoma	17.8%
83	Mucoepidermoid Carcinoma	17.8%
84	Meningioma	17.4%
85	Leukemia, Plasma Cell	17.2%
86	Adenofibroma	17%
87	Fibroadenoma	17%
88	Malignant Fibrous Histiocytoma	17%
89	Carcinoma, Ehrlich Tumor	16.9%
90	Carcinoma, Lewis Lung	16.9%
91	Hydatidiform Mole	16.5%
92	Bowen's Disease	16.1%
93	Rhabdomyosarcoma	16.1%
94	Giant Cell Tumor of Bone	16.1%
95	Composite Lymphoma	15.8%
96	Dermatofibrosarcoma	15.3%
97	Dermatofibrosarcoma Protuberans	15.3%
98	Lymphoma	15.3%
99	Retinoblastoma	15.2%
100	Leukemia, Experimental	15.1%
101	Adenocarcinoma	14.8%
102	Carcinoma in Situ	14.8%
103	Carcinoma, Transitional Cell	14.8%
104	Phyllodes Tumor	14.8%
105	Hemangioendothelioma	14.8%
106	Lipoma	14.8%
107	Myoma	14.8%
108	Myxoma	14.8%
109	Neuroma	14.8%
110	Papilloma	14.8%
111	Pseudomyxoma Peritonei	14.8%
112	Papillomatosis	14.8%
113	Angiolipoma	14.8%
114	Myelolipoma	14.8%
115	Neoplasms, Bone Tissue	14.8%
116	Neoplasms, Fibrous Tissue	14.8%
117	Smooth Muscle Tumor	14.8%
118	Adenomatosis, Pulmonary	14.8%
119	Adenomatous Polyps	14.8%
120	Carcinoma, Large Cell	14.8%
121	Carcinoma, Small Cell	14.8%
122	Desmoplastic Small Round Cell Tumor	14.8%
123	Chondroma	14.8%
124	Enchondroma	14.8%
125	Alveolar rhabdomyosarcoma	14.4%
126	Leukemia L1210	14.3%
127	Leukemia P388	14.3%
128	Acanthoma	14.3%
129	Carcinoma, Lobular	13.4%
130	Plasmacytoma	13.3%
131	Malignant histiocytosis	13.2%
132	Histiocytic sarcoma	13.2%
133	Sarcoma 180	12.6%
134	Endometrial Stromal Sarcoma	12.6%
135	Sarcoma, Experimental	12.5%
136	Thymoma	12.4%
137	Leukemia, Radiation-Induced	12.2%
138	Adenoid Cystic Carcinoma	12.2%
139	Cyst	12.2%
140	fibroma	12.2%
141	Fibromatosis	12.2%
142	Neoplastic Processes	12.2%
143	Neoplastic Syndromes, Hereditary	12.2%
144	Osteoblastoma	12.2%
145	Osteoma	12.2%
146	Pregnancy Complications, Neoplastic	12.2%
147	Rhabdomyoma	12.2%
148	Chondromatosis	12.2%
149	Adenocarcinoma, Clear Cell	12.2%
150	Cholangiocarcinoma	12.2%
151	Cervical Intraepithelial Neoplasia	12.2%
152	Hemangioblastoma	12.2%
153	Lymphoma, Extranodal NK-T-Cell	12.2%
154	Neoplasms, Experimental	11.9%
155	Lymphangioleiomyomatosis	11.7%
156	Neurofibrosarcoma	11.6%
157	Acoustic Neuroma	11.3%
158	Vipoma	11%
159	Fibromatosis, Aggressive	10.9%
160	Fibromatosis, Abdominal	10.9%
161	Klatskin Tumor	10.9%
162	Abdominal Neoplasms	10.3%
163	Erythroplasia	10.3%
164	Follicular cyst	10.3%
165	Head and Neck Neoplasms	10.3%
166	Mucocele	10.3%
167	Pilonidal Cyst	10.3%
168	Soft Tissue Neoplasms	10.3%
169	Thoracic Neoplasms	10.3%
170	Thyroglossal Cyst	10.3%
171	Synovial Cyst	10.3%
172	Aberrant Crypt Foci	10.3%
173	Optic Nerve Glioma	10.1%
174	Hodgkin Disease	9.8%
175	Lymphoma, Non-Hodgkin	9.8%
176	Leukemia, Myelomonocytic, Chronic	9.8%
177	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.8%
178	Multiple Endocrine Neoplasia	9.2%
179	Neoplasms, Radiation-Induced	8.8%
180	Lymphomatoid Granulomatosis	8.8%
181	Paraneoplastic Encephalomyelitis	8.6%
182	Mammary Neoplasms, Experimental	8.4%
183	Carcinoma, Pancreatic Ductal	8.3%
184	Mastocytoma	8.2%
185	Mastocytosis, Systemic	8.1%
186	Leukemia, Myeloid, Chronic-Phase	8.1%
187	Primary amyloidosis	7.9%
188	Hepatocellular Adenoma	7.9%
189	Basal Cell Nevus Syndrome	7.7%
190	Mastocytosis	7.6%
191	Sturge-Weber Syndrome	7.6%
192	Nephroblastoma	7.5%
193	Gastrointestinal Stromal Tumors	7.4%
194	Hemangioma, Cavernous	7.4%
195	Digestive System Neoplasms	7.3%
196	Endocrine Gland Neoplasms	7.3%
197	Eye Neoplasms	7.3%
198	Leukemia, T-Cell	7.3%
199	Nervous System Neoplasms	7.3%
200	Leukemia, B-Cell	7.3%
201	neurofibroma	7.3%
202	Lymphoma, Follicular	7.3%
203	T-Cell Lymphoma	7.3%
204	Mantle cell lymphoma	7.3%
205	Bone neoplasms	7%
206	Leukoplakia	7%
207	Lymphocele	7%
208	Pancreatic Cyst	7%
209	Skin Neoplasms	7%
210	Hematologic Neoplasms	7%
211	Barrett Esophagus	6.8%
212	Breast Cyst	6.8%
213	Actinic keratosis	6.8%
214	Mediastinal Cyst	6.8%
215	Neoplasm Invasiveness	6.8%
216	Neoplasm Metastasis	6.8%
217	Neoplasm Recurrence, Local	6.8%
218	Parovarian Cyst	6.8%
219	Pericardial Cyst	6.8%
220	Splenic Neoplasms	6.8%
221	Thymic Cyst	6.8%
222	Carcinogenesis	6.8%
223	Myxoid cyst	6.8%
224	Metastasis	6.8%
225	Mesoblastic Nephroma	6.7%
226	Retroperitoneal Neoplasms	6.7%
227	Prolactinoma	6.5%
228	Growth Hormone-Secreting Pituitary Adenoma	6.5%
229	Tuberous Sclerosis	6.1%
230	Multiple Endocrine Neoplasia Type 1	6%
231	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	6%
232	Leukemia, Large Granular Lymphocytic	6%
233	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	6%
234	Lymphoma, T-Cell, Cutaneous	6%
235	Lymphoma, AIDS-Related	6%
236	Enteropathy-Associated T-Cell Lymphoma	6%
237	Primary Effusion Lymphoma	6%
238	insulinoma	5.7%
239	Waldenstrom Macroglobulinemia	5.7%
240	Multiple Myeloma	5.7%
241	Dupuytren Contracture	5.6%
242	granulosa cell tumor	5.5%
243	Carcinoma, Ovarian Epithelial	5.5%
244	Urticaria Pigmentosa	5.5%
245	Parathyroid Neoplasms	5.5%
246	Peritoneal Neoplasms	5.5%
247	Thyroid Neoplasm	5.5%
248	Thyroid carcinoma	5.5%
249	Gastrinoma	5.4%
250	Glucagonoma	5.4%
251	Mycosis Fungoides	5.4%
252	Lymphomatoid Papulosis	5.4%
253	Plasmablastic lymphoma	5.4%
254	Adrenocortical carcinoma	5.4%
255	Adenomatous Polyposis Coli	5.1%
256	Corpus Luteum Cyst	5%
257	Ovarian Cysts	5%
258	Liver Neoplasms, Experimental	5%
259	Leydig Cell Tumor	4.9%
260	Tracheal Neoplasms	4.8%
261	Leukoplakia, Oral	4.6%
262	Paraneoplastic Cerebellar Degeneration	4.6%
263	Pancreatic Neoplasm	4.6%
264	Renal Cell Carcinoma	4.6%
265	Papillary Renal Cell Carcinoma	4.6%
266	Mouth Neoplasms	4.5%
267	Central Nervous System Neoplasms	4.5%
268	Vascular Neoplasms	4.5%
269	Thymus Neoplasms	4.5%
270	Nasopharyngeal carcinoma	4.5%
271	Carcinoma, Endometrioid	4.4%
272	Genital Neoplasms, Female	4.4%
273	Pancreatic Pseudocyst	4.4%
274	Lymphatic Metastasis	4.4%
275	Neoplasms, Unknown Primary	4.4%
276	Leukemic Infiltration	4.4%
277	Breast Neoplasms, Male	4.4%
278	Neoplasm Micrometastasis	4.4%
279	Triple Negative Breast Neoplasms	4.4%
280	Choledochal Cyst	4.1%
281	Burkitt Lymphoma	4%
282	Peutz-Jeghers Syndrome	4%
283	Thyroid Nodule	3.9%
284	Esophageal Neoplasms	3.9%
285	Limbic Encephalitis	3.8%
286	Denys-Drash Syndrome	3.8%
287	Sezary Syndrome	3.6%
288	Adrenal Gland Neoplasms	3.4%
289	Gastrointestinal Neoplasms	3.4%
290	Genital Neoplasms, Male	3.4%
291	Liver neoplasms	3.4%
292	Uveal Neoplasms	3.4%
293	Urologic Neoplasms	3.4%
294	Lambert-Eaton Myasthenic Syndrome	3.3%
295	Testicular Neoplasms	3.3%
296	Sebaceous Gland Neoplasms	3.3%
297	Spinal Neoplasms	3.3%
298	Bone Marrow Neoplasms	3.3%
299	Meningeal Neoplasms	3.3%
300	Polycystic Ovary Syndrome	3.3%
301	Opsoclonus-Myoclonus Syndrome	2.9%
302	Meningeal Carcinomatosis	2.7%
303	Palatal Neoplasms	2.6%
304	Ear Neoplasms	2.6%
305	Eyelid Neoplasms	2.6%
306	Lung Neoplasms	2.6%
307	Pleural Neoplasms	2.6%
308	Myelitis, Transverse	2.6%
309	Nose Neoplasms	2.6%
310	Cell Transformation, Viral	2.5%
311	Brain Neoplasms	2.5%
312	Salivary Gland Neoplasms	2.5%
313	Spinal Cord Neoplasms	2.5%
314	Tongue Neoplasms	2.5%
315	Uterine Neoplasms	2.4%
316	Vaginal Neoplasms	2.4%
317	Vulvar Neoplasms	2.4%
318	Uterine Cancer	2.4%
319	Fallopian Tube Neoplasms	2.4%
320	Xeroderma Pigmentosum	2.2%
321	Pituitary Adenoma	2.2%
322	Pituitary Neoplasms	2.2%
323	ovarian neoplasm	2.2%
324	Bronchial Neoplasms	2.1%
325	Pharyngeal Neoplasms	2.1%
326	Multiple Pulmonary Nodules	2.1%
327	Supratentorial Neoplasms	2%
328	Central Nervous System Cysts	2%
329	Endometrial Neoplasms	2%
330	Bile Duct Neoplasms	2%
331	gallbladder neoplasm	2%
332	Intestinal Neoplasms	2%
333	Penile Neoplasms	2%
334	Prostatic Neoplasms	2%
335	Stomach Neoplasms	2%
336	Polycythemia Vera	1.9%
337	Brain Stem Neoplasms	1.8%
338	Laryngeal neoplasm	1.7%
339	Choroid Plexus Papilloma	1.7%
340	Hypopharyngeal Neoplasms	1.7%
341	Pleural Effusion, Malignant	1.7%
342	Hypopharyngeal Cancer	1.7%
343	Zollinger-Ellison syndrome	1.6%
344	Bladder Neoplasm	1.6%
345	Kidney Neoplasm	1.6%
346	Ureteral Neoplasms	1.6%
347	Urethral Neoplasms	1.6%
348	Parotid Neoplasms	1.6%
349	Prostatic Neoplasms, Castration-Resistant	1.6%
350	Nelson Syndrome	1.6%
351	Tonsillar Neoplasms	1.5%
352	Cerebellar Neoplasms	1.4%
353	Cecal Neoplasms	1.3%
354	Duodenal Neoplasms	1.3%
355	Radicular Cyst	1.2%
356	Appendiceal Neoplasms	1.2%
357	Colonic Neoplasms	1.2%
358	Rectal Neoplasms	1.2%
359	Nasopharyngeal Neoplasms	1.2%
360	Colorectal Neoplasms	1.2%
361	Paranasal Sinus Neoplasms	1%
362	Anus Neoplasms	1%
363	Sigmoid Neoplasms	1%
364	Maxillary Sinus Neoplasms	0.9%

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