MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Carcinoma, Small Cell

(UMLS:C0262584)

Definition:: An anaplastic, highly malignant, and usually bronchogenic carcinoma composed of small ovoid cells with scanty neoplasm. It is characterized by a dominant, deeply basophilic nucleus, and absent or indistinct nucleoli. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1286-7)
UMLS ID:: C0262584
MeSH ID:: D018288

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.380

Synonym(s)

Carcinoma, Small Cell

Oat cell carcinoma

Oat cell carcinoma syndrome

Reserve cell carcinoma

Round cell carcinoma

SCC - Small cell carcinoma

Small Cell Cancer

Small Cell Carcinoma

Small Cell NEC

10.

Small Cell Neuroendocrine Carcinoma

11.

Small cell carcinoma

Associated Drug(s)

	Name	Reference(s)	Data Source
1	CAV protocol	6323640	CTD
2	Cyclophosphamide	165045	CTD
3	Etoposide	View details 1851407 7488415 9879292 11398877	CTD
4	Ifosfamide	206339 2156418 6307164	CTD
5	Phenoxybenzamine	16130025	CTD
6	Vincristine	165045	CTD
7	Vindesine	6282107	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Adenocarcinoma	48.4%
2	Carcinoma in Situ	48.4%
3	Carcinoma, Transitional Cell	48.4%
4	Carcinoma, Large Cell	48.4%
5	Basal cell carcinoma	47.3%
6	Carcinoma, Papillary	47.3%
7	Squamous cell carcinoma	47.3%
8	Carcinoma, Basal Cell	47.3%
9	Cystadenocarcinoma	39%
10	Mucoepidermoid Carcinoma	39%
11	Carcinoma, Ehrlich Tumor	38.9%
12	Carcinoma, Lewis Lung	38.9%
13	Adenoid Cystic Carcinoma	36%
14	Adenocarcinoma, Clear Cell	36%
15	Cholangiocarcinoma	36%
16	Cervical Intraepithelial Neoplasia	36%
17	Bowen's Disease	35.1%
18	Adenoma	34.4%
19	Cystadenoma	30.1%
20	Mesothelioma	30.1%
21	Klatskin Tumor	29.9%
22	Neoplasms, Neuroepithelial	26.8%
23	Gliomatosis cerebri	26.8%
24	Carcinoma, Lobular	25.6%
25	leukemia	25.4%
26	Neoplasms, Germ Cell and Embryonal	25.4%
27	Germ Cell Cancer	25.4%
28	Carcinoid Tumor	25.1%
29	Papilloma	22.6%
30	Pseudomyxoma Peritonei	22.6%
31	Papillomatosis	22.6%
32	Adenomatosis, Pulmonary	22.6%
33	Adenomatous Polyps	22.6%
34	Malignant Carcinoid Syndrome	20.8%
35	Choriocarcinoma	20.4%
36	Neuroectodermal Tumors	19.8%
37	Adenofibroma	18.9%
38	Fibroadenoma	18.9%
39	Acanthoma	18.5%
40	Adenoma, Acidophil	18.4%
41	Ganglioneuroma	18.4%
42	Glioma	18.4%
43	Malignant Glioma	18.4%
44	Histiocytic Disorders, Malignant	16.9%
45	Hamartoma	16.4%
46	Neoplasms, Hormone-Dependent	16.4%
47	Neoplasms, Multiple Primary	16.4%
48	Paraneoplastic Syndromes	16.4%
49	Precancerous Conditions	16.4%
50	Neoplasms, Second Primary	16.4%
51	Carcinosarcoma	16.3%
52	Hemangiosarcoma	16.3%
53	lymphangiosarcoma	16.3%
54	Medulloblastoma	16.3%
55	Carcinoid Heart Disease	15.3%
56	Ameloblastoma	14.8%
57	Angiokeratoma	14.8%
58	Chordoma	14.8%
59	Hemangioma	14.8%
60	hemangiopericytoma	14.8%
61	Lymphangioma	14.8%
62	Mesenchymoma	14.8%
63	Nevus	14.8%
64	Teratoma	14.8%
65	Hepatoblastoma	14.8%
66	Mixed Tumor, Mullerian	14.8%
67	Germinoma	14.8%
68	Teratocarcinoma	14.8%
69	Angiofibroma	14.8%
70	Sarcoma	14.8%
71	Carcinoma, Ovarian Epithelial	14.7%
72	melanoma	14.5%
73	Astrocytoma	14.3%
74	Ependymoma	14.3%
75	oligodendroglioma	14.3%
76	Ganglioglioma	14.3%
77	gliosarcoma	14.3%
78	Anaplastic astrocytoma	14.3%
79	Anaplastic Oligodendroglioma	14.3%
80	Carcinoma, Pancreatic Ductal	13.5%
81	Basal Cell Nevus Syndrome	12.9%
82	Chondrosarcoma	12.9%
83	Craniopharyngioma	12.9%
84	leiomyosarcoma	12.9%
85	liposarcoma	12.9%
86	synovial sarcoma	12.9%
87	Neuroectodermal Tumor, Melanotic	12.9%
88	Angiomyolipoma	12.9%
89	Clear Cell Sarcoma of Soft Tissue	12.9%
90	Alveolar Soft Part Sarcoma	12.9%
91	Neuroendocrine Tumors	12.9%
92	Sarcoma, Myeloid	12.9%
93	Adrenocortical carcinoma	12.8%
94	Carcinoma 256, Walker	12.8%
95	Meningioma	12.7%
96	Lymphoma	12.6%
97	Nasopharyngeal carcinoma	12.6%
98	Glioblastoma	12.3%
99	Neuroblastoma	12.3%
100	Glioblastoma Multiforme	12.3%
101	Dermoid Cyst	12.2%
102	Leukemia, Plasma Cell	12.2%
103	Trophoblastic Neoplasms	11.8%
104	Composite Lymphoma	11.8%
105	Leukemia, Experimental	11.7%
106	Ganglioneuroblastoma	11.2%
107	Fibrosarcoma	11.2%
108	Osteosarcoma	11.2%
109	Renal Cell Carcinoma	11%
110	Papillary Renal Cell Carcinoma	11%
111	Cyst	10.8%
112	Neoplastic Processes	10.8%
113	Neoplastic Syndromes, Hereditary	10.8%
114	Pregnancy Complications, Neoplastic	10.8%
115	Carcinoma, Endometrioid	10.8%
116	Neurilemmoma	10.8%
117	Hutchinson's Melanotic Freckle	10.8%
118	Melanoma, Amelanotic	10.8%
119	Neoplasms, Experimental	10.6%
120	Hepatocellular Adenoma	10.5%
121	Malignant Fibrous Histiocytoma	10.4%
122	Retinoblastoma	10.2%
123	Vipoma	10.2%
124	Melanoma, Experimental	10%
125	Gastrinoma	9.9%
126	Glucagonoma	9.9%
127	Plasmacytoma	9.9%
128	Malignant histiocytosis	9.8%
129	Leukemia L1210	9.8%
130	Leukemia P388	9.8%
131	Histiocytic sarcoma	9.8%
132	Phyllodes Tumor	9.7%
133	Dysgerminoma	9.7%
134	Hemangioendothelioma	9.7%
135	Lipoma	9.7%
136	Myoma	9.7%
137	Myxoma	9.7%
138	Neuroma	9.7%
139	Seminoma	9.7%
140	Angiolipoma	9.7%
141	Myelolipoma	9.7%
142	Neoplasms, Bone Tissue	9.7%
143	Neoplasms, Fibrous Tissue	9.7%
144	Smooth Muscle Tumor	9.7%
145	Desmoplastic Small Round Cell Tumor	9.7%
146	Chondroma	9.7%
147	Enchondroma	9.7%
148	Paraganglioma	9.6%
149	Rhabdomyosarcoma	9.6%
150	Giant Cell Tumor of Bone	9.6%
151	Leukemia, Radiation-Induced	9.5%
152	Sarcoma, Experimental	9.1%
153	Thymoma	9%
154	Dermatofibrosarcoma	8.8%
155	Dermatofibrosarcoma Protuberans	8.8%
156	Prolactinoma	8.7%
157	Growth Hormone-Secreting Pituitary Adenoma	8.7%
158	Endometrial Stromal Sarcoma	8.6%
159	Abdominal Neoplasms	8.5%
160	Erythroplasia	8.5%
161	Follicular cyst	8.5%
162	Head and Neck Neoplasms	8.5%
163	Mucocele	8.5%
164	Pilonidal Cyst	8.5%
165	Soft Tissue Neoplasms	8.5%
166	Thoracic Neoplasms	8.5%
167	Thyroglossal Cyst	8.5%
168	Synovial Cyst	8.5%
169	Aberrant Crypt Foci	8.5%
170	Sarcoma 180	8.1%
171	Pheochromocytoma	7.9%
172	Alveolar rhabdomyosarcoma	7.9%
173	Neoplasms, Radiation-Induced	7.9%
174	Lymphangioleiomyomatosis	7.7%
175	Multiple Endocrine Neoplasia	7.4%
176	Hodgkin Disease	7.3%
177	Lymphoma, Non-Hodgkin	7.3%
178	fibroma	7.2%
179	Fibromatosis	7.2%
180	Osteoblastoma	7.2%
181	Osteoma	7.2%
182	Rhabdomyoma	7.2%
183	Chondromatosis	7.2%
184	Hemangioblastoma	7.2%
185	Lymphoma, Extranodal NK-T-Cell	7.2%
186	Paraneoplastic Encephalomyelitis	6.8%
187	Neurofibrosarcoma	6.7%
188	Mammary Neoplasms, Experimental	6.7%
189	Leukemia, Myelomonocytic, Chronic	6.5%
190	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6.5%
191	insulinoma	6.2%
192	Lymphomatoid Granulomatosis	6.2%
193	Optic Nerve Glioma	6%
194	Digestive System Neoplasms	6%
195	Endocrine Gland Neoplasms	6%
196	Eye Neoplasms	6%
197	Nervous System Neoplasms	6%
198	Fibromatosis, Aggressive	6%
199	Fibromatosis, Abdominal	6%
200	Primary amyloidosis	5.9%
201	Bone neoplasms	5.7%
202	Leukoplakia	5.7%
203	Lymphocele	5.7%
204	Pancreatic Cyst	5.7%
205	Skin Neoplasms	5.7%
206	Hematologic Neoplasms	5.7%
207	Nephroblastoma	5.6%
208	Barrett Esophagus	5.6%
209	Breast Cyst	5.6%
210	Actinic keratosis	5.6%
211	Mediastinal Cyst	5.6%
212	Neoplasm Invasiveness	5.6%
213	Neoplasm Metastasis	5.6%
214	Neoplasm Recurrence, Local	5.6%
215	Parovarian Cyst	5.6%
216	Pericardial Cyst	5.6%
217	Splenic Neoplasms	5.6%
218	Thymic Cyst	5.6%
219	Carcinogenesis	5.6%
220	Myxoid cyst	5.6%
221	Metastasis	5.6%
222	Adenomatous Polyposis Coli	5.4%
223	Hydatidiform Mole	5.2%
224	Tuberous Sclerosis	5.1%
225	Mastocytosis	5%
226	Sturge-Weber Syndrome	5%
227	Retroperitoneal Neoplasms	4.9%
228	Gastrointestinal Stromal Tumors	4.9%
229	Hemangioma, Cavernous	4.9%
230	Mastocytoma	4.9%
231	Leukemia, T-Cell	4.8%
232	Leukemia, B-Cell	4.8%
233	Mesoblastic Nephroma	4.8%
234	neurofibroma	4.8%
235	Mastocytosis, Systemic	4.8%
236	Lymphoma, Follicular	4.8%
237	T-Cell Lymphoma	4.8%
238	Mantle cell lymphoma	4.8%
239	Acoustic Neuroma	4.8%
240	Leukemia, Myeloid, Chronic-Phase	4.8%
241	Multiple Endocrine Neoplasia Type 1	4.4%
242	Waldenstrom Macroglobulinemia	4.2%
243	Multiple Myeloma	4.2%
244	Corpus Luteum Cyst	4.1%
245	Ovarian Cysts	4.1%
246	Parathyroid Neoplasms	4.1%
247	Peritoneal Neoplasms	4.1%
248	Thyroid Neoplasm	4.1%
249	Thyroid carcinoma	4.1%
250	Liver Neoplasms, Experimental	3.9%
251	granulosa cell tumor	3.7%
252	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
253	Leukemia, Large Granular Lymphocytic	3.6%
254	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.6%
255	Lymphoma, T-Cell, Cutaneous	3.6%
256	Lymphoma, AIDS-Related	3.6%
257	Enteropathy-Associated T-Cell Lymphoma	3.6%
258	Primary Effusion Lymphoma	3.6%
259	Pancreatic Neoplasm	3.4%
260	Choledochal Cyst	3.4%
261	Tracheal Neoplasms	3.4%
262	Mouth Neoplasms	3.4%
263	Central Nervous System Neoplasms	3.4%
264	Vascular Neoplasms	3.4%
265	Thymus Neoplasms	3.4%
266	Genital Neoplasms, Female	3.3%
267	Pancreatic Pseudocyst	3.3%
268	Peutz-Jeghers Syndrome	3.3%
269	Leukoplakia, Oral	3.3%
270	Paraneoplastic Cerebellar Degeneration	3.3%
271	Lymphatic Metastasis	3.3%
272	Neoplasms, Unknown Primary	3.3%
273	Leukemic Infiltration	3.3%
274	Breast Neoplasms, Male	3.3%
275	Neoplasm Micrometastasis	3.3%
276	Triple Negative Breast Neoplasms	3.3%
277	Dupuytren Contracture	3.1%
278	Urticaria Pigmentosa	3%
279	Mycosis Fungoides	3%
280	Lymphomatoid Papulosis	3%
281	Plasmablastic lymphoma	3%
282	Leydig Cell Tumor	2.9%
283	Esophageal Neoplasms	2.7%
284	Limbic Encephalitis	2.7%
285	Thyroid Nodule	2.6%
286	Adrenal Gland Neoplasms	2.6%
287	Gastrointestinal Neoplasms	2.6%
288	Genital Neoplasms, Male	2.6%
289	Liver neoplasms	2.6%
290	Uveal Neoplasms	2.6%
291	Denys-Drash Syndrome	2.5%
292	Urologic Neoplasms	2.5%
293	Sebaceous Gland Neoplasms	2.5%
294	Spinal Neoplasms	2.5%
295	Bone Marrow Neoplasms	2.5%
296	Polycystic Ovary Syndrome	2.4%
297	Burkitt Lymphoma	2.4%
298	Lambert-Eaton Myasthenic Syndrome	2.4%
299	Testicular Neoplasms	2.4%
300	Meningeal Neoplasms	2.2%
301	Opsoclonus-Myoclonus Syndrome	2.1%
302	Sezary Syndrome	2%
303	Xeroderma Pigmentosum	1.9%
304	Myelitis, Transverse	1.8%
305	Ear Neoplasms	1.7%
306	Eyelid Neoplasms	1.7%
307	Lung Neoplasms	1.7%
308	Nose Neoplasms	1.7%
309	Pleural Neoplasms	1.7%
310	ovarian neoplasm	1.7%
311	Cell Transformation, Viral	1.6%
312	Brain Neoplasms	1.6%
313	Salivary Gland Neoplasms	1.6%
314	Spinal Cord Neoplasms	1.6%
315	Tongue Neoplasms	1.6%
316	Palatal Neoplasms	1.6%
317	Uterine Neoplasms	1.6%
318	Vaginal Neoplasms	1.6%
319	Vulvar Neoplasms	1.6%
320	Uterine Cancer	1.6%
321	Fallopian Tube Neoplasms	1.6%
322	Meningeal Carcinomatosis	1.6%
323	Pituitary Adenoma	1.5%
324	Pituitary Neoplasms	1.5%
325	Pharyngeal Neoplasms	1.4%
326	Central Nervous System Cysts	1.3%
327	Bile Duct Neoplasms	1.3%
328	gallbladder neoplasm	1.3%
329	Intestinal Neoplasms	1.3%
330	Penile Neoplasms	1.3%
331	Prostatic Neoplasms	1.3%
332	Stomach Neoplasms	1.3%
333	Polycythemia Vera	1.3%
334	Bronchial Neoplasms	1.2%
335	Zollinger-Ellison syndrome	1.2%
336	Multiple Pulmonary Nodules	1.2%
337	Supratentorial Neoplasms	1.2%
338	Endometrial Neoplasms	1.2%
339	Laryngeal neoplasm	1.1%
340	Bladder Neoplasm	1.1%
341	Kidney Neoplasm	1.1%
342	Ureteral Neoplasms	1.1%
343	Urethral Neoplasms	1.1%
344	Brain Stem Neoplasms	1%
345	Hypopharyngeal Neoplasms	1%
346	Pleural Effusion, Malignant	1%
347	Hypopharyngeal Cancer	1%
348	Parotid Neoplasms	1%
349	Prostatic Neoplasms, Castration-Resistant	1%
350	Nelson Syndrome	1%
351	Choroid Plexus Papilloma	0.9%
352	Cecal Neoplasms	0.8%
353	Duodenal Neoplasms	0.8%
354	Tonsillar Neoplasms	0.8%
355	Cerebellar Neoplasms	0.8%
356	Nasopharyngeal Neoplasms	0.7%
357	Colorectal Neoplasms	0.7%
358	Radicular Cyst	0.7%
359	Appendiceal Neoplasms	0.7%
360	Colonic Neoplasms	0.7%
361	Rectal Neoplasms	0.7%
362	Paranasal Sinus Neoplasms	0.6%
363	Anus Neoplasms	0.5%
364	Sigmoid Neoplasms	0.5%
365	Maxillary Sinus Neoplasms	0.5%

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