MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Myxedema

(UMLS:C0027145)

Definition:: A condition characterized by a dry, waxy type of swelling (EDEMA) with abnormal deposits of MUCOPOLYSACCHARIDES in the SKIN and other tissues. It is caused by a deficiency of THYROID HORMONES. The skin becomes puffy around the eyes and on the cheeks. The face is dull and expressionless with thickened nose and lips.
UMLS ID:: C0027145
MeSH ID:: D009230

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.550.590

Classification 2:

Name:

Endocrine System Diseases
MeSH Tree Number(s):: C19.874.482.638

Synonym(s)

Myxedema

Hypothyroidism/myxedema

Hypothyroidism/myxoedema

MYXEDEMA

MYXOEDEMA

Mucin in skin

Myxedema, NOS

Myxoedema

Myxoedema, NOS

10.

myxedema

11.

myxoedema

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Amiodarone	20635749	CTD
2	Aripiprazole	19934393	CTD
3	Dexamethasone	19934393	CTD
4	Lithium Carbonate	2773973	CTD
5	Sertraline	19934393	CTD
6	Thyroxine	19934393	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Scleromyxedema	31.1%
2	Myxoid cyst	23.7%
3	Lupus Erythematosus, Cutaneous	20.7%
4	Panniculitis	20.7%
5	Systemic Scleroderma	20.7%
6	Morphea	20.7%
7	Collagen Diseases	20.5%
8	Euthyroid Sick Syndromes	20.5%
9	Goiter	20.5%
10	Hyperthyroidism	20.5%
11	Hyperthyroxinemia	20.5%
12	Mixed Connective Tissue Disease	20.5%
13	Thyroiditis	20.5%
14	Primary Hyperthyroidism	20.5%
15	Congenital Hypothyroidism	16.3%
16	Cartilage Diseases	16.1%
17	Rheumatism	16.1%
18	Chondromalacia	16.1%
19	Lupus Erythematosus, Systemic	15.5%
20	Overlap syndrome	15.5%
21	Panniculitis, Lupus Erythematosus	15.4%
22	Cutis Laxa	14.9%
23	Thyroid Neoplasm	13.6%
24	Thyroid carcinoma	13.6%
25	Graves Disease	13.5%
26	Dermatomyositis	13.4%
27	Lupus Erythematosus, Discoid	13.3%
28	Thyrotoxicosis	13.3%
29	Scleroderma, Limited	13.3%
30	Thyroid Hormone Resistance Syndrome	13.3%
31	Dupuytren Contracture	12%
32	Adrenal Gland Diseases	11.9%
33	Gonadal Disorders	11.9%
34	Parathyroid Diseases	11.9%
35	Mesenteric Panniculitis	10.2%
36	Panniculitis, Peritoneal	10.2%
37	Tietze's Syndrome	10.2%
38	Orbital Cellulitis	10.2%
39	Autoimmune thyroiditis	10.2%
40	Cellulitis	10.1%
41	Hashimoto Disease	9.9%
42	Mucopolysaccharidosis III	9.7%
43	Pseudoxanthoma Elasticum	9.7%
44	Necrobiosis Lipoidica Diabeticorum	9.4%
45	Bone Diseases, Endocrine	8.9%
46	Endocrine Gland Neoplasms	8.9%
47	Thyroid Nodule	8.8%
48	Diabetes Mellitus	8.8%
49	Pituitary Diseases	8.7%
50	Granuloma Annulare	8.6%
51	Adrenal Gland Neoplasms	8.2%
52	Osteochondritis	8.2%
53	Polymyalgia Rheumatica	8.2%
54	Erythema Induratum	8.2%
55	Osteogenesis Imperfecta	8.1%
56	Pyoderma Gangrenosum	8%
57	Keloid	7.9%
58	Noonan Syndrome	7.5%
59	Dwarfism	7%
60	Adrenal Cortex Diseases	6.8%
61	Rheumatoid Arthritis	6.8%
62	Breast Diseases	6.8%
63	Dermatitis	6.8%
64	Exanthema	6.8%
65	Facial Dermatoses	6.8%
66	Hair Diseases	6.8%
67	Hand Dermatoses	6.8%
68	Hyperparathyroidism	6.8%
69	Hypogonadism	6.8%
70	Hypoparathyroidism	6.8%
71	keratoacanthoma	6.8%
72	Keratosis	6.8%
73	Nail Diseases	6.8%
74	Parathyroid Neoplasms	6.8%
75	Photosensitivity Disorders	6.8%
76	Prurigo	6.8%
77	Delayed Puberty	6.8%
78	Precocious Puberty	6.8%
79	Pyoderma	6.8%
80	Rosacea	6.8%
81	Sebaceous Gland Diseases	6.8%
82	Skin Diseases, Vesiculobullous	6.8%
83	Skin Ulcer	6.8%
84	Sweat Gland Diseases	6.8%
85	Skin Diseases, Papulosquamous	6.8%
86	Skin Diseases, Vascular	6.8%
87	Acneiform Eruptions	6.8%
88	Hypogonadotropic hypogonadism	6.8%
89	Ocular Rosacea	6.8%
90	Subcorneal pustular dermatosis	6.8%
91	Erythematotelangiectatic Rosacea	6.8%
92	Papulopustular Rosacea	6.8%
93	Testotoxicosis	6.8%
94	Chronic Actinic Dermatitis	6.8%
95	Juvenile arthritis	6.8%
96	Mucopolysaccharidosis II	6.8%
97	Marfan Syndrome	6.7%
98	Acne Vulgaris	6.7%
99	Contact Dermatitis	6.7%
100	Eczema	6.7%
101	Erythema Multiforme	6.7%
102	Intertrigo	6.7%
103	Neurodermatitis	6.7%
104	Rhinophyma	6.7%
105	Perioral Dermatitis	6.7%
106	Acne	6.7%
107	Lupus Nephritis	6.5%
108	Homocystinuria	6.5%
109	Rheumatoid Nodule	5.9%
110	Dermatitis, Phototoxic	5.9%
111	Pityriasis Lichenoides et Varioliformis Acuta	5.9%
112	Pityriasis Lichenoides	5.9%
113	Laryngomalacia	5.9%
114	Phototoxicity	5.9%
115	Pectus carinatum	5.8%
116	Foot Ulcer	5.8%
117	Dermatitis, Atopic	5.7%
118	Epidermolysis Bullosa	5.7%
119	Dermatitis Herpetiformis	5.4%
120	Xeroderma Pigmentosum	5.4%
121	Foot Diseases	5.4%
122	Acrodermatitis	5.3%
123	Sebaceous Gland Neoplasms	5.3%
124	Porokeratosis	5.3%
125	Gianotti-Crosti Syndrome	5.3%
126	Keratoderma, Palmoplantar	5.3%
127	Skin Abnormalities	5.2%
128	Skin Diseases, Infectious	5.2%
129	Skin Neoplasms	5.2%
130	Testicular Diseases	5.2%
131	Pigmentation Disorders	5.2%
132	Lipomatosis	5.1%
133	Pruritus	5.1%
134	Erythema	5.1%
135	Necrolytic Migratory Erythema	5.1%
136	Cutaneous Fistula	5.1%
137	Nephrogenic Fibrosing Dermopathy	5.1%
138	Nephrogenic Systemic Fibrosis	5.1%
139	Ovarian Diseases	5%
140	Empty Sella Syndrome	5%
141	Hyperpituitarism	5%
142	Hypopituitarism	5%
143	Hypophysitis	5%
144	Felty Syndrome	4.9%
145	Bronchomalacia	4.9%
146	Tracheomalacia	4.9%
147	Dermatitis, Irritant	4.9%
148	Acne Conglobata	4.9%
149	Dermatitis, Photoallergic	4.9%
150	CREST Syndrome	4.9%
151	ovarian neoplasm	4.8%
152	Diabetic Foot	4.6%
153	Urticaria Pigmentosa	4.6%
154	Xeroderma	4.5%
155	Anhidrosis	4.4%
156	Cholesteatoma	4.4%
157	Cushing Syndrome	4.4%
158	Pressure Ulcer	4.4%
159	Folliculitis	4.4%
160	Foot Dermatoses	4.4%
161	Gynecomastia	4.4%
162	Hyperaldosteronism	4.4%
163	Hyperparathyroidism, Secondary	4.4%
164	Hypertrichosis	4.4%
165	Hypoaldosteronism	4.4%
166	Hypohidrosis	4.4%
167	Hypotrichosis	4.4%
168	Leg Ulcer	4.4%
169	Miliaria	4.4%
170	Parakeratosis	4.4%
171	Parapsoriasis	4.4%
172	Pityriasis	4.4%
173	Psoriasis	4.4%
174	Sweet Syndrome	4.4%
175	Hidradenitis	4.4%
176	Onycholysis	4.4%
177	Miliaria Rubra	4.4%
178	Hyperpigmentation	4.4%
179	Lichenoid Eruptions	4.4%
180	Hyperparathyroidism, Primary	4.4%
181	Chloracne	4.4%
182	Rheumatoid Vasculitis	4.2%
183	Testicular Neoplasms	4.2%
184	Adrenocortical carcinoma	4.2%
185	Dermatitis, Occupational	4.1%
186	Gestational Diabetes	4.1%
187	Latent Autoimmune Diabetes in Adults	4.1%
188	Diaper Rash	4.1%
189	Diabetes Insipidus	4%
190	Diabetes Mellitus, Experimental	4%
191	Mastocytosis	4%
192	Dermatitis, Allergic Contact	3.9%
193	Pituitary Adenoma	3.9%
194	Pituitary Neoplasms	3.9%
195	Papillon-Lefevre Disease	3.9%
196	Erythema Infectiosum	3.9%
197	Exanthema Subitum	3.9%
198	Erythema Nodosum	3.8%
199	Ectodermal Dysplasia	3.8%
200	Aplasia Cutis Congenita	3.8%
201	Prolactinoma	3.7%
202	Growth Hormone-Secreting Pituitary Adenoma	3.7%
203	Sicca Syndrome	3.7%
204	Sjogren's Syndrome	3.7%
205	Toxic Epidermal Necrolysis	3.7%
206	Stevens-Johnson Syndrome	3.7%
207	Tinea Capitis	3.5%
208	Onychomycosis	3.5%
209	Hermaphroditism	3.4%
210	Disorders of Sex Development	3.4%
211	Acantholysis	3.4%
212	Addison Disease	3.4%
213	Breast Cyst	3.4%
214	Diabetic Angiopathies	3.4%
215	Actinic keratosis	3.4%
216	Pemphigoid, Benign Mucous Membrane	3.4%
217	Pemphigus	3.4%
218	Piedra	3.4%
219	Sunburn	3.4%
220	Primary Adrenal Insufficiency	3.4%
221	Argyria	3.3%
222	Diabetic Neuropathies	3.3%
223	Hirsutism	3.3%
224	Lactation Disorder	3.3%
225	Mastitis	3.3%
226	Orchitis	3.3%
227	Urticaria	3.3%
228	Diabetic Amyotrophy	3.3%
229	Diabetic Autonomic Neuropathy	3.3%
230	Diabetic Cardiomyopathies	3.3%
231	Adiposis Dolorosa	3.3%
232	Pruritus Vulvae	3.3%
233	Hyperglycemic Hyperosmolar Nonketotic Coma	3.3%
234	Lichen Planus	3.3%
235	Melanosis	3.3%
236	Chloasma	3.3%
237	Pituitary Apoplexy	3.3%
238	Pityriasis Rosea	3.3%
239	Pityriasis Rubra Pilaris	3.3%
240	Vitiligo	3.3%
241	Lichen Nitidus	3.3%
242	Mastocytoma	3.3%
243	Pruritus Ani	3.3%
244	Ovarian Hyperstimulation Syndrome	3.3%
245	Ecthyma	3.3%
246	Hyperprolactinemia	3.3%
247	Nelson Syndrome	3.2%
248	Hyperkeratosis, Epidermolytic	3.2%
249	Lupus Vasculitis, Central Nervous System	3%
250	Ichthyosis, X-Linked	3%
251	Sjogren-Larsson Syndrome	3%
252	Multiple Endocrine Neoplasia	2.9%
253	Pancreatic Neoplasm	2.9%
254	Behcet Syndrome	2.9%
255	Kallmann Syndrome	2.9%
256	granulosa cell tumor	2.8%
257	Carcinoma, Ovarian Epithelial	2.8%
258	Hidradenitis Suppurativa	2.8%
259	Acanthosis Nigricans	2.7%
260	Alopecia Areata	2.7%
261	Lentigo	2.7%
262	Dermatomycoses	2.7%
263	Mucocutaneous Lymph Node Syndrome	2.7%
264	Skin Diseases, Bacterial	2.7%
265	Corpus Luteum Cyst	2.7%
266	Ovarian Cysts	2.7%
267	Drug Eruptions	2.7%
268	Gigantism	2.7%
269	Lipodystrophy	2.7%
270	Livedo Reticularis	2.7%
271	Malignant Atrophic Papulosis	2.7%
272	Diabetic Nephropathy	2.6%
273	Acromegaly	2.6%
274	Polyarteritis Nodosa	2.6%
275	Takayasu Arteritis	2.6%
276	Anovulation	2.6%
277	Diabetic Ketoacidosis	2.6%
278	Oophoritis	2.6%
279	Albinism	2.6%
280	Tinea Pedis	2.5%
281	Erythema Chronicum Migrans	2.5%
282	Alopecia	2.5%
283	Sweating, Gustatory	2.5%
284	Androgenetic Alopecia	2.5%
285	Auriculotemporal Syndrome	2.5%
286	Klinefelter Syndrome	2.5%
287	Lice Infestations	2.5%
288	Varicose Ulcer	2.5%
289	Breast Neoplasms, Male	2.5%
290	Triple Negative Breast Neoplasms	2.5%
291	Galactorrhea	2.5%
292	Nail-Patella Syndrome	2.3%
293	Cryptorchidism	2.2%
294	Porphyrias, Hepatic	2.2%
295	Gonadal Dysgenesis	2.2%
296	Adrenogenital Syndrome	2.2%
297	Ovotesticular Disorders of Sex Development	2.2%
298	Mycetoma	2.2%
299	Lichen Planus, Oral	2.1%
300	Diabetic Retinopathy	2%
301	Larva Migrans	2%
302	Leishmaniasis	2%
303	Molluscum Contagiosum	2%
304	Angioedema	2%
305	Onchocerciasis	2%
306	Chromoblastomycosis	2%
307	Dermatophytosis	2%
308	Sporotrichosis	2%
309	Tinea	2%
310	Tinea Versicolor	2%
311	Trichophytosis	2%
312	Hyalohyphomycosis	2%
313	Polycystic Ovary Syndrome	2%
314	Leydig Cell Tumor	2%
315	Acute Generalized Exanthematous Pustulosis	2%
316	Hyperandrogenism	1.9%
317	Multiple Endocrine Neoplasia Type 1	1.9%
318	Warts	1.7%
319	Candidiasis, Chronic Mucocutaneous	1.6%
320	Cutaneous Candidiasis	1.6%
321	Erysipelas	1.6%
322	Leishmaniasis, Cutaneous	1.6%
323	Serum Sickness	1.6%
324	Staphylococcal Skin Infections	1.6%
325	Variegate Porphyria	1.6%
326	Acute intermittent porphyria	1.6%
327	Porphyria Cutanea Tarda	1.6%
328	Eczema Herpeticum	1.6%
329	Erythrasma	1.6%
330	Carcinoma, Lobular	1.6%
331	Arthritis, Psoriatic	1.6%
332	Fusariosis	1.6%
333	Hereditary Angioedema Type III	1.5%
334	Hereditary Angioedema Types I and II	1.5%
335	Carcinoma, Pancreatic Ductal	1.5%
336	Giant Cell Arteritis	1.5%
337	Temporal Arteritis	1.5%
338	Angioedemas, Hereditary	1.4%
339	Epidermodysplasia Verruciformis	1.4%
340	Herpes Labialis	1.4%
341	Staphylococcal Scalded Skin Syndrome	1.3%
342	Turner Syndrome	1.3%
343	Peutz-Jeghers Syndrome	1.2%
344	Blastomycosis	1.2%
345	HIV-Associated Lipodystrophy Syndrome	1.2%
346	insulinoma	1.2%
347	Gastrinoma	1.2%
348	Glucagonoma	1.2%
349	carbuncle	1.2%
350	Carcinoma, Endometrioid	1.2%
351	Waterhouse-Friderichsen Syndrome	1.2%
352	Condylomata Acuminata	1.2%
353	Furunculosis	1.2%
354	furuncle	1.2%
355	Impetigo	1.2%
356	Rhinoscleroma	1.1%
357	Renal Osteodystrophy	1.1%
358	Renal rickets	1.1%
359	Menkes Kinky Hair Syndrome	1.1%
360	Vipoma	1.1%
361	Adrenoleukodystrophy	0.7%
362	Denys-Drash Syndrome	0.7%

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