MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leukemia, Myeloid, Chronic-Phase

(UMLS:C0023474)

Definition:: The initial phase of chronic myeloid leukemia consisting of an relatively indolent period lasting from 4 to 7 years. Patients range from asymptomatic to those exhibiting ANEMIA; SPLENOMEGALY; and increased cell turnover. There are 5% or fewer blast cells in the blood and bone marrow in this phase.
UMLS ID:: C0023474
MeSH ID:: D015466

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.337.539.250.400

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.190.636.370.400

Synonym(s)

Leukemia, Myeloid, Chronic-Phase

CGL, chronic phase

CML, chronic phase

Chronic Phase CML

Chronic Phase Chronic Granulocytic Leukemia

Chronic Phase Chronic Myelocytic Leukemia

Chronic Phase Chronic Myelogenous Leukemia

Chronic Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive

Chronic Phase Chronic Myeloid Leukemia

10.

Chronic phase chronic myeloid leukemia

11.

chronic granulocytic leukemia, chronic phase

12.

chronic myelocytic leukemia, chronic phase

13.

chronic myelogenous leukemia - chronic phase

14.

chronic myelogenous leukemia, chronic phase

15.

chronic myeloid leukemia - chronic phase

16.

chronic phase CGL

17.

chronic phase CML

18.

chronic phase chronic myelogenous leukemia

19.

granulocytic leukemia, chronic phase

20.

leukemia myelogenous chronic - chronic phase

21.

leukemia, chronic myelogenous, chronic phase

22.

myelocytic leukemia, chronic phase

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dasatinib		23825585	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Leukemia, Myelomonocytic, Chronic	26.4%
2	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	26.4%
3	Thrombocytosis	24.2%
4	Primary Myelofibrosis	23.9%
5	Myelofibrosis	23.9%
6	Myeloid Metaplasia	23.9%
7	bone marrow fibrosis	23.9%
8	Leukemoid Reaction	21.6%
9	Sarcoma, Myeloid	21.6%
10	Polycythemia Vera	20.9%
11	MYELODYSPLASTIC SYNDROME	18.8%
12	Thrombocythemia, Essential	18.6%
13	Bone Marrow Neoplasms	18%
14	Hematologic Neoplasms	15.1%
15	Anemia	14.8%
16	Blood Coagulation Disorders	14.8%
17	Blood Platelet Disorders	14.8%
18	Hemorrhagic Disorders	14.8%
19	Leukocyte Disorders	14.8%
20	Methemoglobinemia	14.8%
21	Neoplasms, Germ Cell and Embryonal	14.8%
22	Neoplasms, Glandular and Epithelial	14.8%
23	Pancytopenia	14.8%
24	Polycythemia	14.8%
25	Sulfhemoglobinemia	14.8%
26	Thrombophilia	14.8%
27	Germ Cell Cancer	14.8%
28	Erythrocytosis	14.8%
29	Disseminated Intravascular Coagulation	14.7%
30	Protein S Deficiency	14.7%
31	Leukemia, Experimental	14.5%
32	Leukemia, Plasma Cell	14.2%
33	Histiocytic Disorders, Malignant	13.2%
34	Leukemia, Radiation-Induced	12.2%
35	Neuroectodermal Tumors	12.2%
36	Hemoglobinuria, Paroxysmal	12%
37	Transfusion Reaction	11.7%
38	Hypotensive Transfusion Reaction	11.7%
39	Pregnancy Complications, Hematologic	11.3%
40	Neoplasms, Neuroepithelial	10.6%
41	Gliomatosis cerebri	10.6%
42	Thrombasthenia	10.6%
43	Antithrombin III Deficiency	10.6%
44	Protein C Deficiency	10.6%
45	Lymphoma	10.6%
46	Leukemia L1210	10.5%
47	Leukemia P388	10.5%
48	Hamartoma	9.8%
49	Lymphatic Diseases	9.8%
50	Neoplasms, Hormone-Dependent	9.8%
51	Neoplasms, Multiple Primary	9.8%
52	Paraneoplastic Syndromes	9.8%
53	Precancerous Conditions	9.8%
54	Neoplasms, Second Primary	9.8%
55	Vitamin K Deficiency	9.7%
56	Carcinosarcoma	9.7%
57	Hemangiosarcoma	9.7%
58	lymphangiosarcoma	9.7%
59	Afibrinogenemia	8.9%
60	Factor VII Deficiency	8.9%
61	Factor X Deficiency	8.9%
62	Factor XII Deficiency	8.9%
63	Hemophilia A	8.9%
64	Composite Lymphoma	8.9%
65	Activated Protein C Resistance	8.9%
66	Factor II deficiency	8.9%
67	Factor VIII Deficiency	8.9%
68	Factor V deficiency	8.9%
69	Factor XI Deficiency	8.9%
70	Hypoprothrombinemias	8.9%
71	melanoma	8.7%
72	Meningioma	8.6%
73	Adenoma	8.1%
74	Ameloblastoma	8.1%
75	Anemia, Hemolytic	8.1%
76	Anemia, Macrocytic	8.1%
77	Angiokeratoma	8.1%
78	Carcinoma	8.1%
79	Chordoma	8.1%
80	Eosinophilia	8.1%
81	Hemangioma	8.1%
82	hemangiopericytoma	8.1%
83	Hypoproteinemia	8.1%
84	Leukopenia	8.1%
85	Lymphangioma	8.1%
86	Mesenchymoma	8.1%
87	Nevus	8.1%
88	Teratoma	8.1%
89	Thrombocytopenia	8.1%
90	Hepatoblastoma	8.1%
91	Mixed Tumor, Mullerian	8.1%
92	Germinoma	8.1%
93	Teratocarcinoma	8.1%
94	Angiofibroma	8.1%
95	Leukostasis	8.1%
96	Sarcoma	8.1%
97	Epithelioma	8.1%
98	Trophoblastic Neoplasms	7.9%
99	Carcinoma 256, Walker	7.8%
100	Waldenstrom Macroglobulinemia	7.8%
101	Anemia, Diamond-Blackfan	7.8%
102	Leukemia, T-Cell	7.7%
103	Leukemia, B-Cell	7.7%
104	Lymphocele	7.6%
105	Thymoma	7.5%
106	Cyst	7.4%
107	Neoplastic Processes	7.4%
108	Neoplastic Syndromes, Hereditary	7.4%
109	Pregnancy Complications, Neoplastic	7.4%
110	Carcinoma, Ehrlich Tumor	7.4%
111	Dermoid Cyst	7.4%
112	Carcinoma, Lewis Lung	7.4%
113	Neoplasms, Experimental	7.3%
114	Malignant histiocytosis	7.3%
115	Histiocytic sarcoma	7.3%
116	Basal cell carcinoma	7.2%
117	Carcinoma, Papillary	7.2%
118	Squamous cell carcinoma	7.2%
119	Chondrosarcoma	7.2%
120	Craniopharyngioma	7.2%
121	Cystadenoma	7.2%
122	leiomyosarcoma	7.2%
123	liposarcoma	7.2%
124	Mesothelioma	7.2%
125	synovial sarcoma	7.2%
126	Neuroectodermal Tumor, Melanotic	7.2%
127	Angiomyolipoma	7.2%
128	Clear Cell Sarcoma of Soft Tissue	7.2%
129	Alveolar Soft Part Sarcoma	7.2%
130	Neuroendocrine Tumors	7.2%
131	Carcinoma, Basal Cell	7.2%
132	Multiple Myeloma	6.7%
133	Adenoma, Acidophil	6.7%
134	Ganglioneuroma	6.7%
135	Glioma	6.7%
136	Malignant Glioma	6.7%
137	Agammaglobulinemia	6.6%
138	Melanoma, Experimental	6.2%
139	Anemia, Neonatal	6.2%
140	Leukocytosis	6.2%
141	Paraproteinemias	6.2%
142	Pelger-Huet Anomaly	6.2%
143	Pleocytosis	6.2%
144	Wiskott-Aldrich Syndrome	6.1%
145	Plasmacytoma	6.1%
146	Cystadenocarcinoma	6%
147	Fibrosarcoma	6%
148	Osteosarcoma	6%
149	Mucoepidermoid Carcinoma	6%
150	Medulloblastoma	5.9%
151	Sarcoma, Experimental	5.9%
152	Neoplasms, Radiation-Induced	5.8%
153	Purpura, Thrombotic Thrombocytopenic	5.8%
154	Hemangioma, Cavernous	5.8%
155	Hodgkin Disease	5.8%
156	Lymphoma, Non-Hodgkin	5.8%
157	Splenic Neoplasms	5.8%
158	Thymus Neoplasms	5.8%
159	Carcinoid Tumor	5.7%
160	Neurilemmoma	5.7%
161	Hutchinson's Melanotic Freckle	5.7%
162	Melanoma, Amelanotic	5.7%
163	Anemia, Sickle Cell	5.7%
164	Thalassemia	5.7%
165	Acanthoma	5.6%
166	Lymphangioleiomyomatosis	5.6%
167	Endometrial Stromal Sarcoma	5.6%
168	Multiple Endocrine Neoplasia	5.6%
169	Infectious Mononucleosis	5.4%
170	Fanconi Anemia	5.4%
171	Adenofibroma	5.4%
172	Fibroadenoma	5.4%
173	Malignant Fibrous Histiocytoma	5.4%
174	Choriocarcinoma	5.4%
175	Carcinoma, Lobular	5.4%
176	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5.1%
177	Leukemia, Large Granular Lymphocytic	5.1%
178	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5.1%
179	Hypergammaglobulinemia	5%
180	Abdominal Neoplasms	4.9%
181	Adenitis	4.9%
182	Erythroplasia	4.9%
183	Follicular cyst	4.9%
184	Head and Neck Neoplasms	4.9%
185	Histiocytosis	4.9%
186	Lymphadenitis	4.9%
187	Lymphangitis	4.9%
188	Lymphedema	4.9%
189	Mucocele	4.9%
190	Pilonidal Cyst	4.9%
191	Soft Tissue Neoplasms	4.9%
192	Splenic Diseases	4.9%
193	Thoracic Neoplasms	4.9%
194	Thymus Hyperplasia	4.9%
195	Thyroglossal Cyst	4.9%
196	Synovial Cyst	4.9%
197	Pseudolymphoma	4.9%
198	Lymphadenopathy	4.9%
199	Aberrant Crypt Foci	4.9%
200	Transfusion-Related Acute Lung Injury	4.9%
201	Ecchymosis	4.9%
202	Petechiae	4.9%
203	Purpura	4.9%
204	Cryoglobulinemia	4.9%
205	Monoclonal Gammopathy of Undetermined Significance	4.9%
206	Adenocarcinoma	4.8%
207	Agranulocytosis	4.8%
208	Anemia, Megaloblastic	4.8%
209	Carcinoma in Situ	4.8%
210	Carcinoma, Transitional Cell	4.8%
211	Phyllodes Tumor	4.8%
212	Dysgerminoma	4.8%
213	Hemangioendothelioma	4.8%
214	Lipoma	4.8%
215	Lymphocytosis	4.8%
216	Myoma	4.8%
217	Myxoma	4.8%
218	Neuroma	4.8%
219	Papilloma	4.8%
220	Pseudomyxoma Peritonei	4.8%
221	Seminoma	4.8%
222	Papillomatosis	4.8%
223	Angiolipoma	4.8%
224	Myelolipoma	4.8%
225	Neoplasms, Bone Tissue	4.8%
226	Neoplasms, Fibrous Tissue	4.8%
227	Smooth Muscle Tumor	4.8%
228	Adenomatosis, Pulmonary	4.8%
229	Adenomatous Polyps	4.8%
230	Carcinoma, Large Cell	4.8%
231	Hypoalbuminemia	4.8%
232	Carcinoma, Small Cell	4.8%
233	Desmoplastic Small Round Cell Tumor	4.8%
234	Chondroma	4.8%
235	Hypereosinophilic syndrome	4.8%
236	Enchondroma	4.8%
237	Thrombotic Microangiopathies	4.8%
238	Bowen's Disease	4.8%
239	Paraganglioma	4.8%
240	Rhabdomyosarcoma	4.8%
241	Giant Cell Tumor of Bone	4.8%
242	Astrocytoma	4.7%
243	Ependymoma	4.7%
244	oligodendroglioma	4.7%
245	Ganglioglioma	4.7%
246	gliosarcoma	4.7%
247	Anaplastic astrocytoma	4.7%
248	Anaplastic Oligodendroglioma	4.7%
249	Paraneoplastic Encephalomyelitis	4.7%
250	Autoimmune thrombocytopenia	4.6%
251	Immune thrombocytopenic purpura	4.6%
252	Mammary Neoplasms, Experimental	4.6%
253	Heavy Chain Disease	4.5%
254	Lymphomatoid Granulomatosis	4.4%
255	Sarcoma 180	4.4%
256	Retinoblastoma	4.3%
257	Malignant Carcinoid Syndrome	4.3%
258	Nephroblastoma	4.2%
259	Dermatofibrosarcoma	4.2%
260	Dermatofibrosarcoma Protuberans	4.2%
261	Purpura, Hyperglobulinemic	4.1%
262	Tuberous Sclerosis	4.1%
263	Primary amyloidosis	4.1%
264	Hemolytic-Uremic Syndrome	4%
265	Digestive System Neoplasms	3.9%
266	Endocrine Gland Neoplasms	3.9%
267	Eye Neoplasms	3.9%
268	Nervous System Neoplasms	3.9%
269	Hydrops Fetalis	3.8%
270	Glioblastoma	3.8%
271	Neuroblastoma	3.8%
272	Glioblastoma Multiforme	3.8%
273	Bone neoplasms	3.8%
274	Leukoplakia	3.8%
275	Lymphoproliferative Disorders	3.8%
276	Pancreatic Cyst	3.8%
277	Skin Neoplasms	3.8%
278	Lymphatic Abnormalities	3.8%
279	Neurofibrosarcoma	3.7%
280	Barrett Esophagus	3.7%
281	Breast Cyst	3.7%
282	Actinic keratosis	3.7%
283	Mediastinal Cyst	3.7%
284	Neoplasm Invasiveness	3.7%
285	Neoplasm Metastasis	3.7%
286	Neoplasm Recurrence, Local	3.7%
287	Parovarian Cyst	3.7%
288	Pericardial Cyst	3.7%
289	Thymic Cyst	3.7%
290	Carcinogenesis	3.7%
291	Myxoid cyst	3.7%
292	Metastasis	3.7%
293	Lymphopenia	3.7%
294	Job Syndrome	3.6%
295	Sickle Cell Trait	3.6%
296	Pheochromocytoma	3.6%
297	Alveolar rhabdomyosarcoma	3.6%
298	Thrombocytopenic purpura	3.5%
299	Waterhouse-Friderichsen Syndrome	3.5%
300	Lymphoma, Follicular	3.5%
301	T-Cell Lymphoma	3.5%
302	Mantle cell lymphoma	3.5%
303	Basal Cell Nevus Syndrome	3.4%
304	Mesoblastic Nephroma	3.4%
305	Ganglioneuroblastoma	3.3%
306	Lymphangiectasis, Intestinal	3.3%
307	Hepatocellular Adenoma	3.2%
308	Adenoid Cystic Carcinoma	3.2%
309	fibroma	3.2%
310	Fibromatosis	3.2%
311	Neutropenia	3.2%
312	Osteoblastoma	3.2%
313	Osteoma	3.2%
314	Rhabdomyoma	3.2%
315	Chondromatosis	3.2%
316	Adenocarcinoma, Clear Cell	3.2%
317	Cholangiocarcinoma	3.2%
318	Cervical Intraepithelial Neoplasia	3.2%
319	Hemangioblastoma	3.2%
320	Lymphoma, Extranodal NK-T-Cell	3.2%
321	Kernicterus	3.1%
322	Multiple Endocrine Neoplasia Type 1	3%
323	Carcinoid Heart Disease	3%
324	Mucocutaneous Lymph Node Syndrome	3%
325	Carcinoma, Pancreatic Ductal	3%
326	Mastocytosis	3%
327	Sturge-Weber Syndrome	3%
328	Eosinophilia-Myalgia Syndrome	3%
329	Corpus Luteum Cyst	3%
330	Ovarian Cysts	3%
331	Chronic granulomatous disease	2.9%
332	Shwartzman Phenomenon	2.9%
333	Gastrointestinal Stromal Tumors	2.9%
334	Scurvy	2.9%
335	Purpura Fulminans	2.9%
336	neurofibroma	2.9%
337	Hydatidiform Mole	2.9%
338	Liver Neoplasms, Experimental	2.8%
339	Eosinophilic Granuloma	2.8%
340	Parathyroid Neoplasms	2.8%
341	Peritoneal Neoplasms	2.8%
342	Thyroid Neoplasm	2.8%
343	Thyroid carcinoma	2.8%
344	Atypical Hemolytic Uremic Syndrome	2.8%
345	Acute Chest Syndrome	2.8%
346	Prolactinoma	2.8%
347	Growth Hormone-Secreting Pituitary Adenoma	2.8%
348	Acoustic Neuroma	2.7%
349	Elephantiasis	2.7%
350	Hypersplenism	2.7%
351	Retroperitoneal Neoplasms	2.7%
352	Sarcoidosis	2.7%
353	Elephantiasis Nostras Verrucosa	2.7%
354	Choledochal Cyst	2.5%
355	Optic Nerve Glioma	2.5%
356	Sezary Syndrome	2.5%
357	Peutz-Jeghers Syndrome	2.4%
358	Pulmonary Eosinophilia	2.4%
359	Eosinophilic Pneumonia	2.4%
360	POEMS Syndrome	2.4%
361	Adenomatous Polyposis Coli	2.4%
362	Pancreatic Neoplasm	2.4%
363	Mastocytoma	2.4%
364	granulosa cell tumor	2.4%
365	Carcinoma, Ovarian Epithelial	2.4%
366	Mastocytosis, Systemic	2.4%
367	Fibromatosis, Aggressive	2.4%
368	Fibromatosis, Abdominal	2.4%
369	Klatskin Tumor	2.4%
370	Febrile Neutropenia	2.4%
371	Anemia, Pernicious	2.4%
372	Lymphoma, T-Cell, Cutaneous	2.4%
373	Lymphoma, AIDS-Related	2.4%
374	Enteropathy-Associated T-Cell Lymphoma	2.4%
375	Primary Effusion Lymphoma	2.4%
376	Vipoma	2.3%
377	Tracheal Neoplasms	2.2%
378	Leukoplakia, Oral	2.2%
379	Paraneoplastic Cerebellar Degeneration	2.2%
380	Granuloma	2.1%
381	Mouth Neoplasms	2.1%
382	Splenic Infarction	2.1%
383	Central Nervous System Neoplasms	2.1%
384	Vascular Neoplasms	2.1%
385	Genital Neoplasms, Female	2%
386	Histiocytosis, Langerhans-Cell	2%
387	Pancreatic Pseudocyst	2%
388	Tumor Lysis Syndrome	2%
389	Lymphatic Metastasis	2%
390	Neoplasms, Unknown Primary	2%
391	Leukemic Infiltration	2%
392	Breast Neoplasms, Male	2%
393	Neoplasm Micrometastasis	2%
394	Triple Negative Breast Neoplasms	2%
395	insulinoma	2%
396	Nasopharyngeal carcinoma	1.9%
397	Esophageal Neoplasms	1.9%
398	Limbic Encephalitis	1.9%
399	Adrenocortical carcinoma	1.8%
400	Mycosis Fungoides	1.8%
401	Lymphomatoid Papulosis	1.8%
402	Plasmablastic lymphoma	1.8%
403	Denys-Drash Syndrome	1.8%
404	Burkitt Lymphoma	1.7%
405	Gastrinoma	1.7%
406	Glucagonoma	1.7%
407	Adrenal Gland Neoplasms	1.7%
408	Gastrointestinal Neoplasms	1.7%
409	Genital Neoplasms, Male	1.7%
410	Liver neoplasms	1.7%
411	Splenic Rupture	1.7%
412	Uveal Neoplasms	1.7%
413	Leydig Cell Tumor	1.7%
414	Urologic Neoplasms	1.7%
415	Pseudoxanthoma Elasticum	1.7%
416	Lambert-Eaton Myasthenic Syndrome	1.7%
417	Testicular Neoplasms	1.7%
418	Sebaceous Gland Neoplasms	1.6%
419	Spinal Neoplasms	1.6%
420	Thyroid Nodule	1.6%
421	Polycystic Ovary Syndrome	1.6%
422	Lymphohistiocytosis, Hemophagocytic	1.6%
423	Erdheim-Chester Disease	1.6%
424	Renal Cell Carcinoma	1.6%
425	Papillary Renal Cell Carcinoma	1.6%
426	Xeroderma Pigmentosum	1.5%
427	Carcinoma, Endometrioid	1.5%
428	Dupuytren Contracture	1.5%
429	Opsoclonus-Myoclonus Syndrome	1.5%
430	Urticaria Pigmentosa	1.4%
431	Autoimmune Lymphoproliferative Syndrome	1.4%
432	Myelitis, Transverse	1.3%
433	Meningeal Neoplasms	1.2%
434	Sarcoidosis, Pulmonary	1.2%
435	ovarian neoplasm	1.2%
436	Nose Neoplasms	1.1%
437	Pituitary Adenoma	1%
438	Pituitary Neoplasms	1%
439	Palatal Neoplasms	1%
440	Ear Neoplasms	1%
441	Eyelid Neoplasms	1%
442	Lung Neoplasms	1%
443	Pleural Neoplasms	1%
444	Cell Transformation, Viral	1%
445	Brain Neoplasms	1%
446	Salivary Gland Neoplasms	1%
447	Spinal Cord Neoplasms	1%
448	Tongue Neoplasms	1%
449	Splenosis	1%
450	Uterine Neoplasms	1%
451	Vaginal Neoplasms	1%
452	Vulvar Neoplasms	1%
453	Uterine Cancer	1%
454	Fallopian Tube Neoplasms	1%
455	Zollinger-Ellison syndrome	0.9%
456	Pharyngeal Neoplasms	0.8%
457	Central Nervous System Cysts	0.8%
458	Bile Duct Neoplasms	0.8%
459	gallbladder neoplasm	0.8%
460	Intestinal Neoplasms	0.8%
461	Penile Neoplasms	0.8%
462	Prostatic Neoplasms	0.8%
463	Stomach Neoplasms	0.8%
464	Meningeal Carcinomatosis	0.8%
465	Laryngeal neoplasm	0.7%
466	Bladder Neoplasm	0.7%
467	Kidney Neoplasm	0.7%
468	Ureteral Neoplasms	0.7%
469	Urethral Neoplasms	0.7%
470	Bronchial Neoplasms	0.7%
471	Multiple Pulmonary Nodules	0.6%
472	Supratentorial Neoplasms	0.6%
473	Endometrial Neoplasms	0.6%
474	Hypopharyngeal Neoplasms	0.5%
475	Pleural Effusion, Malignant	0.5%
476	Hypopharyngeal Cancer	0.5%
477	Parotid Neoplasms	0.5%
478	Prostatic Neoplasms, Castration-Resistant	0.5%
479	Nelson Syndrome	0.5%
480	Brain Stem Neoplasms	0.5%
481	Cecal Neoplasms	0.5%
482	Duodenal Neoplasms	0.5%
483	Nasopharyngeal Neoplasms	0.4%
484	Colorectal Neoplasms	0.4%
485	Tonsillar Neoplasms	0.4%
486	Cerebellar Neoplasms	0.4%
487	Choroid Plexus Papilloma	0.4%
488	Paranasal Sinus Neoplasms	0.4%
489	Radicular Cyst	0.3%
490	Appendiceal Neoplasms	0.3%
491	Colonic Neoplasms	0.3%
492	Rectal Neoplasms	0.3%
493	Maxillary Sinus Neoplasms	0.3%
494	Niemann-Pick Disease, Type C	0.3%
495	Anus Neoplasms	0.2%
496	Sigmoid Neoplasms	0.2%

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