MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leukemia, Plasma Cell

(UMLS:C0023484)

Definition:: A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.
UMLS ID:: C0023484
MeSH ID:: D007952

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.337.595|C04.557.595.500.500

Classification 2:

Name:

Immune System Diseases
MeSH Tree Number(s):: C20.683.515.845.500

Synonym(s)

Leukemia, Plasma Cell

LEUKEMIA PLASMA CELL

LEUKEMIA, PLASMACYTIC

Leukemia Plasmacytic

Plasma Cell Leukemia

Plasma cell leukaemia

Plasma cell leukemia

Plasma cell leukemia, disease

Plasma cell leukemia, morphology

10.

Plasmacytic Leukemia

11.

Plasmacytic leukaemia

12.

Plasmacytic leukemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Bortezomib	17396042	CTD
2	Cyclophosphamide	4571885 9404934	CTD
3	Daunorubicin	4571885	CTD
4	Melphalan	4571885 9404934	CTD
5	Phenylbutazone	4779657	CTD
6	Prednisolone	4571885	CTD
7	Thalidomide	11279644 18037876	CTD
8	VAD protocol	9404934 11553267	CTD
9	Vincristine	4571885	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Plasmacytoma	35.5%
2	Lymphoma	30%
3	Primary amyloidosis	29.6%
4	Neoplasms, Neuroepithelial	27.7%
5	Gliomatosis cerebri	27.7%
6	Neuroectodermal Tumors	27.6%
7	Neoplasms, Germ Cell and Embryonal	27.5%
8	Neoplasms, Glandular and Epithelial	27.5%
9	Germ Cell Cancer	27.5%
10	Sarcoma, Myeloid	27.3%
11	Leukemia, Experimental	26.5%
12	Composite Lymphoma	26.2%
13	melanoma	24.3%
14	Carcinosarcoma	23.5%
15	Hemangiosarcoma	23.5%
16	lymphangiosarcoma	23.5%
17	Medulloblastoma	23.4%
18	Leukemia, Radiation-Induced	23%
19	Leukemia L1210	22.2%
20	Leukemia P388	22.2%
21	Leukemia, T-Cell	22.2%
22	Leukemia, B-Cell	22.2%
23	Histiocytic Disorders, Malignant	22%
24	Meningioma	21.4%
25	Adenoma, Acidophil	21%
26	Ganglioneuroma	21%
27	Glioma	21%
28	Malignant Glioma	21%
29	Carcinoma 256, Walker	20.8%
30	Lymphangioleiomyomatosis	20.4%
31	Basal cell carcinoma	19.5%
32	Carcinoma, Papillary	19.5%
33	Squamous cell carcinoma	19.5%
34	Chondrosarcoma	19.5%
35	Craniopharyngioma	19.5%
36	Cystadenoma	19.5%
37	leiomyosarcoma	19.5%
38	liposarcoma	19.5%
39	Mesothelioma	19.5%
40	synovial sarcoma	19.5%
41	Neuroectodermal Tumor, Melanotic	19.5%
42	Angiomyolipoma	19.5%
43	Clear Cell Sarcoma of Soft Tissue	19.5%
44	Alveolar Soft Part Sarcoma	19.5%
45	Neuroendocrine Tumors	19.5%
46	Carcinoma, Basal Cell	19.5%
47	Carcinoid Tumor	19.3%
48	Neurilemmoma	19.3%
49	Hutchinson's Melanotic Freckle	19.3%
50	Melanoma, Amelanotic	19.3%
51	Melanoma, Experimental	19.1%
52	Hodgkin Disease	19%
53	Lymphoma, Non-Hodgkin	19%
54	Trophoblastic Neoplasms	17.8%
55	Astrocytoma	17.6%
56	Ependymoma	17.6%
57	oligodendroglioma	17.6%
58	Ganglioglioma	17.6%
59	gliosarcoma	17.6%
60	Anaplastic astrocytoma	17.6%
61	Anaplastic Oligodendroglioma	17.6%
62	Leukemia, Myelomonocytic, Chronic	17.5%
63	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	17.5%
64	Cystadenocarcinoma	17.5%
65	Fibrosarcoma	17.5%
66	Osteosarcoma	17.5%
67	Mucoepidermoid Carcinoma	17.5%
68	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	17.4%
69	Leukemia, Large Granular Lymphocytic	17.4%
70	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	17.4%
71	Carcinoma, Ehrlich Tumor	17.2%
72	Dermoid Cyst	17.2%
73	Carcinoma, Lewis Lung	17.2%
74	Adenoma	17.2%
75	Ameloblastoma	17.2%
76	Angiokeratoma	17.2%
77	Carcinoma	17.2%
78	Chordoma	17.2%
79	Hemangioma	17.2%
80	hemangiopericytoma	17.2%
81	Lymphangioma	17.2%
82	Mesenchymoma	17.2%
83	Nevus	17.2%
84	Teratoma	17.2%
85	Hepatoblastoma	17.2%
86	Mixed Tumor, Mullerian	17.2%
87	Germinoma	17.2%
88	Teratocarcinoma	17.2%
89	Angiofibroma	17.2%
90	Sarcoma	17.2%
91	Epithelioma	17.2%
92	Malignant Carcinoid Syndrome	16.8%
93	Adenofibroma	16.5%
94	Fibroadenoma	16.5%
95	Malignant Fibrous Histiocytoma	16.5%
96	Hamartoma	16.4%
97	Neoplasms, Hormone-Dependent	16.4%
98	Neoplasms, Multiple Primary	16.4%
99	Paraneoplastic Syndromes	16.4%
100	Precancerous Conditions	16.4%
101	Neoplasms, Second Primary	16.4%
102	Glioblastoma	16%
103	Neuroblastoma	16%
104	Glioblastoma Multiforme	16%
105	Sezary Syndrome	15.9%
106	Choriocarcinoma	15.8%
107	Carcinoma, Lobular	15.8%
108	Bowen's Disease	15.5%
109	Paraganglioma	15.5%
110	Rhabdomyosarcoma	15.5%
111	Giant Cell Tumor of Bone	15.5%
112	Waldenstrom Macroglobulinemia	15.3%
113	Endometrial Stromal Sarcoma	15.2%
114	Ganglioneuroblastoma	15.2%
115	Lymphomatoid Granulomatosis	14.8%
116	Dermatofibrosarcoma	14.5%
117	Dermatofibrosarcoma Protuberans	14.5%
118	Retinoblastoma	14.4%
119	Acanthoma	14.4%
120	Sarcoma, Experimental	14.3%
121	Thymoma	14.2%
122	Leukemia, Myeloid, Chronic-Phase	14.2%
123	Tumor Lysis Syndrome	13.8%
124	Neurofibrosarcoma	13.8%
125	Malignant histiocytosis	13.7%
126	Histiocytic sarcoma	13.7%
127	Lymphoma, Follicular	13.7%
128	T-Cell Lymphoma	13.7%
129	Mantle cell lymphoma	13.7%
130	Carcinoid Heart Disease	13.6%
131	Pheochromocytoma	13.5%
132	Alveolar rhabdomyosarcoma	13.5%
133	Cyst	13.2%
134	Neoplastic Processes	13.2%
135	Neoplastic Syndromes, Hereditary	13.2%
136	Pregnancy Complications, Neoplastic	13.2%
137	Neoplasms, Experimental	13%
138	leukemia	12.5%
139	Autoimmune Lymphoproliferative Syndrome	12.5%
140	Sarcoma 180	12.4%
141	Multiple Endocrine Neoplasia	12.3%
142	Adenocarcinoma	12.2%
143	Carcinoma in Situ	12.2%
144	Carcinoma, Transitional Cell	12.2%
145	Phyllodes Tumor	12.2%
146	Dysgerminoma	12.2%
147	Hemangioendothelioma	12.2%
148	Lipoma	12.2%
149	Myoma	12.2%
150	Myxoma	12.2%
151	Neuroma	12.2%
152	Papilloma	12.2%
153	Pseudomyxoma Peritonei	12.2%
154	Seminoma	12.2%
155	Papillomatosis	12.2%
156	Angiolipoma	12.2%
157	Myelolipoma	12.2%
158	Neoplasms, Bone Tissue	12.2%
159	Neoplasms, Fibrous Tissue	12.2%
160	Smooth Muscle Tumor	12.2%
161	Adenomatosis, Pulmonary	12.2%
162	Adenomatous Polyps	12.2%
163	Carcinoma, Large Cell	12.2%
164	Carcinoma, Small Cell	12.2%
165	Desmoplastic Small Round Cell Tumor	12.2%
166	Chondroma	12.2%
167	Enchondroma	12.2%
168	Lymphoma, T-Cell, Cutaneous	11.1%
169	Lymphoma, AIDS-Related	11.1%
170	Enteropathy-Associated T-Cell Lymphoma	11.1%
171	Primary Effusion Lymphoma	11.1%
172	Acoustic Neuroma	11%
173	Neoplasms, Radiation-Induced	10.9%
174	Nephroblastoma	10.7%
175	Basal Cell Nevus Syndrome	10.6%
176	Carcinoma, Pancreatic Ductal	10.6%
177	Paraneoplastic Encephalomyelitis	10.1%
178	Optic Nerve Glioma	10%
179	Paraproteinemias	10%
180	Mammary Neoplasms, Experimental	9.9%
181	Mastocytosis	9.9%
182	Infectious Mononucleosis	9.9%
183	Mycosis Fungoides	9.8%
184	Lymphomatoid Papulosis	9.8%
185	Plasmablastic lymphoma	9.8%
186	Leukemia, Plasma Cell	9.8%
187	Adenoid Cystic Carcinoma	9.7%
188	fibroma	9.7%
189	Fibromatosis	9.7%
190	Osteoblastoma	9.7%
191	Osteoma	9.7%
192	Rhabdomyoma	9.7%
193	Chondromatosis	9.7%
194	Adenocarcinoma, Clear Cell	9.7%
195	Cholangiocarcinoma	9.7%
196	Cervical Intraepithelial Neoplasia	9.7%
197	Hemangioblastoma	9.7%
198	Lymphoma, Extranodal NK-T-Cell	9.7%
199	Hepatocellular Adenoma	9.3%
200	Vipoma	9.3%
201	Tuberous Sclerosis	9.3%
202	Abdominal Neoplasms	9.2%
203	Erythroplasia	9.2%
204	Follicular cyst	9.2%
205	Head and Neck Neoplasms	9.2%
206	Mucocele	9.2%
207	Pilonidal Cyst	9.2%
208	Soft Tissue Neoplasms	9.2%
209	Thoracic Neoplasms	9.2%
210	Thyroglossal Cyst	9.2%
211	Synovial Cyst	9.2%
212	Aberrant Crypt Foci	9.2%
213	Hydatidiform Mole	9.1%
214	Mastocytosis, Systemic	9.1%
215	Mesoblastic Nephroma	9%
216	Fibromatosis, Aggressive	8.5%
217	Fibromatosis, Abdominal	8.5%
218	Klatskin Tumor	8.5%
219	Hypergammaglobulinemia	8.4%
220	Monoclonal Gammopathy of Undetermined Significance	8.4%
221	Burkitt Lymphoma	8.4%
222	Sturge-Weber Syndrome	8.3%
223	Gastrointestinal Stromal Tumors	8.2%
224	Hemangioma, Cavernous	8.2%
225	Prolactinoma	8.1%
226	Growth Hormone-Secreting Pituitary Adenoma	8.1%
227	neurofibroma	8.1%
228	Mastocytoma	7.8%
229	Multiple Endocrine Neoplasia Type 1	7.8%
230	Autoimmune Diseases	7.8%
231	Hypersensitivity	7.8%
232	Immunologic Deficiency Syndromes	7.8%
233	Immune reconstitution syndrome	7.8%
234	Immune Reconstitution Inflammatory Syndrome	7.8%
235	Multiple Myeloma	7.7%
236	Digestive System Neoplasms	7.6%
237	Endocrine Gland Neoplasms	7.6%
238	Eye Neoplasms	7.6%
239	Nervous System Neoplasms	7.6%
240	Bone neoplasms	7.4%
241	Leukoplakia	7.4%
242	Lymphocele	7.4%
243	Pancreatic Cyst	7.4%
244	Skin Neoplasms	7.4%
245	Hematologic Neoplasms	7.4%
246	Barrett Esophagus	7.3%
247	Breast Cyst	7.3%
248	Actinic keratosis	7.3%
249	Mediastinal Cyst	7.3%
250	Neoplasm Invasiveness	7.3%
251	Neoplasm Metastasis	7.3%
252	Neoplasm Recurrence, Local	7.3%
253	Parovarian Cyst	7.3%
254	Pericardial Cyst	7.3%
255	Splenic Neoplasms	7.3%
256	Thymic Cyst	7.3%
257	Carcinogenesis	7.3%
258	Myxoid cyst	7.3%
259	Metastasis	7.3%
260	granulosa cell tumor	7.2%
261	Carcinoma, Ovarian Epithelial	7.2%
262	Adenomatous Polyposis Coli	7.2%
263	insulinoma	7.2%
264	Parathyroid Neoplasms	6.7%
265	Peritoneal Neoplasms	6.7%
266	Thyroid Neoplasm	6.7%
267	Thyroid carcinoma	6.7%
268	Gastrinoma	6.6%
269	Glucagonoma	6.6%
270	Liver Neoplasms, Experimental	6.6%
271	Adrenocortical carcinoma	6.5%
272	Transfusion Reaction	6.2%
273	Hypotensive Transfusion Reaction	6.2%
274	Leydig Cell Tumor	6.2%
275	Corpus Luteum Cyst	6.1%
276	Ovarian Cysts	6.1%
277	Nasopharyngeal carcinoma	6%
278	Pancreatic Neoplasm	5.9%
279	Dupuytren Contracture	5.8%
280	Tracheal Neoplasms	5.7%
281	Retroperitoneal Neoplasms	5.7%
282	Renal Cell Carcinoma	5.7%
283	Papillary Renal Cell Carcinoma	5.7%
284	Urticaria Pigmentosa	5.7%
285	Leukoplakia, Oral	5.6%
286	Paraneoplastic Cerebellar Degeneration	5.6%
287	Lambert-Eaton Myasthenic Syndrome	5.5%
288	Carcinoma, Endometrioid	5.5%
289	Denys-Drash Syndrome	5.5%
290	Choledochal Cyst	5.3%
291	Peutz-Jeghers Syndrome	5.2%
292	Glomerulonephritis, Membranoproliferative	5%
293	Esophageal Neoplasms	4.9%
294	Heavy Chain Disease	4.9%
295	Limbic Encephalitis	4.9%
296	Schnitzler Syndrome	4.9%
297	Thyroid Nodule	4.7%
298	Mouth Neoplasms	4.7%
299	Central Nervous System Neoplasms	4.7%
300	Vascular Neoplasms	4.7%
301	Thymus Neoplasms	4.7%
302	Genital Neoplasms, Female	4.6%
303	Pancreatic Pseudocyst	4.6%
304	Lymphatic Metastasis	4.6%
305	Neoplasms, Unknown Primary	4.6%
306	Leukemic Infiltration	4.6%
307	Breast Neoplasms, Male	4.6%
308	Neoplasm Micrometastasis	4.6%
309	Triple Negative Breast Neoplasms	4.6%
310	Testicular Neoplasms	4.4%
311	Cryoglobulinemia	4.2%
312	POEMS Syndrome	4.2%
313	Immune Complex Diseases	4.2%
314	Myelitis, Transverse	4.2%
315	Antiphospholipid Syndrome	4.2%
316	Latex allergy	4.2%
317	Opsoclonus-Myoclonus Syndrome	4%
318	Adrenal Gland Neoplasms	3.9%
319	Gastrointestinal Neoplasms	3.9%
320	Genital Neoplasms, Male	3.9%
321	Liver neoplasms	3.9%
322	Uveal Neoplasms	3.9%
323	Urologic Neoplasms	3.9%
324	Sebaceous Gland Neoplasms	3.8%
325	Spinal Neoplasms	3.8%
326	Bone Marrow Neoplasms	3.8%
327	Polycystic Ovary Syndrome	3.8%
328	Thrombocytopenic purpura	3.7%
329	Environmental Illness	3.5%
330	Lupus Erythematosus, Systemic	3.4%
331	Overlap syndrome	3.4%
332	Nose Neoplasms	3.4%
333	Addison Disease	3.3%
334	Pemphigus	3.3%
335	Xeroderma Pigmentosum	3.3%
336	Autoimmune thyroiditis	3.3%
337	Primary Adrenal Insufficiency	3.3%
338	Lymphopenia	3.3%
339	Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis	3.3%
340	Autoimmune hepatitis	3.3%
341	Autoimmune thrombocytopenia	3.3%
342	Immune thrombocytopenic purpura	3.3%
343	Meningeal Neoplasms	3.3%
344	Palatal Neoplasms	3.3%
345	Pituitary Adenoma	3%
346	Pituitary Neoplasms	3%
347	ovarian neoplasm	2.9%
348	Ear Neoplasms	2.8%
349	Eyelid Neoplasms	2.8%
350	Lung Neoplasms	2.8%
351	Pleural Neoplasms	2.8%
352	Latent Autoimmune Diabetes in Adults	2.8%
353	Agammaglobulinemia	2.8%
354	Dermatitis Herpetiformis	2.8%
355	Kounis Syndrome	2.8%
356	HIV Infections	2.8%
357	Transfusion-Related Acute Lung Injury	2.8%
358	Cell Transformation, Viral	2.7%
359	Brain Neoplasms	2.7%
360	Salivary Gland Neoplasms	2.7%
361	Spinal Cord Neoplasms	2.7%
362	Tongue Neoplasms	2.7%
363	Uterine Neoplasms	2.7%
364	Vaginal Neoplasms	2.7%
365	Vulvar Neoplasms	2.7%
366	Uterine Cancer	2.7%
367	Fallopian Tube Neoplasms	2.7%
368	Meningeal Carcinomatosis	2.6%
369	Asthma, Aspirin-Induced	2.5%
370	anaphylaxis	2.5%
371	Food Allergy	2.5%
372	Anaphylactic shock	2.5%
373	Pharyngeal Neoplasms	2.4%
374	Rheumatoid Arthritis	2.4%
375	Juvenile arthritis	2.4%
376	Graves Disease	2.4%
377	Central Nervous System Cysts	2.4%
378	Bile Duct Neoplasms	2.3%
379	gallbladder neoplasm	2.3%
380	Intestinal Neoplasms	2.3%
381	Penile Neoplasms	2.3%
382	Prostatic Neoplasms	2.3%
383	Stomach Neoplasms	2.3%
384	Anti-Glomerular Basement Membrane Disease	2.3%
385	Serum Sickness	2.3%
386	Polycythemia Vera	2.3%
387	Zollinger-Ellison syndrome	2.3%
388	Bronchial Neoplasms	2.2%
389	Multiple Pulmonary Nodules	2.2%
390	Supratentorial Neoplasms	2.2%
391	Endometrial Neoplasms	2.1%
392	Laryngeal neoplasm	2.1%
393	Respiratory Hypersensitivity	2.1%
394	Bladder Neoplasm	2%
395	Kidney Neoplasm	2%
396	Ureteral Neoplasms	2%
397	Urethral Neoplasms	2%
398	Sick Building Syndrome	2%
399	Multiple Chemical Sensitivity	2%
400	Urticaria	2%
401	Vasculitis, Leukocytoclastic, Cutaneous	2%
402	HTLV-I Infections	2%
403	Job Syndrome	2%
404	Brain Stem Neoplasms	1.9%
405	Hypopharyngeal Neoplasms	1.9%
406	Pleural Effusion, Malignant	1.9%
407	Hypopharyngeal Cancer	1.9%
408	Parotid Neoplasms	1.8%
409	Prostatic Neoplasms, Castration-Resistant	1.8%
410	Kernicterus	1.8%
411	Nelson Syndrome	1.8%
412	Choroid Plexus Papilloma	1.7%
413	Ataxia Telangiectasia	1.7%
414	Myasthenia Gravis	1.7%
415	Uveomeningoencephalitic Syndrome	1.7%
416	Drug Eruptions	1.6%
417	Hydrops Fetalis	1.6%
418	Chronic granulomatous disease	1.6%
419	Granulomatosis with polyangiitis	1.6%
420	Dermatitis, Allergic Contact	1.6%
421	HIV Seropositivity	1.6%
422	Milk Allergy	1.6%
423	Wheat Hypersensitivity	1.6%
424	Cecal Neoplasms	1.6%
425	Duodenal Neoplasms	1.6%
426	Tonsillar Neoplasms	1.6%
427	Cerebellar Neoplasms	1.6%
428	Nasopharyngeal Neoplasms	1.5%
429	Myasthenia Gravis, Autoimmune, Experimental	1.4%
430	Stiff-Person Syndrome	1.4%
431	Colorectal Neoplasms	1.4%
432	Polyradiculoneuropathy	1.4%
433	Polyradiculoneuritis	1.4%
434	Radicular Cyst	1.4%
435	Acquired Immunodeficiency Syndrome	1.4%
436	AIDS related complex	1.4%
437	Felty Syndrome	1.4%
438	Appendiceal Neoplasms	1.4%
439	Colonic Neoplasms	1.4%
440	Rectal Neoplasms	1.4%
441	Lupus Nephritis	1.4%
442	Paranasal Sinus Neoplasms	1.3%
443	AIDS-Related Opportunistic Infections	1.3%
444	Vasculitis, Central Nervous System	1.2%
445	Dermatitis, Atopic	1.2%
446	HIV Wasting Syndrome	1.2%
447	Rheumatoid Vasculitis	1.2%
448	AIDS Dementia Complex	1.2%
449	AIDS-Associated Nephropathy	1.2%
450	Lupus Vasculitis, Central Nervous System	1.2%
451	Anus Neoplasms	1.2%
452	Sigmoid Neoplasms	1.2%
453	Maxillary Sinus Neoplasms	1.1%
454	Angioedema	1.1%
455	Multiple Sclerosis	1.1%
456	Wiskott-Aldrich Syndrome	1.1%
457	Sicca Syndrome	1.1%
458	Sjogren's Syndrome	1.1%
459	Acute Generalized Exanthematous Pustulosis	1.1%
460	HIV-Associated Lipodystrophy Syndrome	1.1%
461	Neuromyelitis Optica	1%
462	Leukoencephalitis, Acute Hemorrhagic	1%
463	Asthma	1%
464	Encephalomyelitis, Acute Disseminated	0.9%
465	Polyradiculoneuropathy, Chronic Inflammatory Demyelinating	0.9%
466	Erythema Nodosum	0.9%
467	Neuritis, Autoimmune, Experimental	0.9%
468	Dermatitis, Photoallergic	0.9%
469	Aspergillosis, Allergic Bronchopulmonary	0.8%
470	Guillain-Barre Syndrome	0.8%
471	Asthma, Exercise-Induced	0.8%
472	Status Asthmaticus	0.8%
473	Multiple Sclerosis, Chronic Progressive	0.8%
474	Multiple Sclerosis, Relapsing-Remitting	0.8%
475	Asthma, Occupational	0.7%
476	Toxic Epidermal Necrolysis	0.7%
477	Stevens-Johnson Syndrome	0.7%
478	Farmer's Lung	0.7%
479	Angioedemas, Hereditary	0.7%
480	Hay fever	0.7%
481	Rhinitis, Allergic, Perennial	0.7%
482	Hereditary Angioedema Type III	0.7%
483	Hereditary Angioedema Types I and II	0.7%
484	Giant Cell Arteritis	0.7%
485	Temporal Arteritis	0.7%
486	Miller Fisher Syndrome	0.4%

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