MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leg Ulcer

(UMLS:C0023223)

Definition:: Ulceration of the skin and underlying structures of the lower extremity. About 90% of the cases are due to venous insufficiency (VARICOSE ULCER), 5% to arterial disease, and the remaining 5% to other causes.
UMLS ID:: C0023223
MeSH ID:: D007871

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.893.592

Synonym(s)

Leg Ulcer

LOWER EXTREMITY ULCER

Leg ulcer

Leg(s) Ulcer(s)

Leg--Ulcers

Lower Extremity Ulcer

Ulcer of leg, NOS

Ulcer of lower extremity

Ulcer of lower limb

10.

Ulcer;leg

11.

leg ulcer

12.

leg ulcers

13.

lower extremity ulcer

14.

lower limb; ulcer

15.

ulcer of lower extremities

16.

ulcer; lower limb

17.

ulcers of lower extremities

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,4-3,6-dianhydromannitol		SIDER
2	Capecitabine		SIDER
3	Diltiazem	3139213	CTD
4	Gabapentin		SIDER
5	Hydroxyurea	View details 8547004 8678547 9095664 11722451 12924084 19889302	CTD SIDER
6	Lithium		SIDER
7	Pentoxifylline	3619234	CTD
8	isosorbide-5-mononitrate		SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Pressure Ulcer	46.7%
2	Pyoderma Gangrenosum	43.3%
3	Breast Diseases	31%
4	Dermatitis	31%
5	Exanthema	31%
6	Facial Dermatoses	31%
7	Hair Diseases	31%
8	Hand Dermatoses	31%
9	keratoacanthoma	31%
10	Keratosis	31%
11	Nail Diseases	31%
12	Photosensitivity Disorders	31%
13	Prurigo	31%
14	Pyoderma	31%
15	Rosacea	31%
16	Sebaceous Gland Diseases	31%
17	Skin Diseases, Vesiculobullous	31%
18	Sweat Gland Diseases	31%
19	Skin Diseases, Papulosquamous	31%
20	Skin Diseases, Vascular	31%
21	Acneiform Eruptions	31%
22	Ocular Rosacea	31%
23	Subcorneal pustular dermatosis	31%
24	Erythematotelangiectatic Rosacea	31%
25	Papulopustular Rosacea	31%
26	Chronic Actinic Dermatitis	31%
27	Lupus Erythematosus, Cutaneous	27.9%
28	Panniculitis	27.9%
29	Systemic Scleroderma	27.9%
30	Morphea	27.9%
31	Acne Vulgaris	26.7%
32	Contact Dermatitis	26.7%
33	Eczema	26.7%
34	Erythema Multiforme	26.7%
35	Intertrigo	26.7%
36	Neurodermatitis	26.7%
37	Rhinophyma	26.7%
38	Perioral Dermatitis	26.7%
39	Acne	26.7%
40	Foot Diseases	22%
41	Dermatitis, Phototoxic	22%
42	Pityriasis Lichenoides et Varioliformis Acuta	22%
43	Pityriasis Lichenoides	22%
44	Phototoxicity	22%
45	Skin Abnormalities	20.9%
46	Skin Diseases, Infectious	20.9%
47	Skin Neoplasms	20.9%
48	Pigmentation Disorders	20.9%
49	Lipomatosis	20.5%
50	Pruritus	20.5%
51	Erythema	20.5%
52	Necrolytic Migratory Erythema	20.5%
53	Cutaneous Fistula	20.5%
54	Nephrogenic Fibrosing Dermopathy	20.5%
55	Nephrogenic Systemic Fibrosis	20.5%
56	Dermatitis Herpetiformis	20.3%
57	Acrodermatitis	20%
58	Anhidrosis	20%
59	Cholesteatoma	20%
60	Dermatitis, Atopic	20%
61	Epidermolysis Bullosa	20%
62	Folliculitis	20%
63	Foot Dermatoses	20%
64	Gynecomastia	20%
65	Hypertrichosis	20%
66	Hypohidrosis	20%
67	Hypotrichosis	20%
68	Miliaria	20%
69	Parakeratosis	20%
70	Parapsoriasis	20%
71	Pityriasis	20%
72	Psoriasis	20%
73	Sebaceous Gland Neoplasms	20%
74	Sweet Syndrome	20%
75	Hidradenitis	20%
76	Onycholysis	20%
77	Miliaria Rubra	20%
78	Hyperpigmentation	20%
79	Porokeratosis	20%
80	Lichenoid Eruptions	20%
81	Gianotti-Crosti Syndrome	20%
82	Chloracne	20%
83	Keratoderma, Palmoplantar	20%
84	Dermatitis, Irritant	19.6%
85	Acne Conglobata	19.6%
86	Connective Tissue Diseases	18.5%
87	Panniculitis, Lupus Erythematosus	18.4%
88	Xeroderma Pigmentosum	17.9%
89	Necrobiosis Lipoidica Diabeticorum	17.9%
90	Lupus Erythematosus, Discoid	17.8%
91	Scleroderma, Limited	17.8%
92	Dermatitis, Photoallergic	17.5%
93	Urticaria Pigmentosa	17.1%
94	Xeroderma	16.2%
95	Dermatomyositis	16.2%
96	Diaper Rash	16.1%
97	Dermatitis, Occupational	15.5%
98	Cutis Laxa	15.3%
99	Mastocytosis	15.1%
100	Lichen Planus	14.8%
101	Melanosis	14.8%
102	Chloasma	14.8%
103	Pityriasis Rosea	14.8%
104	Pityriasis Rubra Pilaris	14.8%
105	Vitiligo	14.8%
106	Dermatitis, Allergic Contact	14.8%
107	Lichen Nitidus	14.8%
108	Papillon-Lefevre Disease	14.6%
109	Erythema Induratum	14.4%
110	Erythema Infectiosum	14.1%
111	Exanthema Subitum	14%
112	Erythema Nodosum	13.7%
113	Acantholysis	13.6%
114	Breast Cyst	13.6%
115	Actinic keratosis	13.6%
116	Pemphigoid, Benign Mucous Membrane	13.6%
117	Pemphigus	13.6%
118	Piedra	13.6%
119	Sunburn	13.6%
120	Argyria	13.3%
121	Ectodermal Dysplasia	13.3%
122	Hirsutism	13.3%
123	Lactation Disorder	13.3%
124	Mastitis	13.3%
125	Urticaria	13.3%
126	Aplasia Cutis Congenita	13.3%
127	Adiposis Dolorosa	13.2%
128	Pruritus Vulvae	13.2%
129	Foot Ulcer	13.2%
130	Mastocytoma	13.1%
131	Pruritus Ani	13.1%
132	Tinea Capitis	12.7%
133	Onychomycosis	12.7%
134	Toxic Epidermal Necrolysis	12.6%
135	Stevens-Johnson Syndrome	12.6%
136	Pseudoxanthoma Elasticum	12.6%
137	Granuloma Annulare	12.4%
138	Acanthosis Nigricans	12.2%
139	Alopecia Areata	12.2%
140	Lentigo	12.2%
141	Ecthyma	11.5%
142	Hyperkeratosis, Epidermolytic	11%
143	Collagen Diseases	10.3%
144	Mixed Connective Tissue Disease	10.3%
145	Mucinoses	10.3%
146	Dermatomycoses	10.2%
147	Mucocutaneous Lymph Node Syndrome	10.2%
148	Skin Diseases, Bacterial	10.2%
149	Alopecia	10.1%
150	Sweating, Gustatory	10.1%
151	Androgenetic Alopecia	10.1%
152	Auriculotemporal Syndrome	10.1%
153	Drug Eruptions	10%
154	Lipodystrophy	10%
155	Livedo Reticularis	10%
156	Malignant Atrophic Papulosis	10%
157	Behcet Syndrome	10%
158	Lice Infestations	9.9%
159	Breast Neoplasms, Male	9.9%
160	Triple Negative Breast Neoplasms	9.9%
161	Polyarteritis Nodosa	9.8%
162	Takayasu Arteritis	9.8%
163	Ichthyosis, X-Linked	9.8%
164	Hidradenitis Suppurativa	9.8%
165	Galactorrhea	9.8%
166	Sjogren-Larsson Syndrome	9.8%
167	Tinea Pedis	8.9%
168	Albinism	8.7%
169	Erythema Chronicum Migrans	8.5%
170	Lichen Planus, Oral	8.4%
171	Nail-Patella Syndrome	8.2%
172	Porphyrias, Hepatic	8.1%
173	Larva Migrans	7.6%
174	Leishmaniasis	7.6%
175	Molluscum Contagiosum	7.6%
176	Angioedema	7.5%
177	Onchocerciasis	7.5%
178	Chromoblastomycosis	7.4%
179	Dermatophytosis	7.4%
180	Sporotrichosis	7.4%
181	Tinea	7.4%
182	Tinea Versicolor	7.4%
183	Trichophytosis	7.4%
184	Hyalohyphomycosis	7.4%
185	Mycetoma	7.3%
186	Cartilage Diseases	7.3%
187	Rheumatism	7.3%
188	Chondromalacia	7.3%
189	Acute Generalized Exanthematous Pustulosis	7.3%
190	Lupus Erythematosus, Systemic	7%
191	Overlap syndrome	7%
192	Scleromyxedema	6.7%
193	Leishmaniasis, Cutaneous	6.1%
194	Eczema Herpeticum	6.1%
195	Warts	6.1%
196	Fusariosis	6%
197	Candidiasis, Chronic Mucocutaneous	5.9%
198	Cutaneous Candidiasis	5.9%
199	Erysipelas	5.9%
200	Serum Sickness	5.9%
201	Staphylococcal Skin Infections	5.9%
202	Variegate Porphyria	5.9%
203	Acute intermittent porphyria	5.9%
204	Porphyria Cutanea Tarda	5.9%
205	Erythrasma	5.9%
206	Carcinoma, Lobular	5.9%
207	Arthritis, Psoriatic	5.8%
208	CREST Syndrome	5.6%
209	Hereditary Angioedema Type III	5.4%
210	Hereditary Angioedema Types I and II	5.4%
211	Dupuytren Contracture	5%
212	Angioedemas, Hereditary	5%
213	Epidermodysplasia Verruciformis	4.9%
214	Herpes Labialis	4.9%
215	Giant Cell Arteritis	4.9%
216	Temporal Arteritis	4.9%
217	Staphylococcal Scalded Skin Syndrome	4.8%
218	Mesenteric Panniculitis	4.5%
219	Panniculitis, Peritoneal	4.5%
220	Tietze's Syndrome	4.5%
221	Orbital Cellulitis	4.5%
222	Myxoid cyst	4.5%
223	Peutz-Jeghers Syndrome	4.5%
224	Myxedema	4.4%
225	carbuncle	4.3%
226	Blastomycosis	4.2%
227	HIV-Associated Lipodystrophy Syndrome	4.2%
228	Condylomata Acuminata	4.1%
229	Furunculosis	4.1%
230	furuncle	4.1%
231	Cellulitis	4%
232	Impetigo	4%
233	Rhinoscleroma	3.8%
234	Menkes Kinky Hair Syndrome	3.5%
235	Osteochondritis	3.4%
236	Polymyalgia Rheumatica	3.4%
237	Osteogenesis Imperfecta	3.4%
238	Keloid	3.3%
239	Noonan Syndrome	2.9%
240	Rheumatoid Arthritis	2.7%
241	Juvenile arthritis	2.7%
242	Lupus Nephritis	2.6%
243	Marfan Syndrome	2.5%
244	Rheumatoid Nodule	2.5%
245	Homocystinuria	2.4%
246	Laryngomalacia	2.3%
247	Pectus carinatum	2.3%
248	Felty Syndrome	2%
249	Bronchomalacia	2%
250	Tracheomalacia	2%
251	Rheumatoid Vasculitis	1.6%
252	Mucopolysaccharidosis III	1.6%
253	Sicca Syndrome	1.4%
254	Sjogren's Syndrome	1.4%
255	Lupus Vasculitis, Central Nervous System	1.1%
256	Mucopolysaccharidosis II	1.1%

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