MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

lymphangiosarcoma

(UMLS:C0024224)

Definition:: A malignant tumor originating from the endothelial cells of lymphatic vessels. Most lymphangiosarcomas arise in an arm secondary to radical mastectomy but they sometimes complicate idiopathic lymphedema. The lymphedema has usually been present for 6 to 10 years before malignant changes develop. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p1866)
UMLS ID:: C0024224
MeSH ID:: D008204

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.375.480|C04.557.450.795.480

Synonym(s)

lymphangiosarcoma

LYMPHANGIOSARCOMA, MALIGNANT

Lymphangioendothelial Sarcoma

Lymphangioendothelial sarcoma

Lymphangioendothelioma, malignant

Lymphangiosarcoma

Malignant Lymphangioendothelioma

Malignant lymphangioendothelioma

lymphangioendothelial; sarcoma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Sirolimus	FAERS: 4		US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrosarcoma	50.4%
2	leiomyosarcoma	50.4%
3	liposarcoma	50.4%
4	synovial sarcoma	50.4%
5	Clear Cell Sarcoma of Soft Tissue	50.4%
6	Alveolar Soft Part Sarcoma	50.4%
7	Carcinosarcoma	49.2%
8	Hemangiosarcoma	49.2%
9	Fibrosarcoma	46.2%
10	Osteosarcoma	46.2%
11	Malignant Fibrous Histiocytoma	44%
12	Sarcoma, Myeloid	43.9%
13	Phyllodes Tumor	42.4%
14	Desmoplastic Small Round Cell Tumor	42.4%
15	Lymphangioma	40.7%
16	Rhabdomyosarcoma	38.7%
17	Angiomyolipoma	37.4%
18	leukemia	37.1%
19	Neoplasms, Germ Cell and Embryonal	37.1%
20	Neoplasms, Glandular and Epithelial	37.1%
21	Germ Cell Cancer	37.1%
22	Carcinoma 256, Walker	37%
23	Dermatofibrosarcoma	36.6%
24	Dermatofibrosarcoma Protuberans	36.6%
25	Neuroectodermal Tumors	34.7%
26	Neoplasms, Neuroepithelial	33.3%
27	Gliomatosis cerebri	33.3%
28	Sarcoma, Experimental	33.1%
29	Alveolar rhabdomyosarcoma	32.9%
30	Sarcoma 180	30.2%
31	melanoma	29.2%
32	Giant Cell Tumor of Bone	29%
33	Histiocytic Disorders, Malignant	27.7%
34	Endometrial Stromal Sarcoma	27.4%
35	Lymphangioleiomyomatosis	27%
36	Medulloblastoma	26.3%
37	Neurofibrosarcoma	26.3%
38	Adenoma, Acidophil	25.2%
39	Ganglioneuroma	25.2%
40	Glioma	25.2%
41	Malignant Glioma	25.2%
42	Meningioma	25.1%
43	Lipoma	25%
44	Myoma	25%
45	Myxoma	25%
46	Angiolipoma	25%
47	Myelolipoma	25%
48	Neoplasms, Bone Tissue	25%
49	Neoplasms, Fibrous Tissue	25%
50	Smooth Muscle Tumor	25%
51	Chondroma	25%
52	Enchondroma	25%
53	Adenofibroma	24.6%
54	Fibroadenoma	24.6%
55	Basal cell carcinoma	24.4%
56	Carcinoma, Papillary	24.4%
57	Squamous cell carcinoma	24.4%
58	Craniopharyngioma	24.4%
59	Cystadenoma	24.4%
60	Mesothelioma	24.4%
61	Neuroectodermal Tumor, Melanotic	24.4%
62	Neuroendocrine Tumors	24.4%
63	Carcinoma, Basal Cell	24.4%
64	Leukemia, Plasma Cell	23.5%
65	Carcinoid Tumor	23.2%
66	Neurilemmoma	23.2%
67	Hutchinson's Melanotic Freckle	23.2%
68	Melanoma, Amelanotic	23.2%
69	Adenoma	23.1%
70	Ameloblastoma	23.1%
71	Angiokeratoma	23.1%
72	Carcinoma	23.1%
73	Chordoma	23.1%
74	Hemangioma	23.1%
75	hemangiopericytoma	23.1%
76	Mesenchymoma	23.1%
77	Nevus	23.1%
78	Teratoma	23.1%
79	Hepatoblastoma	23.1%
80	Mixed Tumor, Mullerian	23.1%
81	Germinoma	23.1%
82	Teratocarcinoma	23.1%
83	Angiofibroma	23.1%
84	Epithelioma	23.1%
85	Composite Lymphoma	23%
86	Hamartoma	22.4%
87	Neoplasms, Hormone-Dependent	22.4%
88	Neoplasms, Multiple Primary	22.4%
89	Paraneoplastic Syndromes	22.4%
90	Precancerous Conditions	22.4%
91	Neoplasms, Second Primary	22.4%
92	Lymphoma	22.1%
93	Melanoma, Experimental	21.9%
94	Cystadenocarcinoma	21.9%
95	Mucoepidermoid Carcinoma	21.9%
96	Carcinoma, Ehrlich Tumor	21.7%
97	Dermoid Cyst	21.7%
98	Carcinoma, Lewis Lung	21.7%
99	Trophoblastic Neoplasms	21.5%
100	Leukemia, Experimental	21.3%
101	Astrocytoma	21.2%
102	Ependymoma	21.2%
103	oligodendroglioma	21.2%
104	Ganglioglioma	21.2%
105	gliosarcoma	21.2%
106	Anaplastic astrocytoma	21.2%
107	Anaplastic Oligodendroglioma	21.2%
108	Malignant Carcinoid Syndrome	20.2%
109	fibroma	19.5%
110	Fibromatosis	19.5%
111	Osteoblastoma	19.5%
112	Osteoma	19.5%
113	Rhabdomyoma	19.5%
114	Chondromatosis	19.5%
115	Bowen's Disease	19.4%
116	Paraganglioma	19.4%
117	Glioblastoma	19.2%
118	Neuroblastoma	19.2%
119	Glioblastoma Multiforme	19.2%
120	Choriocarcinoma	18.4%
121	Carcinoma, Lobular	18.4%
122	Ganglioneuroblastoma	18.2%
123	Leukemia L1210	18%
124	Leukemia P388	18%
125	Acanthoma	18%
126	Leukemia, Radiation-Induced	18%
127	Plasmacytoma	17.4%
128	Malignant histiocytosis	17.2%
129	Histiocytic sarcoma	17.2%
130	Thymoma	17.1%
131	Pheochromocytoma	16.9%
132	Cyst	16.8%
133	Neoplastic Processes	16.8%
134	Neoplastic Syndromes, Hereditary	16.8%
135	Pregnancy Complications, Neoplastic	16.8%
136	Fibromatosis, Aggressive	16.7%
137	Fibromatosis, Abdominal	16.7%
138	Neoplasms, Experimental	16.5%
139	Adenocarcinoma	16.3%
140	Carcinoma in Situ	16.3%
141	Carcinoma, Transitional Cell	16.3%
142	Dysgerminoma	16.3%
143	Hemangioendothelioma	16.3%
144	Neuroma	16.3%
145	Papilloma	16.3%
146	Pseudomyxoma Peritonei	16.3%
147	Seminoma	16.3%
148	Papillomatosis	16.3%
149	Adenomatosis, Pulmonary	16.3%
150	Adenomatous Polyps	16.3%
151	Carcinoma, Large Cell	16.3%
152	Carcinoma, Small Cell	16.3%
153	Retinoblastoma	16.1%
154	Carcinoid Heart Disease	15.8%
155	Mastocytosis	15.3%
156	Gastrointestinal Stromal Tumors	15.1%
157	lymphangiosarcoma	14.8%
158	Mastocytoma	14.7%
159	Mastocytosis, Systemic	14.6%
160	Multiple Endocrine Neoplasia	14.1%
161	Hodgkin Disease	13.7%
162	Lymphoma, Non-Hodgkin	13.7%
163	Neoplasms, Radiation-Induced	13.2%
164	Sarcoma	13.2%
165	Adenoid Cystic Carcinoma	13%
166	Adenocarcinoma, Clear Cell	13%
167	Cholangiocarcinoma	13%
168	Cervical Intraepithelial Neoplasia	13%
169	Hemangioblastoma	13%
170	Lymphoma, Extranodal NK-T-Cell	13%
171	Lymphomatoid Granulomatosis	12.5%
172	Abdominal Neoplasms	12.4%
173	Erythroplasia	12.4%
174	Follicular cyst	12.4%
175	Head and Neck Neoplasms	12.4%
176	Mucocele	12.4%
177	Pilonidal Cyst	12.4%
178	Soft Tissue Neoplasms	12.4%
179	Thoracic Neoplasms	12.4%
180	Thyroglossal Cyst	12.4%
181	Synovial Cyst	12.4%
182	Aberrant Crypt Foci	12.4%
183	Paraneoplastic Encephalomyelitis	12.2%
184	Leukemia, Myelomonocytic, Chronic	12.2%
185	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	12.2%
186	Mammary Neoplasms, Experimental	12%
187	Acoustic Neuroma	12%
188	Nephroblastoma	11.8%
189	Carcinoma, Pancreatic Ductal	11.8%
190	Basal Cell Nevus Syndrome	11.6%
191	Primary amyloidosis	11.5%
192	Klatskin Tumor	11.3%
193	Hydatidiform Mole	11%
194	Hepatocellular Adenoma	10.9%
195	Optic Nerve Glioma	10.8%
196	Vipoma	10.3%
197	Dupuytren Contracture	10.3%
198	Tuberous Sclerosis	10.1%
199	Mesoblastic Nephroma	10.1%
200	Urticaria Pigmentosa	10.1%
201	Sturge-Weber Syndrome	10%
202	Hemangioma, Cavernous	9.8%
203	Leukemia, T-Cell	9.7%
204	Leukemia, B-Cell	9.7%
205	Digestive System Neoplasms	9.7%
206	Endocrine Gland Neoplasms	9.7%
207	Eye Neoplasms	9.7%
208	Nervous System Neoplasms	9.7%
209	neurofibroma	9.7%
210	Leukemia, Myeloid, Chronic-Phase	9.7%
211	Lymphoma, Follicular	9.7%
212	T-Cell Lymphoma	9.7%
213	Mantle cell lymphoma	9.7%
214	Bone neoplasms	9.4%
215	Leukoplakia	9.4%
216	Lymphocele	9.4%
217	Pancreatic Cyst	9.4%
218	Skin Neoplasms	9.4%
219	Hematologic Neoplasms	9.4%
220	Prolactinoma	9.3%
221	Growth Hormone-Secreting Pituitary Adenoma	9.3%
222	Barrett Esophagus	9.2%
223	Breast Cyst	9.2%
224	Actinic keratosis	9.2%
225	Mediastinal Cyst	9.2%
226	Neoplasm Invasiveness	9.2%
227	Neoplasm Metastasis	9.2%
228	Neoplasm Recurrence, Local	9.2%
229	Parovarian Cyst	9.2%
230	Pericardial Cyst	9.2%
231	Splenic Neoplasms	9.2%
232	Thymic Cyst	9.2%
233	Carcinogenesis	9.2%
234	Myxoid cyst	9.2%
235	Metastasis	9.2%
236	Multiple Endocrine Neoplasia Type 1	8.9%
237	Waldenstrom Macroglobulinemia	8.6%
238	Multiple Myeloma	8.6%
239	granulosa cell tumor	8.1%
240	Carcinoma, Ovarian Epithelial	8.1%
241	insulinoma	8%
242	Parathyroid Neoplasms	7.9%
243	Peritoneal Neoplasms	7.9%
244	Thyroid Neoplasm	7.9%
245	Thyroid carcinoma	7.9%
246	Adenomatous Polyposis Coli	7.8%
247	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
248	Leukemia, Large Granular Lymphocytic	7.7%
249	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
250	Retroperitoneal Neoplasms	7.7%
251	Lymphoma, T-Cell, Cutaneous	7.7%
252	Lymphoma, AIDS-Related	7.7%
253	Enteropathy-Associated T-Cell Lymphoma	7.7%
254	Primary Effusion Lymphoma	7.7%
255	Liver Neoplasms, Experimental	7.6%
256	Gastrinoma	7.4%
257	Glucagonoma	7.4%
258	Adrenocortical carcinoma	7.4%
259	Corpus Luteum Cyst	7.3%
260	Ovarian Cysts	7.3%
261	Leydig Cell Tumor	6.9%
262	Pancreatic Neoplasm	6.8%
263	Tracheal Neoplasms	6.7%
264	Mycosis Fungoides	6.7%
265	Lymphomatoid Papulosis	6.7%
266	Plasmablastic lymphoma	6.7%
267	Nasopharyngeal carcinoma	6.6%
268	Leukoplakia, Oral	6.6%
269	Paraneoplastic Cerebellar Degeneration	6.6%
270	Renal Cell Carcinoma	6.4%
271	Papillary Renal Cell Carcinoma	6.4%
272	Choledochal Cyst	6.2%
273	Carcinoma, Endometrioid	6.2%
274	Peutz-Jeghers Syndrome	6.1%
275	Mouth Neoplasms	5.9%
276	Central Nervous System Neoplasms	5.9%
277	Vascular Neoplasms	5.9%
278	Thymus Neoplasms	5.9%
279	Denys-Drash Syndrome	5.8%
280	Genital Neoplasms, Female	5.8%
281	Pancreatic Pseudocyst	5.8%
282	Lymphatic Metastasis	5.7%
283	Neoplasms, Unknown Primary	5.7%
284	Leukemic Infiltration	5.7%
285	Breast Neoplasms, Male	5.7%
286	Neoplasm Micrometastasis	5.7%
287	Triple Negative Breast Neoplasms	5.7%
288	Esophageal Neoplasms	5.7%
289	Limbic Encephalitis	5.6%
290	Burkitt Lymphoma	5.5%
291	Thyroid Nodule	5.5%
292	Lambert-Eaton Myasthenic Syndrome	5%
293	Testicular Neoplasms	5%
294	Sezary Syndrome	4.8%
295	Adrenal Gland Neoplasms	4.8%
296	Gastrointestinal Neoplasms	4.8%
297	Genital Neoplasms, Male	4.8%
298	Liver neoplasms	4.8%
299	Uveal Neoplasms	4.8%
300	Urologic Neoplasms	4.7%
301	Sebaceous Gland Neoplasms	4.6%
302	Spinal Neoplasms	4.6%
303	Bone Marrow Neoplasms	4.6%
304	Polycystic Ovary Syndrome	4.6%
305	Opsoclonus-Myoclonus Syndrome	4.4%
306	Meningeal Neoplasms	4.1%
307	Myelitis, Transverse	3.9%
308	Nose Neoplasms	3.8%
309	Xeroderma Pigmentosum	3.7%
310	Palatal Neoplasms	3.7%
311	Ear Neoplasms	3.4%
312	Eyelid Neoplasms	3.4%
313	Lung Neoplasms	3.4%
314	Pleural Neoplasms	3.4%
315	Pituitary Adenoma	3.4%
316	Pituitary Neoplasms	3.4%
317	ovarian neoplasm	3.3%
318	Cell Transformation, Viral	3.3%
319	Brain Neoplasms	3.3%
320	Salivary Gland Neoplasms	3.3%
321	Spinal Cord Neoplasms	3.3%
322	Tongue Neoplasms	3.3%
323	Uterine Neoplasms	3.2%
324	Vaginal Neoplasms	3.2%
325	Vulvar Neoplasms	3.2%
326	Uterine Cancer	3.2%
327	Meningeal Carcinomatosis	3.2%
328	Fallopian Tube Neoplasms	3.2%
329	Pharyngeal Neoplasms	2.8%
330	Central Nervous System Cysts	2.8%
331	Bile Duct Neoplasms	2.7%
332	gallbladder neoplasm	2.7%
333	Intestinal Neoplasms	2.7%
334	Penile Neoplasms	2.7%
335	Prostatic Neoplasms	2.7%
336	Stomach Neoplasms	2.7%
337	Polycythemia Vera	2.7%
338	Bronchial Neoplasms	2.7%
339	Multiple Pulmonary Nodules	2.6%
340	Supratentorial Neoplasms	2.6%
341	Endometrial Neoplasms	2.6%
342	Zollinger-Ellison syndrome	2.6%
343	Laryngeal neoplasm	2.5%
344	Bladder Neoplasm	2.3%
345	Kidney Neoplasm	2.3%
346	Ureteral Neoplasms	2.3%
347	Urethral Neoplasms	2.3%
348	Brain Stem Neoplasms	2.2%
349	Hypopharyngeal Neoplasms	2.2%
350	Pleural Effusion, Malignant	2.2%
351	Hypopharyngeal Cancer	2.2%
352	Parotid Neoplasms	2.2%
353	Prostatic Neoplasms, Castration-Resistant	2.2%
354	Nelson Syndrome	2.1%
355	Choroid Plexus Papilloma	2.1%
356	Tonsillar Neoplasms	1.9%
357	Cerebellar Neoplasms	1.9%
358	Cecal Neoplasms	1.8%
359	Duodenal Neoplasms	1.8%
360	Nasopharyngeal Neoplasms	1.6%
361	Colorectal Neoplasms	1.6%
362	Radicular Cyst	1.6%
363	Appendiceal Neoplasms	1.6%
364	Colonic Neoplasms	1.6%
365	Rectal Neoplasms	1.6%
366	Paranasal Sinus Neoplasms	1.5%
367	Anus Neoplasms	1.3%
368	Sigmoid Neoplasms	1.3%
369	Maxillary Sinus Neoplasms	1.3%

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