MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leishmaniasis

(UMLS:C0023281)

Definition:: A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).
UMLS ID:: C0023281
MeSH ID:: D007896

Classification 1:

Name:

Parasitic Diseases
MeSH Tree Number(s):: C03.752.300.500|C03.858.560

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.838.775.560

Synonym(s)

Leishmaniasis

Leishmania; infection

Leishmaniasis, unspecified

Leishmaniosis

infection; Leishmania

leishmania infection

leishmania infections

leishmaniases

leishmaniasis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methotrexate	FAERS: 6		OFFSIDES US FAERS
2	Bosentan	FAERS: 1		US FAERS
3	Interleukin 1 Receptor Antagonist Protein	FAERS: 1		US FAERS
4	Norgestrel	FAERS: 1		US FAERS
5	Sunitinib	FAERS: 1		US FAERS
6	liposomal amphotericin B	FAERS: 1	View details 7979623 11846524 17205440 20404924 21063981	CTD US FAERS
7	5,7-dihydroxy-8-(2-methylbutanoyl)-6-(3-methylbutyl)-4-phenyl-chroman-2-one		22285848	CTD
8	Amlodipine			OFFSIDES
9	Antimony		View details 10953559 12019027 15220340 21063981 21182181	CTD
10	Antimony Sodium Gluconate		View details 7945751 7960131 8059918 20139272	CTD
11	Arsenicals		15220340	CTD
12	Atovaquone		21809846	CTD
13	Doxycycline			OFFSIDES
14	Maytansine		10029309	CTD
15	Meglumine Antimoniate		View details 8192513 9225422 12019027 15381810 19911167 30599190	CTD
16	N,N'-diphenyl-4-methoxybenzamidine		29128607	CTD
17	Naproxen			OFFSIDES
18	Nelfinavir		20361030	CTD
19	Nitric Oxide		17218153	CTD
20	Pentamidine		15340016 21809846 29128607	CTD
21	Prednisone			OFFSIDES
22	Ramipril			OFFSIDES
23	Trifluralin		7492115	CTD
24	Zidovudine			OFFSIDES
25	balsalazide			OFFSIDES
26	fenarimol		18372651	CTD
27	marbofloxacin		16242844	CTD
28	miltefosine		17205440	CTD
29	tafenoquine		20837750	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Larva Migrans	39.3%
2	Onchocerciasis	37%
3	Lice Infestations	34.7%
4	Trypanosomiasis	28.6%
5	Protozoan Infections, Animal	23.1%
6	Giardiasis	22.7%
7	Cryptosporidiosis	22.4%
8	Amebiasis	22.2%
9	Coccidiosis	22.2%
10	Malaria	22.2%
11	Acanthamoeba Infection	22.2%
12	Trichomonas Infections	22.2%
13	Ciliophora Infections	22.2%
14	Balamuthia Infection	22.2%
15	Babesiosis	22%
16	African Trypanosomiasis	21.7%
17	Chagas Disease	21.7%
18	Helminthiasis	19.5%
19	Mite Infestations	18.5%
20	Myiasis	18.5%
21	Tick Infestations	18.5%
22	Helminthiasis, Animal	16.2%
23	Parasitic Diseases, Animal	16.1%
24	Liver Diseases, Parasitic	15.6%
25	Malaria, Cerebral	15.5%
26	Acanthamoeba Keratitis	15.5%
27	Intestinal Diseases, Parasitic	15.4%
28	Pregnancy Complications, Parasitic	15.4%
29	Parasitemia	15.2%
30	Entamoebiasis	15.1%
31	Malaria, Falciparum	15.1%
32	Malaria, Vivax	15.1%
33	Toxoplasmosis	15.1%
34	Isosporiasis	15.1%
35	Pyoderma Gangrenosum	15.1%
36	Hypodermyiasis	15%
37	Chagas Cardiomyopathy	14.6%
38	Lupus Erythematosus, Cutaneous	13.8%
39	Panniculitis	13.8%
40	Systemic Scleroderma	13.8%
41	Morphea	13.8%
42	Fascioliasis	13.6%
43	Liver Abscess, Amebic	13.4%
44	Opportunistic Infections	13.3%
45	Toxocariasis	12.8%
46	Breast Diseases	12.8%
47	Dermatitis	12.8%
48	Exanthema	12.8%
49	Facial Dermatoses	12.8%
50	Hair Diseases	12.8%
51	Hand Dermatoses	12.8%
52	keratoacanthoma	12.8%
53	Keratosis	12.8%
54	Nail Diseases	12.8%
55	Photosensitivity Disorders	12.8%
56	Prurigo	12.8%
57	Pyoderma	12.8%
58	Rosacea	12.8%
59	Sebaceous Gland Diseases	12.8%
60	Skin Diseases, Vesiculobullous	12.8%
61	Skin Ulcer	12.8%
62	Sweat Gland Diseases	12.8%
63	Skin Diseases, Papulosquamous	12.8%
64	Skin Diseases, Vascular	12.8%
65	Acneiform Eruptions	12.8%
66	Ocular Rosacea	12.8%
67	Subcorneal pustular dermatosis	12.8%
68	Erythematotelangiectatic Rosacea	12.8%
69	Papulopustular Rosacea	12.8%
70	Chronic Actinic Dermatitis	12.8%
71	Dirofilariasis	12.6%
72	Echinococcosis, Hepatic	12.4%
73	Acne Vulgaris	12.1%
74	Contact Dermatitis	12.1%
75	Eczema	12.1%
76	Erythema Multiforme	12.1%
77	Intertrigo	12.1%
78	Neurodermatitis	12.1%
79	Rhinophyma	12.1%
80	Perioral Dermatitis	12.1%
81	Acne	12.1%
82	Cestode Infections	12%
83	Nematode infections	12%
84	Trematode Infections	12%
85	Trichomonas Vaginitis	12%
86	Dermatomycoses	11.9%
87	Skin Diseases, Bacterial	11.9%
88	Blackwater Fever	11.7%
89	Strongyle Infections, Equine	11.3%
90	Dermatitis, Atopic	11.3%
91	Epidermolysis Bullosa	11.3%
92	Erythema Infectiosum	11.1%
93	Xeroderma Pigmentosum	11%
94	Exanthema Subitum	11%
95	Foot Diseases	10.6%
96	Protozoan Infections	10.6%
97	Skin Abnormalities	10.3%
98	Skin Neoplasms	10.3%
99	Pigmentation Disorders	10.3%
100	Erythema Induratum	10.3%
101	Lipomatosis	10.2%
102	Pruritus	10.2%
103	Erythema	10.2%
104	Necrolytic Migratory Erythema	10.2%
105	Cutaneous Fistula	10.2%
106	Nephrogenic Fibrosing Dermopathy	10.2%
107	Nephrogenic Systemic Fibrosis	10.2%
108	Dermatitis Herpetiformis	10.2%
109	Acrodermatitis	10.1%
110	Sebaceous Gland Neoplasms	10.1%
111	Porokeratosis	10.1%
112	Gianotti-Crosti Syndrome	10.1%
113	Keratoderma, Palmoplantar	10.1%
114	Foot Ulcer	10%
115	Dermatitis, Phototoxic	9.9%
116	Pityriasis Lichenoides et Varioliformis Acuta	9.9%
117	Pityriasis Lichenoides	9.9%
118	Phototoxicity	9.9%
119	Dermatomyositis	9.6%
120	Necrobiosis Lipoidica Diabeticorum	9.5%
121	Ecthyma	9.5%
122	Panniculitis, Lupus Erythematosus	9.5%
123	Neurocysticercosis	9.3%
124	Mycetoma	9.2%
125	Tinea Capitis	9.2%
126	Onychomycosis	9.2%
127	Xeroderma	8.7%
128	Dermatitis, Photoallergic	8.5%
129	Mastocytosis	8.4%
130	Diphyllobothriasis	8.4%
131	Echinococcosis	8.4%
132	Hymenolepiasis	8.4%
133	Opisthorchiasis	8.4%
134	Schistosomiasis	8.4%
135	Secernentea Infections	8.4%
136	Hidradenitis Suppurativa	8.3%
137	Urticaria Pigmentosa	8.3%
138	Lupus Erythematosus, Discoid	8.1%
139	Scleroderma, Limited	8.1%
140	Superinfection	8%
141	Connective Tissue Diseases	8%
142	Dermatitis, Irritant	7.9%
143	Acne Conglobata	7.9%
144	Cutis Laxa	7.9%
145	Toxoplasmosis, Cerebral	7.9%
146	Molluscum Contagiosum	7.9%
147	Toxoplasmosis, Congenital	7.8%
148	Chromoblastomycosis	7.7%
149	Dermatophytosis	7.7%
150	Sporotrichosis	7.7%
151	Tinea	7.7%
152	Tinea Versicolor	7.7%
153	Trichophytosis	7.7%
154	Hyalohyphomycosis	7.7%
155	Pseudoxanthoma Elasticum	7.7%
156	Anhidrosis	7.6%
157	Cholesteatoma	7.6%
158	Pressure Ulcer	7.6%
159	Folliculitis	7.6%
160	Foot Dermatoses	7.6%
161	Gynecomastia	7.6%
162	Hypertrichosis	7.6%
163	Hypohidrosis	7.6%
164	Hypotrichosis	7.6%
165	Leg Ulcer	7.6%
166	Miliaria	7.6%
167	Parakeratosis	7.6%
168	Parapsoriasis	7.6%
169	Pityriasis	7.6%
170	Psoriasis	7.6%
171	Sweet Syndrome	7.6%
172	Hidradenitis	7.6%
173	Onycholysis	7.6%
174	Miliaria Rubra	7.6%
175	Hyperpigmentation	7.6%
176	Lichenoid Eruptions	7.6%
177	Chloracne	7.6%
178	Ectodermal Dysplasia	7.5%
179	Aplasia Cutis Congenita	7.5%
180	Erythema Chronicum Migrans	7.5%
181	Erythema Nodosum	7.1%
182	Dermatitis, Occupational	6.9%
183	Warts	6.8%
184	Leishmaniasis	6.7%
185	Tinea Pedis	6.7%
186	Cysticercosis	6.7%
187	Schistosomiasis japonica	6.7%
188	Schistosomiasis mansoni	6.7%
189	Sparganosis	6.7%
190	Ascaridida Infections	6.7%
191	Oxyurida Infections	6.7%
192	Candidiasis, Chronic Mucocutaneous	6.6%
193	Cutaneous Candidiasis	6.6%
194	Dermatitis, Allergic Contact	6.6%
195	Erysipelas	6.6%
196	Staphylococcal Skin Infections	6.6%
197	Papillon-Lefevre Disease	6.6%
198	Erythrasma	6.6%
199	Toxic Epidermal Necrolysis	6.6%
200	Stevens-Johnson Syndrome	6.6%
201	Acantholysis	6.1%
202	Breast Cyst	6.1%
203	Actinic keratosis	6.1%
204	Pemphigoid, Benign Mucous Membrane	6.1%
205	Pemphigus	6.1%
206	Piedra	6.1%
207	Sunburn	6.1%
208	Granuloma Annulare	6.1%
209	Argyria	6%
210	Hirsutism	6%
211	Lactation Disorder	6%
212	Mastitis	6%
213	Urticaria	6%
214	Adiposis Dolorosa	6%
215	Pruritus Vulvae	6%
216	Mastocytoma	6%
217	Pruritus Ani	6%
218	Diaper Rash	5.9%
219	AIDS-Related Opportunistic Infections	5.9%
220	Ascariasis	5.8%
221	Filariasis	5.8%
222	Gnathostomiasis	5.8%
223	Hookworm Infections	5.8%
224	Oxyuriasis	5.8%
225	Strongyloidiasis	5.8%
226	Trichinellosis	5.8%
227	Trichostrongyloidiasis	5.8%
228	Eczema Herpeticum	5.8%
229	Ichthyosis, X-Linked	5.8%
230	Sjogren-Larsson Syndrome	5.7%
231	Fusariosis	5.7%
232	Behcet Syndrome	5.6%
233	Hyperkeratosis, Epidermolytic	5.4%
234	Loiasis	5.4%
235	Enterobiasis	5.4%
236	Blastomycosis	5.2%
237	Mucocutaneous Lymph Node Syndrome	5.1%
238	Drug Eruptions	5%
239	Lipodystrophy	5%
240	Livedo Reticularis	5%
241	Malignant Atrophic Papulosis	5%
242	Albinism	5%
243	Lichen Planus	5%
244	Melanosis	5%
245	Chloasma	5%
246	Pityriasis Rosea	5%
247	Pityriasis Rubra Pilaris	5%
248	Vitiligo	5%
249	Lichen Nitidus	5%
250	Polyarteritis Nodosa	5%
251	Takayasu Arteritis	5%
252	Epidermodysplasia Verruciformis	5%
253	Herpes Labialis	5%
254	Leishmaniasis, Cutaneous	5%
255	Staphylococcal Scalded Skin Syndrome	4.9%
256	Rhinoscleroma	4.7%
257	Nail-Patella Syndrome	4.4%
258	Condylomata Acuminata	4.3%
259	Porphyrias, Hepatic	4.3%
260	Furunculosis	4.3%
261	furuncle	4.3%
262	Impetigo	4.3%
263	Collagen Diseases	4.3%
264	Mixed Connective Tissue Disease	4.3%
265	Mucinoses	4.3%
266	Leishmaniasis, Visceral	4.2%
267	carbuncle	4.1%
268	Alopecia	4.1%
269	Sweating, Gustatory	4.1%
270	Androgenetic Alopecia	4.1%
271	Auriculotemporal Syndrome	4.1%
272	Varicose Ulcer	4%
273	Breast Neoplasms, Male	4%
274	Triple Negative Breast Neoplasms	4%
275	Galactorrhea	4%
276	Acanthosis Nigricans	3.7%
277	Alopecia Areata	3.7%
278	Lentigo	3.7%
279	Cartilage Diseases	3.5%
280	Rheumatism	3.5%
281	Chondromalacia	3.5%
282	Lupus Erythematosus, Systemic	3.4%
283	Overlap syndrome	3.4%
284	Angioedema	3.4%
285	Acute Generalized Exanthematous Pustulosis	3.3%
286	Lichen Planus, Oral	3%
287	Giant Cell Arteritis	3%
288	Temporal Arteritis	3%
289	CREST Syndrome	2.9%
290	Serum Sickness	2.8%
291	Variegate Porphyria	2.8%
292	Acute intermittent porphyria	2.8%
293	Porphyria Cutanea Tarda	2.8%
294	Carcinoma, Lobular	2.8%
295	Arthritis, Psoriatic	2.8%
296	Dupuytren Contracture	2.8%
297	Scleromyxedema	2.5%
298	Cellulitis	2.4%
299	Menkes Kinky Hair Syndrome	2.3%
300	HIV-Associated Lipodystrophy Syndrome	2.2%
301	Angioedemas, Hereditary	2.1%
302	Diabetic Foot	2.1%
303	Hereditary Angioedema Type III	2%
304	Hereditary Angioedema Types I and II	2%
305	Mesenteric Panniculitis	2%
306	Panniculitis, Peritoneal	2%
307	Tietze's Syndrome	2%
308	Orbital Cellulitis	2%
309	Myxoid cyst	2%
310	Myxedema	2%
311	Noonan Syndrome	1.9%
312	Peutz-Jeghers Syndrome	1.8%
313	Osteochondritis	1.7%
314	Polymyalgia Rheumatica	1.7%
315	Marfan Syndrome	1.7%
316	Osteogenesis Imperfecta	1.7%
317	Keloid	1.7%
318	Homocystinuria	1.6%
319	Rheumatoid Arthritis	1.5%
320	Juvenile arthritis	1.5%
321	Lupus Nephritis	1.4%
322	Laryngomalacia	1.3%
323	Pectus carinatum	1.3%
324	Rheumatoid Nodule	1.1%
325	Felty Syndrome	0.9%
326	Bronchomalacia	0.9%
327	Tracheomalacia	0.9%
328	Rheumatoid Vasculitis	0.8%
329	Mucopolysaccharidosis III	0.8%
330	Sicca Syndrome	0.7%
331	Sjogren's Syndrome	0.7%
332	Lupus Vasculitis, Central Nervous System	0.7%
333	Mucopolysaccharidosis II	0.6%

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