MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acantholysis

(UMLS:C0000887)

Definition:: Separation of the prickle cells of the stratum spinosum of the epidermis, resulting in atrophy of the prickle cell layer. It is seen in diseases such as pemphigus vulgaris (see PEMPHIGUS) and DARIER DISEASE.
UMLS ID:: C0000887
MeSH ID:: D000051

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.865.070

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.035

Synonym(s)

Acantholysis

acantholysis

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Vemurafenib	FAERS: 4		US FAERS
2	Nifedipine	FAERS: 3		US FAERS
3	Carbamazepine	FAERS: 1		US FAERS
4	Cyclosporine	FAERS: 1		US FAERS
5	Enalapril	FAERS: 1		US FAERS
6	Imiquimod	FAERS: 1		US FAERS
7	Losartan	FAERS: 1		US FAERS
8	Methotrexate	FAERS: 1		US FAERS
9	Teriparatide	FAERS: 1		US FAERS
10	Valsartan	FAERS: 1		US FAERS
11	fludarabine	FAERS: 1		US FAERS
12	venetoclax	FAERS: 1		US FAERS
13	Acarbose			OFFSIDES
14	Acebutolol			OFFSIDES
15	Ampicillin			OFFSIDES
16	Capecitabine			OFFSIDES
17	Cefixime			OFFSIDES
18	Docetaxel			OFFSIDES
19	Letrozole			OFFSIDES
20	Lubiprostone			OFFSIDES
21	Nabumetone			OFFSIDES
22	Ribavirin			OFFSIDES
23	Rifaximin			OFFSIDES
24	Sodium Dodecyl Sulfate		17763283	CTD
25	Sodium picosulfate			OFFSIDES
26	Tretinoin		17763283	CTD
27	Vancomycin			OFFSIDES
28	lacidipine			OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Pigmentation Disorders	36.8%
2	Erythema Multiforme	33.9%
3	Nephrogenic Fibrosing Dermopathy	31%
4	Nephrogenic Systemic Fibrosis	31%
5	Infarction	30.5%
6	Postoperative Hemorrhage	30.5%
7	Shock, Hemorrhagic	30.5%
8	Systemic Inflammatory Response Syndrome	30.5%
9	Polydipsia	28.1%
10	Ascites	27.9%
11	Fibrosis	27.9%
12	Gliosis	27.9%
13	Growth Disorders	27.9%
14	Hemorrhage	27.9%
15	Hyperbilirubinemia	27.9%
16	Hyperplasia	27.9%
17	Hypomenorrhea	27.9%
18	Inflammation	27.9%
19	Intraoperative Complications	27.9%
20	Ischemia	27.9%
21	Lithiasis	27.9%
22	Malacoplakia	27.9%
23	Menstruation Disturbances	27.9%
24	Metaplasia	27.9%
25	Nerve Degeneration	27.9%
26	Ochronosis	27.9%
27	Polymenorrhea	27.9%
28	Postoperative Complications	27.9%
29	Sclerosis	27.9%
30	Shock	27.9%
31	Ulcer	27.9%
32	Hyperammonemia	27.9%
33	Hyperamylasemia	27.9%
34	Teratogenesis	27.9%
35	Cardiac Death	27.9%
36	Hypovolemia	27.9%
37	Hyperuricemia	27.9%
38	Leukoaraiosis	27.9%
39	Dysbacteriosis	27.9%
40	Delayed Graft Function	27.9%
41	Cirrhosis	27.9%
42	Neointima	27.9%
43	Dysbiosis	27.9%
44	Dermatitis Herpetiformis	27.4%
45	Epidermolysis Bullosa	25%
46	Sudden infant death syndrome	25%
47	Pyoderma Gangrenosum	24.3%
48	Pemphigoid, Benign Mucous Membrane	24.1%
49	Pemphigus	24.1%
50	Vascular Remodeling	22.5%
51	Granuloma Annulare	22.1%
52	Menorrhagia	21.9%
53	Extravasation of Diagnostic and Therapeutic Materials	21.8%
54	Neoplastic Processes	21.8%
55	Lupus Erythematosus, Cutaneous	21.1%
56	Necrosis	21.1%
57	Panniculitis	21.1%
58	Systemic Scleroderma	21.1%
59	Granulomatosis, Orofacial	21.1%
60	Morphea	21.1%
61	Respiratory Aspiration	21.1%
62	Breast Diseases	20.9%
63	Dermatitis	20.9%
64	Exanthema	20.9%
65	Facial Dermatoses	20.9%
66	Hair Diseases	20.9%
67	Hand Dermatoses	20.9%
68	keratoacanthoma	20.9%
69	Keratosis	20.9%
70	Nail Diseases	20.9%
71	Photosensitivity Disorders	20.9%
72	Prurigo	20.9%
73	Pyoderma	20.9%
74	Rosacea	20.9%
75	Sebaceous Gland Diseases	20.9%
76	Skin Ulcer	20.9%
77	Sweat Gland Diseases	20.9%
78	Skin Diseases, Papulosquamous	20.9%
79	Skin Diseases, Vascular	20.9%
80	Acneiform Eruptions	20.9%
81	Ocular Rosacea	20.9%
82	Erythematotelangiectatic Rosacea	20.9%
83	Papulopustular Rosacea	20.9%
84	Chronic Actinic Dermatitis	20.9%
85	Chromosome Aberrations	20.7%
86	Dehydration	20.7%
87	Granuloma	20.7%
88	Leukocytosis	20.7%
89	Pruritus	20.7%
90	Erythema	20.7%
91	Pleocytosis	20.7%
92	Necrolytic Migratory Erythema	20.7%
93	Cutaneous Fistula	20.7%
94	Acute Disease	20.5%
95	Acute-Phase Reaction	20.5%
96	Amenorrhea	20.5%
97	Chronic disease	20.5%
98	Critical Illness	20.5%
99	Sudden death	20.5%
100	Fat necrosis	20.5%
101	Gangrene	20.5%
102	Graft Occlusion, Vascular	20.5%
103	Granuloma, Plasma Cell	20.5%
104	Hematoma	20.5%
105	Iatrogenic Disease	20.5%
106	Multiple Organ Failure	20.5%
107	Oligomenorrhea	20.5%
108	Premenstrual syndrome	20.5%
109	Recurrence	20.5%
110	Retrograde Degeneration	20.5%
111	Retroperitoneal fibrosis	20.5%
112	Serositis	20.5%
113	Subcutaneous Emphysema	20.5%
114	Surgical Wound Dehiscence	20.5%
115	Syndrome	20.5%
116	Wallerian Degeneration	20.5%
117	Pyogenic granuloma	20.5%
118	Exsanguination	20.5%
119	Disease Progression	20.5%
120	Seroma	20.5%
121	Premenstrual Tension	20.5%
122	Delayed Emergence from Anesthesia	20.5%
123	Infant Death	20.5%
124	Anastomotic Leak	20.5%
125	Intraoperative Awareness	20.5%
126	Acne Vulgaris	20.3%
127	Contact Dermatitis	20.3%
128	Eczema	20.3%
129	Intertrigo	20.3%
130	Neurodermatitis	20.3%
131	Rhinophyma	20.3%
132	Perioral Dermatitis	20.3%
133	Incisional hernia	20.3%
134	Acne	20.3%
135	Chromosomal Instability	20.3%
136	jaundice	20.3%
137	Pain, Postoperative	19.3%
138	Endotoxic shock	18.9%
139	Septic Shock	18.9%
140	Toxic Shock Syndrome	18.9%
141	Dysmenorrhea	18.8%
142	Failed Back Surgery Syndrome	18.8%
143	Postoperative Nausea and Vomiting	18.7%
144	Dermatitis, Phototoxic	17.9%
145	Pityriasis Lichenoides et Varioliformis Acuta	17.9%
146	Pityriasis Lichenoides	17.9%
147	Phototoxicity	17.9%
148	Foot Ulcer	17.6%
149	Dermatitis, Atopic	17.3%
150	Genomic Instability	17.1%
151	Eye Hemorrhage	16.9%
152	Tissue Adhesions	16.9%
153	Hematoma, Epidural, Spinal	16.9%
154	Jaundice, Obstructive	16.7%
155	Muscle Weakness	16.6%
156	Chromosome Fragility	16.5%
157	Hemoptysis	16.4%
158	Foot Diseases	16.4%
159	Acrodermatitis	16.2%
160	Ecchymosis	16.2%
161	Petechiae	16.2%
162	Purpura	16.2%
163	Sebaceous Gland Neoplasms	16.2%
164	Xeroderma Pigmentosum	16.2%
165	Porokeratosis	16.2%
166	Gianotti-Crosti Syndrome	16.2%
167	Keratoderma, Palmoplantar	16.2%
168	Azotemia	16.2%
169	Asphyxia	16.1%
170	Granuloma, Respiratory Tract	16.1%
171	Shock, Traumatic	16.1%
172	Toxic Epidermal Necrolysis	16%
173	Stevens-Johnson Syndrome	16%
174	Skin Abnormalities	15.8%
175	Skin Diseases, Infectious	15.8%
176	Skin Neoplasms	15.8%
177	Panniculitis, Lupus Erythematosus	15.6%
178	Disease susceptibility	15.5%
179	Fetal Death	15.5%
180	Foreign-Body Reaction	15.5%
181	Gastrointestinal Hemorrhage	15.5%
182	Hemarthrosis	15.5%
183	Hemoperitoneum	15.5%
184	Hemothorax	15.5%
185	Lipomatosis	15.5%
186	Neoplasm Invasiveness	15.5%
187	Neoplasm Metastasis	15.5%
188	Neoplasm Recurrence, Local	15.5%
189	Postpericardiotomy Syndrome	15.5%
190	Prosthesis Failure	15.5%
191	Reperfusion Injury	15.5%
192	Injection Site Reaction	15.5%
193	Retrobulbar Hemorrhage	15.5%
194	Aseptic Necrosis of Bone	15.5%
195	Peritoneal Fibrosis	15.5%
196	Carcinogenesis	15.5%
197	Neurogenic Inflammation	15.5%
198	Perinatal death	15.5%
199	Infusion site reaction	15.5%
200	Corneal Endothelial Cell Loss	15.5%
201	Encapsulating Peritoneal Sclerosis	15.5%
202	Vasoplegia	15.5%
203	Suppuration	15.5%
204	Metastasis	15.5%
205	Sinus Arrhythmia	15.3%
206	Atrial Fibrillation	15.3%
207	Atrial Flutter	15.3%
208	Dental Pulp Necrosis	15.3%
209	Granuloma, Foreign-Body	15.3%
210	Hirsutism	15.3%
211	Mediastinal Emphysema	15.3%
212	Surgical Wound Infection	15.3%
213	Ventricular Fibrillation	15.3%
214	Ventricular Flutter	15.3%
215	Parasystole	15.3%
216	Paroxysmal atrial fibrillation	15.3%
217	Facies	15.3%
218	Bradycardia	15.3%
219	Embryo Loss	15.3%
220	Afferent Loop Syndrome	15.1%
221	Sex Chromosome Aberrations	15.1%
222	Short Bowel Syndrome	15.1%
223	Uterine hemorrhage	15.1%
224	No-Reflow Phenomenon	15.1%
225	Necrobiosis Lipoidica Diabeticorum	15.1%
226	Hematoma, Subdural, Spinal	15.1%
227	Dermatitis, Irritant	15%
228	Acne Conglobata	15%
229	Dermatitis, Photoallergic	14.8%
230	Signs and Symptoms	14.6%
231	Pathological Conditions, Anatomical	14.6%
232	Alopecia	14.5%
233	Androgenetic Alopecia	14.5%
234	Sick Sinus Syndrome	14.1%
235	Trisomy	14.1%
236	Urticaria Pigmentosa	13.9%
237	Cardiotoxicity	13.9%
238	Epistaxis	13.8%
239	Anhidrosis	13.6%
240	Cholesteatoma	13.6%
241	Pressure Ulcer	13.6%
242	Folliculitis	13.6%
243	Foot Dermatoses	13.6%
244	Gynecomastia	13.6%
245	Hypertrichosis	13.6%
246	Hypohidrosis	13.6%
247	Hypotrichosis	13.6%
248	Leg Ulcer	13.6%
249	Miliaria	13.6%
250	Parakeratosis	13.6%
251	Parapsoriasis	13.6%
252	Pityriasis	13.6%
253	Psoriasis	13.6%
254	Xeroderma	13.6%
255	Sweet Syndrome	13.6%
256	Hidradenitis	13.6%
257	Onycholysis	13.6%
258	Miliaria Rubra	13.6%
259	Hyperpigmentation	13.6%
260	Lichenoid Eruptions	13.6%
261	Chloracne	13.6%
262	Dermatomyositis	13.6%
263	Lupus Erythematosus, Discoid	13.6%
264	Scleroderma, Limited	13.6%
265	Hematemesis	13.3%
266	Purpura Fulminans	13.2%
267	Erythema Induratum	13%
268	Cross Infection	12.8%
269	Hyphema	12.8%
270	Retinal Neovascularization	12.8%
271	Septicemia	12.8%
272	Vitreous Hemorrhage	12.8%
273	Sepsis	12.8%
274	Drowning	12.7%
275	Keloid	12.7%
276	Abscess	12.6%
277	Empyema	12.6%
278	Femur Head Necrosis	12.6%
279	Fetal Resorption	12.6%
280	Lymphatic Metastasis	12.6%
281	Neoplasms, Unknown Primary	12.6%
282	Peptic Ulcer Hemorrhage	12.6%
283	Sudden Cardiac Death	12.6%
284	Leukemic Infiltration	12.6%
285	Premenstrual Dysphoric Disorder	12.6%
286	Choroidal Neovascularization	12.6%
287	Primary Graft Dysfunction	12.6%
288	Neoplasm Micrometastasis	12.6%
289	Dumping Syndrome	12.5%
290	Dermatitis, Occupational	12.5%
291	Cicatrix, Hypertrophic	12.5%
292	Sinus Arrest, Cardiac	12.5%
293	Metrorrhagia	12.4%
294	Diaper Rash	12.4%
295	Cutis Laxa	12.3%
296	Fetal Growth Retardation	12.3%
297	DNA Degradation, Necrotic	12.3%
298	Aneuploidy	12.2%
299	Mastocytosis	12.2%
300	Polyploidy	12.2%
301	Microsatellite Instability	12.2%
302	Hematoma, Subdural	12.2%
303	Hematoma, Epidural, Cranial	12.2%
304	Connective Tissue Diseases	12.2%
305	Heart Block	12.2%
306	Tachycardia	12.2%
307	Tachyarrhythmia	12.2%
308	Livedo Reticularis	12.2%
309	Cicatrix	12.2%
310	Hematuria	12.1%
311	Chromosome Breakage	12.1%
312	Brain Death	12%
313	Shock, Cardiogenic	12%
314	Dermatitis, Allergic Contact	12%
315	Papillon-Lefevre Disease	11.9%
316	Viremia	11.9%
317	Parasitemia	11.9%
318	Cellulitis	11.9%
319	Erythema Infectiosum	11.9%
320	Exanthema Subitum	11.8%
321	Erythema Nodosum	11.6%
322	Ectodermal Dysplasia	11.5%
323	Aplasia Cutis Congenita	11.5%
324	Phantom pain	11.3%
325	Phantom Limb Pain	11.3%
326	Pseudoxanthoma Elasticum	11.2%
327	Hematoma, Subdural, Intracranial	10.9%
328	Hematoma, Subdural, Chronic	10.9%
329	Hematoma, Subdural, Acute	10.9%
330	Tinea Capitis	10.7%
331	Onychomycosis	10.7%
332	Breast Cyst	10.3%
333	Actinic keratosis	10.3%
334	Piedra	10.3%
335	Retinal Hemorrhage	10.3%
336	Sunburn	10.3%
337	Giant Cell Epulis	10.3%
338	Choroid Hemorrhage	10.2%
339	Melena	10.2%
340	Argyria	10.2%
341	Lactation Disorder	10.2%
342	Mastitis	10.2%
343	Urticaria	10.2%
344	Lichen Planus	10.1%
345	Melanosis	10.1%
346	Chloasma	10.1%
347	Pityriasis Rosea	10.1%
348	Pityriasis Rubra Pilaris	10.1%
349	Vitiligo	10.1%
350	Lichen Nitidus	10.1%
351	Adiposis Dolorosa	10.1%
352	Pruritus Vulvae	10.1%
353	Postpartum Hemorrhage	10.1%
354	Long QT Syndrome	10.1%
355	Tinea Pedis	10%
356	Mastocytoma	10%
357	Pruritus Ani	10%
358	Gingival Hemorrhage	10%
359	Monosomy	10%
360	Tetraploidy	10%
361	Stillbirth	10%
362	Ecthyma	10%
363	Adams-Stokes Syndrome	9.9%
364	Atrioventricular Block	9.9%
365	Bundle-Branch Block	9.9%
366	Atrial Premature Complexes	9.9%
367	Sinoatrial Block	9.9%
368	Tachycardia, Paroxysmal	9.9%
369	Supraventricular tachycardia	9.9%
370	Tachycardia, Ventricular	9.9%
371	Tachycardia, Reciprocating	9.9%
372	Subarachnoid Hemorrhage	9.9%
373	Cerebral Hemorrhage	9.9%
374	Micronuclei, Chromosome-Defective	9.9%
375	Hyperkeratosis, Epidermolytic	9.8%
376	Thrombocytopenic purpura	9.7%
377	Purpura, Hyperglobulinemic	9.4%
378	Asthenia	9.3%
379	Body Temperature Changes	9.3%
380	Calculi	9.3%
381	Cyanosis	9.3%
382	Edema	9.3%
383	Failure to Thrive	9.3%
384	Fatigue	9.3%
385	Feminization	9.3%
386	Fetal Distress	9.3%
387	Hernia	9.3%
388	Hypertrophy	9.3%
389	Motion Sickness	9.3%
390	Nails, Malformed	9.3%
391	polyps	9.3%
392	Rupture, Spontaneous	9.3%
393	Signs and Symptoms, Digestive	9.3%
394	Signs and Symptoms, Respiratory	9.3%
395	Skin Manifestations	9.3%
396	Chills	9.3%
397	Lassitude	9.3%
398	Enterocele	9.3%
399	Atheroma	9.3%
400	Pseudophakia	9.3%
401	Urological Manifestations	9.3%
402	Stenosis	9.3%
403	Facial asymmetry	9.3%
404	Mobility Limitation	9.3%
405	Somnolence	9.3%
406	Plaque, Amyloid	9.3%
407	Plaque, Atherosclerotic	9.3%
408	Abdominal Pain	9.2%
409	Bacteremia	9.2%
410	Cell Transformation, Viral	9.1%
411	Fungemia	9%
412	Ichthyosis, X-Linked	9%
413	Sjogren-Larsson Syndrome	9%
414	Tachycardia, Atrioventricular Nodal Reentry	8.9%
415	Tachycardia, Ectopic Atrial	8.9%
416	Tachycardia, Ectopic Junctional	8.9%
417	Sinus Tachycardia	8.9%
418	Torsades de Pointes	8.9%
419	Accelerated Idioventricular Rhythm	8.9%
420	Behcet Syndrome	8.8%
421	Subacute Combined Degeneration	8.7%
422	Eosinophilic Granuloma	8.6%
423	Hidradenitis Suppurativa	8.5%
424	Endotoxemia	8.5%
425	Purpura, Thrombotic Thrombocytopenic	8.4%
426	Acanthosis Nigricans	8.4%
427	Alopecia Areata	8.4%
428	Lentigo	8.4%
429	Dermatomycoses	8.2%
430	Mucocutaneous Lymph Node Syndrome	8.2%
431	Romano-Ward Syndrome	8.2%
432	Skin Diseases, Bacterial	8.2%
433	Drug Eruptions	8.1%
434	Lipodystrophy	8.1%
435	Malignant Atrophic Papulosis	8.1%
436	Polyarteritis Nodosa	8%
437	Takayasu Arteritis	8%
438	Abdomen, Acute	7.9%
439	Albinism	7.8%
440	Sweating, Gustatory	7.7%
441	Auriculotemporal Syndrome	7.7%
442	Erythema Chronicum Migrans	7.7%
443	Kernicterus	7.6%
444	Lice Infestations	7.6%
445	Varicose Ulcer	7.6%
446	Breast Neoplasms, Male	7.6%
447	Triple Negative Breast Neoplasms	7.6%
448	Galactorrhea	7.5%
449	Eye pain	7.5%
450	Granuloma, Laryngeal	7.4%
451	Muscular Atrophy	7.4%
452	Cyst	7.3%
453	Eye Manifestations	7.3%
454	Neurologic Manifestations	7.3%
455	Renal Colic	7.3%
456	Myocardial Reperfusion Injury	7.2%
457	Leukoplakia	7%
458	Cardiac Output, High	7%
459	Myocardial Stunning	7%
460	Reticulocytosis	7%
461	Low Cardiac Output Syndrome	7%
462	Airway Remodeling	7%
463	Collagen Diseases	7%
464	Mixed Connective Tissue Disease	7%
465	Mucinoses	7%
466	Nail-Patella Syndrome	6.9%
467	Ventricular Remodeling	6.9%
468	Intermittent Claudication	6.8%
469	Anorexia	6.8%
470	Anoxia	6.8%
471	Constipation	6.8%
472	Diarrhea	6.8%
473	Dyspepsia	6.8%
474	Eructation	6.8%
475	Fever	6.8%
476	Flatulence	6.8%
477	Flushing	6.8%
478	Halitosis	6.8%
479	Heartburn	6.8%
480	Diaphragmatic Hernia	6.8%
481	Hiccough	6.8%
482	Hypercalciuria	6.8%
483	Hypercapnia	6.8%
484	Hyperphagia	6.8%
485	Intestinal Polyps	6.8%
486	Nausea	6.8%
487	Pallor	6.8%
488	Psychophysiologic Disorders	6.8%
489	Splenomegaly	6.8%
490	Vomiting	6.8%
491	Hypocapnia	6.8%
492	Porphyrias, Hepatic	6.8%
493	Dyschezia	6.8%
494	Hypoxia	6.8%
495	Hyperoxia	6.8%
496	Lower Urinary Tract Symptoms	6.8%
497	Hypoxemia	6.8%
498	Urinoma	6.8%
499	Autoimmune thrombocytopenia	6.7%
500	Immune thrombocytopenic purpura	6.7%
501	Mycetoma	6.6%
502	Lichen Planus, Oral	6.4%
503	Sarcopenia	6.3%
504	Larva Migrans	6.1%
505	Leishmaniasis	6.1%
506	Molluscum Contagiosum	6.1%
507	Angioedema	6.1%
508	Onchocerciasis	6.1%
509	Philadelphia Chromosome	6%
510	Chromoblastomycosis	6%
511	Dermatophytosis	6%
512	Sporotrichosis	6%
513	Tinea	6%
514	Tinea Versicolor	6%
515	Trichophytosis	6%
516	Hyalohyphomycosis	6%
517	Candidemia	6%
518	Acute Generalized Exanthematous Pustulosis	6%
519	Waterhouse-Friderichsen Syndrome	5.9%
520	Back Pain	5.6%
521	Bulimia	5.6%
522	Neck Pain	5.6%
523	Chest Pain	5.6%
524	Colonic Polyps	5.6%
525	Dizziness	5.6%
526	Dysuria	5.6%
527	Facial Pain	5.6%
528	Fever of Unknown Origin	5.6%
529	Flank Pain	5.6%
530	Headache	5.6%
531	Nocturia	5.6%
532	Pain, Intractable	5.6%
533	Pelvic Pain	5.6%
534	Snoring	5.6%
535	Chronic pain	5.6%
536	Lightheadedness	5.6%
537	Pain, Referred	5.6%
538	Prostatism	5.6%
539	Throbbing Headache	5.6%
540	Labor Pain	5.6%
541	Cancer Pain	5.6%
542	Nociceptive Pain	5.6%
543	Hypergammaglobulinemia	5.6%
544	Basal Ganglia Hemorrhage	5.5%
545	Cartilage Diseases	5.5%
546	Rheumatism	5.5%
547	Chondromalacia	5.5%
548	Diverticulum	5.4%
549	Diverticulosis	5.4%
550	Respiratory Tract Fistula	5.4%
551	Lupus Erythematosus, Systemic	5.3%
552	Overlap syndrome	5.3%
553	Gait Ataxia	5.2%
554	Apnea	5.2%
555	Cheyne-Stokes Respiration	5.2%
556	Decerebrate State	5.2%
557	Dyspnea	5.2%
558	Cardiomegaly	5.2%
559	Hemiparesis	5.2%
560	Hepatomegaly	5.2%
561	Hyperventilation	5.2%
562	Meningism	5.2%
563	Mouth Breathing	5.2%
564	Paresis	5.2%
565	Parovarian Cyst	5.2%
566	Seizures	5.2%
567	Sensation Disorders	5.2%
568	Sneezing	5.2%
569	Spermatocele	5.2%
570	Oral Fistula	5.2%
571	Complex partial seizures	5.2%
572	Tachypnea	5.2%
573	Monoparesis	5.2%
574	Gait Disorders, Neurologic	5.2%
575	Neuromuscular Manifestations	5.2%
576	Cardiac Hypertrophy	5.2%
577	Warts	5.1%
578	Putaminal Hemorrhage	5.1%
579	Edema, Cardiac	5.1%
580	Mental Fatigue	5.1%
581	Orthostatic intolerance	5.1%
582	Hypoventilation	5.1%
583	Vaginal Fistula	5%
584	Rectocele	5%
585	Emaciation	5%
586	Low Back Pain	5%
587	Visceral Pain	5%
588	Body Weight Changes	5%
589	Candidiasis, Chronic Mucocutaneous	5%
590	Cutaneous Candidiasis	5%
591	Leishmaniasis, Cutaneous	5%
592	Eczema Herpeticum	5%
593	Erysipelas	5%
594	Serum Sickness	5%
595	Staphylococcal Skin Infections	5%
596	Variegate Porphyria	5%
597	Acute intermittent porphyria	5%
598	Porphyria Cutanea Tarda	5%
599	Erythrasma	5%
600	Carcinoma, Lobular	5%
601	Arthritis, Psoriatic	4.9%
602	Fusariosis	4.9%
603	CREST Syndrome	4.9%
604	Cachexia	4.7%
605	Hoarseness	4.6%
606	Scleromyxedema	4.5%
607	Akathisia	4.5%
608	Restlessness	4.5%
609	Psychomotor Agitation	4.5%
610	Hereditary Angioedema Type III	4.4%
611	Hereditary Angioedema Types I and II	4.4%
612	Vesicovaginal Fistula	4.4%
613	Sleep Wake Disorders	4.4%
614	Giant Cell Arteritis	4.4%
615	Temporal Arteritis	4.4%
616	Gait Apraxia	4.3%
617	Pupil Disorders	4.3%
618	Neurobehavioral Manifestations	4.3%
619	Biliary Fistula	4.3%
620	Gastric Fistula	4.3%
621	Congenital diaphragmatic hernia	4.3%
622	Morning Sickness	4.3%
623	Anosmia	4.2%
624	Ataxia	4.2%
625	Athetosis	4.2%
626	Catalepsy	4.2%
627	Dental Fistula	4.2%
628	Dystonia	4.2%
629	Hemiplegia	4.2%
630	Locked-In Syndrome	4.2%
631	Muscle Hypertonia	4.2%
632	Muscle hypotonia	4.2%
633	Myoclonus	4.2%
634	Myotonia	4.2%
635	Neuralgia	4.2%
636	Oroantral Fistula	4.2%
637	Paraplegia	4.2%
638	Pseudobulbar Palsy	4.2%
639	Quadriplegia	4.2%
640	Spasm	4.2%
641	Spastic Paraplegia	4.2%
642	Status Epilepticus	4.2%
643	Taste Disorders	4.2%
644	Tremor	4.2%
645	Monoplegia	4.2%
646	Hypokinesia	4.2%
647	Left Ventricular Hypertrophy	4.2%
648	Gastroparesis	4.2%
649	Right Ventricular Hypertrophy	4.2%
650	Paraparesis	4.2%
651	Bradykinesia	4.2%
652	Waxy flexibility	4.2%
653	Action Tremor	4.2%
654	Resting Tremor	4.2%
655	Dysosmia	4.2%
656	Quadriparesis	4.2%
657	Olfaction Disorders	4.2%
658	Myokymia	4.2%
659	Somatosensory Disorders	4.2%
660	Neuropathic pain	4.2%
661	Hyperkinesia	4.2%
662	Intention tremor	4.2%
663	Angioedemas, Hereditary	4.2%
664	Nasal Polyps	4.2%
665	Rectal Prolapse	4.2%
666	Uterine Prolapse	4.2%
667	Vaginal Prolapse	4.2%
668	Epidermodysplasia Verruciformis	4.2%
669	Herpes Labialis	4.2%
670	Weight Gain	4.1%
671	Diabetic Foot	4.1%
672	Pleural Rub	4.1%
673	Rales	4.1%
674	Respiratory Sounds	4.1%
675	Rhonchi	4.1%
676	Stridor	4.1%
677	Wheezing	4.1%
678	Asterixis	4.1%
679	Ballismus	4.1%
680	Staphylococcal Scalded Skin Syndrome	4.1%
681	Vertigo	4.1%
682	Dupuytren Contracture	4.1%
683	Pain	4.1%
684	Ache	4.1%
685	Meningocele	4%
686	Oliguria	4%
687	Polyuria	4%
688	Proteinuria	4%
689	Urinary Calculi	4%
690	Encephalocele	4%
691	Underweight	4%
692	Overweight	4%
693	Alexia	4%
694	Dyslexia	4%
695	Umbilical hernia	3.8%
696	Toothache	3.8%
697	Body Weight	3.8%
698	Peutz-Jeghers Syndrome	3.8%
699	Hyperemesis Gravidarum	3.8%
700	Blastomycosis	3.7%
701	Dysgeusia	3.7%
702	Formication	3.7%
703	Hyperalgesia	3.7%
704	Hyperesthesia	3.7%
705	Hypesthesia	3.7%
706	Language Disorders	3.7%
707	Numbness	3.7%
708	Paresthesia	3.7%
709	Paraparesis, Spastic	3.7%
710	Trismus	3.7%
711	Epilepsia Partialis Continua	3.7%
712	Hypogeusia	3.7%
713	Brown-Sequard Syndrome	3.7%
714	Lockjaw	3.7%
715	Allodynia	3.7%
716	Ageusia	3.7%
717	HIV-Associated Lipodystrophy Syndrome	3.7%
718	Alice in Wonderland Syndrome	3.7%
719	carbuncle	3.7%
720	Condylomata Acuminata	3.6%
721	Furunculosis	3.5%
722	furuncle	3.5%
723	Agraphia	3.5%
724	Anomia	3.5%
725	Cluttering	3.5%
726	Language Development Disorders	3.5%
727	Speech Disorders	3.5%
728	Syncope	3.5%
729	Stupor	3.5%
730	Dysgraphia	3.5%
731	Presyncope	3.5%
732	Dyslalia	3.5%
733	Impetigo	3.5%
734	Vision Disorders	3.5%
735	Metamorphopsia	3.5%
736	Visual Impairment	3.5%
737	Voice Disorders	3.5%
738	Voice Disturbance	3.5%
739	Bronchial Fistula	3.4%
740	Mesenteric Panniculitis	3.4%
741	Metatarsalgia	3.4%
742	Pancreatic Fistula	3.4%
743	Panniculitis, Peritoneal	3.4%
744	Tietze's Syndrome	3.4%
745	Orbital Cellulitis	3.4%
746	Myxoid cyst	3.4%
747	Gagging	3.4%
748	Anisocoria	3.4%
749	Confusion	3.4%
750	Facial paralysis	3.4%
751	Intestinal Fistula	3.4%
752	Lethargy	3.4%
753	Memory Disorders	3.4%
754	Muscle Cramp	3.4%
755	Perceptual Disorders	3.4%
756	Psychomotor Disorders	3.4%
757	Tonic Pupil	3.4%
758	Anhedonia	3.4%
759	Disorientation	3.4%
760	Gastroschisis	3.4%
761	Enterocutaneous Fistula	3.4%
762	Fetal Hypoxia	3.4%
763	Facial Paresis	3.4%
764	Memory Loss	3.4%
765	Hemisensory Neglect	3.4%
766	Dysacusis	3.4%
767	Aphasia	3.4%
768	Articulation Disorders	3.4%
769	Echolalia	3.4%
770	Stuttering	3.4%
771	Dysphasia	3.4%
772	Myxedema	3.4%
773	Rhinoscleroma	3.4%
774	Dyspnea, Paroxysmal	3.4%
775	Mastodynia	3.4%
776	Respiratory Paralysis	3.4%
777	Salivary Gland Fistula	3.4%
778	Leukoplakia, Oral	3.4%
779	Dysarthria	3.3%
780	Chorea	3.3%
781	Cystocele	3.3%
782	Tetany	3.3%
783	Urinary Incontinence	3.3%
784	Breakthrough Pain	3.3%
785	Albuminuria	3.3%
786	Hemoglobinuria	3.3%
787	Menkes Kinky Hair Syndrome	3.3%
788	Diplopia	3%
789	Muscle Rigidity	3%
790	Muscle Spasticity	3%
791	Scotoma	3%
792	Photophobia	3%
793	Cogwheel Rigidity	3%
794	Hemifacial Spasm	3%
795	Amaurosis	3%
796	Blindness	3%
797	Nuchal Rigidity	3%
798	Angina Pectoris	3%
799	Agnosia	3%
800	Apraxias	3%
801	Hallucinations	3%
802	Hemianopsia	3%
803	Hyperacusis	3%
804	Tinnitus	3%
805	Visual Agnosia	3%
806	Anosognosia	3%
807	Wernicke-Korsakoff Syndrome	3%
808	Phonophobia	3%
809	Hearing Loss	3%
810	Cerebellar Ataxia	3%
811	Torticollis	3%
812	Sciatica	3%
813	Urge Incontinence	3%
814	Tardive Dyskinesia	3%
815	Jet Lag Syndrome	2.9%
816	Reflex, Abnormal	2.9%
817	Hyporeflexia	2.9%
818	Hyperreflexia	2.9%
819	Consciousness Disorders	2.9%
820	Mental Retardation	2.9%
821	Depressed Level of Consciousness	2.9%
822	Mental deficiency	2.9%
823	Intellectual Disability	2.9%
824	Catatonia	2.8%
825	Musculoskeletal Pain	2.8%
826	Ophthalmoplegia	2.8%
827	External Ophthalmoplegia	2.8%
828	Amaurosis Fugax	2.8%
829	Blindness, Cortical	2.8%
830	Dyscalculia	2.8%
831	Angina, Unstable	2.8%
832	Birth Weight	2.8%
833	Aphonia	2.8%
834	Arthralgia	2.8%
835	Sleep Deprivation	2.8%
836	Polyarthralgia	2.8%
837	Dysphonia	2.8%
838	Deafness	2.8%
839	Hearing Loss, Sudden	2.8%
840	Gerstmann Syndrome	2.8%
841	Hearing Loss, Bilateral	2.8%
842	Hearing Loss, High-Frequency	2.8%
843	Hearing Loss, Mixed Conductive-Sensorineural	2.8%
844	Prosopagnosia	2.8%
845	Apraxia, Ideomotor	2.8%
846	Persistent Vegetative State	2.8%
847	Charles Bonnet Syndrome	2.8%
848	Hearing Loss, Unilateral	2.8%
849	Complete Hearing Loss	2.8%
850	Alien Hand Syndrome	2.8%
851	Deaf Mutism	2.8%
852	Osteochondritis	2.8%
853	Polymyalgia Rheumatica	2.8%
854	Cerebrospinal Fluid Otorrhea	2.8%
855	Cerebrospinal Fluid Rhinorrhea	2.8%
856	Mutism	2.8%
857	Selective Mutism	2.8%
858	Obesity	2.7%
859	Osteogenesis Imperfecta	2.7%
860	Angina Pectoris, Variant	2.7%
861	Alexia, Pure	2.7%
862	Amblyopia	2.5%
863	Amnesia	2.5%
864	Delirium	2.5%
865	Horner Syndrome	2.5%
866	Noonan Syndrome	2.5%
867	Dissociative Amnesia	2.5%
868	Color blindness	2.5%
869	Global Amnesia	2.5%
870	Rectal Fistula	2.5%
871	Anal Fistula	2.5%
872	Shoulder Pain	2.5%
873	Pediatric Obesity	2.4%
874	Vocal Cord Paralysis	2.4%
875	Urinary Bladder Fistula	2.4%
876	Retrograde amnesia	2.3%
877	Amnesia, Anterograde	2.3%
878	Rheumatoid Arthritis	2.3%
879	Juvenile arthritis	2.3%
880	Marfan Syndrome	2.3%
881	Hydrops Fetalis	2.2%
882	Lupus Nephritis	2.2%
883	Homocystinuria	2.2%
884	Fetal Weight	2.2%
885	Akathisia, Drug-Induced	2.2%
886	Myalgia	2.1%
887	Dyskinesia, Drug-Induced	2.1%
888	Alcohol Withdrawal Seizures	2.1%
889	Arteriovenous fistula	2.1%
890	Amnesia, Transient Global	2%
891	Rheumatoid Nodule	2%
892	Laryngomalacia	2%
893	Pectus carinatum	2%
894	Auditory Perceptual Disorders	1.9%
895	Kidney Calculi	1.8%
896	Ureteral Calculi	1.8%
897	Ophthalmoplegic Migraine	1.7%
898	Felty Syndrome	1.7%
899	Bronchomalacia	1.7%
900	Tracheomalacia	1.7%
901	Progressive supranuclear palsy	1.7%
902	Rheumatoid Vasculitis	1.4%
903	Mucopolysaccharidosis III	1.4%
904	Sicca Syndrome	1.2%
905	Sjogren's Syndrome	1.2%
906	Kearns-Sayre syndrome	1.2%
907	Lupus Vasculitis, Central Nervous System	1%
908	Mucopolysaccharidosis II	1%

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