MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Medulloblastoma

(UMLS:C0025149)

Definition:: A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)
UMLS ID:: C0025149
MeSH ID:: D008527

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.600.380.515|C04.557.465.625.600.590.500|C04.557.470.670.380.515|C04.557.470.670.590.500|C04.557.580.625.600.380.515|C04.557.580.625.600.590.500

Synonym(s)

Medulloblastoma

BRAIN TUMOR, MEDULLOBLASTOMA

INTRACRANIAL NEOPLASM, MEDULLOBLASTOMA

MDB - Medulloblastoma

MEDULLOBLASTOMA

MEDULLOBLASTOMA, MALIGNANT

Medulloblastoma NOS

Medulloblastoma, NOS

Medulloblastoma, no ICD-O subtype

10.

Medulloblastoma, no International Classification of Diseases for Oncology subtype

11.

Medulloblastomas

12.

brain medulloblastoma tumors

13.

central nervous system mass lesions cerebellum medulloblastoma

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Thalidomide	FAERS: 3		US FAERS
2	Isotretinoin	FAERS: 2		US FAERS
3	Clomiphene	FAERS: 1		US FAERS
4	Deferasirox	FAERS: 1		US FAERS
5	Etoposide	FAERS: 1	21880625	CTD OFFSIDES US FAERS
6	Glatiramer Acetate	FAERS: 1		US FAERS
7	Lenalidomide	FAERS: 1		US FAERS
8	Topotecan	FAERS: 1		US FAERS
9	homosalate	FAERS: 1		US FAERS
10	3,4-dihydroxybenzohydroxamic acid		15133626	CTD
11	ABT-737		21880625	CTD
12	Aluminum Hydroxide			OFFSIDES
13	Bortezomib		19213072	CTD
14	Busulfan		14595385	CTD
15	Carboplatin		19701718	CTD
16	Carmustine		4739170 15133626 16243814	CTD
17	Cyclophosphamide		19701718	CTD
18	Cytarabine		22362285	CTD OFFSIDES
19	Dactinomycin			OFFSIDES
20	Estradiol		21351254	CTD
21	ICE protocol 3		8913079	CTD
22	Leucovorin		3465876	CTD
23	Melphalan		8043096	CTD
24	Methotrexate		View details 2204409 3359561 3465876 4739170 9243235 11019787 12105306 19117694	CTD
25	Oxazepam			OFFSIDES
26	Pentamidine			OFFSIDES
27	Platinum		16314621	CTD
28	Procarbazine		3359561	CTD
29	Sorafenib		19001435	CTD
30	Temozolomide	Canada Vigilance: 1	16243814 19107490	CTD Canada Vigilance
31	Tenofovir			OFFSIDES
32	Thiotepa		14595385	CTD OFFSIDES
33	Tretinoin		17453147	CTD
34	Vincristine		View details 939971 3359561 7099798 19701718 19890797	CTD
35	Vorinostat		16645722	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Ganglioneuroma	61.3%
2	Astrocytoma	57.5%
3	Ependymoma	57.5%
4	oligodendroglioma	57.5%
5	Ganglioglioma	57.5%
6	gliosarcoma	57.5%
7	Anaplastic astrocytoma	57.5%
8	Anaplastic Oligodendroglioma	57.5%
9	Retinoblastoma	45.2%
10	Glioblastoma	43.1%
11	Neuroblastoma	43.1%
12	Glioblastoma Multiforme	43.1%
13	Craniopharyngioma	42.9%
14	Neuroectodermal Tumor, Melanotic	42.9%
15	Neuroendocrine Tumors	42.9%
16	melanoma	38.2%
17	Glioma	37%
18	Malignant Glioma	37%
19	Medulloblastoma	36.8%
20	Adenoma, Acidophil	35.9%
21	Ganglioneuroblastoma	35.9%
22	leukemia	35.8%
23	Optic Nerve Glioma	34.3%
24	Meningioma	34.2%
25	Histiocytic Disorders, Malignant	31.5%
26	Carcinoid Tumor	31.3%
27	Trophoblastic Neoplasms	30.9%
28	Neurilemmoma	30.6%
29	Basal cell carcinoma	28.6%
30	Carcinoma, Papillary	28.6%
31	Squamous cell carcinoma	28.6%
32	Cystadenoma	28.6%
33	Mesothelioma	28.6%
34	Carcinoma, Basal Cell	28.6%
35	Adenoma	28.2%
36	Carcinoma	28.2%
37	Epithelioma	28.2%
38	Lymphoma	28.1%
39	Melanoma, Experimental	27.7%
40	Chordoma	27.3%
41	Teratoma	27.3%
42	Germinoma	27.3%
43	Teratocarcinoma	27.3%
44	Composite Lymphoma	26.9%
45	Carcinosarcoma	26.3%
46	Hemangiosarcoma	26.3%
47	lymphangiosarcoma	26.3%
48	Paraganglioma	26.1%
49	Carcinoma, Ehrlich Tumor	24.9%
50	Carcinoma, Lewis Lung	24.9%
51	Leukemia, Experimental	24.4%
52	Hutchinson's Melanotic Freckle	24.3%
53	Melanoma, Amelanotic	24.3%
54	Dermoid Cyst	24.1%
55	Neoplasms, Germ Cell and Embryonal	24.1%
56	Germ Cell Cancer	24.1%
57	Leukemia, Plasma Cell	23.4%
58	Neoplasms, Glandular and Epithelial	23.4%
59	Cystadenocarcinoma	23.4%
60	Mucoepidermoid Carcinoma	23.4%
61	Hamartoma	23.4%
62	Neoplasms, Hormone-Dependent	23.4%
63	Neoplasms, Multiple Primary	23.4%
64	Paraneoplastic Syndromes	23.4%
65	Precancerous Conditions	23.4%
66	Neoplasms, Second Primary	23.4%
67	Carcinoma, Lobular	23.3%
68	Carcinoma 256, Walker	23.2%
69	Neuroectodermal Tumors	22.8%
70	Choriocarcinoma	22.6%
71	Leukemia, Radiation-Induced	22.1%
72	Malignant Carcinoid Syndrome	21.6%
73	Neoplasms, Neuroepithelial	21.3%
74	Gliomatosis cerebri	21.3%
75	Cyst	20.7%
76	Neoplastic Processes	20.7%
77	Neoplastic Syndromes, Hereditary	20.7%
78	Pregnancy Complications, Neoplastic	20.7%
79	Neoplasms, Experimental	20.5%
80	Acanthoma	19.9%
81	Multiple Endocrine Neoplasia	19.8%
82	Ameloblastoma	19.1%
83	Angiokeratoma	19.1%
84	Hemangioma	19.1%
85	hemangiopericytoma	19.1%
86	Lymphangioma	19.1%
87	Mesenchymoma	19.1%
88	Nevus	19.1%
89	Hepatoblastoma	19.1%
90	Mixed Tumor, Mullerian	19.1%
91	Angiofibroma	19.1%
92	Sarcoma	19.1%
93	Chondrosarcoma	19%
94	leiomyosarcoma	19%
95	liposarcoma	19%
96	synovial sarcoma	19%
97	Angiomyolipoma	19%
98	Clear Cell Sarcoma of Soft Tissue	19%
99	Alveolar Soft Part Sarcoma	19%
100	Sarcoma, Myeloid	19%
101	Adenofibroma	18.4%
102	Fibroadenoma	18.4%
103	Neoplasms, Radiation-Induced	18.3%
104	Bowen's Disease	18.2%
105	Endometrial Stromal Sarcoma	18.1%
106	Sarcoma, Experimental	17.9%
107	Thymoma	17.8%
108	Pheochromocytoma	17.8%
109	Tuberous Sclerosis	17.2%
110	Nephroblastoma	16.8%
111	Plasmacytoma	16.8%
112	Malignant histiocytosis	16.7%
113	Histiocytic sarcoma	16.7%
114	Basal Cell Nevus Syndrome	16.6%
115	Adenocarcinoma	16.3%
116	Carcinoma in Situ	16.3%
117	Carcinoma, Transitional Cell	16.3%
118	Papilloma	16.3%
119	Pseudomyxoma Peritonei	16.3%
120	Papillomatosis	16.3%
121	Adenomatosis, Pulmonary	16.3%
122	Adenomatous Polyps	16.3%
123	Carcinoma, Large Cell	16.3%
124	Carcinoma, Small Cell	16.3%
125	Acoustic Neuroma	15.5%
126	Fibrosarcoma	15.4%
127	Osteosarcoma	15.4%
128	Dysgerminoma	15.4%
129	Neuroma	15.4%
130	Seminoma	15.4%
131	Lymphangioleiomyomatosis	15.3%
132	Carcinoid Heart Disease	15.2%
133	Leukemia L1210	15.1%
134	Leukemia P388	15.1%
135	Hodgkin Disease	14.9%
136	Lymphoma, Non-Hodgkin	14.9%
137	Paraneoplastic Encephalomyelitis	14.5%
138	Mammary Neoplasms, Experimental	14.3%
139	Hepatocellular Adenoma	14.1%
140	Carcinoma, Pancreatic Ductal	13.7%
141	Malignant Fibrous Histiocytoma	13.6%
142	Primary amyloidosis	13.5%
143	Neurofibrosarcoma	13.4%
144	Lymphomatoid Granulomatosis	13.1%
145	Prolactinoma	12.8%
146	Growth Hormone-Secreting Pituitary Adenoma	12.8%
147	Mesoblastic Nephroma	12.5%
148	neurofibroma	12%
149	Vipoma	12%
150	Abdominal Neoplasms	11.9%
151	Erythroplasia	11.9%
152	Follicular cyst	11.9%
153	Head and Neck Neoplasms	11.9%
154	Mucocele	11.9%
155	Pilonidal Cyst	11.9%
156	Soft Tissue Neoplasms	11.9%
157	Thoracic Neoplasms	11.9%
158	Thyroglossal Cyst	11.9%
159	Synovial Cyst	11.9%
160	Aberrant Crypt Foci	11.9%
161	Rhabdomyosarcoma	11.9%
162	Giant Cell Tumor of Bone	11.9%
163	Carcinoma, Ovarian Epithelial	11.7%
164	Sarcoma 180	11.5%
165	Waldenstrom Macroglobulinemia	11.3%
166	Multiple Myeloma	11.3%
167	Adenomatous Polyposis Coli	11.2%
168	Phyllodes Tumor	10.9%
169	Hemangioendothelioma	10.9%
170	Lipoma	10.9%
171	Myoma	10.9%
172	Myxoma	10.9%
173	Angiolipoma	10.9%
174	Myelolipoma	10.9%
175	Neoplasms, Bone Tissue	10.9%
176	Neoplasms, Fibrous Tissue	10.9%
177	Smooth Muscle Tumor	10.9%
178	Desmoplastic Small Round Cell Tumor	10.9%
179	Chondroma	10.9%
180	Enchondroma	10.9%
181	Digestive System Neoplasms	10.7%
182	Endocrine Gland Neoplasms	10.7%
183	Eye Neoplasms	10.7%
184	Nervous System Neoplasms	10.7%
185	Bone neoplasms	10.6%
186	Leukoplakia	10.6%
187	Lymphocele	10.6%
188	Pancreatic Cyst	10.6%
189	Skin Neoplasms	10.6%
190	Hematologic Neoplasms	10.6%
191	Multiple Endocrine Neoplasia Type 1	10.5%
192	Barrett Esophagus	10.5%
193	Breast Cyst	10.5%
194	Actinic keratosis	10.5%
195	Mediastinal Cyst	10.5%
196	Neoplasm Invasiveness	10.5%
197	Neoplasm Metastasis	10.5%
198	Neoplasm Recurrence, Local	10.5%
199	Parovarian Cyst	10.5%
200	Pericardial Cyst	10.5%
201	Splenic Neoplasms	10.5%
202	Thymic Cyst	10.5%
203	Carcinogenesis	10.5%
204	Myxoid cyst	10.5%
205	Metastasis	10.5%
206	Adenoid Cystic Carcinoma	10.4%
207	Adenocarcinoma, Clear Cell	10.4%
208	Cholangiocarcinoma	10.4%
209	Cervical Intraepithelial Neoplasia	10.4%
210	Hydatidiform Mole	10.2%
211	Dermatofibrosarcoma	10.1%
212	Dermatofibrosarcoma Protuberans	10.1%
213	Liver Neoplasms, Experimental	10%
214	Nasopharyngeal carcinoma	9.7%
215	Leukemia, Myelomonocytic, Chronic	9.5%
216	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.5%
217	Corpus Luteum Cyst	9.3%
218	Ovarian Cysts	9.3%
219	Parathyroid Neoplasms	9.2%
220	Peritoneal Neoplasms	9.2%
221	Thyroid Neoplasm	9.2%
222	Thyroid carcinoma	9.2%
223	insulinoma	8.7%
224	Mastocytosis	8.6%
225	Sturge-Weber Syndrome	8.6%
226	Gastrointestinal Stromal Tumors	8.5%
227	Hemangioma, Cavernous	8.5%
228	granulosa cell tumor	8.5%
229	Choledochal Cyst	8.5%
230	Leukemia, T-Cell	8.5%
231	Leukemia, B-Cell	8.5%
232	Lymphoma, Follicular	8.5%
233	T-Cell Lymphoma	8.5%
234	Mantle cell lymphoma	8.5%
235	Pancreatic Neoplasm	8.4%
236	Peutz-Jeghers Syndrome	8.4%
237	Alveolar rhabdomyosarcoma	8.3%
238	Adrenocortical carcinoma	8.1%
239	Klatskin Tumor	7.4%
240	Renal Cell Carcinoma	7.4%
241	Papillary Renal Cell Carcinoma	7.4%
242	Denys-Drash Syndrome	7.3%
243	Tracheal Neoplasms	7.2%
244	Leukoplakia, Oral	7.1%
245	Paraneoplastic Cerebellar Degeneration	7.1%
246	Gastrinoma	7%
247	Glucagonoma	7%
248	Carcinoma, Endometrioid	7%
249	fibroma	6.8%
250	Fibromatosis	6.8%
251	Osteoblastoma	6.8%
252	Osteoma	6.8%
253	Rhabdomyoma	6.8%
254	Chondromatosis	6.8%
255	Hemangioblastoma	6.8%
256	Lymphoma, Extranodal NK-T-Cell	6.8%
257	Esophageal Neoplasms	6.5%
258	Limbic Encephalitis	6.4%
259	Retroperitoneal Neoplasms	6.4%
260	Xeroderma Pigmentosum	6.1%
261	Mastocytoma	6%
262	Lambert-Eaton Myasthenic Syndrome	6%
263	Testicular Neoplasms	6%
264	Mastocytosis, Systemic	5.9%
265	Leukemia, Myeloid, Chronic-Phase	5.9%
266	Leydig Cell Tumor	5.7%
267	Mouth Neoplasms	5.6%
268	Central Nervous System Neoplasms	5.6%
269	Vascular Neoplasms	5.6%
270	Thymus Neoplasms	5.6%
271	Genital Neoplasms, Female	5.6%
272	Pancreatic Pseudocyst	5.6%
273	Lymphatic Metastasis	5.6%
274	Neoplasms, Unknown Primary	5.6%
275	Leukemic Infiltration	5.6%
276	Breast Neoplasms, Male	5.6%
277	Neoplasm Micrometastasis	5.6%
278	Triple Negative Breast Neoplasms	5.6%
279	Opsoclonus-Myoclonus Syndrome	5.5%
280	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5.3%
281	Leukemia, Large Granular Lymphocytic	5.3%
282	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5.3%
283	Lymphoma, T-Cell, Cutaneous	5.3%
284	Lymphoma, AIDS-Related	5.3%
285	Enteropathy-Associated T-Cell Lymphoma	5.3%
286	Primary Effusion Lymphoma	5.3%
287	Thyroid Nodule	5.1%
288	Adrenal Gland Neoplasms	5.1%
289	Gastrointestinal Neoplasms	5.1%
290	Genital Neoplasms, Male	5.1%
291	Liver neoplasms	5.1%
292	Uveal Neoplasms	5.1%
293	Myelitis, Transverse	5.1%
294	Urologic Neoplasms	5%
295	Sebaceous Gland Neoplasms	5%
296	Spinal Neoplasms	5%
297	Bone Marrow Neoplasms	5%
298	Polycystic Ovary Syndrome	5%
299	Fibromatosis, Aggressive	4.7%
300	Fibromatosis, Abdominal	4.7%
301	Burkitt Lymphoma	4.3%
302	ovarian neoplasm	4.1%
303	Nose Neoplasms	4.1%
304	Pituitary Adenoma	3.9%
305	Pituitary Neoplasms	3.9%
306	Dupuytren Contracture	3.8%
307	Urticaria Pigmentosa	3.7%
308	Mycosis Fungoides	3.7%
309	Lymphomatoid Papulosis	3.7%
310	Plasmablastic lymphoma	3.7%
311	Zollinger-Ellison syndrome	3.5%
312	Palatal Neoplasms	3.5%
313	Meningeal Neoplasms	3.2%
314	Sezary Syndrome	3%
315	Ear Neoplasms	2.9%
316	Eyelid Neoplasms	2.9%
317	Lung Neoplasms	2.9%
318	Pleural Neoplasms	2.9%
319	Cell Transformation, Viral	2.9%
320	Brain Neoplasms	2.8%
321	Salivary Gland Neoplasms	2.8%
322	Spinal Cord Neoplasms	2.8%
323	Tongue Neoplasms	2.8%
324	Uterine Neoplasms	2.8%
325	Vaginal Neoplasms	2.8%
326	Vulvar Neoplasms	2.8%
327	Uterine Cancer	2.8%
328	Fallopian Tube Neoplasms	2.8%
329	Pharyngeal Neoplasms	2.6%
330	Central Nervous System Cysts	2.6%
331	Bile Duct Neoplasms	2.6%
332	gallbladder neoplasm	2.6%
333	Intestinal Neoplasms	2.6%
334	Penile Neoplasms	2.6%
335	Prostatic Neoplasms	2.6%
336	Stomach Neoplasms	2.6%
337	Polycythemia Vera	2.5%
338	Laryngeal neoplasm	2.4%
339	Bladder Neoplasm	2.3%
340	Kidney Neoplasm	2.3%
341	Ureteral Neoplasms	2.3%
342	Urethral Neoplasms	2.3%
343	Meningeal Carcinomatosis	2%
344	Bronchial Neoplasms	1.8%
345	Multiple Pulmonary Nodules	1.8%
346	Supratentorial Neoplasms	1.8%
347	Endometrial Neoplasms	1.8%
348	Hypopharyngeal Neoplasms	1.6%
349	Pleural Effusion, Malignant	1.6%
350	Hypopharyngeal Cancer	1.6%
351	Parotid Neoplasms	1.6%
352	Prostatic Neoplasms, Castration-Resistant	1.6%
353	Nelson Syndrome	1.6%
354	Cecal Neoplasms	1.4%
355	Duodenal Neoplasms	1.4%
356	Nasopharyngeal Neoplasms	1.3%
357	Colorectal Neoplasms	1.3%
358	Paranasal Sinus Neoplasms	1.2%
359	Brain Stem Neoplasms	1.2%
360	Tonsillar Neoplasms	1.1%
361	Cerebellar Neoplasms	1.1%
362	Radicular Cyst	1%
363	Appendiceal Neoplasms	1%
364	Colonic Neoplasms	1%
365	Rectal Neoplasms	1%
366	Choroid Plexus Papilloma	1%
367	Maxillary Sinus Neoplasms	0.9%
368	Anus Neoplasms	0.7%
369	Sigmoid Neoplasms	0.7%

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