MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Aberrant Crypt Foci

(UMLS:C1879526)

Definition:: Clusters of colonic crypts that appear different from the surrounding mucosa when visualized after staining. They are of interest as putative precursors to colorectal adenomas and potential biomarkers for colorectal carcinoma.
UMLS ID:: C1879526
MeSH ID:: D058739

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.834.020

Synonym(s)

Aberrant Crypt Foci

ACF

Aberrant Crypt Focus

aberrant crypt foci

Associated Drug(s)

	Name	Reference(s)	Data Source
1	1,2-Dimethylhydrazine	View details 16733082 22326950 22750881 29031619 29108773 29155087 29999212 30090573 30720227	CTD
2	2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine	View details 9111214 9163695 10357789 12351151 12636105 14507667 14656947 15059925 20660995	CTD
3	2-amino-3-methylimidazo(4,5-f)quinoline	12628520	CTD
4	4-methoxycinnamic acid	22326950	CTD
5	5-hydroxymethylfurfural	19382817 22006426	CTD
6	Artesunate	29031619	CTD
7	Aspirin	29031619	CTD
8	Azoxymethane	View details 16984374 20681671 22351042 28659405	CTD
9	Capsaicin	29155087	CTD
10	Copper	11983831	CTD
11	Deoxycholic Acid	12636105	CTD
12	Resveratrol	16733082	CTD
13	Sulindac	29999212	CTD
14	Ursodeoxycholic Acid	12636105	CTD
15	asiatic acid	29108773	CTD
16	chlorophyllin	12628520	CTD
17	chromium hexavalent ion	25352572	CTD
18	epigallocatechin gallate	29999212	CTD
19	geraniol	21445532	CTD
20	kaempferol	29999212	CTD
21	mofezolac	21510291	CTD
22	pterostilbene	19549798 20681671	CTD
23	zingerone	30720227	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Erythroplasia	42.9%
2	Leukoplakia	28.6%
3	Barrett Esophagus	27.9%
4	Actinic keratosis	27.9%
5	Hamartoma	23.1%
6	Neoplasms, Hormone-Dependent	23.1%
7	Neoplasms, Multiple Primary	23.1%
8	Paraneoplastic Syndromes	23.1%
9	Neoplasms, Second Primary	23.1%
10	Lymphomatoid Granulomatosis	18.9%
11	Leukoplakia, Oral	15.4%
12	Cyst	15%
13	Neoplastic Processes	15%
14	Neoplastic Syndromes, Hereditary	15%
15	Pregnancy Complications, Neoplastic	15%
16	Carcinoma, Ehrlich Tumor	14.9%
17	Dermoid Cyst	14.9%
18	Carcinoma, Lewis Lung	14.9%
19	Carcinoma 256, Walker	14.8%
20	Neoplasms, Experimental	14.6%
21	Abdominal Neoplasms	14.3%
22	Follicular cyst	14.3%
23	Head and Neck Neoplasms	14.3%
24	leukemia	14.3%
25	Mucocele	14.3%
26	Neoplasms, Germ Cell and Embryonal	14.3%
27	Neoplasms, Glandular and Epithelial	14.3%
28	Pilonidal Cyst	14.3%
29	Soft Tissue Neoplasms	14.3%
30	Thoracic Neoplasms	14.3%
31	Thyroglossal Cyst	14.3%
32	Synovial Cyst	14.3%
33	Germ Cell Cancer	14.3%
34	Neuroectodermal Tumors	13.6%
35	Neoplasms, Neuroepithelial	13.3%
36	Gliomatosis cerebri	13.3%
37	Multiple Endocrine Neoplasia	12.8%
38	melanoma	12.4%
39	Carcinosarcoma	12.4%
40	Hemangiosarcoma	12.4%
41	Leukemia L1210	12.4%
42	Leukemia P388	12.4%
43	lymphangiosarcoma	12.4%
44	Acanthoma	12.4%
45	Paraneoplastic Encephalomyelitis	12.3%
46	Trophoblastic Neoplasms	12.1%
47	Leukemia, Experimental	12%
48	Mammary Neoplasms, Experimental	12%
49	Medulloblastoma	11.9%
50	Melanoma, Experimental	11.8%
51	Sarcoma 180	11.7%
52	Adenoma, Acidophil	11.5%
53	Ganglioneuroma	11.5%
54	Glioma	11.5%
55	Malignant Glioma	11.5%
56	Basal cell carcinoma	11.1%
57	Carcinoma, Papillary	11.1%
58	Squamous cell carcinoma	11.1%
59	Chondrosarcoma	11.1%
60	Craniopharyngioma	11.1%
61	Cystadenoma	11.1%
62	leiomyosarcoma	11.1%
63	liposarcoma	11.1%
64	Mesothelioma	11.1%
65	synovial sarcoma	11.1%
66	Neuroectodermal Tumor, Melanotic	11.1%
67	Angiomyolipoma	11.1%
68	Clear Cell Sarcoma of Soft Tissue	11.1%
69	Alveolar Soft Part Sarcoma	11.1%
70	Neuroendocrine Tumors	11.1%
71	Sarcoma, Myeloid	11.1%
72	Carcinoma, Basal Cell	11.1%
73	Carcinoid Tumor	11%
74	Neurilemmoma	11%
75	Hutchinson's Melanotic Freckle	11%
76	Melanoma, Amelanotic	11%
77	Sarcoma, Experimental	11%
78	Meningioma	11%
79	Neoplasms, Radiation-Induced	10.8%
80	Astrocytoma	10.6%
81	Ependymoma	10.6%
82	oligodendroglioma	10.6%
83	Ganglioglioma	10.6%
84	gliosarcoma	10.6%
85	Anaplastic astrocytoma	10.6%
86	Anaplastic Oligodendroglioma	10.6%
87	Cystadenocarcinoma	10.5%
88	Fibrosarcoma	10.5%
89	Osteosarcoma	10.5%
90	Mucoepidermoid Carcinoma	10.5%
91	Adenoma	10.3%
92	Ameloblastoma	10.3%
93	Angiokeratoma	10.3%
94	Carcinoma	10.3%
95	Chordoma	10.3%
96	Hemangioma	10.3%
97	hemangiopericytoma	10.3%
98	Lymphangioma	10.3%
99	Malignant Carcinoid Syndrome	10.3%
100	Mesenchymoma	10.3%
101	Nevus	10.3%
102	Retroperitoneal Neoplasms	10.3%
103	Teratoma	10.3%
104	Hepatoblastoma	10.3%
105	Mixed Tumor, Mullerian	10.3%
106	Germinoma	10.3%
107	Teratocarcinoma	10.3%
108	Angiofibroma	10.3%
109	Sarcoma	10.3%
110	Epithelioma	10.3%
111	Choriocarcinoma	10.2%
112	Carcinoma, Lobular	10.2%
113	Adenofibroma	10.2%
114	Fibroadenoma	10.2%
115	Malignant Fibrous Histiocytoma	10.2%
116	Glioblastoma	10.1%
117	Neuroblastoma	10.1%
118	Glioblastoma Multiforme	10.1%
119	Digestive System Neoplasms	10%
120	Endocrine Gland Neoplasms	10%
121	Eye Neoplasms	10%
122	Nervous System Neoplasms	10%
123	Ganglioneuroblastoma	9.9%
124	Bowen's Disease	9.9%
125	Paraganglioma	9.9%
126	Rhabdomyosarcoma	9.9%
127	Giant Cell Tumor of Bone	9.9%
128	Leukemia, Radiation-Induced	9.7%
129	Dermatofibrosarcoma	9.6%
130	Dermatofibrosarcoma Protuberans	9.6%
131	Bone neoplasms	9.5%
132	Lymphocele	9.5%
133	Pancreatic Cyst	9.5%
134	Skin Neoplasms	9.5%
135	Hematologic Neoplasms	9.5%
136	Multiple Endocrine Neoplasia Type 1	9.4%
137	Breast Cyst	9.3%
138	Histiocytic Disorders, Malignant	9.3%
139	Mediastinal Cyst	9.3%
140	Neoplasm Invasiveness	9.3%
141	Neoplasm Metastasis	9.3%
142	Neoplasm Recurrence, Local	9.3%
143	Parovarian Cyst	9.3%
144	Pericardial Cyst	9.3%
145	Splenic Neoplasms	9.3%
146	Thymic Cyst	9.3%
147	Carcinogenesis	9.3%
148	Myxoid cyst	9.3%
149	Metastasis	9.3%
150	Pheochromocytoma	9.3%
151	Alveolar rhabdomyosarcoma	9.3%
152	Thymoma	9.2%
153	Leukemia, Plasma Cell	9.2%
154	Xeroderma Pigmentosum	9%
155	Adenocarcinoma	8.5%
156	Carcinoma in Situ	8.5%
157	Carcinoma, Transitional Cell	8.5%
158	Phyllodes Tumor	8.5%
159	Dysgerminoma	8.5%
160	Hemangioendothelioma	8.5%
161	Lipoma	8.5%
162	Myoma	8.5%
163	Myxoma	8.5%
164	Neuroma	8.5%
165	Papilloma	8.5%
166	Pseudomyxoma Peritonei	8.5%
167	Seminoma	8.5%
168	Papillomatosis	8.5%
169	Angiolipoma	8.5%
170	Myelolipoma	8.5%
171	Neoplasms, Bone Tissue	8.5%
172	Neoplasms, Fibrous Tissue	8.5%
173	Smooth Muscle Tumor	8.5%
174	Adenomatosis, Pulmonary	8.5%
175	Adenomatous Polyps	8.5%
176	Carcinoma, Large Cell	8.5%
177	Carcinoma, Small Cell	8.5%
178	Desmoplastic Small Round Cell Tumor	8.5%
179	Chondroma	8.5%
180	Enchondroma	8.5%
181	Parathyroid Neoplasms	8.3%
182	Peritoneal Neoplasms	8.3%
183	Thyroid Neoplasm	8.3%
184	Thyroid carcinoma	8.3%
185	Tuberous Sclerosis	8.2%
186	Carcinoid Heart Disease	8.2%
187	Composite Lymphoma	8%
188	Retinoblastoma	7.9%
189	Hydatidiform Mole	7.8%
190	Carcinoma, Pancreatic Ductal	7.7%
191	Tracheal Neoplasms	7.6%
192	Adenoid Cystic Carcinoma	7.6%
193	fibroma	7.6%
194	Fibromatosis	7.6%
195	Osteoblastoma	7.6%
196	Osteoma	7.6%
197	Rhabdomyoma	7.6%
198	Chondromatosis	7.6%
199	Adenocarcinoma, Clear Cell	7.6%
200	Cholangiocarcinoma	7.6%
201	Cervical Intraepithelial Neoplasia	7.6%
202	Hemangioblastoma	7.6%
203	Lymphoma, Extranodal NK-T-Cell	7.6%
204	Paraneoplastic Cerebellar Degeneration	7.3%
205	Liver Neoplasms, Experimental	7.3%
206	Acoustic Neuroma	7.3%
207	Neurofibrosarcoma	7.1%
208	Fibromatosis, Aggressive	7.1%
209	Fibromatosis, Abdominal	7.1%
210	Klatskin Tumor	7.1%
211	Basal Cell Nevus Syndrome	7.1%
212	Vipoma	7.1%
213	Mouth Neoplasms	7%
214	Pancreatic Neoplasm	7%
215	Central Nervous System Neoplasms	7%
216	Vascular Neoplasms	7%
217	Thymus Neoplasms	7%
218	Lymphoma	6.9%
219	Endometrial Stromal Sarcoma	6.9%
220	Genital Neoplasms, Female	6.8%
221	Pancreatic Pseudocyst	6.8%
222	Plasmacytoma	6.8%
223	Corpus Luteum Cyst	6.8%
224	Ovarian Cysts	6.8%
225	Nephroblastoma	6.8%
226	Malignant histiocytosis	6.7%
227	Lymphatic Metastasis	6.7%
228	Neoplasms, Unknown Primary	6.7%
229	Leukemic Infiltration	6.7%
230	Breast Neoplasms, Male	6.7%
231	Histiocytic sarcoma	6.7%
232	Neoplasm Micrometastasis	6.7%
233	Triple Negative Breast Neoplasms	6.7%
234	Thyroid Nodule	6.7%
235	Hepatocellular Adenoma	6.7%
236	Lymphangioleiomyomatosis	6.6%
237	Optic Nerve Glioma	6.4%
238	insulinoma	6.3%
239	Esophageal Neoplasms	6.1%
240	Gastrinoma	6.1%
241	Glucagonoma	6.1%
242	Limbic Encephalitis	6.1%
243	Meningeal Neoplasms	5.6%
244	Choledochal Cyst	5.6%
245	Leukemia, Myelomonocytic, Chronic	5.6%
246	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	5.6%
247	Prolactinoma	5.5%
248	Growth Hormone-Secreting Pituitary Adenoma	5.5%
249	Adenomatous Polyposis Coli	5.5%
250	Peutz-Jeghers Syndrome	5.4%
251	Leydig Cell Tumor	5.3%
252	Lambert-Eaton Myasthenic Syndrome	5.3%
253	Testicular Neoplasms	5.3%
254	Adrenal Gland Neoplasms	5.3%
255	Gastrointestinal Neoplasms	5.3%
256	Genital Neoplasms, Male	5.3%
257	Liver neoplasms	5.3%
258	Uveal Neoplasms	5.3%
259	Urologic Neoplasms	5.2%
260	Sebaceous Gland Neoplasms	5.1%
261	Spinal Neoplasms	5.1%
262	Bone Marrow Neoplasms	5.1%
263	Mastocytoma	5%
264	Hodgkin Disease	5%
265	Lymphoma, Non-Hodgkin	5%
266	Meningeal Carcinomatosis	5%
267	Mastocytosis, Systemic	5%
268	Polycystic Ovary Syndrome	5%
269	Leukemia, Myeloid, Chronic-Phase	4.9%
270	Mesoblastic Nephroma	4.9%
271	Adrenocortical carcinoma	4.9%
272	granulosa cell tumor	4.7%
273	Carcinoma, Ovarian Epithelial	4.7%
274	Opsoclonus-Myoclonus Syndrome	4.6%
275	Palatal Neoplasms	4.5%
276	Ear Neoplasms	4.3%
277	Eyelid Neoplasms	4.3%
278	Lung Neoplasms	4.3%
279	Pleural Neoplasms	4.3%
280	Nose Neoplasms	4.3%
281	Mastocytosis	4.3%
282	Sturge-Weber Syndrome	4.3%
283	Cell Transformation, Viral	4.2%
284	Brain Neoplasms	4.2%
285	Salivary Gland Neoplasms	4.2%
286	Spinal Cord Neoplasms	4.2%
287	Tongue Neoplasms	4.2%
288	Gastrointestinal Stromal Tumors	4.2%
289	Renal Cell Carcinoma	4.2%
290	Hemangioma, Cavernous	4.2%
291	Papillary Renal Cell Carcinoma	4.2%
292	Leukemia, T-Cell	4.1%
293	Uterine Neoplasms	4.1%
294	Vaginal Neoplasms	4.1%
295	Vulvar Neoplasms	4.1%
296	Uterine Cancer	4.1%
297	Leukemia, B-Cell	4.1%
298	Fallopian Tube Neoplasms	4.1%
299	neurofibroma	4.1%
300	Lymphoma, Follicular	4.1%
301	T-Cell Lymphoma	4.1%
302	Mantle cell lymphoma	4.1%
303	Myelitis, Transverse	4%
304	Carcinoma, Endometrioid	4%
305	Primary amyloidosis	4%
306	Bronchial Neoplasms	3.8%
307	Denys-Drash Syndrome	3.8%
308	Multiple Pulmonary Nodules	3.8%
309	Nasopharyngeal carcinoma	3.8%
310	Pituitary Adenoma	3.7%
311	Pituitary Neoplasms	3.7%
312	Supratentorial Neoplasms	3.7%
313	Endometrial Neoplasms	3.7%
314	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
315	Leukemia, Large Granular Lymphocytic	3.7%
316	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.7%
317	Lymphoma, T-Cell, Cutaneous	3.7%
318	Lymphoma, AIDS-Related	3.7%
319	Enteropathy-Associated T-Cell Lymphoma	3.7%
320	Primary Effusion Lymphoma	3.7%
321	Dupuytren Contracture	3.6%
322	Urticaria Pigmentosa	3.5%
323	Pharyngeal Neoplasms	3.5%
324	Brain Stem Neoplasms	3.5%
325	Mycosis Fungoides	3.4%
326	Lymphomatoid Papulosis	3.4%
327	Plasmablastic lymphoma	3.4%
328	Central Nervous System Cysts	3.4%
329	ovarian neoplasm	3.4%
330	Bile Duct Neoplasms	3.4%
331	gallbladder neoplasm	3.4%
332	Intestinal Neoplasms	3.4%
333	Penile Neoplasms	3.4%
334	Prostatic Neoplasms	3.4%
335	Stomach Neoplasms	3.4%
336	Choroid Plexus Papilloma	3.3%
337	Polycythemia Vera	3.3%
338	Hypopharyngeal Neoplasms	3%
339	Pleural Effusion, Malignant	3%
340	Hypopharyngeal Cancer	3%
341	Parotid Neoplasms	3%
342	Prostatic Neoplasms, Castration-Resistant	3%
343	Nelson Syndrome	2.9%
344	Laryngeal neoplasm	2.9%
345	Waldenstrom Macroglobulinemia	2.9%
346	Multiple Myeloma	2.9%
347	Tonsillar Neoplasms	2.8%
348	Cerebellar Neoplasms	2.8%
349	Bladder Neoplasm	2.8%
350	Kidney Neoplasm	2.8%
351	Ureteral Neoplasms	2.8%
352	Urethral Neoplasms	2.8%
353	Zollinger-Ellison syndrome	2.5%
354	Cecal Neoplasms	2.5%
355	Duodenal Neoplasms	2.5%
356	Burkitt Lymphoma	2.4%
357	Sezary Syndrome	2.3%
358	Radicular Cyst	2.3%
359	Appendiceal Neoplasms	2.3%
360	Colonic Neoplasms	2.3%
361	Rectal Neoplasms	2.3%
362	Nasopharyngeal Neoplasms	2.1%
363	Colorectal Neoplasms	2.1%
364	Anus Neoplasms	1.9%
365	Sigmoid Neoplasms	1.9%
366	Paranasal Sinus Neoplasms	1.9%
367	Maxillary Sinus Neoplasms	1.7%

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