MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Scleromyxedema

(UMLS:C0263390)

Definition:: A connective tissue disorder characterized by widespread thickening of SKIN with a cobblestone-like appearance. It is caused by proliferation of FIBROBLASTS and deposition of MUCIN in the DERMIS in the absence of thyroid disease. Most scleromyxedema cases are associated with a MONOCLONAL GAMMOPATHY, immunoglobulin IgG-lambda.
UMLS ID:: C0263390
MeSH ID:: D053718

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.550.875

Synonym(s)

Scleromyxedema

Arndt-Gottron syndrome

Lichen myxedematosus

Lichen myxoedematosus

Lichenoid myxedema

Lichenoid myxoedema

Papular mucinosis

Scleromyxoedema

lichen myxedematosus

10.

lichen; myxedematosus

11.

myxedematosus; lichen

12.

papular mucinosis

13.

scleromyxedema

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Isotretinoin		2050852	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Myxoid cyst	31.8%
2	Myxedema	31.1%
3	Collagen Diseases	31%
4	Mixed Connective Tissue Disease	31%
5	Lupus Erythematosus, Cutaneous	27.9%
6	Panniculitis	27.9%
7	Systemic Scleroderma	27.9%
8	Morphea	27.9%
9	Cartilage Diseases	22%
10	Rheumatism	22%
11	Chondromalacia	22%
12	Lupus Erythematosus, Systemic	20.9%
13	Overlap syndrome	20.9%
14	Cutis Laxa	18.6%
15	Panniculitis, Lupus Erythematosus	18.4%
16	Lupus Erythematosus, Discoid	17.8%
17	Scleroderma, Limited	17.8%
18	Dermatomyositis	16.2%
19	Dupuytren Contracture	15%
20	Mesenteric Panniculitis	13.6%
21	Panniculitis, Peritoneal	13.6%
22	Tietze's Syndrome	13.6%
23	Orbital Cellulitis	13.6%
24	Cellulitis	12.1%
25	Necrobiosis Lipoidica Diabeticorum	11.3%
26	Mucopolysaccharidosis III	11.2%
27	Pseudoxanthoma Elasticum	10.9%
28	Granuloma Annulare	10.7%
29	Breast Diseases	10.3%
30	Dermatitis	10.3%
31	Exanthema	10.3%
32	Facial Dermatoses	10.3%
33	Hair Diseases	10.3%
34	Hand Dermatoses	10.3%
35	keratoacanthoma	10.3%
36	Keratosis	10.3%
37	Nail Diseases	10.3%
38	Osteochondritis	10.3%
39	Photosensitivity Disorders	10.3%
40	Polymyalgia Rheumatica	10.3%
41	Prurigo	10.3%
42	Pyoderma	10.3%
43	Rosacea	10.3%
44	Sebaceous Gland Diseases	10.3%
45	Skin Diseases, Vesiculobullous	10.3%
46	Skin Ulcer	10.3%
47	Sweat Gland Diseases	10.3%
48	Skin Diseases, Papulosquamous	10.3%
49	Skin Diseases, Vascular	10.3%
50	Acneiform Eruptions	10.3%
51	Ocular Rosacea	10.3%
52	Subcorneal pustular dermatosis	10.3%
53	Erythematotelangiectatic Rosacea	10.3%
54	Papulopustular Rosacea	10.3%
55	Chronic Actinic Dermatitis	10.3%
56	Osteogenesis Imperfecta	10.1%
57	Pyoderma Gangrenosum	10%
58	Keloid	9.8%
59	Erythema Induratum	9.2%
60	Acne Vulgaris	8.9%
61	Contact Dermatitis	8.9%
62	Eczema	8.9%
63	Erythema Multiforme	8.9%
64	Intertrigo	8.9%
65	Neurodermatitis	8.9%
66	Rhinophyma	8.9%
67	Perioral Dermatitis	8.9%
68	Acne	8.9%
69	Noonan Syndrome	8.6%
70	Rheumatoid Arthritis	8.2%
71	Juvenile arthritis	8.2%
72	Lupus Nephritis	7.8%
73	Foot Ulcer	7.7%
74	Marfan Syndrome	7.6%
75	Mucopolysaccharidosis II	7.5%
76	Rheumatoid Nodule	7.4%
77	Homocystinuria	7.3%
78	Foot Diseases	7.3%
79	Dermatitis, Phototoxic	7.3%
80	Pityriasis Lichenoides et Varioliformis Acuta	7.3%
81	Pityriasis Lichenoides	7.3%
82	Phototoxicity	7.3%
83	Skin Abnormalities	7%
84	Skin Diseases, Infectious	7%
85	Skin Neoplasms	7%
86	Pigmentation Disorders	7%
87	Laryngomalacia	6.9%
88	Lipomatosis	6.8%
89	Pruritus	6.8%
90	Erythema	6.8%
91	Necrolytic Migratory Erythema	6.8%
92	Cutaneous Fistula	6.8%
93	Nephrogenic Fibrosing Dermopathy	6.8%
94	Pectus carinatum	6.8%
95	Nephrogenic Systemic Fibrosis	6.8%
96	Dermatitis Herpetiformis	6.8%
97	Acrodermatitis	6.7%
98	Anhidrosis	6.7%
99	Cholesteatoma	6.7%
100	Pressure Ulcer	6.7%
101	Dermatitis, Atopic	6.7%
102	Epidermolysis Bullosa	6.7%
103	Folliculitis	6.7%
104	Foot Dermatoses	6.7%
105	Gynecomastia	6.7%
106	Hypertrichosis	6.7%
107	Hypohidrosis	6.7%
108	Hypotrichosis	6.7%
109	Leg Ulcer	6.7%
110	Miliaria	6.7%
111	Parakeratosis	6.7%
112	Parapsoriasis	6.7%
113	Pityriasis	6.7%
114	Psoriasis	6.7%
115	Sebaceous Gland Neoplasms	6.7%
116	Sweet Syndrome	6.7%
117	Hidradenitis	6.7%
118	Onycholysis	6.7%
119	Miliaria Rubra	6.7%
120	Hyperpigmentation	6.7%
121	Porokeratosis	6.7%
122	Lichenoid Eruptions	6.7%
123	Gianotti-Crosti Syndrome	6.7%
124	Chloracne	6.7%
125	Keratoderma, Palmoplantar	6.7%
126	Dermatitis, Irritant	6.5%
127	Acne Conglobata	6.5%
128	Xeroderma Pigmentosum	6%
129	Felty Syndrome	5.9%
130	Bronchomalacia	5.9%
131	Tracheomalacia	5.9%
132	Dermatitis, Photoallergic	5.8%
133	Urticaria Pigmentosa	5.7%
134	CREST Syndrome	5.6%
135	Xeroderma	5.4%
136	Diaper Rash	5.4%
137	Dermatitis, Occupational	5.2%
138	Mastocytosis	5%
139	Lichen Planus	4.9%
140	Melanosis	4.9%
141	Chloasma	4.9%
142	Pityriasis Rosea	4.9%
143	Pityriasis Rubra Pilaris	4.9%
144	Vitiligo	4.9%
145	Dermatitis, Allergic Contact	4.9%
146	Lichen Nitidus	4.9%
147	Rheumatoid Vasculitis	4.9%
148	Papillon-Lefevre Disease	4.9%
149	Erythema Infectiosum	4.7%
150	Exanthema Subitum	4.7%
151	Erythema Nodosum	4.6%
152	Acantholysis	4.5%
153	Breast Cyst	4.5%
154	Actinic keratosis	4.5%
155	Pemphigoid, Benign Mucous Membrane	4.5%
156	Pemphigus	4.5%
157	Piedra	4.5%
158	Sunburn	4.5%
159	Argyria	4.4%
160	Ectodermal Dysplasia	4.4%
161	Hirsutism	4.4%
162	Lactation Disorder	4.4%
163	Mastitis	4.4%
164	Urticaria	4.4%
165	Aplasia Cutis Congenita	4.4%
166	Adiposis Dolorosa	4.4%
167	Pruritus Vulvae	4.4%
168	Mastocytoma	4.4%
169	Pruritus Ani	4.4%
170	Sicca Syndrome	4.2%
171	Sjogren's Syndrome	4.2%
172	Tinea Capitis	4.2%
173	Onychomycosis	4.2%
174	Toxic Epidermal Necrolysis	4.2%
175	Stevens-Johnson Syndrome	4.2%
176	Acanthosis Nigricans	4.1%
177	Alopecia Areata	4.1%
178	Lentigo	4.1%
179	Ecthyma	3.8%
180	Hyperkeratosis, Epidermolytic	3.7%
181	Dermatomycoses	3.4%
182	Mucocutaneous Lymph Node Syndrome	3.4%
183	Skin Diseases, Bacterial	3.4%
184	Alopecia	3.4%
185	Sweating, Gustatory	3.4%
186	Androgenetic Alopecia	3.4%
187	Auriculotemporal Syndrome	3.4%
188	Drug Eruptions	3.3%
189	Lipodystrophy	3.3%
190	Livedo Reticularis	3.3%
191	Malignant Atrophic Papulosis	3.3%
192	Behcet Syndrome	3.3%
193	Lice Infestations	3.3%
194	Varicose Ulcer	3.3%
195	Breast Neoplasms, Male	3.3%
196	Triple Negative Breast Neoplasms	3.3%
197	Polyarteritis Nodosa	3.3%
198	Takayasu Arteritis	3.3%
199	Ichthyosis, X-Linked	3.3%
200	Hidradenitis Suppurativa	3.3%
201	Galactorrhea	3.3%
202	Sjogren-Larsson Syndrome	3.3%
203	Lupus Vasculitis, Central Nervous System	3.2%
204	Tinea Pedis	3%
205	Albinism	2.9%
206	Erythema Chronicum Migrans	2.8%
207	Lichen Planus, Oral	2.8%
208	Nail-Patella Syndrome	2.7%
209	Porphyrias, Hepatic	2.7%
210	Larva Migrans	2.5%
211	Leishmaniasis	2.5%
212	Molluscum Contagiosum	2.5%
213	Angioedema	2.5%
214	Onchocerciasis	2.5%
215	Chromoblastomycosis	2.5%
216	Dermatophytosis	2.5%
217	Sporotrichosis	2.5%
218	Tinea	2.5%
219	Tinea Versicolor	2.5%
220	Trichophytosis	2.5%
221	Hyalohyphomycosis	2.5%
222	Mycetoma	2.4%
223	Acute Generalized Exanthematous Pustulosis	2.4%
224	Leishmaniasis, Cutaneous	2%
225	Eczema Herpeticum	2%
226	Warts	2%
227	Fusariosis	2%
228	Candidiasis, Chronic Mucocutaneous	2%
229	Cutaneous Candidiasis	2%
230	Erysipelas	2%
231	Serum Sickness	2%
232	Staphylococcal Skin Infections	2%
233	Variegate Porphyria	2%
234	Acute intermittent porphyria	2%
235	Porphyria Cutanea Tarda	2%
236	Erythrasma	2%
237	Carcinoma, Lobular	2%
238	Arthritis, Psoriatic	1.9%
239	Hereditary Angioedema Type III	1.8%
240	Hereditary Angioedema Types I and II	1.8%
241	Angioedemas, Hereditary	1.7%
242	Epidermodysplasia Verruciformis	1.6%
243	Herpes Labialis	1.6%
244	Giant Cell Arteritis	1.6%
245	Temporal Arteritis	1.6%
246	Diabetic Foot	1.6%
247	Staphylococcal Scalded Skin Syndrome	1.6%
248	Peutz-Jeghers Syndrome	1.5%
249	carbuncle	1.4%
250	Blastomycosis	1.4%
251	HIV-Associated Lipodystrophy Syndrome	1.4%
252	Condylomata Acuminata	1.4%
253	Furunculosis	1.4%
254	furuncle	1.4%
255	Impetigo	1.3%
256	Rhinoscleroma	1.3%
257	Menkes Kinky Hair Syndrome	1.2%

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