MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leukemia, Myelomonocytic, Chronic

(UMLS:C0023480)

Definition:: A myelodysplastic-myeloproliferative disease characterized by monocytosis, increased monocytes in the bone marrow, variable degrees of dysplasia, but an absence of immature granulocytes in the blood.
UMLS ID:: C0023480
MeSH ID:: D015477

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.337.539.522

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.378.190.615.510

Synonym(s)

Leukemia, Myelomonocytic, Chronic

CMML

CMML (chronic myelomonocytic leukemia)

CMML - Chronic myelomonocytic leukaemia

CMML - Chronic myelomonocytic leukemia

Chronic Myelomonocytic Leukemia

Chronic Myelomonocytic Leukemia (CMML)

Chronic myelomonocytic leukaemia

Chronic myelomonocytic leukemia

10.

chronic myelomonocytic leukaemia

11.

chronic myelomonocytic leukemia

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Amifostine	10688811	CTD
2	Ciprofloxacin	10688811	CTD
3	Cytarabine	15981233	CTD
4	Decitabine	18055864	CTD
5	Dexamethasone	10688811	CTD
6	Mercaptopurine	10644815	CTD
7	Pentoxifylline	10688811	CTD
8	Vincristine	15981233	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	48.4%
2	Sarcoma, Myeloid	29%
3	Leukemia, Myeloid, Chronic-Phase	26.4%
4	MYELODYSPLASTIC SYNDROME	22.8%
5	Bone Marrow Neoplasms	21.7%
6	Polycythemia Vera	19.4%
7	Thrombocythemia, Essential	18.7%
8	Thrombocytosis	18.7%
9	Disseminated Intravascular Coagulation	17.8%
10	Protein S Deficiency	17.8%
11	Leukemia, Plasma Cell	17.5%
12	Leukemia, Experimental	17.2%
13	Hematologic Neoplasms	16.9%
14	Anemia	16.7%
15	Blood Coagulation Disorders	16.7%
16	Blood Platelet Disorders	16.7%
17	Hemorrhagic Disorders	16.7%
18	Leukocyte Disorders	16.7%
19	Methemoglobinemia	16.7%
20	Neoplasms, Germ Cell and Embryonal	16.7%
21	Neoplasms, Glandular and Epithelial	16.7%
22	Pancytopenia	16.7%
23	Polycythemia	16.7%
24	Sulfhemoglobinemia	16.7%
25	Thrombophilia	16.7%
26	Germ Cell Cancer	16.7%
27	Erythrocytosis	16.7%
28	Hemoglobinuria, Paroxysmal	16.1%
29	Leukemoid Reaction	16.1%
30	Primary Myelofibrosis	15.1%
31	Myelofibrosis	15.1%
32	Myeloid Metaplasia	15.1%
33	bone marrow fibrosis	15.1%
34	Histiocytic Disorders, Malignant	15%
35	Neuroectodermal Tumors	14.8%
36	Leukemia, Radiation-Induced	14.5%
37	Leukemia L1210	13.8%
38	Leukemia P388	13.8%
39	Neoplasms, Neuroepithelial	13.6%
40	Gliomatosis cerebri	13.6%
41	Transfusion Reaction	13.2%
42	Hypotensive Transfusion Reaction	13.2%
43	Thrombasthenia	13.1%
44	Antithrombin III Deficiency	13.1%
45	Protein C Deficiency	13.1%
46	Pregnancy Complications, Hematologic	12.7%
47	Carcinosarcoma	12.2%
48	Hemangiosarcoma	12.2%
49	lymphangiosarcoma	12.2%
50	Lymphoma	12%
51	Vitamin K Deficiency	11.7%
52	melanoma	11.6%
53	Afibrinogenemia	11.4%
54	Factor VII Deficiency	11.4%
55	Factor X Deficiency	11.4%
56	Factor XII Deficiency	11.4%
57	Hemophilia A	11.4%
58	Activated Protein C Resistance	11.4%
59	Factor II deficiency	11.4%
60	Factor VIII Deficiency	11.4%
61	Factor V deficiency	11.4%
62	Factor XI Deficiency	11.4%
63	Hypoprothrombinemias	11.4%
64	Anemia, Diamond-Blackfan	11.3%
65	Composite Lymphoma	10.9%
66	Meningioma	10.6%
67	Hamartoma	10.5%
68	Lymphatic Diseases	10.5%
69	Neoplasms, Hormone-Dependent	10.5%
70	Neoplasms, Multiple Primary	10.5%
71	Paraneoplastic Syndromes	10.5%
72	Precancerous Conditions	10.5%
73	Neoplasms, Second Primary	10.5%
74	Leukemia, T-Cell	10.3%
75	Leukemia, B-Cell	10.3%
76	Carcinoma 256, Walker	10.2%
77	Waldenstrom Macroglobulinemia	9.8%
78	Adenoma	9.8%
79	Ameloblastoma	9.8%
80	Anemia, Hemolytic	9.8%
81	Anemia, Macrocytic	9.8%
82	Angiokeratoma	9.8%
83	Carcinoma	9.8%
84	Chordoma	9.8%
85	Eosinophilia	9.8%
86	Hemangioma	9.8%
87	hemangiopericytoma	9.8%
88	Hypoproteinemia	9.8%
89	Leukopenia	9.8%
90	Lymphangioma	9.8%
91	Mesenchymoma	9.8%
92	Nevus	9.8%
93	Teratoma	9.8%
94	Thrombocytopenia	9.8%
95	Hepatoblastoma	9.8%
96	Mixed Tumor, Mullerian	9.8%
97	Germinoma	9.8%
98	Teratocarcinoma	9.8%
99	Angiofibroma	9.8%
100	Leukostasis	9.8%
101	Sarcoma	9.8%
102	Epithelioma	9.8%
103	Basal cell carcinoma	9.7%
104	Carcinoma, Papillary	9.7%
105	Squamous cell carcinoma	9.7%
106	Chondrosarcoma	9.7%
107	Craniopharyngioma	9.7%
108	Cystadenoma	9.7%
109	leiomyosarcoma	9.7%
110	liposarcoma	9.7%
111	Mesothelioma	9.7%
112	synovial sarcoma	9.7%
113	Neuroectodermal Tumor, Melanotic	9.7%
114	Angiomyolipoma	9.7%
115	Clear Cell Sarcoma of Soft Tissue	9.7%
116	Alveolar Soft Part Sarcoma	9.7%
117	Neuroendocrine Tumors	9.7%
118	Carcinoma, Basal Cell	9.7%
119	Adenoma, Acidophil	9.6%
120	Ganglioneuroma	9.6%
121	Glioma	9.6%
122	Malignant Glioma	9.6%
123	Medulloblastoma	9.5%
124	Trophoblastic Neoplasms	9.3%
125	Thymoma	9.2%
126	Carcinoma, Ehrlich Tumor	9.1%
127	Dermoid Cyst	9.1%
128	Carcinoma, Lewis Lung	9.1%
129	Malignant histiocytosis	8.9%
130	Histiocytic sarcoma	8.9%
131	Carcinoid Tumor	8.6%
132	Neurilemmoma	8.6%
133	Hutchinson's Melanotic Freckle	8.6%
134	Melanoma, Amelanotic	8.6%
135	Multiple Myeloma	8.6%
136	Melanoma, Experimental	8.6%
137	Lymphocele	8.5%
138	Cystadenocarcinoma	8.4%
139	Fibrosarcoma	8.4%
140	Osteosarcoma	8.4%
141	Mucoepidermoid Carcinoma	8.4%
142	Fanconi Anemia	8.1%
143	Agammaglobulinemia	8%
144	Wiskott-Aldrich Syndrome	8%
145	Purpura, Thrombotic Thrombocytopenic	7.9%
146	Cyst	7.9%
147	Neoplastic Processes	7.9%
148	Neoplastic Syndromes, Hereditary	7.9%
149	Pregnancy Complications, Neoplastic	7.9%
150	Adenofibroma	7.8%
151	Fibroadenoma	7.8%
152	Malignant Fibrous Histiocytoma	7.8%
153	Hemangioma, Cavernous	7.8%
154	Neoplasms, Experimental	7.8%
155	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
156	Leukemia, Large Granular Lymphocytic	7.7%
157	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
158	Astrocytoma	7.6%
159	Ependymoma	7.6%
160	oligodendroglioma	7.6%
161	Ganglioglioma	7.6%
162	gliosarcoma	7.6%
163	Anaplastic astrocytoma	7.6%
164	Anaplastic Oligodendroglioma	7.6%
165	Lymphangioleiomyomatosis	7.5%
166	Anemia, Neonatal	7.5%
167	Leukocytosis	7.5%
168	Paraproteinemias	7.5%
169	Pelger-Huet Anomaly	7.5%
170	Pleocytosis	7.5%
171	Plasmacytoma	7.4%
172	Anemia, Sickle Cell	7.4%
173	Thalassemia	7.4%
174	Acanthoma	7.3%
175	Choriocarcinoma	7.3%
176	Carcinoma, Lobular	7.3%
177	Sarcoma, Experimental	7.2%
178	Endometrial Stromal Sarcoma	7.2%
179	Bowen's Disease	7.2%
180	Paraganglioma	7.2%
181	Rhabdomyosarcoma	7.2%
182	Giant Cell Tumor of Bone	7.2%
183	Malignant Carcinoid Syndrome	7.2%
184	Hodgkin Disease	7.1%
185	Lymphoma, Non-Hodgkin	7.1%
186	Glioblastoma	6.7%
187	Neuroblastoma	6.7%
188	Splenic Neoplasms	6.7%
189	Glioblastoma Multiforme	6.7%
190	Thymus Neoplasms	6.7%
191	Dermatofibrosarcoma	6.6%
192	Dermatofibrosarcoma Protuberans	6.6%
193	Infectious Mononucleosis	6.6%
194	Cryoglobulinemia	6.5%
195	Monoclonal Gammopathy of Undetermined Significance	6.5%
196	Adenocarcinoma	6.5%
197	Agranulocytosis	6.5%
198	Anemia, Megaloblastic	6.5%
199	Carcinoma in Situ	6.5%
200	Carcinoma, Transitional Cell	6.5%
201	Phyllodes Tumor	6.5%
202	Dysgerminoma	6.5%
203	Hemangioendothelioma	6.5%
204	Lipoma	6.5%
205	Lymphocytosis	6.5%
206	Myoma	6.5%
207	Myxoma	6.5%
208	Neuroma	6.5%
209	Papilloma	6.5%
210	Pseudomyxoma Peritonei	6.5%
211	Seminoma	6.5%
212	Papillomatosis	6.5%
213	Angiolipoma	6.5%
214	Myelolipoma	6.5%
215	Neoplasms, Bone Tissue	6.5%
216	Neoplasms, Fibrous Tissue	6.5%
217	Smooth Muscle Tumor	6.5%
218	Adenomatosis, Pulmonary	6.5%
219	Adenomatous Polyps	6.5%
220	Carcinoma, Large Cell	6.5%
221	Hypoalbuminemia	6.5%
222	Carcinoma, Small Cell	6.5%
223	Desmoplastic Small Round Cell Tumor	6.5%
224	Chondroma	6.5%
225	Hypereosinophilic syndrome	6.5%
226	Enchondroma	6.5%
227	Thrombotic Microangiopathies	6.5%
228	Multiple Endocrine Neoplasia	6.3%
229	Autoimmune thrombocytopenia	6.3%
230	Immune thrombocytopenic purpura	6.3%
231	Neoplasms, Radiation-Induced	6.2%
232	Retinoblastoma	6.2%
233	Ganglioneuroblastoma	6.2%
234	Hypergammaglobulinemia	6.1%
235	Sarcoma 180	6.1%
236	Pheochromocytoma	6%
237	Alveolar rhabdomyosarcoma	6%
238	Transfusion-Related Acute Lung Injury	6%
239	Ecchymosis	5.9%
240	Petechiae	5.9%
241	Purpura	5.9%
242	Heavy Chain Disease	5.9%
243	Lymphomatoid Granulomatosis	5.8%
244	Neurofibrosarcoma	5.8%
245	Hemolytic-Uremic Syndrome	5.6%
246	Abdominal Neoplasms	5.6%
247	Adenitis	5.6%
248	Erythroplasia	5.6%
249	Follicular cyst	5.6%
250	Head and Neck Neoplasms	5.6%
251	Histiocytosis	5.6%
252	Lymphadenitis	5.6%
253	Lymphangitis	5.6%
254	Lymphedema	5.6%
255	Mucocele	5.6%
256	Pilonidal Cyst	5.6%
257	Purpura, Hyperglobulinemic	5.6%
258	Soft Tissue Neoplasms	5.6%
259	Splenic Diseases	5.6%
260	Thoracic Neoplasms	5.6%
261	Thymus Hyperplasia	5.6%
262	Thyroglossal Cyst	5.6%
263	Synovial Cyst	5.6%
264	Pseudolymphoma	5.6%
265	Lymphadenopathy	5.6%
266	Aberrant Crypt Foci	5.6%
267	Carcinoid Heart Disease	5.5%
268	Paraneoplastic Encephalomyelitis	5.4%
269	Mammary Neoplasms, Experimental	5.3%
270	Sickle Cell Trait	5.2%
271	Nephroblastoma	5.1%
272	Thrombocytopenic purpura	5%
273	Lymphopenia	5%
274	Hydrops Fetalis	4.9%
275	Primary amyloidosis	4.9%
276	Job Syndrome	4.9%
277	Adenoid Cystic Carcinoma	4.8%
278	fibroma	4.8%
279	Fibromatosis	4.8%
280	Neutropenia	4.8%
281	Osteoblastoma	4.8%
282	Osteoma	4.8%
283	Rhabdomyoma	4.8%
284	Chondromatosis	4.8%
285	Adenocarcinoma, Clear Cell	4.8%
286	Cholangiocarcinoma	4.8%
287	Cervical Intraepithelial Neoplasia	4.8%
288	Hemangioblastoma	4.8%
289	Lymphoma, Extranodal NK-T-Cell	4.8%
290	Lymphoma, Follicular	4.8%
291	T-Cell Lymphoma	4.8%
292	Mantle cell lymphoma	4.8%
293	Basal Cell Nevus Syndrome	4.6%
294	Tuberous Sclerosis	4.6%
295	Carcinoma, Pancreatic Ductal	4.4%
296	Waterhouse-Friderichsen Syndrome	4.4%
297	Digestive System Neoplasms	4.4%
298	Endocrine Gland Neoplasms	4.4%
299	Eye Neoplasms	4.4%
300	Nervous System Neoplasms	4.4%
301	Atypical Hemolytic Uremic Syndrome	4.4%
302	Acoustic Neuroma	4.4%
303	Hepatocellular Adenoma	4.3%
304	Bone neoplasms	4.2%
305	Leukoplakia	4.2%
306	Lymphoproliferative Disorders	4.2%
307	Pancreatic Cyst	4.2%
308	Skin Neoplasms	4.2%
309	Lymphatic Abnormalities	4.2%
310	Mesoblastic Nephroma	4.2%
311	Barrett Esophagus	4.2%
312	Breast Cyst	4.2%
313	Hydatidiform Mole	4.2%
314	Actinic keratosis	4.2%
315	Mediastinal Cyst	4.2%
316	Neoplasm Invasiveness	4.2%
317	Neoplasm Metastasis	4.2%
318	Neoplasm Recurrence, Local	4.2%
319	Parovarian Cyst	4.2%
320	Pericardial Cyst	4.2%
321	Thymic Cyst	4.2%
322	Carcinogenesis	4.2%
323	Myxoid cyst	4.2%
324	Metastasis	4.2%
325	Acute Chest Syndrome	4%
326	Fibromatosis, Aggressive	4%
327	Fibromatosis, Abdominal	4%
328	Klatskin Tumor	4%
329	Febrile Neutropenia	4%
330	Mastocytosis	4%
331	Sturge-Weber Syndrome	4%
332	Eosinophilia-Myalgia Syndrome	4%
333	Lymphangiectasis, Intestinal	3.9%
334	Optic Nerve Glioma	3.9%
335	Chronic granulomatous disease	3.9%
336	Shwartzman Phenomenon	3.9%
337	Gastrointestinal Stromal Tumors	3.9%
338	Scurvy	3.9%
339	Purpura Fulminans	3.9%
340	neurofibroma	3.9%
341	Eosinophilic Granuloma	3.8%
342	Multiple Endocrine Neoplasia Type 1	3.7%
343	Kernicterus	3.7%
344	Vipoma	3.7%
345	Prolactinoma	3.7%
346	Growth Hormone-Secreting Pituitary Adenoma	3.7%
347	Pulmonary Eosinophilia	3.7%
348	Eosinophilic Pneumonia	3.7%
349	Lymphoma, T-Cell, Cutaneous	3.7%
350	Lymphoma, AIDS-Related	3.7%
351	Enteropathy-Associated T-Cell Lymphoma	3.7%
352	Primary Effusion Lymphoma	3.7%
353	Mastocytoma	3.6%
354	Sezary Syndrome	3.6%
355	Mastocytosis, Systemic	3.6%
356	Anemia, Pernicious	3.6%
357	Parathyroid Neoplasms	3.4%
358	Peritoneal Neoplasms	3.4%
359	Thyroid Neoplasm	3.4%
360	Thyroid carcinoma	3.4%
361	Mucocutaneous Lymph Node Syndrome	3.3%
362	Liver Neoplasms, Experimental	3.3%
363	Corpus Luteum Cyst	3.3%
364	Ovarian Cysts	3.3%
365	Elephantiasis	3.3%
366	Hypersplenism	3.3%
367	Retroperitoneal Neoplasms	3.3%
368	Sarcoidosis	3.3%
369	POEMS Syndrome	3.3%
370	Elephantiasis Nostras Verrucosa	3.3%
371	granulosa cell tumor	3.2%
372	Carcinoma, Ovarian Epithelial	3.2%
373	Adenomatous Polyposis Coli	3.2%
374	Mycosis Fungoides	3.1%
375	Lymphomatoid Papulosis	3.1%
376	Plasmablastic lymphoma	3.1%
377	insulinoma	3%
378	Pancreatic Neoplasm	2.9%
379	Choledochal Cyst	2.8%
380	Tracheal Neoplasms	2.8%
381	Adrenocortical carcinoma	2.8%
382	Peutz-Jeghers Syndrome	2.7%
383	Leukoplakia, Oral	2.7%
384	Paraneoplastic Cerebellar Degeneration	2.7%
385	Gastrinoma	2.7%
386	Glucagonoma	2.7%
387	Burkitt Lymphoma	2.6%
388	Nasopharyngeal carcinoma	2.6%
389	Leydig Cell Tumor	2.6%
390	Granuloma	2.5%
391	Mouth Neoplasms	2.5%
392	Splenic Infarction	2.5%
393	Central Nervous System Neoplasms	2.5%
394	Vascular Neoplasms	2.5%
395	Dupuytren Contracture	2.5%
396	Genital Neoplasms, Female	2.5%
397	Histiocytosis, Langerhans-Cell	2.5%
398	Pancreatic Pseudocyst	2.5%
399	Tumor Lysis Syndrome	2.5%
400	Lymphatic Metastasis	2.4%
401	Neoplasms, Unknown Primary	2.4%
402	Leukemic Infiltration	2.4%
403	Breast Neoplasms, Male	2.4%
404	Neoplasm Micrometastasis	2.4%
405	Triple Negative Breast Neoplasms	2.4%
406	Urticaria Pigmentosa	2.4%
407	Renal Cell Carcinoma	2.4%
408	Papillary Renal Cell Carcinoma	2.4%
409	Esophageal Neoplasms	2.3%
410	Denys-Drash Syndrome	2.3%
411	Limbic Encephalitis	2.3%
412	Carcinoma, Endometrioid	2.3%
413	Pseudoxanthoma Elasticum	2.2%
414	Thyroid Nodule	2.2%
415	Lymphohistiocytosis, Hemophagocytic	2.2%
416	Erdheim-Chester Disease	2.2%
417	Lambert-Eaton Myasthenic Syndrome	2.1%
418	Testicular Neoplasms	2.1%
419	Adrenal Gland Neoplasms	2%
420	Gastrointestinal Neoplasms	2%
421	Genital Neoplasms, Male	2%
422	Liver neoplasms	2%
423	Splenic Rupture	2%
424	Uveal Neoplasms	2%
425	Urologic Neoplasms	2%
426	Sebaceous Gland Neoplasms	2%
427	Spinal Neoplasms	2%
428	Polycystic Ovary Syndrome	1.9%
429	Opsoclonus-Myoclonus Syndrome	1.8%
430	Autoimmune Lymphoproliferative Syndrome	1.7%
431	Xeroderma Pigmentosum	1.7%
432	Myelitis, Transverse	1.6%
433	Meningeal Neoplasms	1.6%
434	Sarcoidosis, Pulmonary	1.6%
435	Nose Neoplasms	1.5%
436	Palatal Neoplasms	1.4%
437	ovarian neoplasm	1.4%
438	Pituitary Adenoma	1.3%
439	Pituitary Neoplasms	1.3%
440	Ear Neoplasms	1.3%
441	Eyelid Neoplasms	1.3%
442	Lung Neoplasms	1.3%
443	Pleural Neoplasms	1.3%
444	Cell Transformation, Viral	1.3%
445	Brain Neoplasms	1.3%
446	Salivary Gland Neoplasms	1.3%
447	Spinal Cord Neoplasms	1.3%
448	Tongue Neoplasms	1.3%
449	Splenosis	1.3%
450	Uterine Neoplasms	1.3%
451	Vaginal Neoplasms	1.3%
452	Vulvar Neoplasms	1.3%
453	Uterine Cancer	1.3%
454	Fallopian Tube Neoplasms	1.3%
455	Meningeal Carcinomatosis	1.2%
456	Pharyngeal Neoplasms	1.1%
457	Central Nervous System Cysts	1.1%
458	Bile Duct Neoplasms	1.1%
459	gallbladder neoplasm	1.1%
460	Intestinal Neoplasms	1.1%
461	Penile Neoplasms	1.1%
462	Prostatic Neoplasms	1.1%
463	Stomach Neoplasms	1.1%
464	Zollinger-Ellison syndrome	1.1%
465	Bronchial Neoplasms	1%
466	Multiple Pulmonary Nodules	1%
467	Laryngeal neoplasm	1%
468	Supratentorial Neoplasms	1%
469	Endometrial Neoplasms	1%
470	Bladder Neoplasm	0.9%
471	Kidney Neoplasm	0.9%
472	Ureteral Neoplasms	0.9%
473	Urethral Neoplasms	0.9%
474	Hypopharyngeal Neoplasms	0.8%
475	Pleural Effusion, Malignant	0.8%
476	Hypopharyngeal Cancer	0.8%
477	Parotid Neoplasms	0.8%
478	Prostatic Neoplasms, Castration-Resistant	0.8%
479	Nelson Syndrome	0.8%
480	Brain Stem Neoplasms	0.8%
481	Choroid Plexus Papilloma	0.7%
482	Cecal Neoplasms	0.7%
483	Duodenal Neoplasms	0.7%
484	Tonsillar Neoplasms	0.7%
485	Cerebellar Neoplasms	0.7%
486	Nasopharyngeal Neoplasms	0.6%
487	Colorectal Neoplasms	0.6%
488	Radicular Cyst	0.6%
489	Appendiceal Neoplasms	0.6%
490	Colonic Neoplasms	0.6%
491	Rectal Neoplasms	0.6%
492	Paranasal Sinus Neoplasms	0.5%
493	Maxillary Sinus Neoplasms	0.4%
494	Anus Neoplasms	0.4%
495	Sigmoid Neoplasms	0.4%
496	Niemann-Pick Disease, Type C	0.4%

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