MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Systemic Scleroderma

(UMLS:C0036421)

Definition:: A chronic multi-system disorder of CONNECTIVE TISSUE. It is characterized by SCLEROSIS in the SKIN, the LUNGS, the HEART, the GASTROINTESTINAL TRACT, the KIDNEYS, and the MUSCULOSKELETAL SYSTEM. Other important features include diseased small BLOOD VESSELS and AUTOANTIBODIES. The disorder is named for its most prominent feature (hard skin), and classified into subsets by the extent of skin thickening: LIMITED SCLERODERMA and DIFFUSE SCLERODERMA.
UMLS ID:: C0036421
MeSH ID:: D012595

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.799|C17.800.784

Synonym(s)

Systemic Scleroderma

Diffuse Scleroderma

Diffuse Sclerosis

PROGRESSIVE SYSTEMIC SCLEROSIS

PSS

PSS - Progressive systemic sclerosis

Progressive Systemic Sclerosis

Progressive system sclerosis

Progressive systemic sclerosis

10.

SCLEROSIS, SYSTEMIC

11.

SS - Systemic sclerosis

12.

SSc, Diffuse Sclerosis

13.

SYSTEMIC SCLEROSIS

14.

Scleroderma syndrome

15.

Scleroderma, Diffuse

16.

Scleroderma, Systemic

17.

Scleroderma;progressive

Associated Drug(s)

	Name	Number of Reports	Data Source
1	treprostinil	FAERS: 5	US FAERS
2	Methotrexate	FAERS: 3	US FAERS
3	ambrisentan	FAERS: 3	US FAERS
4	Bosentan	FAERS: 2	US FAERS
5	Capecitabine	FAERS: 2	US FAERS
6	Mycophenolic Acid	FAERS: 2	US FAERS
7	Prednisone	FAERS: 2	US FAERS
8	4-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamide	FAERS: 1	US FAERS
9	Dabigatran	FAERS: 1	US FAERS
10	Dasatinib	FAERS: 1	US FAERS
11	Epoprostenol	FAERS: 1	US FAERS
12	Esomeprazole	FAERS: 1	US FAERS
13	Exenatide	FAERS: 1	US FAERS
14	PCI 32765	FAERS: 1	US FAERS
15	Rosuvastatin Calcium	FAERS: 1	US FAERS
16	Zoledronic Acid	FAERS: 1	US FAERS
17	macitentan	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Lupus Erythematosus, Cutaneous	57.1%
2	Panniculitis	57.1%
3	Morphea	57.1%
4	Panniculitis, Lupus Erythematosus	49.4%
5	Pyoderma Gangrenosum	49.3%
6	Acne Vulgaris	41.4%
7	Contact Dermatitis	41.4%
8	Eczema	41.4%
9	Erythema Multiforme	41.4%
10	Intertrigo	41.4%
11	Lupus Erythematosus, Discoid	41.4%
12	Neurodermatitis	41.4%
13	Rhinophyma	41.4%
14	Perioral Dermatitis	41.4%
15	Acne	41.4%
16	Dermatitis, Phototoxic	40.3%
17	Pityriasis Lichenoides et Varioliformis Acuta	40.3%
18	Pityriasis Lichenoides	40.3%
19	Phototoxicity	40.3%
20	Cutis Laxa	38.9%
21	Necrobiosis Lipoidica Diabeticorum	38.4%
22	Breast Diseases	38.1%
23	Collagen Diseases	38.1%
24	Dermatitis	38.1%
25	Exanthema	38.1%
26	Facial Dermatoses	38.1%
27	Hair Diseases	38.1%
28	Hand Dermatoses	38.1%
29	keratoacanthoma	38.1%
30	Keratosis	38.1%
31	Mixed Connective Tissue Disease	38.1%
32	Nail Diseases	38.1%
33	Photosensitivity Disorders	38.1%
34	Prurigo	38.1%
35	Pyoderma	38.1%
36	Rosacea	38.1%
37	Sebaceous Gland Diseases	38.1%
38	Skin Diseases, Vesiculobullous	38.1%
39	Skin Ulcer	38.1%
40	Sweat Gland Diseases	38.1%
41	Skin Diseases, Papulosquamous	38.1%
42	Skin Diseases, Vascular	38.1%
43	Mucinoses	38.1%
44	Acneiform Eruptions	38.1%
45	Ocular Rosacea	38.1%
46	Subcorneal pustular dermatosis	38.1%
47	Erythematotelangiectatic Rosacea	38.1%
48	Papulopustular Rosacea	38.1%
49	Chronic Actinic Dermatitis	38.1%
50	Foot Ulcer	37.6%
51	Dermatomyositis	36.7%
52	Dermatitis, Atopic	35%
53	Epidermolysis Bullosa	35%
54	Dermatitis, Irritant	33.9%
55	Acne Conglobata	33.9%
56	Dermatitis Herpetiformis	33.3%
57	Dermatitis, Photoallergic	33.3%
58	Erythema Induratum	33.1%
59	Acrodermatitis	32.9%
60	Sebaceous Gland Neoplasms	32.9%
61	Porokeratosis	32.9%
62	Gianotti-Crosti Syndrome	32.9%
63	Keratoderma, Palmoplantar	32.9%
64	Xeroderma Pigmentosum	32.7%
65	Diaper Rash	30.3%
66	Pseudoxanthoma Elasticum	30.2%
67	Granuloma Annulare	29.9%
68	Cartilage Diseases	29.6%
69	Foot Diseases	29.6%
70	Rheumatism	29.6%
71	Chondromalacia	29.6%
72	Urticaria Pigmentosa	29.6%
73	Lupus Erythematosus, Systemic	28.6%
74	Skin Abnormalities	28.6%
75	Skin Diseases, Infectious	28.6%
76	Skin Neoplasms	28.6%
77	Overlap syndrome	28.6%
78	Pigmentation Disorders	28.6%
79	Dermatitis, Occupational	28.2%
80	Lipomatosis	28.1%
81	Pruritus	28.1%
82	Erythema	28.1%
83	Necrolytic Migratory Erythema	28.1%
84	Cutaneous Fistula	28.1%
85	Nephrogenic Fibrosing Dermopathy	28.1%
86	Nephrogenic Systemic Fibrosis	28.1%
87	Anhidrosis	27.9%
88	Cholesteatoma	27.9%
89	Pressure Ulcer	27.9%
90	Folliculitis	27.9%
91	Foot Dermatoses	27.9%
92	Gynecomastia	27.9%
93	Hypertrichosis	27.9%
94	Hypohidrosis	27.9%
95	Hypotrichosis	27.9%
96	Leg Ulcer	27.9%
97	Miliaria	27.9%
98	Parakeratosis	27.9%
99	Parapsoriasis	27.9%
100	Pityriasis	27.9%
101	Psoriasis	27.9%
102	Sweet Syndrome	27.9%
103	Hidradenitis	27.9%
104	Onycholysis	27.9%
105	Miliaria Rubra	27.9%
106	Hyperpigmentation	27.9%
107	Lichenoid Eruptions	27.9%
108	Scleromyxedema	27.9%
109	Chloracne	27.9%
110	Xeroderma	27.6%
111	Dermatitis, Allergic Contact	27%
112	Papillon-Lefevre Disease	26.8%
113	Erythema Infectiosum	25.1%
114	Exanthema Subitum	25%
115	Toxic Epidermal Necrolysis	24.9%
116	Stevens-Johnson Syndrome	24.9%
117	Erythema Nodosum	24.6%
118	Tinea Capitis	23.3%
119	Onychomycosis	23.3%
120	Ectodermal Dysplasia	23.3%
121	Aplasia Cutis Congenita	23.3%
122	Hyperkeratosis, Epidermolytic	23%
123	Lichen Planus	23%
124	Melanosis	23%
125	Chloasma	23%
126	Pityriasis Rosea	23%
127	Pityriasis Rubra Pilaris	23%
128	Vitiligo	23%
129	Lichen Nitidus	23%
130	Mastocytosis	22.1%
131	Dupuytren Contracture	22%
132	Acantholysis	21.1%
133	Breast Cyst	21.1%
134	Ecthyma	21.1%
135	Actinic keratosis	21.1%
136	Mesenteric Panniculitis	21.1%
137	Panniculitis, Peritoneal	21.1%
138	Pemphigoid, Benign Mucous Membrane	21.1%
139	Pemphigus	21.1%
140	Piedra	21.1%
141	Sunburn	21.1%
142	Tietze's Syndrome	21.1%
143	Orbital Cellulitis	21.1%
144	Myxoid cyst	21.1%
145	Argyria	20.7%
146	Hirsutism	20.7%
147	Lactation Disorder	20.7%
148	Mastitis	20.7%
149	Myxedema	20.7%
150	Urticaria	20.7%
151	Acanthosis Nigricans	20.6%
152	Alopecia Areata	20.6%
153	Lentigo	20.6%
154	Adiposis Dolorosa	20.5%
155	Pruritus Vulvae	20.5%
156	Mastocytoma	20.4%
157	Pruritus Ani	20.4%
158	Ichthyosis, X-Linked	19.3%
159	Sjogren-Larsson Syndrome	19.2%
160	Hidradenitis Suppurativa	19.1%
161	Behcet Syndrome	18.6%
162	Cellulitis	18.3%
163	Tinea Pedis	17.9%
164	Alopecia	17.4%
165	Sweating, Gustatory	17.4%
166	Androgenetic Alopecia	17.4%
167	Auriculotemporal Syndrome	17.4%
168	Lice Infestations	17.1%
169	Varicose Ulcer	17.1%
170	Breast Neoplasms, Male	17.1%
171	Triple Negative Breast Neoplasms	17.1%
172	Galactorrhea	16.9%
173	Osteochondritis	16.9%
174	Polymyalgia Rheumatica	16.9%
175	Dermatomycoses	16.7%
176	Mucocutaneous Lymph Node Syndrome	16.7%
177	Skin Diseases, Bacterial	16.7%
178	Osteogenesis Imperfecta	16.6%
179	Albinism	16.5%
180	Drug Eruptions	16.4%
181	Lipodystrophy	16.4%
182	Livedo Reticularis	16.4%
183	Malignant Atrophic Papulosis	16.4%
184	Keloid	16.2%
185	Polyarteritis Nodosa	16.2%
186	Takayasu Arteritis	16.2%
187	Erythema Chronicum Migrans	16.1%
188	Lichen Planus, Oral	15.6%
189	Connective Tissue Diseases	15%
190	Mycetoma	14.7%
191	Systemic Scleroderma	14.3%
192	Rheumatoid Arthritis	14%
193	Nail-Patella Syndrome	14%
194	Juvenile arthritis	14%
195	Larva Migrans	13.8%
196	Leishmaniasis	13.8%
197	Molluscum Contagiosum	13.8%
198	Porphyrias, Hepatic	13.8%
199	Angioedema	13.7%
200	Onchocerciasis	13.6%
201	Noonan Syndrome	13.6%
202	Chromoblastomycosis	13.5%
203	Dermatophytosis	13.5%
204	Rheumatoid Nodule	13.5%
205	Sporotrichosis	13.5%
206	Tinea	13.5%
207	Tinea Versicolor	13.5%
208	Trichophytosis	13.5%
209	Hyalohyphomycosis	13.5%
210	Acute Generalized Exanthematous Pustulosis	13.4%
211	Lupus Nephritis	13.4%
212	Marfan Syndrome	12.2%
213	Leishmaniasis, Cutaneous	12.1%
214	Eczema Herpeticum	12.1%
215	Laryngomalacia	12%
216	Fusariosis	12%
217	Pectus carinatum	11.9%
218	Homocystinuria	11.8%
219	Warts	11.6%
220	Hereditary Angioedema Type III	11.3%
221	Hereditary Angioedema Types I and II	11.3%
222	Candidiasis, Chronic Mucocutaneous	11.2%
223	Cutaneous Candidiasis	11.2%
224	Felty Syndrome	11.2%
225	Bronchomalacia	11.2%
226	Tracheomalacia	11.2%
227	Erysipelas	11.2%
228	Serum Sickness	11.2%
229	Staphylococcal Skin Infections	11.2%
230	Variegate Porphyria	11.2%
231	Acute intermittent porphyria	11.2%
232	Porphyria Cutanea Tarda	11.2%
233	Erythrasma	11.1%
234	Carcinoma, Lobular	11.1%
235	Arthritis, Psoriatic	11.1%
236	Scleroderma, Limited	10.3%
237	Angioedemas, Hereditary	10.2%
238	Epidermodysplasia Verruciformis	10.1%
239	Herpes Labialis	10.1%
240	Diabetic Foot	10%
241	Staphylococcal Scalded Skin Syndrome	9.9%
242	Peutz-Jeghers Syndrome	9.6%
243	Rheumatoid Vasculitis	9.6%
244	Mucopolysaccharidosis III	9.4%
245	carbuncle	9.3%
246	Giant Cell Arteritis	8.8%
247	Temporal Arteritis	8.8%
248	Condylomata Acuminata	8.6%
249	Furunculosis	8.6%
250	furuncle	8.6%
251	Impetigo	8.5%
252	Blastomycosis	8.4%
253	Sicca Syndrome	8.4%
254	Sjogren's Syndrome	8.4%
255	HIV-Associated Lipodystrophy Syndrome	8.3%
256	Rhinoscleroma	7.6%
257	Menkes Kinky Hair Syndrome	6.6%
258	Mucopolysaccharidosis II	6.5%
259	Lupus Vasculitis, Central Nervous System	6.1%
260	CREST Syndrome	4.1%

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