MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Craniopharyngioma

(UMLS:C0010276)

Definition:: A benign pituitary-region neoplasm that originates from Rathke's pouch. The two major histologic and clinical subtypes are adamantinous (or classical) craniopharyngioma and papillary craniopharyngioma. The adamantinous form presents in children and adolescents as an expanding cystic lesion in the pituitary region. The cystic cavity is filled with a black viscous substance and histologically the tumor is composed of adamantinomatous epithelium and areas of calcification and necrosis. Papillary craniopharyngiomas occur in adults, and histologically feature a squamous epithelium with papillations. (From Joynt, Clinical Neurology, 1998, Ch14, p50)
UMLS ID:: C0010276
MeSH ID:: D003397

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.200|C04.557.580.625.200

Synonym(s)

Craniopharyngioma

ADAMANTINOMA, PITUITARY

BRAIN TUMOR, CRANIOPHARYNGIOMA

CRANIOPHARYNGIOMA

CRANIOPHARYNGIOMA, BENIGN

Craniopharyngioma (WHO Grade I)

Cystoma

INTRACRANIAL NEOPLASM, CRANIOPHARYNGIOMA

Neoplasm of Rathke's Pouch

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Cabergoline	FAERS: 6	US FAERS
2	Hydrocortisone	FAERS: 4	US FAERS
3	Rivaroxaban	FAERS: 1	US FAERS
4	dolutegravir	FAERS: 1	US FAERS
5	rofecoxib	FAERS: 1	US FAERS
6	teriflunomide	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplasms, Neuroepithelial	58.4%
2	Gliomatosis cerebri	58.4%
3	Neuroectodermal Tumor, Melanotic	58.1%
4	Neuroendocrine Tumors	58.1%
5	melanoma	46.5%
6	Neurilemmoma	44.1%
7	Paraganglioma	43.2%
8	Medulloblastoma	42.9%
9	Adenoma, Acidophil	42.3%
10	Ganglioneuroma	42.3%
11	Glioma	42.3%
12	Malignant Glioma	42.3%
13	Carcinoid Tumor	40.3%
14	Hutchinson's Melanotic Freckle	36.4%
15	Melanoma, Amelanotic	36.4%
16	Pheochromocytoma	35.9%
17	Astrocytoma	34.4%
18	Ependymoma	34.4%
19	oligodendroglioma	34.4%
20	Ganglioglioma	34.4%
21	gliosarcoma	34.4%
22	Anaplastic astrocytoma	34.4%
23	Anaplastic Oligodendroglioma	34.4%
24	Malignant Carcinoid Syndrome	33.4%
25	leukemia	33.3%
26	Neoplasms, Glandular and Epithelial	33.3%
27	Chordoma	32.6%
28	Teratoma	32.6%
29	Germinoma	32.6%
30	Teratocarcinoma	32.6%
31	Melanoma, Experimental	31.1%
32	Glioblastoma	30.5%
33	Neuroblastoma	30.5%
34	Glioblastoma Multiforme	30.5%
35	Ganglioneuroblastoma	28.5%
36	Meningioma	27.6%
37	Trophoblastic Neoplasms	26.7%
38	Carcinoid Heart Disease	25.5%
39	Retinoblastoma	25.5%
40	Histiocytic Disorders, Malignant	25%
41	Dermoid Cyst	24.8%
42	Carcinosarcoma	24.4%
43	Hemangiosarcoma	24.4%
44	lymphangiosarcoma	24.4%
45	Dysgerminoma	21.5%
46	Neuroma	21.5%
47	Seminoma	21.5%
48	Hamartoma	20.9%
49	Neoplasms, Hormone-Dependent	20.9%
50	Neoplasms, Multiple Primary	20.9%
51	Paraneoplastic Syndromes	20.9%
52	Precancerous Conditions	20.9%
53	Neoplasms, Second Primary	20.9%
54	Carcinoma 256, Walker	20.3%
55	Lymphoma	20%
56	Adenoma	19.6%
57	Ameloblastoma	19.6%
58	Angiokeratoma	19.6%
59	Carcinoma	19.6%
60	Hemangioma	19.6%
61	hemangiopericytoma	19.6%
62	Lymphangioma	19.6%
63	Mesenchymoma	19.6%
64	Nevus	19.6%
65	Hepatoblastoma	19.6%
66	Mixed Tumor, Mullerian	19.6%
67	Angiofibroma	19.6%
68	Composite Lymphoma	19.6%
69	Sarcoma	19.6%
70	Epithelioma	19.6%
71	Leukemia, Plasma Cell	19.5%
72	Basal cell carcinoma	19.4%
73	Carcinoma, Papillary	19.4%
74	Squamous cell carcinoma	19.4%
75	Chondrosarcoma	19.4%
76	Cystadenoma	19.4%
77	leiomyosarcoma	19.4%
78	liposarcoma	19.4%
79	Mesothelioma	19.4%
80	synovial sarcoma	19.4%
81	Angiomyolipoma	19.4%
82	Clear Cell Sarcoma of Soft Tissue	19.4%
83	Alveolar Soft Part Sarcoma	19.4%
84	Sarcoma, Myeloid	19.4%
85	Carcinoma, Basal Cell	19.4%
86	Acoustic Neuroma	19%
87	Choriocarcinoma	18.9%
88	Leukemia, Experimental	18.5%
89	Carcinoma, Ehrlich Tumor	18.2%
90	Carcinoma, Lewis Lung	18.2%
91	Cystadenocarcinoma	16.9%
92	Fibrosarcoma	16.9%
93	Osteosarcoma	16.9%
94	Mucoepidermoid Carcinoma	16.9%
95	Neoplasms, Germ Cell and Embryonal	16.7%
96	Germ Cell Cancer	16.7%
97	Optic Nerve Glioma	15.9%
98	Cyst	15.8%
99	Neoplastic Processes	15.8%
100	Neoplastic Syndromes, Hereditary	15.8%
101	Pregnancy Complications, Neoplastic	15.8%
102	Leukemia, Radiation-Induced	15.6%
103	Adenofibroma	15.6%
104	Fibroadenoma	15.6%
105	Malignant Fibrous Histiocytoma	15.6%
106	Neoplasms, Experimental	15.5%
107	Plasmacytoma	14.8%
108	Neuroectodermal Tumors	14.8%
109	Malignant histiocytosis	14.6%
110	Leukemia L1210	14.6%
111	Leukemia P388	14.6%
112	Histiocytic sarcoma	14.6%
113	Acanthoma	14.6%
114	Carcinoma, Lobular	14.6%
115	Sarcoma, Experimental	14.5%
116	Endometrial Stromal Sarcoma	14.4%
117	Bowen's Disease	14.4%
118	Rhabdomyosarcoma	14.4%
119	Giant Cell Tumor of Bone	14.4%
120	Thymoma	14.4%
121	Neurofibrosarcoma	14.3%
122	Dermatofibrosarcoma	13.2%
123	Dermatofibrosarcoma Protuberans	13.2%
124	Adenocarcinoma	12.9%
125	Carcinoma in Situ	12.9%
126	Carcinoma, Transitional Cell	12.9%
127	Phyllodes Tumor	12.9%
128	Hemangioendothelioma	12.9%
129	Lipoma	12.9%
130	Myoma	12.9%
131	Myxoma	12.9%
132	Papilloma	12.9%
133	Pseudomyxoma Peritonei	12.9%
134	Papillomatosis	12.9%
135	Angiolipoma	12.9%
136	Myelolipoma	12.9%
137	Neoplasms, Bone Tissue	12.9%
138	Neoplasms, Fibrous Tissue	12.9%
139	Smooth Muscle Tumor	12.9%
140	Adenomatosis, Pulmonary	12.9%
141	Adenomatous Polyps	12.9%
142	Carcinoma, Large Cell	12.9%
143	Carcinoma, Small Cell	12.9%
144	Desmoplastic Small Round Cell Tumor	12.9%
145	Lymphangioleiomyomatosis	12.9%
146	Chondroma	12.9%
147	Enchondroma	12.9%
148	neurofibroma	12.9%
149	Vipoma	12.8%
150	Multiple Endocrine Neoplasia	12.6%
151	Neoplasms, Radiation-Induced	12.4%
152	Hydatidiform Mole	12.2%
153	Sarcoma 180	12.1%
154	Alveolar rhabdomyosarcoma	12%
155	Hodgkin Disease	11.7%
156	Lymphoma, Non-Hodgkin	11.7%
157	Abdominal Neoplasms	11.1%
158	Erythroplasia	11.1%
159	Follicular cyst	11.1%
160	Head and Neck Neoplasms	11.1%
161	Mucocele	11.1%
162	Pilonidal Cyst	11.1%
163	Soft Tissue Neoplasms	11.1%
164	Thoracic Neoplasms	11.1%
165	Thyroglossal Cyst	11.1%
166	Synovial Cyst	11.1%
167	Aberrant Crypt Foci	11.1%
168	Paraneoplastic Encephalomyelitis	10.8%
169	Mammary Neoplasms, Experimental	10.6%
170	Lymphomatoid Granulomatosis	10.3%
171	Nephroblastoma	10.1%
172	Primary amyloidosis	9.8%
173	Craniopharyngioma	9.7%
174	Leukemia, Myelomonocytic, Chronic	9.7%
175	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.7%
176	Adenoid Cystic Carcinoma	9.6%
177	fibroma	9.6%
178	Fibromatosis	9.6%
179	Osteoblastoma	9.6%
180	Osteoma	9.6%
181	Rhabdomyoma	9.6%
182	Chondromatosis	9.6%
183	Adenocarcinoma, Clear Cell	9.6%
184	Cholangiocarcinoma	9.6%
185	Cervical Intraepithelial Neoplasia	9.6%
186	Hemangioblastoma	9.6%
187	Lymphoma, Extranodal NK-T-Cell	9.6%
188	Basal Cell Nevus Syndrome	9.2%
189	Tuberous Sclerosis	9.2%
190	Carcinoma, Pancreatic Ductal	8.8%
191	Digestive System Neoplasms	8.8%
192	Endocrine Gland Neoplasms	8.8%
193	Eye Neoplasms	8.8%
194	Nervous System Neoplasms	8.8%
195	Hepatocellular Adenoma	8.7%
196	Bone neoplasms	8.5%
197	Leukoplakia	8.5%
198	Lymphocele	8.5%
199	Pancreatic Cyst	8.5%
200	Skin Neoplasms	8.5%
201	Hematologic Neoplasms	8.5%
202	Mesoblastic Nephroma	8.5%
203	Barrett Esophagus	8.3%
204	Breast Cyst	8.3%
205	Actinic keratosis	8.3%
206	Mediastinal Cyst	8.3%
207	Neoplasm Invasiveness	8.3%
208	Neoplasm Metastasis	8.3%
209	Neoplasm Recurrence, Local	8.3%
210	Parovarian Cyst	8.3%
211	Pericardial Cyst	8.3%
212	Splenic Neoplasms	8.3%
213	Thymic Cyst	8.3%
214	Carcinogenesis	8.3%
215	Myxoid cyst	8.3%
216	Metastasis	8.3%
217	Fibromatosis, Aggressive	8%
218	Fibromatosis, Abdominal	8%
219	Klatskin Tumor	8%
220	Mastocytosis	7.9%
221	Sturge-Weber Syndrome	7.9%
222	Gastrointestinal Stromal Tumors	7.8%
223	Hemangioma, Cavernous	7.8%
224	Leukemia, T-Cell	7.7%
225	Leukemia, B-Cell	7.7%
226	Lymphoma, Follicular	7.7%
227	T-Cell Lymphoma	7.7%
228	Mantle cell lymphoma	7.7%
229	Multiple Endocrine Neoplasia Type 1	7.5%
230	Prolactinoma	7.4%
231	Growth Hormone-Secreting Pituitary Adenoma	7.4%
232	Waldenstrom Macroglobulinemia	7.4%
233	Multiple Myeloma	7.4%
234	Mastocytoma	7.3%
235	Mastocytosis, Systemic	7.2%
236	Leukemia, Myeloid, Chronic-Phase	7.2%
237	Parathyroid Neoplasms	6.7%
238	Peritoneal Neoplasms	6.7%
239	Thyroid Neoplasm	6.7%
240	Thyroid carcinoma	6.7%
241	Liver Neoplasms, Experimental	6.6%
242	Corpus Luteum Cyst	6.6%
243	Ovarian Cysts	6.6%
244	Retroperitoneal Neoplasms	6.5%
245	granulosa cell tumor	6.4%
246	Carcinoma, Ovarian Epithelial	6.4%
247	Adenomatous Polyposis Coli	6.3%
248	insulinoma	6%
249	Pancreatic Neoplasm	5.8%
250	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
251	Leukemia, Large Granular Lymphocytic	5.8%
252	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
253	Lymphoma, T-Cell, Cutaneous	5.7%
254	Lymphoma, AIDS-Related	5.7%
255	Enteropathy-Associated T-Cell Lymphoma	5.7%
256	Primary Effusion Lymphoma	5.7%
257	Choledochal Cyst	5.6%
258	Tracheal Neoplasms	5.6%
259	Adrenocortical carcinoma	5.5%
260	Peutz-Jeghers Syndrome	5.5%
261	Leukoplakia, Oral	5.5%
262	Paraneoplastic Cerebellar Degeneration	5.4%
263	Gastrinoma	5.4%
264	Glucagonoma	5.4%
265	Nasopharyngeal carcinoma	5.2%
266	Leydig Cell Tumor	5.1%
267	Mouth Neoplasms	5%
268	Central Nervous System Neoplasms	5%
269	Vascular Neoplasms	5%
270	Thymus Neoplasms	5%
271	Dupuytren Contracture	4.9%
272	Genital Neoplasms, Female	4.9%
273	Pancreatic Pseudocyst	4.9%
274	Lymphatic Metastasis	4.9%
275	Neoplasms, Unknown Primary	4.9%
276	Leukemic Infiltration	4.9%
277	Breast Neoplasms, Male	4.9%
278	Neoplasm Micrometastasis	4.9%
279	Triple Negative Breast Neoplasms	4.9%
280	Urticaria Pigmentosa	4.8%
281	Renal Cell Carcinoma	4.8%
282	Papillary Renal Cell Carcinoma	4.8%
283	Mycosis Fungoides	4.8%
284	Lymphomatoid Papulosis	4.8%
285	Plasmablastic lymphoma	4.8%
286	Esophageal Neoplasms	4.7%
287	Denys-Drash Syndrome	4.7%
288	Limbic Encephalitis	4.7%
289	Carcinoma, Endometrioid	4.6%
290	Thyroid Nodule	4.3%
291	Lambert-Eaton Myasthenic Syndrome	4.1%
292	Testicular Neoplasms	4.1%
293	Burkitt Lymphoma	4.1%
294	Adrenal Gland Neoplasms	4.1%
295	Gastrointestinal Neoplasms	4.1%
296	Genital Neoplasms, Male	4.1%
297	Liver neoplasms	4.1%
298	Uveal Neoplasms	4.1%
299	Urologic Neoplasms	4%
300	Sebaceous Gland Neoplasms	3.9%
301	Spinal Neoplasms	3.9%
302	Bone Marrow Neoplasms	3.9%
303	Polycystic Ovary Syndrome	3.9%
304	Opsoclonus-Myoclonus Syndrome	3.7%
305	Sezary Syndrome	3.4%
306	Xeroderma Pigmentosum	3.3%
307	Myelitis, Transverse	3.3%
308	Meningeal Neoplasms	3.3%
309	Nose Neoplasms	3%
310	Palatal Neoplasms	2.8%
311	ovarian neoplasm	2.8%
312	Pituitary Adenoma	2.7%
313	Pituitary Neoplasms	2.7%
314	Ear Neoplasms	2.7%
315	Eyelid Neoplasms	2.7%
316	Lung Neoplasms	2.7%
317	Pleural Neoplasms	2.7%
318	Cell Transformation, Viral	2.6%
319	Brain Neoplasms	2.6%
320	Salivary Gland Neoplasms	2.6%
321	Spinal Cord Neoplasms	2.6%
322	Tongue Neoplasms	2.6%
323	Uterine Neoplasms	2.6%
324	Vaginal Neoplasms	2.6%
325	Vulvar Neoplasms	2.6%
326	Uterine Cancer	2.6%
327	Fallopian Tube Neoplasms	2.6%
328	Meningeal Carcinomatosis	2.4%
329	Pharyngeal Neoplasms	2.3%
330	Central Nervous System Cysts	2.2%
331	Bile Duct Neoplasms	2.2%
332	gallbladder neoplasm	2.2%
333	Intestinal Neoplasms	2.2%
334	Penile Neoplasms	2.2%
335	Prostatic Neoplasms	2.2%
336	Stomach Neoplasms	2.2%
337	Zollinger-Ellison syndrome	2.2%
338	Polycythemia Vera	2.2%
339	Bronchial Neoplasms	2%
340	Multiple Pulmonary Nodules	2%
341	Laryngeal neoplasm	2%
342	Supratentorial Neoplasms	1.9%
343	Endometrial Neoplasms	1.9%
344	Bladder Neoplasm	1.9%
345	Kidney Neoplasm	1.9%
346	Ureteral Neoplasms	1.9%
347	Urethral Neoplasms	1.9%
348	Hypopharyngeal Neoplasms	1.6%
349	Pleural Effusion, Malignant	1.6%
350	Hypopharyngeal Cancer	1.6%
351	Parotid Neoplasms	1.6%
352	Prostatic Neoplasms, Castration-Resistant	1.6%
353	Nelson Syndrome	1.6%
354	Brain Stem Neoplasms	1.6%
355	Choroid Plexus Papilloma	1.4%
356	Cecal Neoplasms	1.4%
357	Duodenal Neoplasms	1.4%
358	Tonsillar Neoplasms	1.3%
359	Cerebellar Neoplasms	1.3%
360	Nasopharyngeal Neoplasms	1.2%
361	Colorectal Neoplasms	1.2%
362	Radicular Cyst	1.1%
363	Appendiceal Neoplasms	1.1%
364	Colonic Neoplasms	1.1%
365	Rectal Neoplasms	1.1%
366	Paranasal Sinus Neoplasms	1.1%
367	Maxillary Sinus Neoplasms	0.9%
368	Anus Neoplasms	0.9%
369	Sigmoid Neoplasms	0.9%

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