MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Clear Cell Sarcoma of Soft Tissue

(UMLS:C0206651)

Definition:: A sarcoma of young adults occurring in the lower extremities and acral regions. It is found intimately bound to tendons as a circumscribed but unencapsulated melanin-bearing tumor of neuroectodermal origin. Clear cell sarcoma is associated with a specific t(12;22)(q13;q12) translocation.
UMLS ID:: C0206651
MeSH ID:: D018227

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.565.800|C04.557.450.795.800

Synonym(s)

Clear Cell Sarcoma of Soft Tissue

Chordoid Sarcoma

Clear Cell Sarcoma of Soft Parts

Clear cell sarcoma

Clear cell sarcoma (except of Kidney M-89643)

Clear cell sarcoma (except of kidney M8964/3)

Clear cell sarcoma - not kidney

Clear cell sarcoma of soft tissue

Clear cell sarcoma/Malignant melanoma of soft parts (excluding Clear cell sarcoma of the kidney)

10.

Malignant Melanoma of Soft Parts

11.

Malignant Melanoma of the Soft Parts

12.

Malignant melanoma of soft tissue

13.

Malignant melanoma of soft tissues

14.

Melanoma, malignant, of soft parts

15.

clear cell sarcoma

16.

clear cell sarcoma of soft tissue

17.

malignant melanoma of soft parts

18.

malignant melanoma of soft tissue

19.

soft tissue neoplasm malignant melanoma

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Dimethyl Fumarate	FAERS: 1	US FAERS
2	Sunitinib	FAERS: 1	US FAERS
3	pazopanib	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Chondrosarcoma	71%
2	synovial sarcoma	71%
3	Fibrosarcoma	61.8%
4	Osteosarcoma	61.8%
5	leiomyosarcoma	58.1%
6	liposarcoma	58.1%
7	Alveolar Soft Part Sarcoma	58.1%
8	Malignant Fibrous Histiocytoma	57.3%
9	Giant Cell Tumor of Bone	52.8%
10	Carcinosarcoma	50.4%
11	Hemangiosarcoma	50.4%
12	lymphangiosarcoma	50.4%
13	Dermatofibrosarcoma	48.3%
14	Dermatofibrosarcoma Protuberans	48.3%
15	Phyllodes Tumor	47.3%
16	Myxoma	47.3%
17	Neoplasms, Bone Tissue	47.3%
18	Neoplasms, Fibrous Tissue	47.3%
19	Desmoplastic Small Round Cell Tumor	47.3%
20	Chondroma	47.3%
21	Enchondroma	47.3%
22	Angiomyolipoma	45.2%
23	Sarcoma, Myeloid	45.2%
24	Rhabdomyosarcoma	43.2%
25	Carcinoma 256, Walker	36.1%
26	Alveolar rhabdomyosarcoma	35.9%
27	Sarcoma, Experimental	35.5%
28	fibroma	35.3%
29	Fibromatosis	35.3%
30	Osteoblastoma	35.3%
31	Osteoma	35.3%
32	Chondromatosis	35.3%
33	leukemia	33.3%
34	Neoplasms, Germ Cell and Embryonal	33.3%
35	Neoplasms, Glandular and Epithelial	33.3%
36	Germ Cell Cancer	33.3%
37	Adenofibroma	31.7%
38	Fibroadenoma	31.7%
39	Neurofibrosarcoma	31.6%
40	Sarcoma 180	31.6%
41	Lipoma	30.1%
42	Myoma	30.1%
43	Angiolipoma	30.1%
44	Myelolipoma	30.1%
45	Smooth Muscle Tumor	30.1%
46	Neuroectodermal Tumors	29.5%
47	Fibromatosis, Aggressive	29.3%
48	Fibromatosis, Abdominal	29.3%
49	Mastocytosis	29.1%
50	Gastrointestinal Stromal Tumors	28.8%
51	Neoplasms, Neuroepithelial	27.3%
52	Gliomatosis cerebri	27.3%
53	Endometrial Stromal Sarcoma	27.2%
54	Mastocytoma	26.7%
55	Mastocytosis, Systemic	26.5%
56	Histiocytic Disorders, Malignant	25%
57	melanoma	23.2%
58	Sarcoma	22.8%
59	Clear Cell Sarcoma of Soft Tissue	22.6%
60	Rhabdomyoma	22.5%
61	Lymphangioleiomyomatosis	21.5%
62	Meningioma	21.1%
63	Hamartoma	20.9%
64	Neoplasms, Hormone-Dependent	20.9%
65	Neoplasms, Multiple Primary	20.9%
66	Paraneoplastic Syndromes	20.9%
67	Precancerous Conditions	20.9%
68	Neoplasms, Second Primary	20.9%
69	Lymphoma	20%
70	Adenoma	19.6%
71	Ameloblastoma	19.6%
72	Angiokeratoma	19.6%
73	Carcinoma	19.6%
74	Chordoma	19.6%
75	Hemangioma	19.6%
76	hemangiopericytoma	19.6%
77	Lymphangioma	19.6%
78	Mesenchymoma	19.6%
79	Nevus	19.6%
80	Teratoma	19.6%
81	Hepatoblastoma	19.6%
82	Mixed Tumor, Mullerian	19.6%
83	Germinoma	19.6%
84	Teratocarcinoma	19.6%
85	Angiofibroma	19.6%
86	Composite Lymphoma	19.6%
87	Epithelioma	19.6%
88	Leukemia, Plasma Cell	19.5%
89	Basal cell carcinoma	19.4%
90	Carcinoma, Papillary	19.4%
91	Squamous cell carcinoma	19.4%
92	Craniopharyngioma	19.4%
93	Cystadenoma	19.4%
94	Mesothelioma	19.4%
95	Neuroectodermal Tumor, Melanotic	19.4%
96	Neuroendocrine Tumors	19.4%
97	Carcinoma, Basal Cell	19.4%
98	Adenoma, Acidophil	19.2%
99	Ganglioneuroma	19.2%
100	Glioma	19.2%
101	Malignant Glioma	19.2%
102	Medulloblastoma	19%
103	Trophoblastic Neoplasms	18.7%
104	Leukemia, Experimental	18.5%
105	Carcinoma, Ehrlich Tumor	18.2%
106	Dermoid Cyst	18.2%
107	Carcinoma, Lewis Lung	18.2%
108	Dupuytren Contracture	18.1%
109	Urticaria Pigmentosa	17.8%
110	Carcinoid Tumor	17.3%
111	Neurilemmoma	17.3%
112	Hutchinson's Melanotic Freckle	17.3%
113	Melanoma, Amelanotic	17.3%
114	Melanoma, Experimental	17.2%
115	Cystadenocarcinoma	16.9%
116	Mucoepidermoid Carcinoma	16.9%
117	Cyst	15.8%
118	Neoplastic Processes	15.8%
119	Neoplastic Syndromes, Hereditary	15.8%
120	Pregnancy Complications, Neoplastic	15.8%
121	Leukemia, Radiation-Induced	15.6%
122	Neoplasms, Experimental	15.5%
123	Astrocytoma	15.3%
124	Ependymoma	15.3%
125	oligodendroglioma	15.3%
126	Ganglioglioma	15.3%
127	gliosarcoma	15.3%
128	Anaplastic astrocytoma	15.3%
129	Anaplastic Oligodendroglioma	15.3%
130	Plasmacytoma	14.8%
131	Malignant histiocytosis	14.6%
132	Leukemia L1210	14.6%
133	Leukemia P388	14.6%
134	Histiocytic sarcoma	14.6%
135	Acanthoma	14.6%
136	Choriocarcinoma	14.6%
137	Carcinoma, Lobular	14.6%
138	Bowen's Disease	14.4%
139	Paraganglioma	14.4%
140	Thymoma	14.4%
141	Malignant Carcinoid Syndrome	14.3%
142	Glioblastoma	13.3%
143	Neuroblastoma	13.3%
144	Glioblastoma Multiforme	13.3%
145	Adenocarcinoma	12.9%
146	Carcinoma in Situ	12.9%
147	Carcinoma, Transitional Cell	12.9%
148	Dysgerminoma	12.9%
149	Hemangioendothelioma	12.9%
150	Neuroma	12.9%
151	Papilloma	12.9%
152	Pseudomyxoma Peritonei	12.9%
153	Seminoma	12.9%
154	Papillomatosis	12.9%
155	Adenomatosis, Pulmonary	12.9%
156	Adenomatous Polyps	12.9%
157	Carcinoma, Large Cell	12.9%
158	Carcinoma, Small Cell	12.9%
159	Multiple Endocrine Neoplasia	12.6%
160	Neoplasms, Radiation-Induced	12.4%
161	Retinoblastoma	12.4%
162	Ganglioneuroblastoma	12.4%
163	Pheochromocytoma	12%
164	Hodgkin Disease	11.7%
165	Lymphoma, Non-Hodgkin	11.7%
166	Abdominal Neoplasms	11.1%
167	Erythroplasia	11.1%
168	Follicular cyst	11.1%
169	Head and Neck Neoplasms	11.1%
170	Mucocele	11.1%
171	Pilonidal Cyst	11.1%
172	Soft Tissue Neoplasms	11.1%
173	Thoracic Neoplasms	11.1%
174	Thyroglossal Cyst	11.1%
175	Synovial Cyst	11.1%
176	Aberrant Crypt Foci	11.1%
177	Carcinoid Heart Disease	10.9%
178	Paraneoplastic Encephalomyelitis	10.8%
179	Mammary Neoplasms, Experimental	10.6%
180	Lymphomatoid Granulomatosis	10.3%
181	Nephroblastoma	10.1%
182	Primary amyloidosis	9.8%
183	Leukemia, Myelomonocytic, Chronic	9.7%
184	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	9.7%
185	Adenoid Cystic Carcinoma	9.6%
186	Adenocarcinoma, Clear Cell	9.6%
187	Cholangiocarcinoma	9.6%
188	Cervical Intraepithelial Neoplasia	9.6%
189	Hemangioblastoma	9.6%
190	Lymphoma, Extranodal NK-T-Cell	9.6%
191	Basal Cell Nevus Syndrome	9.2%
192	Tuberous Sclerosis	9.2%
193	Carcinoma, Pancreatic Ductal	8.8%
194	Digestive System Neoplasms	8.8%
195	Endocrine Gland Neoplasms	8.8%
196	Eye Neoplasms	8.8%
197	Nervous System Neoplasms	8.8%
198	Acoustic Neuroma	8.7%
199	Hepatocellular Adenoma	8.7%
200	Bone neoplasms	8.5%
201	Leukoplakia	8.5%
202	Lymphocele	8.5%
203	Pancreatic Cyst	8.5%
204	Skin Neoplasms	8.5%
205	Hematologic Neoplasms	8.5%
206	Mesoblastic Nephroma	8.5%
207	Barrett Esophagus	8.3%
208	Breast Cyst	8.3%
209	Hydatidiform Mole	8.3%
210	Actinic keratosis	8.3%
211	Mediastinal Cyst	8.3%
212	Neoplasm Invasiveness	8.3%
213	Neoplasm Metastasis	8.3%
214	Neoplasm Recurrence, Local	8.3%
215	Parovarian Cyst	8.3%
216	Pericardial Cyst	8.3%
217	Splenic Neoplasms	8.3%
218	Thymic Cyst	8.3%
219	Carcinogenesis	8.3%
220	Myxoid cyst	8.3%
221	Metastasis	8.3%
222	Klatskin Tumor	8%
223	Sturge-Weber Syndrome	7.9%
224	Optic Nerve Glioma	7.9%
225	Hemangioma, Cavernous	7.8%
226	Leukemia, T-Cell	7.7%
227	Leukemia, B-Cell	7.7%
228	neurofibroma	7.7%
229	Lymphoma, Follicular	7.7%
230	T-Cell Lymphoma	7.7%
231	Mantle cell lymphoma	7.7%
232	Multiple Endocrine Neoplasia Type 1	7.5%
233	Vipoma	7.5%
234	Prolactinoma	7.4%
235	Growth Hormone-Secreting Pituitary Adenoma	7.4%
236	Waldenstrom Macroglobulinemia	7.4%
237	Multiple Myeloma	7.4%
238	Leukemia, Myeloid, Chronic-Phase	7.2%
239	Parathyroid Neoplasms	6.7%
240	Peritoneal Neoplasms	6.7%
241	Thyroid Neoplasm	6.7%
242	Thyroid carcinoma	6.7%
243	Liver Neoplasms, Experimental	6.6%
244	Corpus Luteum Cyst	6.6%
245	Ovarian Cysts	6.6%
246	Retroperitoneal Neoplasms	6.5%
247	granulosa cell tumor	6.4%
248	Carcinoma, Ovarian Epithelial	6.4%
249	Adenomatous Polyposis Coli	6.3%
250	insulinoma	6%
251	Pancreatic Neoplasm	5.8%
252	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
253	Leukemia, Large Granular Lymphocytic	5.8%
254	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	5.8%
255	Lymphoma, T-Cell, Cutaneous	5.7%
256	Lymphoma, AIDS-Related	5.7%
257	Enteropathy-Associated T-Cell Lymphoma	5.7%
258	Primary Effusion Lymphoma	5.7%
259	Choledochal Cyst	5.6%
260	Tracheal Neoplasms	5.6%
261	Adrenocortical carcinoma	5.5%
262	Peutz-Jeghers Syndrome	5.5%
263	Leukoplakia, Oral	5.5%
264	Paraneoplastic Cerebellar Degeneration	5.4%
265	Gastrinoma	5.4%
266	Glucagonoma	5.4%
267	Nasopharyngeal carcinoma	5.2%
268	Leydig Cell Tumor	5.1%
269	Mouth Neoplasms	5%
270	Central Nervous System Neoplasms	5%
271	Vascular Neoplasms	5%
272	Thymus Neoplasms	5%
273	Genital Neoplasms, Female	4.9%
274	Pancreatic Pseudocyst	4.9%
275	Lymphatic Metastasis	4.9%
276	Neoplasms, Unknown Primary	4.9%
277	Leukemic Infiltration	4.9%
278	Breast Neoplasms, Male	4.9%
279	Neoplasm Micrometastasis	4.9%
280	Triple Negative Breast Neoplasms	4.9%
281	Renal Cell Carcinoma	4.8%
282	Papillary Renal Cell Carcinoma	4.8%
283	Mycosis Fungoides	4.8%
284	Lymphomatoid Papulosis	4.8%
285	Plasmablastic lymphoma	4.8%
286	Esophageal Neoplasms	4.7%
287	Denys-Drash Syndrome	4.7%
288	Limbic Encephalitis	4.7%
289	Carcinoma, Endometrioid	4.6%
290	Thyroid Nodule	4.3%
291	Lambert-Eaton Myasthenic Syndrome	4.1%
292	Testicular Neoplasms	4.1%
293	Burkitt Lymphoma	4.1%
294	Adrenal Gland Neoplasms	4.1%
295	Gastrointestinal Neoplasms	4.1%
296	Genital Neoplasms, Male	4.1%
297	Liver neoplasms	4.1%
298	Uveal Neoplasms	4.1%
299	Urologic Neoplasms	4%
300	Sebaceous Gland Neoplasms	3.9%
301	Spinal Neoplasms	3.9%
302	Bone Marrow Neoplasms	3.9%
303	Polycystic Ovary Syndrome	3.9%
304	Opsoclonus-Myoclonus Syndrome	3.7%
305	Sezary Syndrome	3.4%
306	Xeroderma Pigmentosum	3.3%
307	Myelitis, Transverse	3.3%
308	Meningeal Neoplasms	3.3%
309	Nose Neoplasms	3%
310	Palatal Neoplasms	2.8%
311	ovarian neoplasm	2.8%
312	Pituitary Adenoma	2.7%
313	Pituitary Neoplasms	2.7%
314	Ear Neoplasms	2.7%
315	Eyelid Neoplasms	2.7%
316	Lung Neoplasms	2.7%
317	Pleural Neoplasms	2.7%
318	Cell Transformation, Viral	2.6%
319	Brain Neoplasms	2.6%
320	Salivary Gland Neoplasms	2.6%
321	Spinal Cord Neoplasms	2.6%
322	Tongue Neoplasms	2.6%
323	Uterine Neoplasms	2.6%
324	Vaginal Neoplasms	2.6%
325	Vulvar Neoplasms	2.6%
326	Uterine Cancer	2.6%
327	Fallopian Tube Neoplasms	2.6%
328	Meningeal Carcinomatosis	2.4%
329	Pharyngeal Neoplasms	2.3%
330	Central Nervous System Cysts	2.2%
331	Bile Duct Neoplasms	2.2%
332	gallbladder neoplasm	2.2%
333	Intestinal Neoplasms	2.2%
334	Penile Neoplasms	2.2%
335	Prostatic Neoplasms	2.2%
336	Stomach Neoplasms	2.2%
337	Zollinger-Ellison syndrome	2.2%
338	Polycythemia Vera	2.2%
339	Bronchial Neoplasms	2%
340	Multiple Pulmonary Nodules	2%
341	Laryngeal neoplasm	2%
342	Supratentorial Neoplasms	1.9%
343	Endometrial Neoplasms	1.9%
344	Bladder Neoplasm	1.9%
345	Kidney Neoplasm	1.9%
346	Ureteral Neoplasms	1.9%
347	Urethral Neoplasms	1.9%
348	Hypopharyngeal Neoplasms	1.6%
349	Pleural Effusion, Malignant	1.6%
350	Hypopharyngeal Cancer	1.6%
351	Parotid Neoplasms	1.6%
352	Prostatic Neoplasms, Castration-Resistant	1.6%
353	Nelson Syndrome	1.6%
354	Brain Stem Neoplasms	1.6%
355	Choroid Plexus Papilloma	1.4%
356	Cecal Neoplasms	1.4%
357	Duodenal Neoplasms	1.4%
358	Tonsillar Neoplasms	1.3%
359	Cerebellar Neoplasms	1.3%
360	Nasopharyngeal Neoplasms	1.2%
361	Colorectal Neoplasms	1.2%
362	Radicular Cyst	1.1%
363	Appendiceal Neoplasms	1.1%
364	Colonic Neoplasms	1.1%
365	Rectal Neoplasms	1.1%
366	Paranasal Sinus Neoplasms	1.1%
367	Maxillary Sinus Neoplasms	0.9%
368	Anus Neoplasms	0.9%
369	Sigmoid Neoplasms	0.9%

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