MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Cholesteatoma

(UMLS:C0008373)

Definition:: A non-neoplastic mass of keratin-producing squamous EPITHELIUM, frequently occurring in the MENINGES; bones of the skull, and most commonly in the MIDDLE EAR and MASTOID region. Cholesteatoma can be congenital or acquired. Cholesteatoma is not a tumor nor is it associated with high CHOLESTEROL.
UMLS ID:: C0008373
MeSH ID:: D002781

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.428.260

Synonym(s)

Cholesteatoma

CHOLESTEATOMA

Cholesteatoma, NOS

Cholesteatoma, unspecified

Epidermoid cholesteatoma

Unspecified cholesteatoma, unspecified ear

cholesteatoma

cholesteatomas

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Isotretinoin	FAERS: 8	US FAERS
2	Sertraline	FAERS: 4	US FAERS
3	Alendronate	FAERS: 2	US FAERS
4	NuvaRing	FAERS: 2	US FAERS
5	Azithromycin	FAERS: 1	US FAERS
6	Ciprodex	FAERS: 1	US FAERS
7	Deferasirox	FAERS: 1	US FAERS
8	Duloxetine Hydrochloride	FAERS: 1	US FAERS
9	Nalbuphine	FAERS: 1	US FAERS
10	Tiotropium Bromide	FAERS: 1	US FAERS
11	Valproic Acid	FAERS: 1	US FAERS
12	Valsartan	FAERS: 1	US FAERS
13	apixaban	FAERS: 1	US FAERS
14	deflazacort	FAERS: 1	US FAERS
15	Amoxicillin		OFFSIDES
16	Estrogens, Conjugated (USP)		OFFSIDES
17	Lovastatin		OFFSIDES
18	Tretinoin		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Parakeratosis	46.7%
2	Porokeratosis	33.3%
3	Keratoderma, Palmoplantar	33.3%
4	Actinic keratosis	31.8%
5	Breast Diseases	31%
6	Dermatitis	31%
7	Exanthema	31%
8	Facial Dermatoses	31%
9	Hair Diseases	31%
10	Hand Dermatoses	31%
11	keratoacanthoma	31%
12	Nail Diseases	31%
13	Photosensitivity Disorders	31%
14	Prurigo	31%
15	Pyoderma	31%
16	Rosacea	31%
17	Sebaceous Gland Diseases	31%
18	Skin Diseases, Vesiculobullous	31%
19	Skin Ulcer	31%
20	Sweat Gland Diseases	31%
21	Skin Diseases, Papulosquamous	31%
22	Skin Diseases, Vascular	31%
23	Acneiform Eruptions	31%
24	Ocular Rosacea	31%
25	Subcorneal pustular dermatosis	31%
26	Erythematotelangiectatic Rosacea	31%
27	Papulopustular Rosacea	31%
28	Chronic Actinic Dermatitis	31%
29	Pyoderma Gangrenosum	30%
30	Lupus Erythematosus, Cutaneous	27.9%
31	Panniculitis	27.9%
32	Systemic Scleroderma	27.9%
33	Morphea	27.9%
34	Xeroderma	27%
35	Acne Vulgaris	26.7%
36	Contact Dermatitis	26.7%
37	Eczema	26.7%
38	Erythema Multiforme	26.7%
39	Intertrigo	26.7%
40	Neurodermatitis	26.7%
41	Rhinophyma	26.7%
42	Perioral Dermatitis	26.7%
43	Acne	26.7%
44	Papillon-Lefevre Disease	24.4%
45	Foot Ulcer	23.1%
46	Foot Diseases	22%
47	Dermatitis, Phototoxic	22%
48	Pityriasis Lichenoides et Varioliformis Acuta	22%
49	Pityriasis Lichenoides	22%
50	Phototoxicity	22%
51	Skin Abnormalities	20.9%
52	Skin Diseases, Infectious	20.9%
53	Skin Neoplasms	20.9%
54	Pigmentation Disorders	20.9%
55	Lipomatosis	20.5%
56	Pruritus	20.5%
57	Erythema	20.5%
58	Necrolytic Migratory Erythema	20.5%
59	Cutaneous Fistula	20.5%
60	Nephrogenic Fibrosing Dermopathy	20.5%
61	Nephrogenic Systemic Fibrosis	20.5%
62	Dermatitis Herpetiformis	20.3%
63	Acrodermatitis	20%
64	Anhidrosis	20%
65	Pressure Ulcer	20%
66	Dermatitis, Atopic	20%
67	Epidermolysis Bullosa	20%
68	Folliculitis	20%
69	Foot Dermatoses	20%
70	Gynecomastia	20%
71	Hypertrichosis	20%
72	Hypohidrosis	20%
73	Hypotrichosis	20%
74	Leg Ulcer	20%
75	Miliaria	20%
76	Parapsoriasis	20%
77	Pityriasis	20%
78	Psoriasis	20%
79	Sebaceous Gland Neoplasms	20%
80	Sweet Syndrome	20%
81	Hidradenitis	20%
82	Onycholysis	20%
83	Miliaria Rubra	20%
84	Hyperpigmentation	20%
85	Lichenoid Eruptions	20%
86	Gianotti-Crosti Syndrome	20%
87	Chloracne	20%
88	Dermatitis, Irritant	19.6%
89	Acne Conglobata	19.6%
90	Connective Tissue Diseases	18.5%
91	Panniculitis, Lupus Erythematosus	18.4%
92	Xeroderma Pigmentosum	17.9%
93	Necrobiosis Lipoidica Diabeticorum	17.9%
94	Lupus Erythematosus, Discoid	17.8%
95	Scleroderma, Limited	17.8%
96	Dermatitis, Photoallergic	17.5%
97	Urticaria Pigmentosa	17.1%
98	Dermatomyositis	16.2%
99	Diaper Rash	16.1%
100	Hyperkeratosis, Epidermolytic	15.6%
101	Dermatitis, Occupational	15.5%
102	Cutis Laxa	15.3%
103	Mastocytosis	15.1%
104	Lichen Planus	14.8%
105	Melanosis	14.8%
106	Chloasma	14.8%
107	Pityriasis Rosea	14.8%
108	Pityriasis Rubra Pilaris	14.8%
109	Vitiligo	14.8%
110	Dermatitis, Allergic Contact	14.8%
111	Lichen Nitidus	14.8%
112	Erythema Induratum	14.4%
113	Erythema Infectiosum	14.1%
114	Exanthema Subitum	14%
115	Ichthyosis, X-Linked	13.8%
116	Erythema Nodosum	13.7%
117	Sjogren-Larsson Syndrome	13.7%
118	Acantholysis	13.6%
119	Breast Cyst	13.6%
120	Pemphigoid, Benign Mucous Membrane	13.6%
121	Pemphigus	13.6%
122	Piedra	13.6%
123	Sunburn	13.6%
124	Argyria	13.3%
125	Ectodermal Dysplasia	13.3%
126	Hirsutism	13.3%
127	Lactation Disorder	13.3%
128	Mastitis	13.3%
129	Urticaria	13.3%
130	Aplasia Cutis Congenita	13.3%
131	Adiposis Dolorosa	13.2%
132	Pruritus Vulvae	13.2%
133	Mastocytoma	13.1%
134	Pruritus Ani	13.1%
135	Tinea Capitis	12.7%
136	Onychomycosis	12.7%
137	Toxic Epidermal Necrolysis	12.6%
138	Stevens-Johnson Syndrome	12.6%
139	Pseudoxanthoma Elasticum	12.6%
140	Granuloma Annulare	12.4%
141	Acanthosis Nigricans	12.2%
142	Alopecia Areata	12.2%
143	Lentigo	12.2%
144	Ecthyma	11.5%
145	Collagen Diseases	10.3%
146	Mixed Connective Tissue Disease	10.3%
147	Mucinoses	10.3%
148	Dermatomycoses	10.2%
149	Mucocutaneous Lymph Node Syndrome	10.2%
150	Skin Diseases, Bacterial	10.2%
151	Alopecia	10.1%
152	Sweating, Gustatory	10.1%
153	Androgenetic Alopecia	10.1%
154	Auriculotemporal Syndrome	10.1%
155	Drug Eruptions	10%
156	Lipodystrophy	10%
157	Livedo Reticularis	10%
158	Malignant Atrophic Papulosis	10%
159	Behcet Syndrome	10%
160	Lice Infestations	9.9%
161	Varicose Ulcer	9.9%
162	Breast Neoplasms, Male	9.9%
163	Triple Negative Breast Neoplasms	9.9%
164	Polyarteritis Nodosa	9.8%
165	Takayasu Arteritis	9.8%
166	Hidradenitis Suppurativa	9.8%
167	Galactorrhea	9.8%
168	Tinea Pedis	8.9%
169	Albinism	8.7%
170	Erythema Chronicum Migrans	8.5%
171	Lichen Planus, Oral	8.4%
172	Nail-Patella Syndrome	8.2%
173	Porphyrias, Hepatic	8.1%
174	Larva Migrans	7.6%
175	Leishmaniasis	7.6%
176	Molluscum Contagiosum	7.6%
177	Angioedema	7.5%
178	Onchocerciasis	7.5%
179	Chromoblastomycosis	7.4%
180	Dermatophytosis	7.4%
181	Sporotrichosis	7.4%
182	Tinea	7.4%
183	Tinea Versicolor	7.4%
184	Trichophytosis	7.4%
185	Hyalohyphomycosis	7.4%
186	Mycetoma	7.3%
187	Cartilage Diseases	7.3%
188	Rheumatism	7.3%
189	Chondromalacia	7.3%
190	Acute Generalized Exanthematous Pustulosis	7.3%
191	Lupus Erythematosus, Systemic	7%
192	Overlap syndrome	7%
193	Scleromyxedema	6.7%
194	Leishmaniasis, Cutaneous	6.1%
195	Eczema Herpeticum	6.1%
196	Warts	6.1%
197	Fusariosis	6%
198	Candidiasis, Chronic Mucocutaneous	5.9%
199	Cutaneous Candidiasis	5.9%
200	Erysipelas	5.9%
201	Serum Sickness	5.9%
202	Staphylococcal Skin Infections	5.9%
203	Variegate Porphyria	5.9%
204	Acute intermittent porphyria	5.9%
205	Porphyria Cutanea Tarda	5.9%
206	Erythrasma	5.9%
207	Carcinoma, Lobular	5.9%
208	Arthritis, Psoriatic	5.8%
209	CREST Syndrome	5.6%
210	Hereditary Angioedema Type III	5.4%
211	Hereditary Angioedema Types I and II	5.4%
212	Dupuytren Contracture	5%
213	Angioedemas, Hereditary	5%
214	Epidermodysplasia Verruciformis	4.9%
215	Herpes Labialis	4.9%
216	Giant Cell Arteritis	4.9%
217	Temporal Arteritis	4.9%
218	Diabetic Foot	4.9%
219	Staphylococcal Scalded Skin Syndrome	4.8%
220	Mesenteric Panniculitis	4.5%
221	Panniculitis, Peritoneal	4.5%
222	Tietze's Syndrome	4.5%
223	Orbital Cellulitis	4.5%
224	Myxoid cyst	4.5%
225	Peutz-Jeghers Syndrome	4.5%
226	Myxedema	4.4%
227	carbuncle	4.3%
228	Blastomycosis	4.2%
229	HIV-Associated Lipodystrophy Syndrome	4.2%
230	Condylomata Acuminata	4.1%
231	Furunculosis	4.1%
232	furuncle	4.1%
233	Cellulitis	4%
234	Impetigo	4%
235	Rhinoscleroma	3.8%
236	Menkes Kinky Hair Syndrome	3.5%
237	Osteochondritis	3.4%
238	Polymyalgia Rheumatica	3.4%
239	Osteogenesis Imperfecta	3.4%
240	Keloid	3.3%
241	Noonan Syndrome	2.9%
242	Rheumatoid Arthritis	2.7%
243	Juvenile arthritis	2.7%
244	Lupus Nephritis	2.6%
245	Marfan Syndrome	2.5%
246	Rheumatoid Nodule	2.5%
247	Homocystinuria	2.4%
248	Laryngomalacia	2.3%
249	Pectus carinatum	2.3%
250	Felty Syndrome	2%
251	Bronchomalacia	2%
252	Tracheomalacia	2%
253	Rheumatoid Vasculitis	1.6%
254	Mucopolysaccharidosis III	1.6%
255	Sicca Syndrome	1.4%
256	Sjogren's Syndrome	1.4%
257	Lupus Vasculitis, Central Nervous System	1.1%
258	Mucopolysaccharidosis II	1.1%

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