MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Histiocytic Disorders, Malignant

(UMLS:C0019613)

Definition:: Distinctive neoplastic disorders of histiocytes. Included are malignant neoplasms of MACROPHAGES and DENDRITIC CELLS.
UMLS ID:: C0019613
MeSH ID:: D015620

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.227

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.250.390

Synonym(s)

Histiocytic Disorders, Malignant

Malignant histiocytic disorder

malig neoplasm histiocytic disorder

malignant histiocytic disorder

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Cytarabine	2466511	CTD
2	Lomustine	21418164	CTD
3	Methotrexate	766954	CTD
4	Mitoxantrone	2466511	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Neoplasms, Neuroepithelial	32%
2	Gliomatosis cerebri	32%
3	Medulloblastoma	31.5%
4	Neuroectodermal Tumors	30.5%
5	melanoma	29.8%
6	leukemia	27.9%
7	Neoplasms, Germ Cell and Embryonal	27.9%
8	Neoplasms, Glandular and Epithelial	27.9%
9	Germ Cell Cancer	27.9%
10	Carcinosarcoma	27.7%
11	Hemangiosarcoma	27.7%
12	lymphangiosarcoma	27.7%
13	Adenoma, Acidophil	27.6%
14	Ganglioneuroma	27.6%
15	Glioma	27.6%
16	Malignant Glioma	27.6%
17	Carcinoid Tumor	26.6%
18	Neurilemmoma	26.6%
19	Hutchinson's Melanotic Freckle	26.6%
20	Melanoma, Amelanotic	26.6%
21	Astrocytoma	25.5%
22	Ependymoma	25.5%
23	oligodendroglioma	25.5%
24	Ganglioglioma	25.5%
25	gliosarcoma	25.5%
26	Anaplastic astrocytoma	25.5%
27	Anaplastic Oligodendroglioma	25.5%
28	Basal cell carcinoma	25%
29	Carcinoma, Papillary	25%
30	Squamous cell carcinoma	25%
31	Chondrosarcoma	25%
32	Craniopharyngioma	25%
33	Cystadenoma	25%
34	leiomyosarcoma	25%
35	liposarcoma	25%
36	Mesothelioma	25%
37	synovial sarcoma	25%
38	Neuroectodermal Tumor, Melanotic	25%
39	Angiomyolipoma	25%
40	Clear Cell Sarcoma of Soft Tissue	25%
41	Alveolar Soft Part Sarcoma	25%
42	Neuroendocrine Tumors	25%
43	Composite Lymphoma	25%
44	Sarcoma, Myeloid	25%
45	Carcinoma, Basal Cell	25%
46	Malignant Carcinoid Syndrome	25%
47	Lymphoma	24.7%
48	Carcinoma 256, Walker	24.6%
49	Glioblastoma	24.4%
50	Neuroblastoma	24.4%
51	Glioblastoma Multiforme	24.4%
52	Ganglioneuroblastoma	23.9%
53	Histiocytosis, Langerhans-Cell	23.7%
54	Cystadenocarcinoma	23.7%
55	Fibrosarcoma	23.7%
56	Osteosarcoma	23.7%
57	Mucoepidermoid Carcinoma	23.7%
58	Lymphohistiocytosis, Hemophagocytic	23.6%
59	Erdheim-Chester Disease	23.6%
60	Thymoma	23.5%
61	Adenofibroma	23%
62	Fibroadenoma	23%
63	Malignant Fibrous Histiocytoma	23%
64	Melanoma, Experimental	22.9%
65	Lymphocele	22.8%
66	Meningioma	22.4%
67	Bowen's Disease	22.3%
68	Paraganglioma	22.3%
69	Rhabdomyosarcoma	22.3%
70	Giant Cell Tumor of Bone	22.3%
71	Leukemia, Plasma Cell	22%
72	Dermatofibrosarcoma	21.6%
73	Dermatofibrosarcoma Protuberans	21.6%
74	Lymphangioleiomyomatosis	21.4%
75	Pheochromocytoma	21%
76	Alveolar rhabdomyosarcoma	21%
77	Adenitis	20.9%
78	Lymphadenitis	20.9%
79	Lymphangitis	20.9%
80	Lymphedema	20.9%
81	Splenic Diseases	20.9%
82	Thymus Hyperplasia	20.9%
83	Pseudolymphoma	20.9%
84	Lymphadenopathy	20.9%
85	Thymus Neoplasms	20.7%
86	Adenoma	20.5%
87	Ameloblastoma	20.5%
88	Angiokeratoma	20.5%
89	Carcinoma	20.5%
90	Chordoma	20.5%
91	Hemangioma	20.5%
92	hemangiopericytoma	20.5%
93	Lymphangioma	20.5%
94	Mesenchymoma	20.5%
95	Nevus	20.5%
96	Teratoma	20.5%
97	Hepatoblastoma	20.5%
98	Mixed Tumor, Mullerian	20.5%
99	Germinoma	20.5%
100	Teratocarcinoma	20.5%
101	Angiofibroma	20.5%
102	Sarcoma	20.5%
103	Epithelioma	20.5%
104	Carcinoid Heart Disease	20.4%
105	Carcinoma, Ehrlich Tumor	19.7%
106	Dermoid Cyst	19.7%
107	Carcinoma, Lewis Lung	19.7%
108	Choriocarcinoma	19%
109	Carcinoma, Lobular	19%
110	Neurofibrosarcoma	18.4%
111	Hodgkin Disease	18%
112	Lymphoma, Non-Hodgkin	18%
113	Trophoblastic Neoplasms	17.8%
114	Leukemia, Experimental	17.7%
115	Leukemia L1210	17.6%
116	Leukemia P388	17.6%
117	Acanthoma	17.6%
118	Retinoblastoma	17.3%
119	Splenic Neoplasms	17.2%
120	Endometrial Stromal Sarcoma	17.2%
121	Adenocarcinoma	16.9%
122	Carcinoma in Situ	16.9%
123	Carcinoma, Transitional Cell	16.9%
124	Phyllodes Tumor	16.9%
125	Dysgerminoma	16.9%
126	Hemangioendothelioma	16.9%
127	Lipoma	16.9%
128	Myoma	16.9%
129	Myxoma	16.9%
130	Neuroma	16.9%
131	Papilloma	16.9%
132	Pseudomyxoma Peritonei	16.9%
133	Seminoma	16.9%
134	Papillomatosis	16.9%
135	Angiolipoma	16.9%
136	Myelolipoma	16.9%
137	Neoplasms, Bone Tissue	16.9%
138	Neoplasms, Fibrous Tissue	16.9%
139	Smooth Muscle Tumor	16.9%
140	Adenomatosis, Pulmonary	16.9%
141	Adenomatous Polyps	16.9%
142	Carcinoma, Large Cell	16.9%
143	Carcinoma, Small Cell	16.9%
144	Desmoplastic Small Round Cell Tumor	16.9%
145	Chondroma	16.9%
146	Enchondroma	16.9%
147	Sarcoma 180	16.3%
148	Lymphangiectasis, Intestinal	16.2%
149	Leukemia, T-Cell	15.9%
150	Leukemia, B-Cell	15.9%
151	Lymphoproliferative Disorders	15.8%
152	Lymphatic Abnormalities	15.8%
153	Lymphomatoid Granulomatosis	15.6%
154	Sarcoma, Experimental	15.5%
155	Plasmacytoma	15.3%
156	Adenoid Cystic Carcinoma	15.1%
157	fibroma	15.1%
158	Fibromatosis	15.1%
159	Osteoblastoma	15.1%
160	Osteoma	15.1%
161	Rhabdomyoma	15.1%
162	Chondromatosis	15.1%
163	Adenocarcinoma, Clear Cell	15.1%
164	Cholangiocarcinoma	15.1%
165	Cervical Intraepithelial Neoplasia	15.1%
166	Hemangioblastoma	15.1%
167	Lymphoma, Extranodal NK-T-Cell	15.1%
168	Leukemia, Myelomonocytic, Chronic	15%
169	Waldenstrom Macroglobulinemia	15%
170	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	15%
171	Leukemia, Radiation-Induced	14.9%
172	Lymphoma, Follicular	14.8%
173	T-Cell Lymphoma	14.8%
174	Mantle cell lymphoma	14.8%
175	Hamartoma	14.6%
176	Neoplasms, Hormone-Dependent	14.6%
177	Neoplasms, Multiple Primary	14.6%
178	Paraneoplastic Syndromes	14.6%
179	Precancerous Conditions	14.6%
180	Neoplasms, Second Primary	14.6%
181	Sezary Syndrome	14.6%
182	Acoustic Neuroma	14.3%
183	Fibromatosis, Aggressive	14.2%
184	Fibromatosis, Abdominal	14.2%
185	Klatskin Tumor	14.2%
186	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	13.8%
187	Leukemia, Large Granular Lymphocytic	13.8%
188	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	13.8%
189	Elephantiasis	13.6%
190	Hypersplenism	13.6%
191	Sarcoidosis	13.6%
192	Elephantiasis Nostras Verrucosa	13.6%
193	Carcinoma, Pancreatic Ductal	13.3%
194	Lymphoma, T-Cell, Cutaneous	13.2%
195	Lymphoma, AIDS-Related	13.2%
196	Enteropathy-Associated T-Cell Lymphoma	13.2%
197	Primary Effusion Lymphoma	13.2%
198	Leukemia, Myeloid, Chronic-Phase	13.2%
199	Optic Nerve Glioma	12.9%
200	Mycosis Fungoides	12.5%
201	Lymphomatoid Papulosis	12.5%
202	Plasmablastic lymphoma	12.5%
203	Vipoma	12.4%
204	Mucocutaneous Lymph Node Syndrome	12.3%
205	Hematologic Neoplasms	12.3%
206	Hydatidiform Mole	12.2%
207	Hemangioma, Cavernous	12%
208	Basal Cell Nevus Syndrome	11.9%
209	Eosinophilic Granuloma	11.5%
210	Mastocytoma	11.3%
211	Mastocytosis, Systemic	11.2%
212	Hepatocellular Adenoma	11.1%
213	Agammaglobulinemia	11%
214	Cyst	10.9%
215	Neoplastic Processes	10.9%
216	Neoplastic Syndromes, Hereditary	10.9%
217	Pregnancy Complications, Neoplastic	10.9%
218	Multiple Endocrine Neoplasia	10.9%
219	Neoplasms, Experimental	10.7%
220	Granuloma	10.3%
221	Splenic Infarction	10.3%
222	Mastocytosis	10.2%
223	Sturge-Weber Syndrome	10.2%
224	Tumor Lysis Syndrome	10.2%
225	Nephroblastoma	10.1%
226	Heavy Chain Disease	10.1%
227	Gastrointestinal Stromal Tumors	10.1%
228	Primary amyloidosis	10.1%
229	Multiple Myeloma	10%
230	neurofibroma	9.9%
231	Paraneoplastic Encephalomyelitis	9.7%
232	Mammary Neoplasms, Experimental	9.5%
233	Burkitt Lymphoma	9.5%
234	Bone Marrow Neoplasms	9.5%
235	Prolactinoma	9.4%
236	Growth Hormone-Secreting Pituitary Adenoma	9.4%
237	Abdominal Neoplasms	9.3%
238	Erythroplasia	9.3%
239	Follicular cyst	9.3%
240	Head and Neck Neoplasms	9.3%
241	Mucocele	9.3%
242	Pilonidal Cyst	9.3%
243	Soft Tissue Neoplasms	9.3%
244	Thoracic Neoplasms	9.3%
245	Thyroglossal Cyst	9.3%
246	Synovial Cyst	9.3%
247	Aberrant Crypt Foci	9.3%
248	Mesoblastic Nephroma	9.2%
249	insulinoma	9.2%
250	Infectious Mononucleosis	8.9%
251	Gastrinoma	8.9%
252	Glucagonoma	8.9%
253	Dupuytren Contracture	8.6%
254	Neoplasms, Radiation-Induced	8.5%
255	Urticaria Pigmentosa	8.5%
256	Adrenocortical carcinoma	8.4%
257	Splenic Rupture	8.3%
258	granulosa cell tumor	8.2%
259	Carcinoma, Ovarian Epithelial	8.2%
260	Disseminated Intravascular Coagulation	8.1%
261	Protein S Deficiency	8.1%
262	Multiple Endocrine Neoplasia Type 1	8.1%
263	Leydig Cell Tumor	8%
264	Polycythemia Vera	7.7%
265	Adenomatous Polyposis Coli	7.7%
266	Sarcoidosis, Pulmonary	7.6%
267	Thrombocythemia, Essential	7.5%
268	Tuberous Sclerosis	7.4%
269	Renal Cell Carcinoma	7.3%
270	Papillary Renal Cell Carcinoma	7.3%
271	Digestive System Neoplasms	7.3%
272	Endocrine Gland Neoplasms	7.3%
273	Eye Neoplasms	7.3%
274	Nervous System Neoplasms	7.3%
275	Carcinoma, Endometrioid	7.2%
276	Bone neoplasms	7%
277	Leukoplakia	7%
278	Pancreatic Cyst	7%
279	Skin Neoplasms	7%
280	Nasopharyngeal carcinoma	7%
281	Anemia	7%
282	Blood Coagulation Disorders	7%
283	Blood Platelet Disorders	7%
284	Bone Marrow Diseases	7%
285	Hemorrhagic Disorders	7%
286	Leukocyte Disorders	7%
287	Methemoglobinemia	7%
288	Pancytopenia	7%
289	Polycythemia	7%
290	Sulfhemoglobinemia	7%
291	Thrombophilia	7%
292	Erythrocytosis	7%
293	Barrett Esophagus	6.9%
294	Breast Cyst	6.9%
295	Actinic keratosis	6.9%
296	Mediastinal Cyst	6.9%
297	Neoplasm Invasiveness	6.9%
298	Neoplasm Metastasis	6.9%
299	Neoplasm Recurrence, Local	6.9%
300	Parathyroid Neoplasms	6.9%
301	Parovarian Cyst	6.9%
302	Pericardial Cyst	6.9%
303	Peritoneal Neoplasms	6.9%
304	Thymic Cyst	6.9%
305	Thyroid Neoplasm	6.9%
306	Thyroid carcinoma	6.9%
307	Carcinogenesis	6.9%
308	Myxoid cyst	6.9%
309	Autoimmune Lymphoproliferative Syndrome	6.9%
310	Metastasis	6.9%
311	Retroperitoneal Neoplasms	6.8%
312	Tracheal Neoplasms	6.3%
313	Liver Neoplasms, Experimental	6.2%
314	Leukoplakia, Oral	6.1%
315	Thrombasthenia	6.1%
316	Antithrombin III Deficiency	6.1%
317	Protein C Deficiency	6.1%
318	Paraneoplastic Cerebellar Degeneration	6.1%
319	Splenosis	6%
320	Pancreatic Neoplasm	5.9%
321	Thrombocytosis	5.9%
322	Denys-Drash Syndrome	5.8%
323	Afibrinogenemia	5.6%
324	Factor VII Deficiency	5.6%
325	Factor X Deficiency	5.6%
326	Factor XII Deficiency	5.6%
327	Hemophilia A	5.6%
328	Thyroid Nodule	5.6%
329	Activated Protein C Resistance	5.6%
330	Factor II deficiency	5.6%
331	Factor VIII Deficiency	5.6%
332	Factor V deficiency	5.6%
333	Factor XI Deficiency	5.6%
334	Hypoprothrombinemias	5.6%
335	Transfusion Reaction	5.5%
336	Hypotensive Transfusion Reaction	5.5%
337	Corpus Luteum Cyst	5.4%
338	Ovarian Cysts	5.4%
339	Vitamin K Deficiency	5.4%
340	Esophageal Neoplasms	5.3%
341	Pregnancy Complications, Hematologic	5.3%
342	Limbic Encephalitis	5.2%
343	Mouth Neoplasms	5.2%
344	Central Nervous System Neoplasms	5.2%
345	Vascular Neoplasms	5.2%
346	Genital Neoplasms, Female	5.1%
347	Pancreatic Pseudocyst	5.1%
348	Lymphatic Metastasis	5%
349	Neoplasms, Unknown Primary	5%
350	Leukemic Infiltration	5%
351	Breast Neoplasms, Male	5%
352	Neoplasm Micrometastasis	5%
353	Triple Negative Breast Neoplasms	5%
354	Hemoglobinuria, Paroxysmal	5%
355	Leukemoid Reaction	5%
356	Niemann-Pick Disease, Type C	4.7%
357	Lambert-Eaton Myasthenic Syndrome	4.6%
358	Testicular Neoplasms	4.6%
359	Choledochal Cyst	4.6%
360	Anemia, Hemolytic	4.5%
361	Anemia, Macrocytic	4.5%
362	Eosinophilia	4.5%
363	Hypoproteinemia	4.5%
364	Leukopenia	4.5%
365	Thrombocytopenia	4.5%
366	Leukostasis	4.5%
367	MYELODYSPLASTIC SYNDROME	4.5%
368	Peutz-Jeghers Syndrome	4.5%
369	Anemia, Diamond-Blackfan	4.4%
370	Meningeal Neoplasms	4.2%
371	Adrenal Gland Neoplasms	4.2%
372	Gastrointestinal Neoplasms	4.2%
373	Genital Neoplasms, Male	4.2%
374	Liver neoplasms	4.2%
375	Uveal Neoplasms	4.2%
376	Urologic Neoplasms	4.1%
377	Opsoclonus-Myoclonus Syndrome	4.1%
378	Purpura, Thrombotic Thrombocytopenic	4.1%
379	Sebaceous Gland Neoplasms	4.1%
380	Spinal Neoplasms	4.1%
381	Polycystic Ovary Syndrome	4%
382	Wiskott-Aldrich Syndrome	4%
383	Palatal Neoplasms	3.9%
384	Nose Neoplasms	3.8%
385	Meningeal Carcinomatosis	3.7%
386	Myelitis, Transverse	3.6%
387	Anemia, Sickle Cell	3.6%
388	Thalassemia	3.6%
389	Anemia, Neonatal	3.4%
390	Ear Neoplasms	3.4%
391	Eyelid Neoplasms	3.4%
392	Leukocytosis	3.4%
393	Lung Neoplasms	3.4%
394	Paraproteinemias	3.4%
395	Pelger-Huet Anomaly	3.4%
396	Pleural Neoplasms	3.4%
397	Pleocytosis	3.4%
398	Primary Myelofibrosis	3.4%
399	Agranulocytosis	3.4%
400	Anemia, Megaloblastic	3.4%
401	Lymphocytosis	3.4%
402	Myelofibrosis	3.4%
403	Myeloid Metaplasia	3.4%
404	Hypoalbuminemia	3.4%
405	Hypereosinophilic syndrome	3.4%
406	bone marrow fibrosis	3.4%
407	Thrombotic Microangiopathies	3.4%
408	Cell Transformation, Viral	3.4%
409	Brain Neoplasms	3.4%
410	Salivary Gland Neoplasms	3.4%
411	Spinal Cord Neoplasms	3.4%
412	Tongue Neoplasms	3.4%
413	Pituitary Adenoma	3.3%
414	Pituitary Neoplasms	3.3%
415	Cryoglobulinemia	3.3%
416	Monoclonal Gammopathy of Undetermined Significance	3.3%
417	Uterine Neoplasms	3.3%
418	Vaginal Neoplasms	3.3%
419	Vulvar Neoplasms	3.3%
420	Uterine Cancer	3.3%
421	Fallopian Tube Neoplasms	3.3%
422	Autoimmune thrombocytopenia	3.2%
423	Immune thrombocytopenic purpura	3.2%
424	Bronchial Neoplasms	3.1%
425	Multiple Pulmonary Nodules	3%
426	Hemolytic-Uremic Syndrome	3%
427	Supratentorial Neoplasms	3%
428	Endometrial Neoplasms	3%
429	Pharyngeal Neoplasms	2.9%
430	ovarian neoplasm	2.9%
431	Sickle Cell Trait	2.9%
432	Purpura, Hyperglobulinemic	2.8%
433	Central Nervous System Cysts	2.8%
434	Bile Duct Neoplasms	2.8%
435	gallbladder neoplasm	2.8%
436	Intestinal Neoplasms	2.8%
437	Neutropenia	2.8%
438	Penile Neoplasms	2.8%
439	Prostatic Neoplasms	2.8%
440	Stomach Neoplasms	2.8%
441	Brain Stem Neoplasms	2.8%
442	Hypergammaglobulinemia	2.8%
443	Fanconi Anemia	2.8%
444	Transfusion-Related Acute Lung Injury	2.7%
445	Ecchymosis	2.7%
446	Petechiae	2.7%
447	Purpura	2.7%
448	Xeroderma Pigmentosum	2.7%
449	Choroid Plexus Papilloma	2.7%
450	Thrombocytopenic purpura	2.7%
451	Atypical Hemolytic Uremic Syndrome	2.6%
452	Lymphopenia	2.6%
453	Job Syndrome	2.5%
454	Hypopharyngeal Neoplasms	2.5%
455	Pleural Effusion, Malignant	2.5%
456	Hypopharyngeal Cancer	2.5%
457	Febrile Neutropenia	2.5%
458	Laryngeal neoplasm	2.5%
459	Parotid Neoplasms	2.5%
460	Prostatic Neoplasms, Castration-Resistant	2.5%
461	Nelson Syndrome	2.5%
462	Hydrops Fetalis	2.4%
463	Bladder Neoplasm	2.4%
464	Kidney Neoplasm	2.4%
465	Ureteral Neoplasms	2.4%
466	Urethral Neoplasms	2.4%
467	Tonsillar Neoplasms	2.3%
468	Cerebellar Neoplasms	2.3%
469	Zollinger-Ellison syndrome	2.2%
470	Acute Chest Syndrome	2.2%
471	Pulmonary Eosinophilia	2.1%
472	Eosinophilic Pneumonia	2.1%
473	Cecal Neoplasms	2.1%
474	Duodenal Neoplasms	2.1%
475	Waterhouse-Friderichsen Syndrome	2.1%
476	Anemia, Pernicious	2.1%
477	Eosinophilia-Myalgia Syndrome	2%
478	Chronic granulomatous disease	2%
479	Shwartzman Phenomenon	2%
480	Scurvy	2%
481	Radicular Cyst	2%
482	Purpura Fulminans	2%
483	Appendiceal Neoplasms	2%
484	Colonic Neoplasms	2%
485	Rectal Neoplasms	2%
486	Nasopharyngeal Neoplasms	1.9%
487	Colorectal Neoplasms	1.8%
488	Kernicterus	1.7%
489	Paranasal Sinus Neoplasms	1.7%
490	POEMS Syndrome	1.7%
491	Anus Neoplasms	1.7%
492	Sigmoid Neoplasms	1.7%
493	Maxillary Sinus Neoplasms	1.5%
494	Pseudoxanthoma Elasticum	1.1%

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