MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Rhabdomyosarcoma

(UMLS:C0035412)

Definition:: A malignant solid tumor arising from mesenchymal tissues which normally differentiate to form striated muscle. It can occur in a wide variety of sites. It is divided into four distinct types: pleomorphic, predominantly in male adults; alveolar (RHABDOMYOSARCOMA, ALVEOLAR), mainly in adolescents and young adults; embryonal (RHABDOMYOSARCOMA, EMBRYONAL), predominantly in infants and children; and botryoidal, also in young children. It is one of the most frequently occurring soft tissue sarcomas and the most common in children under 15. (From Dorland, 27th ed; Holland et al., Cancer Medicine, 3d ed, p2186; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, pp1647-9)
UMLS ID:: C0035412
MeSH ID:: D012208

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.590.550.660|C04.557.450.795.550.660

Synonym(s)

Rhabdomyosarcoma

RHABDOMYOSARCOMA

RHABDOMYOSARCOMA, MALIGNANT

Rhabdomyosarcoma NOS

Rhabdomyosarcoma, NOS

Rhabdomyosarcoma, no subtype

Rhabdosarcoma

[M]Rhabdomyosarcoma NOS

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Melphalan	FAERS: 4	8062269 11846301	CTD US FAERS
2	Tamoxifen	FAERS: 3		US FAERS
3	pazopanib	FAERS: 3		US FAERS
4	Omeprazole	FAERS: 2		US FAERS
5	pimecrolimus	FAERS: 2		OFFSIDES US FAERS
6	Dactinomycin	FAERS: 1	View details 857581 9191535 11378345 15591910 18989167	CTD OFFSIDES US FAERS
7	Dimethyl Fumarate	FAERS: 1		US FAERS
8	Everolimus	FAERS: 1		US FAERS
9	Gefitinib	FAERS: 1		US FAERS
10	Ifosfamide	FAERS: 1	View details 1574040 3114437 7978043 8950339 9374361 9569955 11846301 15354722 19826134	CTD US FAERS
11	Imatinib Mesylate	FAERS: 1		US FAERS
12	Isotretinoin	FAERS: 1		US FAERS
13	Pregabalin	FAERS: 1		US FAERS
14	rasagiline	FAERS: 1		US FAERS
15	teriflunomide	FAERS: 1		US FAERS
16	Bortezomib		18342500	CTD
17	Chlorpromazine			OFFSIDES
18	Ciclopirox		21217783	CTD
19	Clofarabine			OFFSIDES
20	Cobalt		20934443 22982072	CTD
21	Cyclophosphamide		857581 9191535 18989167	CTD
22	Cytarabine		19821538	CTD
23	Dacarbazine		857581	CTD
24	Decitabine		19155313	CTD
25	Dioctyl Sulfosuccinic Acid			OFFSIDES
26	Doxorubicin		View details 857581 7251903 21624110 23300809	CTD
27	Estradiol		1219538	CTD
28	Etoposide		View details 857581 3152939 11846301 15354722	CTD OFFSIDES
29	FLLL 32		21109950	CTD
30	Hydrocortisone		19821538	CTD OFFSIDES
31	Irinotecan		8504425	CTD
32	Mesna		3114437	CTD
33	Methotrexate		19821538 21624110	CTD
34	Mitoxantrone		6684503	CTD
35	Nickel		15929896 20934443 22982072	CTD
36	Polymyxin B			OFFSIDES
37	Sunitinib	Canada Vigilance: 1		Canada Vigilance
38	Tamoxifen			OFFSIDES
39	Temozolomide	Canada Vigilance: 1		Canada Vigilance
40	Topotecan			OFFSIDES
41	Tretinoin		15982179 16116481 16283617	CTD
42	Trimetazidine			OFFSIDES
43	Tungsten		View details 15929896 20934443 22982072 25620057	CTD
44	Valproic Acid		19155313	CTD
45	Vinblastine		15591910	CTD
46	Vincristine		View details 857581 9191535 11846301 18989167	CTD
47	candesartan cilexetil			OFFSIDES
48	dexamethasone acetate			OFFSIDES
49	fosfluconazole			OFFSIDES
50	mithramycin A		857581	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	leiomyosarcoma	52.8%
2	Alveolar Soft Part Sarcoma	52.8%
3	Chondrosarcoma	43.2%
4	liposarcoma	43.2%
5	synovial sarcoma	43.2%
6	Clear Cell Sarcoma of Soft Tissue	43.2%
7	Carcinosarcoma	38.7%
8	Hemangiosarcoma	38.7%
9	lymphangiosarcoma	38.7%
10	Fibrosarcoma	37.5%
11	Osteosarcoma	37.5%
12	Phyllodes Tumor	35.1%
13	Myoma	35.1%
14	Smooth Muscle Tumor	35.1%
15	Desmoplastic Small Round Cell Tumor	35.1%
16	Malignant Fibrous Histiocytoma	34.6%
17	Angiomyolipoma	33.6%
18	Sarcoma, Myeloid	33.6%
19	leukemia	29.7%
20	Neoplasms, Germ Cell and Embryonal	29.7%
21	Neoplasms, Glandular and Epithelial	29.7%
22	Germ Cell Cancer	29.7%
23	Sarcoma, Experimental	27.5%
24	Carcinoma 256, Walker	26.1%
25	Dermatofibrosarcoma	25.7%
26	Dermatofibrosarcoma Protuberans	25.7%
27	Neuroectodermal Tumors	24.4%
28	Rhabdomyoma	23.3%
29	Lipoma	22.3%
30	Myxoma	22.3%
31	Angiolipoma	22.3%
32	Myelolipoma	22.3%
33	Neoplasms, Bone Tissue	22.3%
34	Neoplasms, Fibrous Tissue	22.3%
35	Chondroma	22.3%
36	Enchondroma	22.3%
37	Histiocytic Disorders, Malignant	22.3%
38	Giant Cell Tumor of Bone	22.2%
39	Sarcoma 180	21.7%
40	Neoplasms, Neuroepithelial	21.3%
41	Gliomatosis cerebri	21.3%
42	Endometrial Stromal Sarcoma	19.7%
43	Hamartoma	19.5%
44	Neoplasms, Hormone-Dependent	19.5%
45	Neoplasms, Multiple Primary	19.5%
46	Paraneoplastic Syndromes	19.5%
47	Precancerous Conditions	19.5%
48	Neoplasms, Second Primary	19.5%
49	Sarcoma	18.8%
50	Lymphoma	17.9%
51	Neurofibrosarcoma	17.4%
52	melanoma	17.3%
53	Meningioma	17.3%
54	Composite Lymphoma	16.2%
55	Adenoma	16.1%
56	Ameloblastoma	16.1%
57	Angiokeratoma	16.1%
58	Carcinoma	16.1%
59	Chordoma	16.1%
60	Hemangioma	16.1%
61	hemangiopericytoma	16.1%
62	Lymphangioma	16.1%
63	Mesenchymoma	16.1%
64	Nevus	16.1%
65	Teratoma	16.1%
66	Hepatoblastoma	16.1%
67	Mixed Tumor, Mullerian	16.1%
68	Germinoma	16.1%
69	Teratocarcinoma	16.1%
70	Angiofibroma	16.1%
71	Epithelioma	16.1%
72	Lymphangioleiomyomatosis	16%
73	Trophoblastic Neoplasms	15.9%
74	Leukemia, Experimental	15.8%
75	Adenofibroma	15.5%
76	Fibroadenoma	15.5%
77	Leukemia, Plasma Cell	15.5%
78	fibroma	14.8%
79	Fibromatosis	14.8%
80	Osteoblastoma	14.8%
81	Osteoma	14.8%
82	Chondromatosis	14.8%
83	Cyst	14.8%
84	Neoplastic Processes	14.8%
85	Neoplastic Syndromes, Hereditary	14.8%
86	Pregnancy Complications, Neoplastic	14.8%
87	Carcinoma, Ehrlich Tumor	14.8%
88	Dermoid Cyst	14.8%
89	Carcinoma, Lewis Lung	14.8%
90	Neoplasms, Experimental	14.5%
91	Basal cell carcinoma	14.4%
92	Carcinoma, Papillary	14.4%
93	Squamous cell carcinoma	14.4%
94	Craniopharyngioma	14.4%
95	Cystadenoma	14.4%
96	Mesothelioma	14.4%
97	Neuroectodermal Tumor, Melanotic	14.4%
98	Neuroendocrine Tumors	14.4%
99	Carcinoma, Basal Cell	14.4%
100	Mastocytosis	13.8%
101	Gastrointestinal Stromal Tumors	13.6%
102	Adenoma, Acidophil	13.4%
103	Ganglioneuroma	13.4%
104	Glioma	13.4%
105	Malignant Glioma	13.4%
106	Leukemia, Radiation-Induced	13.3%
107	Melanoma, Experimental	12.5%
108	Plasmacytoma	12.2%
109	Malignant histiocytosis	12.1%
110	Histiocytic sarcoma	12.1%
111	Cystadenocarcinoma	12%
112	Mucoepidermoid Carcinoma	12%
113	Medulloblastoma	11.9%
114	Thymoma	11.7%
115	Neoplasms, Radiation-Induced	11.6%
116	Carcinoid Tumor	11.4%
117	Neurilemmoma	11.4%
118	Hutchinson's Melanotic Freckle	11.4%
119	Melanoma, Amelanotic	11.4%
120	Leukemia L1210	11.3%
121	Leukemia P388	11.3%
122	Acanthoma	11.3%
123	Mastocytoma	11.2%
124	Mastocytosis, Systemic	11.2%
125	Multiple Endocrine Neoplasia	11.1%
126	Rhabdomyosarcoma	11.1%
127	Fibromatosis, Aggressive	11.1%
128	Fibromatosis, Abdominal	11.1%
129	Choriocarcinoma	10.7%
130	Carcinoma, Lobular	10.7%
131	Abdominal Neoplasms	9.9%
132	Erythroplasia	9.9%
133	Follicular cyst	9.9%
134	Head and Neck Neoplasms	9.9%
135	Mucocele	9.9%
136	Pilonidal Cyst	9.9%
137	Soft Tissue Neoplasms	9.9%
138	Thoracic Neoplasms	9.9%
139	Thyroglossal Cyst	9.9%
140	Synovial Cyst	9.9%
141	Aberrant Crypt Foci	9.9%
142	Hodgkin Disease	9.7%
143	Lymphoma, Non-Hodgkin	9.7%
144	Adenocarcinoma	9.6%
145	Carcinoma in Situ	9.6%
146	Carcinoma, Transitional Cell	9.6%
147	Dysgerminoma	9.6%
148	Hemangioendothelioma	9.6%
149	Neuroma	9.6%
150	Papilloma	9.6%
151	Pseudomyxoma Peritonei	9.6%
152	Seminoma	9.6%
153	Papillomatosis	9.6%
154	Adenomatosis, Pulmonary	9.6%
155	Adenomatous Polyps	9.6%
156	Carcinoma, Large Cell	9.6%
157	Carcinoma, Small Cell	9.6%
158	Bowen's Disease	9.5%
159	Paraganglioma	9.5%
160	Astrocytoma	9.5%
161	Ependymoma	9.5%
162	oligodendroglioma	9.5%
163	Ganglioglioma	9.5%
164	gliosarcoma	9.5%
165	Anaplastic astrocytoma	9.5%
166	Anaplastic Oligodendroglioma	9.5%
167	Paraneoplastic Encephalomyelitis	9.4%
168	Mammary Neoplasms, Experimental	9.2%
169	Retinoblastoma	8.7%
170	Malignant Carcinoid Syndrome	8.5%
171	Nephroblastoma	8.5%
172	Alveolar rhabdomyosarcoma	8.3%
173	Tuberous Sclerosis	8.2%
174	Primary amyloidosis	8.2%
175	Lymphomatoid Granulomatosis	8.1%
176	Digestive System Neoplasms	7.8%
177	Endocrine Gland Neoplasms	7.8%
178	Eye Neoplasms	7.8%
179	Nervous System Neoplasms	7.8%
180	Glioblastoma	7.6%
181	Neuroblastoma	7.6%
182	Glioblastoma Multiforme	7.6%
183	Bone neoplasms	7.6%
184	Leukoplakia	7.6%
185	Lymphocele	7.6%
186	Pancreatic Cyst	7.6%
187	Skin Neoplasms	7.6%
188	Hematologic Neoplasms	7.6%
189	Barrett Esophagus	7.4%
190	Breast Cyst	7.4%
191	Actinic keratosis	7.4%
192	Mediastinal Cyst	7.4%
193	Neoplasm Invasiveness	7.4%
194	Neoplasm Metastasis	7.4%
195	Neoplasm Recurrence, Local	7.4%
196	Parovarian Cyst	7.4%
197	Pericardial Cyst	7.4%
198	Splenic Neoplasms	7.4%
199	Thymic Cyst	7.4%
200	Carcinogenesis	7.4%
201	Myxoid cyst	7.4%
202	Metastasis	7.4%
203	Leukemia, Myelomonocytic, Chronic	7.2%
204	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.2%
205	Pheochromocytoma	7.1%
206	Dupuytren Contracture	6.9%
207	Basal Cell Nevus Syndrome	6.8%
208	Mesoblastic Nephroma	6.8%
209	Urticaria Pigmentosa	6.7%
210	Ganglioneuroblastoma	6.6%
211	Hepatocellular Adenoma	6.5%
212	Adenoid Cystic Carcinoma	6.3%
213	Adenocarcinoma, Clear Cell	6.3%
214	Cholangiocarcinoma	6.3%
215	Cervical Intraepithelial Neoplasia	6.3%
216	Hemangioblastoma	6.3%
217	Lymphoma, Extranodal NK-T-Cell	6.3%
218	Waldenstrom Macroglobulinemia	6.1%
219	Multiple Myeloma	6.1%
220	Multiple Endocrine Neoplasia Type 1	6%
221	Carcinoid Heart Disease	6%
222	Carcinoma, Pancreatic Ductal	5.9%
223	Sturge-Weber Syndrome	5.9%
224	Corpus Luteum Cyst	5.9%
225	Ovarian Cysts	5.9%
226	Hemangioma, Cavernous	5.8%
227	Leukemia, T-Cell	5.8%
228	Leukemia, B-Cell	5.8%
229	neurofibroma	5.8%
230	Hydatidiform Mole	5.7%
231	Lymphoma, Follicular	5.7%
232	T-Cell Lymphoma	5.7%
233	Mantle cell lymphoma	5.7%
234	Liver Neoplasms, Experimental	5.6%
235	Parathyroid Neoplasms	5.6%
236	Peritoneal Neoplasms	5.6%
237	Thyroid Neoplasm	5.6%
238	Thyroid carcinoma	5.6%
239	Prolactinoma	5.5%
240	Growth Hormone-Secreting Pituitary Adenoma	5.5%
241	Acoustic Neuroma	5.4%
242	Retroperitoneal Neoplasms	5.4%
243	Choledochal Cyst	5%
244	Optic Nerve Glioma	4.9%
245	Peutz-Jeghers Syndrome	4.9%
246	Adenomatous Polyposis Coli	4.8%
247	Pancreatic Neoplasm	4.8%
248	granulosa cell tumor	4.8%
249	Carcinoma, Ovarian Epithelial	4.8%
250	Leukemia, Myeloid, Chronic-Phase	4.8%
251	Klatskin Tumor	4.7%
252	Vipoma	4.6%
253	Tracheal Neoplasms	4.4%
254	Leukoplakia, Oral	4.3%
255	Paraneoplastic Cerebellar Degeneration	4.3%
256	Mouth Neoplasms	4.1%
257	Central Nervous System Neoplasms	4.1%
258	Vascular Neoplasms	4.1%
259	Thymus Neoplasms	4.1%
260	Genital Neoplasms, Female	4.1%
261	Pancreatic Pseudocyst	4.1%
262	Lymphatic Metastasis	4%
263	Neoplasms, Unknown Primary	4%
264	Leukemic Infiltration	4%
265	Breast Neoplasms, Male	4%
266	Neoplasm Micrometastasis	4%
267	Triple Negative Breast Neoplasms	4%
268	insulinoma	4%
269	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
270	Leukemia, Large Granular Lymphocytic	3.8%
271	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
272	Lymphoma, T-Cell, Cutaneous	3.8%
273	Lymphoma, AIDS-Related	3.8%
274	Enteropathy-Associated T-Cell Lymphoma	3.8%
275	Primary Effusion Lymphoma	3.8%
276	Nasopharyngeal carcinoma	3.7%
277	Esophageal Neoplasms	3.7%
278	Limbic Encephalitis	3.7%
279	Adrenocortical carcinoma	3.7%
280	Denys-Drash Syndrome	3.5%
281	Gastrinoma	3.4%
282	Glucagonoma	3.4%
283	Adrenal Gland Neoplasms	3.4%
284	Gastrointestinal Neoplasms	3.4%
285	Genital Neoplasms, Male	3.4%
286	Liver neoplasms	3.4%
287	Uveal Neoplasms	3.4%
288	Leydig Cell Tumor	3.4%
289	Urologic Neoplasms	3.3%
290	Lambert-Eaton Myasthenic Syndrome	3.3%
291	Testicular Neoplasms	3.3%
292	Sebaceous Gland Neoplasms	3.3%
293	Spinal Neoplasms	3.3%
294	Bone Marrow Neoplasms	3.3%
295	Thyroid Nodule	3.2%
296	Polycystic Ovary Syndrome	3.2%
297	Renal Cell Carcinoma	3.2%
298	Papillary Renal Cell Carcinoma	3.2%
299	Xeroderma Pigmentosum	3%
300	Carcinoma, Endometrioid	3%
301	Opsoclonus-Myoclonus Syndrome	2.9%
302	Mycosis Fungoides	2.8%
303	Lymphomatoid Papulosis	2.8%
304	Plasmablastic lymphoma	2.8%
305	Burkitt Lymphoma	2.7%
306	Myelitis, Transverse	2.6%
307	Meningeal Neoplasms	2.4%
308	ovarian neoplasm	2.3%
309	Nose Neoplasms	2.2%
310	Sezary Syndrome	2.1%
311	Pituitary Adenoma	2%
312	Pituitary Neoplasms	2%
313	Palatal Neoplasms	2%
314	Ear Neoplasms	2%
315	Eyelid Neoplasms	2%
316	Lung Neoplasms	2%
317	Pleural Neoplasms	2%
318	Cell Transformation, Viral	2%
319	Brain Neoplasms	1.9%
320	Salivary Gland Neoplasms	1.9%
321	Spinal Cord Neoplasms	1.9%
322	Tongue Neoplasms	1.9%
323	Uterine Neoplasms	1.9%
324	Vaginal Neoplasms	1.9%
325	Vulvar Neoplasms	1.9%
326	Uterine Cancer	1.9%
327	Fallopian Tube Neoplasms	1.9%
328	Zollinger-Ellison syndrome	1.8%
329	Pharyngeal Neoplasms	1.7%
330	Central Nervous System Cysts	1.6%
331	Bile Duct Neoplasms	1.6%
332	gallbladder neoplasm	1.6%
333	Intestinal Neoplasms	1.6%
334	Penile Neoplasms	1.6%
335	Prostatic Neoplasms	1.6%
336	Stomach Neoplasms	1.6%
337	Polycythemia Vera	1.6%
338	Meningeal Carcinomatosis	1.6%
339	Laryngeal neoplasm	1.5%
340	Bladder Neoplasm	1.4%
341	Kidney Neoplasm	1.4%
342	Ureteral Neoplasms	1.4%
343	Urethral Neoplasms	1.4%
344	Bronchial Neoplasms	1.3%
345	Multiple Pulmonary Nodules	1.3%
346	Supratentorial Neoplasms	1.3%
347	Endometrial Neoplasms	1.3%
348	Hypopharyngeal Neoplasms	1.1%
349	Pleural Effusion, Malignant	1.1%
350	Hypopharyngeal Cancer	1.1%
351	Parotid Neoplasms	1.1%
352	Prostatic Neoplasms, Castration-Resistant	1.1%
353	Nelson Syndrome	1.1%
354	Brain Stem Neoplasms	1%
355	Cecal Neoplasms	0.9%
356	Duodenal Neoplasms	0.9%
357	Nasopharyngeal Neoplasms	0.8%
358	Colorectal Neoplasms	0.8%
359	Tonsillar Neoplasms	0.8%
360	Cerebellar Neoplasms	0.8%
361	Choroid Plexus Papilloma	0.8%
362	Paranasal Sinus Neoplasms	0.7%
363	Radicular Cyst	0.7%
364	Appendiceal Neoplasms	0.7%
365	Colonic Neoplasms	0.7%
366	Rectal Neoplasms	0.7%
367	Maxillary Sinus Neoplasms	0.5%
368	Anus Neoplasms	0.5%
369	Sigmoid Neoplasms	0.5%

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