MetaADEDB 2.0 @ LMMD
Glioblastoma
(UMLS:C0017636)
Definition:
A malignant form of astrocytoma histologically characterized by pleomorphism of cells, nuclear atypia, microhemorrhage, and necrosis. They may arise in any region of the central nervous system, with a predilection for the cerebral hemispheres, basal ganglia, and commissural pathways. Clinical presentation most frequently occurs in the fifth or sixth decade of life with focal neurologic signs or seizures.
UMLS ID:
C0017636
MeSH ID:
D005909
Classification:
Name:
Neoplasms
MeSH Tree Number(s):
C04.557.465.625.600.380.080.335|C04.557.470.670.380.080.335|C04.557.580.625.600.380.080.335
Synonym(s)
1.
Glioblastoma
2.
ASTROCYTOMA, GRADES 3-4
3.
GBM
4.
GBM (Glioblastoma)
5.
Glioblastoma NOS
6.
Glioblastoma multiforme
7.
Glioblastoma, NOS
8.
Glioblastoma, Not Otherwise Specified
9.
Glioblastoma, no ICD-O subtype
10.
Glioblastoma, no International Classification of Diseases for Oncology subtype
11.
Grade IV Astrocytic Neoplasm
12.
Grade IV Astrocytic Tumor
13.
WHO Grade IV Glioma
14.
glioblastoma
15.
glioblastoma; unspecified site
Associated Drug(s)
NameNumber of ReportsReference(s)Data Source
1TemozolomideFAERS: 73
Canada Vigilance: 17

View details

15570079
15865885
16757971
17372135
17495388
18089819
18398572
18771084
19204207
19239041
20167086
20354191
20435409
20684359
23522185
27519711
 		CTD
OFFSIDES
Canada Vigilance
US FAERS
2Glatiramer AcetateFAERS: 9
Canada Vigilance: 1		Canada Vigilance
OFFSIDES
US FAERS
3LevetiracetamFAERS: 9US FAERS
4ThalidomideFAERS: 914654909CTD
US FAERS
5Dimethyl FumarateFAERS: 7US FAERS
6Fingolimod HydrochlorideFAERS: 7US FAERS
7eltrombopagFAERS: 5US FAERS
84-methyl-N-(3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)phenyl)-3-((4-pyridin-3-ylpyrimidin-2-yl)amino)benzamideFAERS: 4US FAERS
9IsotretinoinFAERS: 4US FAERS
10LenalidomideFAERS: 4US FAERS
11FentanylFAERS: 3US FAERS
12LacosamideFAERS: 3US FAERS
13LamotrigineFAERS: 3US FAERS
14Medroxyprogesterone AcetateFAERS: 3US FAERS
15Zoledronic AcidFAERS: 3
Canada Vigilance: 1		Canada Vigilance
US FAERS
16apixabanFAERS: 3US FAERS
17CladribineFAERS: 2US FAERS
18ClozapineFAERS: 2OFFSIDES
US FAERS
19Imatinib MesylateFAERS: 2US FAERS
20LapatinibFAERS: 2OFFSIDES
US FAERS
21LetrozoleFAERS: 2US FAERS
22PhenytoinFAERS: 2US FAERS
23TopiramateFAERS: 2US FAERS
24mirabegronFAERS: 2US FAERS
254-AminopyridineFAERS: 1US FAERS
264-hydroxybutyric acidFAERS: 1US FAERS
27AprepitantFAERS: 1US FAERS
28AzacitidineFAERS: 1US FAERS
29AzathioprineFAERS: 1US FAERS
30BosentanFAERS: 1US FAERS
31CitalopramFAERS: 1US FAERS
32Ezetimibe, Simvastatin Drug CombinationFAERS: 1US FAERS
33HydroxyureaFAERS: 1US FAERS
34Imatinib MesylateFAERS: 1US FAERS
35LatanoprostFAERS: 1US FAERS
36LomustineFAERS: 118089819CTD
US FAERS
37LosartanFAERS: 1US FAERS
38MDV 3100FAERS: 1US FAERS
39MethotrexateFAERS: 1OFFSIDES
US FAERS
40Mycophenolic AcidFAERS: 1US FAERS
41NorgestrelFAERS: 1US FAERS
42OctreotideFAERS: 1US FAERS
43ProcarbazineFAERS: 1US FAERS
44RivastigmineFAERS: 1US FAERS
45RosiglitazoneFAERS: 1US FAERS
46Rosuvastatin CalciumFAERS: 1US FAERS
47Ruxolitinib phosphateFAERS: 1US FAERS
48SimvastatinFAERS: 1OFFSIDES
US FAERS
49TestosteroneFAERS: 117162496CTD
US FAERS
50ValsartanFAERS: 1
Canada Vigilance: 1		Canada Vigilance
US FAERS
51[(19S)-10,19-Diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4(9),5,7,10,15(20)-heptaen-7-yl] 4-piperidin-1-ylpiperidine-1-carboxylate;hydron;chloride;trihydrateFAERS: 1US FAERS
52ambrisentanFAERS: 1US FAERS
53anagrelideFAERS: 1US FAERS
54candesartanFAERS: 1US FAERS
55eltrombopagFAERS: 1US FAERS
56macitentanFAERS: 1US FAERS
57pazopanibFAERS: 1US FAERS
58pomalidomideFAERS: 1US FAERS
59rofecoxibFAERS: 1US FAERS
60temsirolimusFAERS: 121267448CTD
US FAERS
61treprostinilFAERS: 1US FAERS
62venetoclaxFAERS: 1US FAERS
631-(2-chloroethyl)-1-nitrosourea18089819CTD
642,5-dimethylcelecoxib18485224CTD
654,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid18590702CTD
66AICA ribonucleotide19625624CTD
67Adenosine TriphosphateOFFSIDES
68Aspirin12870263CTD
69BetahistineOFFSIDES
70BetaxololOFFSIDES
71Bortezomib18771084CTD
72Canertinib15956251CTD
73Capsaicin18405923CTD
74Carboplatin12483326
18771084		CTD
75Carmustine

View details

6354414
10773252
11096723
15110396
15570079
15603970
15655414
15850984
16187019
16874663
17099729
17121897
18089819
18584351
18590702
18679580
18771084
19204207
19637364
20221717
20435409
20556481
21210161
21296415
 		CTD
76Chloroquine15727424CTD
77Cilengitide19239041CTD
78ClobazamOFFSIDES
79Crizotinib22162573CTD
80CyclizineOFFSIDES
81Cycloheximide7841041
7861226		CTD
82Dacarbazine12592361
12853885		CTD
83Dactinomycin7841041
7861226		CTD
84DaunorubicinOFFSIDES
85Dexamethasone18398572CTD
86Diazepam16059654CTD
87Doxorubicin17150277CTD
88Ethylnitrosourea7231638
16436596		CTD
89EtoposideOFFSIDES
90EverolimusSIDER
91Fenretinide16187019CTD
92Fluconazole18398572CTD
93Flucytosine18398572CTD
94Gefitinib18771084CTD
95Genistein16598420CTD
96GlycerolOFFSIDES
97Indomethacin12870263CTD
98Irinotecan15570079CTD
99IsoniazidOFFSIDES
100Isoxazoles15850984CTD
101Manganese Compounds17043766CTD
102Melphalan18584351CTD
103Mitomycin15655414CTD
104Nifedipine7841041
7861226		CTD
105Nimustine18089819CTD
106Okadaic Acid17312396CTD
107PP24223440206CTD
108Paclitaxel7481858
17701358
18098270		CTD
109PravastatinOFFSIDES
110Prednisone acetateOFFSIDES
111Quercetin19804834CTD
112RamiprilOFFSIDES
113Resveratrol21029458CTD
114SotalolOFFSIDES
115Streptonigrin15655414CTD
116Sulfasalazine15328202CTD
117SumatriptanOFFSIDES
118Teniposide20221717CTD
119Topotecan19139825CTD
120Tretinoin17312396
17701358
18098270		CTD
OFFSIDES
121Valproic Acid19239041CTD
122Vindesine7438126CTD
123baicalein19804834CTD
124biochanin A16598420CTD
125butylidenephthalide16987298CTD
126decanedioic acid-4,4'-(1,3-propanediylbis(oxy))bis(benzoic acid) copolymer19123896CTD
127dehydroeburicoic acid19848398CTD
128dexamethasone 21-phosphateOFFSIDES
129dexamethasone acetateOFFSIDES
130diallyl trisulfide23754639CTD
131eburicoic acid19848398CTD
132evodiamine23774672CTD
133fotemustine12592361
12853885
20556481		CTD
134geldanamycin12811834CTD
135hypericin16059654CTD
136liposomal amphotericin B18398572CTD
137monodansylcadaverine16170020CTD
138myricetin19804834CTD
139perfluorodecanoic acid17162496CTD
140perfluorooctane sulfonic acid17162496CTD
141perifosine21267448CTD
142plerixafor octahydrochloride17121897CTD
143rizatriptanOFFSIDES
144sennoside A&BOFFSIDES
145tianeptineOFFSIDES
146trichostatin A18801729CTD
147turmeric extract17596214CTD
Similar ADE(s)
NameSemantic Similarity
1Medulloblastoma43.1%
2Ependymoma41.7%
3oligodendroglioma41.7%
4Ganglioglioma41.7%
5gliosarcoma41.7%
6Anaplastic Oligodendroglioma41.7%
7Ganglioneuroma38.3%
8Craniopharyngioma30.5%
9Neuroectodermal Tumor, Melanotic30.5%
10Neuroendocrine Tumors30.5%
11leukemia30.4%
12melanoma24.7%
13Retinoblastoma24.6%
14Histiocytic Disorders, Malignant24.4%
15Adenoma22.7%
16Carcinoma22.7%
17Epithelioma22.7%
18Meningioma22.7%
19Adenoma, Acidophil22.4%
20Chordoma22.3%
21Teratoma22.3%
22Germinoma22.3%
23Teratocarcinoma22.3%
24Trophoblastic Neoplasms22.1%
25Hamartoma20.5%
26Neoplasms, Hormone-Dependent20.5%
27Neoplasms, Multiple Primary20.5%
28Paraneoplastic Syndromes20.5%
29Precancerous Conditions20.5%
30Neoplasms, Second Primary20.5%
31Lymphoma20.4%
32Neoplasms, Germ Cell and Embryonal20.3%
33Germ Cell Cancer20.3%
34Optic Nerve Glioma20.3%
35Neoplasms, Glandular and Epithelial20%
36Basal cell carcinoma19.7%
37Carcinoma, Papillary19.7%
38Squamous cell carcinoma19.7%
39Cystadenoma19.7%
40Mesothelioma19.7%
41Carcinoma, Basal Cell19.7%
42Carcinosarcoma19.2%
43Hemangiosarcoma19.2%
44lymphangiosarcoma19.2%
45Carcinoid Tumor18.9%
46Neurilemmoma18.7%
47Carcinoma, Ehrlich Tumor18.1%
48Carcinoma, Lewis Lung18.1%
49Composite Lymphoma17.9%
50Dermoid Cyst17.8%
51Leukemia, Experimental17.3%
52Paraganglioma17%
53Neuroectodermal Tumors16.9%
54Cyst16.6%
55Neoplastic Processes16.6%
56Neoplastic Syndromes, Hereditary16.6%
57Pregnancy Complications, Neoplastic16.6%
58Neoplasms, Experimental16.4%
59Leukemia, Plasma Cell16%
60Melanoma, Experimental15.9%
61Carcinoma 256, Walker15.6%
62Ameloblastoma15.5%
63Angiokeratoma15.5%
64Hemangioma15.5%
65hemangiopericytoma15.5%
66Lymphangioma15.5%
67Mesenchymoma15.5%
68Nevus15.5%
69Hepatoblastoma15.5%
70Mixed Tumor, Mullerian15.5%
71Angiofibroma15.5%
72Sarcoma15.5%
73Cystadenocarcinoma15.5%
74Mucoepidermoid Carcinoma15.5%
75Neuroblastoma15.2%
76Leukemia, Radiation-Induced15.1%
77Neoplasms, Neuroepithelial14.4%
78Gliomatosis cerebri14.4%
79Hutchinson's Melanotic Freckle14.2%
80Melanoma, Amelanotic14.2%
81Carcinoma, Lobular14.2%
82Acanthoma14.1%
83Choriocarcinoma13.9%
84Neoplasms, Radiation-Induced13.7%
85Chondrosarcoma13.3%
86leiomyosarcoma13.3%
87liposarcoma13.3%
88synovial sarcoma13.3%
89Angiomyolipoma13.3%
90Clear Cell Sarcoma of Soft Tissue13.3%
91Alveolar Soft Part Sarcoma13.3%
92Sarcoma, Myeloid13.3%
93Multiple Endocrine Neoplasia13.2%
94Plasmacytoma12.5%
95Malignant histiocytosis12.5%
96Histiocytic sarcoma12.5%
97Sarcoma, Experimental12.4%
98Thymoma12.3%
99Adenocarcinoma12.3%
100Carcinoma in Situ12.3%
101Carcinoma, Transitional Cell12.3%
102Papilloma12.3%
103Pseudomyxoma Peritonei12.3%
104Papillomatosis12.3%
105Adenomatosis, Pulmonary12.3%
106Adenomatous Polyps12.3%
107Carcinoma, Large Cell12.3%
108Carcinoma, Small Cell12.3%
109Adenofibroma12.2%
110Fibroadenoma12.2%
111Dysgerminoma11.9%
112Neuroma11.9%
113Seminoma11.9%
114Malignant Carcinoid Syndrome11.7%
115Endometrial Stromal Sarcoma11.6%
116Ganglioneuroblastoma11.4%
117Bowen's Disease11.4%
118Leukemia L121010.9%
119Leukemia P38810.9%
120Paraneoplastic Encephalomyelitis10.5%
121Fibrosarcoma10.4%
122Osteosarcoma10.4%
123Tuberous Sclerosis10.4%
124Hodgkin Disease10.4%
125Lymphoma, Non-Hodgkin10.4%
126Pheochromocytoma10.4%
127Mammary Neoplasms, Experimental10.3%
128Abdominal Neoplasms10.1%
129Erythroplasia10.1%
130Follicular cyst10.1%
131Head and Neck Neoplasms10.1%
132Mucocele10.1%
133Pilonidal Cyst10.1%
134Soft Tissue Neoplasms10.1%
135Thoracic Neoplasms10.1%
136Thyroglossal Cyst10.1%
137Synovial Cyst10.1%
138Aberrant Crypt Foci10.1%
139Nephroblastoma10%
140Lymphangioleiomyomatosis9.6%
141Primary amyloidosis9%
142Malignant Fibrous Histiocytoma9%
143Basal Cell Nevus Syndrome8.8%
144Hepatocellular Adenoma8.7%
145Digestive System Neoplasms8.5%
146Endocrine Gland Neoplasms8.5%
147Eye Neoplasms8.5%
148Nervous System Neoplasms8.5%
149Lymphomatoid Granulomatosis8.5%
150Phyllodes Tumor8.3%
151Hemangioendothelioma8.3%
152Lipoma8.3%
153Myoma8.3%
154Myxoma8.3%
155Angiolipoma8.3%
156Myelolipoma8.3%
157Neoplasms, Bone Tissue8.3%
158Neoplasms, Fibrous Tissue8.3%
159Smooth Muscle Tumor8.3%
160Desmoplastic Small Round Cell Tumor8.3%
161Chondroma8.3%
162Enchondroma8.3%
163Bone neoplasms8.3%
164Leukoplakia8.3%
165Lymphocele8.3%
166Pancreatic Cyst8.3%
167Skin Neoplasms8.3%
168Hematologic Neoplasms8.3%
169Barrett Esophagus8.1%
170Breast Cyst8.1%
171Actinic keratosis8.1%
172Mediastinal Cyst8.1%
173Neoplasm Invasiveness8.1%
174Neoplasm Metastasis8.1%
175Neoplasm Recurrence, Local8.1%
176Parovarian Cyst8.1%
177Pericardial Cyst8.1%
178Splenic Neoplasms8.1%
179Thymic Cyst8.1%
180Carcinogenesis8.1%
181Myxoid cyst8.1%
182Metastasis8.1%
183Sarcoma 1808%
184neurofibroma7.9%
185Glioma7.9%
186Malignant Glioma7.9%
187Mesoblastic Nephroma7.6%
188Prolactinoma7.6%
189Growth Hormone-Secreting Pituitary Adenoma7.6%
190Rhabdomyosarcoma7.6%
191Giant Cell Tumor of Bone7.6%
192Acoustic Neuroma7.3%
193Neurofibrosarcoma7.2%
194Adenoid Cystic Carcinoma7.1%
195Adenocarcinoma, Clear Cell7.1%
196Cholangiocarcinoma7.1%
197Cervical Intraepithelial Neoplasia7.1%
198Waldenstrom Macroglobulinemia7%
199Multiple Myeloma7%
200Carcinoid Heart Disease7%
201Carcinoma, Pancreatic Ductal7%
202Corpus Luteum Cyst6.8%
203Ovarian Cysts6.8%
204Carcinoma, Ovarian Epithelial6.7%
205Leukemia, Myelomonocytic, Chronic6.7%
206Multiple Endocrine Neoplasia Type 16.7%
207Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative6.7%
208Liver Neoplasms, Experimental6.5%
209Hydatidiform Mole6.3%
210Parathyroid Neoplasms6.1%
211Peritoneal Neoplasms6.1%
212Thyroid Neoplasm6.1%
213Thyroid carcinoma6.1%
214Dermatofibrosarcoma6.1%
215Dermatofibrosarcoma Protuberans6.1%
216Adenomatous Polyposis Coli6.1%
217Choledochal Cyst5.9%
218Peutz-Jeghers Syndrome5.8%
219Vipoma5.7%
220Mastocytosis5.7%
221Sturge-Weber Syndrome5.7%
222Gastrointestinal Stromal Tumors5.6%
223Hemangioma, Cavernous5.6%
224Leukemia, T-Cell5.6%
225Leukemia, B-Cell5.6%
226Lymphoma, Follicular5.5%
227T-Cell Lymphoma5.5%
228Mantle cell lymphoma5.5%
229Pancreatic Neoplasm5.4%
230Nasopharyngeal carcinoma5.3%
231Retroperitoneal Neoplasms5.2%
232granulosa cell tumor5%
233Astrocytoma4.7%
234fibroma4.7%
235Fibromatosis4.7%
236Osteoblastoma4.7%
237Osteoma4.7%
238Rhabdomyoma4.7%
239Chondromatosis4.7%
240Hemangioblastoma4.7%
241Anaplastic astrocytoma4.7%
242Lymphoma, Extranodal NK-T-Cell4.7%
243Alveolar rhabdomyosarcoma4.7%
244Tracheal Neoplasms4.7%
245Leukoplakia, Oral4.6%
246Paraneoplastic Cerebellar Degeneration4.6%
247insulinoma4.6%
248Klatskin Tumor4.5%
249Adrenocortical carcinoma4.4%
250Mouth Neoplasms4.2%
251Central Nervous System Neoplasms4.2%
252Vascular Neoplasms4.2%
253Thymus Neoplasms4.2%
254Genital Neoplasms, Female4.2%
255Pancreatic Pseudocyst4.2%
256Lymphatic Metastasis4.2%
257Neoplasms, Unknown Primary4.2%
258Leukemic Infiltration4.2%
259Breast Neoplasms, Male4.2%
260Neoplasm Micrometastasis4.2%
261Triple Negative Breast Neoplasms4.2%
262Esophageal Neoplasms4.1%
263Limbic Encephalitis4%
264Renal Cell Carcinoma3.9%
265Papillary Renal Cell Carcinoma3.9%
266Denys-Drash Syndrome3.9%
267Mastocytoma3.8%
268Mastocytosis, Systemic3.8%
269Leukemia, Myeloid, Chronic-Phase3.8%
270Xeroderma Pigmentosum3.7%
271Lambert-Eaton Myasthenic Syndrome3.6%
272Testicular Neoplasms3.6%
273Carcinoma, Endometrioid3.6%
274Adrenal Gland Neoplasms3.6%
275Gastrointestinal Neoplasms3.6%
276Genital Neoplasms, Male3.6%
277Liver neoplasms3.6%
278Uveal Neoplasms3.6%
279Urologic Neoplasms3.5%
280Sebaceous Gland Neoplasms3.5%
281Spinal Neoplasms3.5%
282Bone Marrow Neoplasms3.5%
283Polycystic Ovary Syndrome3.5%
284Gastrinoma3.4%
285Glucagonoma3.4%
286Opsoclonus-Myoclonus Syndrome3.3%
287Thyroid Nodule3.2%
288Precursor B-Cell Lymphoblastic Leukemia-Lymphoma3.2%
289Leukemia, Large Granular Lymphocytic3.2%
290Precursor T-Cell Lymphoblastic Leukemia-Lymphoma3.2%
291Lymphoma, T-Cell, Cutaneous3.1%
292Lymphoma, AIDS-Related3.1%
293Enteropathy-Associated T-Cell Lymphoma3.1%
294Primary Effusion Lymphoma3.1%
295Glioblastoma3.1%
296Glioblastoma Multiforme3.1%
297Fibromatosis, Aggressive2.9%
298Fibromatosis, Abdominal2.9%
299Myelitis, Transverse2.9%
300Leydig Cell Tumor2.9%
301ovarian neoplasm2.6%
302Burkitt Lymphoma2.4%
303Nose Neoplasms2.3%
304Meningeal Neoplasms2.2%
305Pituitary Adenoma2.2%
306Pituitary Neoplasms2.2%
307Zollinger-Ellison syndrome2.1%
308Dupuytren Contracture2%
309Urticaria Pigmentosa2%
310Palatal Neoplasms2%
311Mycosis Fungoides2%
312Lymphomatoid Papulosis2%
313Plasmablastic lymphoma2%
314Ear Neoplasms1.9%
315Eyelid Neoplasms1.9%
316Lung Neoplasms1.9%
317Pleural Neoplasms1.9%
318Cell Transformation, Viral1.9%
319Brain Neoplasms1.9%
320Salivary Gland Neoplasms1.9%
321Spinal Cord Neoplasms1.9%
322Tongue Neoplasms1.9%
323Uterine Neoplasms1.9%
324Vaginal Neoplasms1.9%
325Vulvar Neoplasms1.9%
326Uterine Cancer1.9%
327Fallopian Tube Neoplasms1.9%
328Pharyngeal Neoplasms1.7%
329Central Nervous System Cysts1.6%
330Bile Duct Neoplasms1.6%
331gallbladder neoplasm1.6%
332Intestinal Neoplasms1.6%
333Penile Neoplasms1.6%
334Prostatic Neoplasms1.6%
335Stomach Neoplasms1.6%
336Polycythemia Vera1.6%
337Sezary Syndrome1.5%
338Laryngeal neoplasm1.5%
339Bladder Neoplasm1.4%
340Kidney Neoplasm1.4%
341Ureteral Neoplasms1.4%
342Urethral Neoplasms1.4%
343Meningeal Carcinomatosis1.3%
344Bronchial Neoplasms1.1%
345Multiple Pulmonary Nodules1.1%
346Supratentorial Neoplasms1.1%
347Endometrial Neoplasms1.1%
348Hypopharyngeal Neoplasms0.9%
349Pleural Effusion, Malignant0.9%
350Hypopharyngeal Cancer0.9%
351Parotid Neoplasms0.9%
352Prostatic Neoplasms, Castration-Resistant0.9%
353Nelson Syndrome0.9%
354Cecal Neoplasms0.8%
355Duodenal Neoplasms0.8%
356Nasopharyngeal Neoplasms0.7%
357Colorectal Neoplasms0.7%
358Brain Stem Neoplasms0.7%
359Paranasal Sinus Neoplasms0.7%
360Tonsillar Neoplasms0.6%
361Cerebellar Neoplasms0.6%
362Radicular Cyst0.5%
363Appendiceal Neoplasms0.5%
364Colonic Neoplasms0.5%
365Rectal Neoplasms0.5%
366Choroid Plexus Papilloma0.5%
367Maxillary Sinus Neoplasms0.4%
368Anus Neoplasms0.3%
369Sigmoid Neoplasms0.3%
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