MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Exanthema Subitum

(UMLS:C0015231)

Definition:: An acute, short-lived, viral disease of infants and young children characterized by a high fever at onset that drops to normal after 3-4 days and the concomitant appearance of a macular or maculopapular rash that appears first on the trunk and then spreads to other areas. It is the sixth of the classical exanthematous diseases and is caused by HHV-6; (HERPESVIRUS 6, HUMAN). (From Dorland, 27th ed)
UMLS ID:: C0015231
MeSH ID:: D005077

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.256.466.850.290|C02.825.290

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.257.335|C17.800.838.790.290

Synonym(s)

Exanthema Subitum

Exanthem subitum

Exanthema subitum

Exanthema subitum [sixth disease]

Exanthema subitum [sixth disease], unspecified

Pseudorubella

ROSEOLA

ROSEOLA INFANTUM

Roseola

10.

Roseola infantum

11.

Roseola infantum, unspecified

12.

SIXTH DISEASE

13.

Sixth disease

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Ondansetron	FAERS: 3	US FAERS
2	Amoxicillin	FAERS: 1	US FAERS
3	miglustat	FAERS: 1	US FAERS
4	Amiodarone		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Erythema Infectiosum	43.5%
2	Warts	40.5%
3	Molluscum Contagiosum	39.7%
4	Eczema Herpeticum	32.9%
5	Pyoderma Gangrenosum	30%
6	Condylomata Acuminata	29.4%
7	Epidermodysplasia Verruciformis	29.3%
8	Herpes Labialis	28.9%
9	Lupus Erythematosus, Cutaneous	25%
10	Panniculitis	25%
11	Systemic Scleroderma	25%
12	Morphea	25%
13	Xeroderma Pigmentosum	23.5%
14	Acne Vulgaris	23.3%
15	Dermatitis, Atopic	23.3%
16	Contact Dermatitis	23.3%
17	Eczema	23.3%
18	Epidermolysis Bullosa	23.3%
19	Erythema Multiforme	23.3%
20	Intertrigo	23.3%
21	Neurodermatitis	23.3%
22	Rhinophyma	23.3%
23	Perioral Dermatitis	23.3%
24	Acne	23.3%
25	Epstein-Barr Virus Infections	22.5%
26	Breast Diseases	22.3%
27	Dermatitis	22.3%
28	Facial Dermatoses	22.3%
29	Hair Diseases	22.3%
30	Hand Dermatoses	22.3%
31	keratoacanthoma	22.3%
32	Keratosis	22.3%
33	Nail Diseases	22.3%
34	Photosensitivity Disorders	22.3%
35	Prurigo	22.3%
36	Pyoderma	22.3%
37	Rosacea	22.3%
38	Sebaceous Gland Diseases	22.3%
39	Skin Diseases, Vesiculobullous	22.3%
40	Skin Ulcer	22.3%
41	Sweat Gland Diseases	22.3%
42	Skin Diseases, Papulosquamous	22.3%
43	Skin Diseases, Vascular	22.3%
44	Acneiform Eruptions	22.3%
45	Ocular Rosacea	22.3%
46	Subcorneal pustular dermatosis	22.3%
47	Erythematotelangiectatic Rosacea	22.3%
48	Papulopustular Rosacea	22.3%
49	Chronic Actinic Dermatitis	22.3%
50	Dermatitis, Phototoxic	21.1%
51	Pityriasis Lichenoides et Varioliformis Acuta	21.1%
52	Pityriasis Lichenoides	21.1%
53	Phototoxicity	21.1%
54	Dermatitis Herpetiformis	20.2%
55	Acrodermatitis	20%
56	Sebaceous Gland Neoplasms	20%
57	Porokeratosis	20%
58	Gianotti-Crosti Syndrome	20%
59	Keratoderma, Palmoplantar	20%
60	Erythema Induratum	19.9%
61	Foot Ulcer	19.9%
62	Panniculitis, Lupus Erythematosus	19.8%
63	Necrobiosis Lipoidica Diabeticorum	19.5%
64	Foot Diseases	19.2%
65	Skin Abnormalities	18.8%
66	Skin Neoplasms	18.8%
67	Pigmentation Disorders	18.8%
68	Lipomatosis	18.5%
69	Pruritus	18.5%
70	Erythema	18.5%
71	Necrolytic Migratory Erythema	18.5%
72	Cutaneous Fistula	18.5%
73	Nephrogenic Fibrosing Dermopathy	18.5%
74	Nephrogenic Systemic Fibrosis	18.5%
75	Dermatomyositis	18.4%
76	Dermatitis, Photoallergic	18.4%
77	Cytomegalovirus Infections	18%
78	Varicella Zoster Virus Infection	18%
79	Xeroderma	17.6%
80	Pseudorabies	17.2%
81	Urticaria Pigmentosa	16.9%
82	Dermatitis, Irritant	16.5%
83	Acne Conglobata	16.5%
84	Ecthyma	16.1%
85	Pseudoxanthoma Elasticum	16.1%
86	Tinea Capitis	16%
87	Onychomycosis	16%
88	Dermatomycoses	15.9%
89	Skin Diseases, Bacterial	15.9%
90	Mastocytosis	15.8%
91	Ectodermal Dysplasia	15.6%
92	Lupus Erythematosus, Discoid	15.6%
93	Aplasia Cutis Congenita	15.6%
94	Scleroderma, Limited	15.6%
95	Polyomavirus Infections	15.5%
96	Cutis Laxa	15.4%
97	Erythema Nodosum	14.8%
98	Rift Valley Fever	14.8%
99	Toxic Epidermal Necrolysis	14.8%
100	Stevens-Johnson Syndrome	14.8%
101	Arbovirus Infections	14.6%
102	Dermatitis, Occupational	14.6%
103	Dermatitis, Allergic Contact	14.2%
104	Papillon-Lefevre Disease	14.1%
105	Anhidrosis	14%
106	Cholesteatoma	14%
107	Pressure Ulcer	14%
108	Folliculitis	14%
109	Foot Dermatoses	14%
110	Gynecomastia	14%
111	Hypertrichosis	14%
112	Hypohidrosis	14%
113	Hypotrichosis	14%
114	Leg Ulcer	14%
115	Miliaria	14%
116	Parakeratosis	14%
117	Parapsoriasis	14%
118	Pityriasis	14%
119	Psoriasis	14%
120	Sweet Syndrome	14%
121	Hidradenitis	14%
122	Onycholysis	14%
123	Miliaria Rubra	14%
124	Hyperpigmentation	14%
125	Lichenoid Eruptions	14%
126	Chloracne	14%
127	Hidradenitis Suppurativa	13.9%
128	Dengue Fever	13.9%
129	Yellow Fever	13.9%
130	Mycetoma	13.7%
131	Hepatitis B	13.4%
132	Keratitis, Herpetic	13.4%
133	Cytomegalovirus Retinitis	13.4%
134	Herpes Zoster Ophthalmicus	13.4%
135	Connective Tissue Diseases	13.2%
136	Diaper Rash	13.1%
137	Erythema Chronicum Migrans	13.1%
138	Ichthyosis, X-Linked	12.9%
139	Hemorrhagic Fever, Crimean	12.9%
140	Sjogren-Larsson Syndrome	12.8%
141	Leukoencephalopathy, Progressive Multifocal	12.8%
142	Lice Infestations	12.7%
143	Hyperkeratosis, Epidermolytic	12.7%
144	Chickenpox	12.6%
145	Hepatitis E	12.6%
146	Phlebotomus Fever	12.4%
147	Granuloma Annulare	12.3%
148	Subacute Sclerosing Panencephalitis	12.2%
149	Hepatitis, Viral, Human	12.1%
150	Behcet Syndrome	12%
151	Viremia	12%
152	Tinea Pedis	12%
153	Acantholysis	11.8%
154	Breast Cyst	11.8%
155	Actinic keratosis	11.8%
156	Pemphigoid, Benign Mucous Membrane	11.8%
157	Pemphigus	11.8%
158	Piedra	11.8%
159	Sunburn	11.8%
160	Genital Herpes	11.7%
161	Argyria	11.7%
162	Exanthema Subitum	11.7%
163	Hirsutism	11.7%
164	Lactation Disorder	11.7%
165	Mastitis	11.7%
166	Urticaria	11.7%
167	Adiposis Dolorosa	11.6%
168	Pruritus Vulvae	11.6%
169	Mastocytoma	11.6%
170	Pruritus Ani	11.6%
171	Bell Palsy	11.3%
172	Zika Virus Infection	11.2%
173	West Nile Fever	11.2%
174	Larva Migrans	11%
175	Leishmaniasis	11%
176	Onchocerciasis	10.9%
177	Albinism	10.9%
178	Chromoblastomycosis	10.8%
179	Dermatophytosis	10.8%
180	Sporotrichosis	10.8%
181	Tinea	10.8%
182	Tinea Versicolor	10.8%
183	Trichophytosis	10.8%
184	Hyalohyphomycosis	10.8%
185	Acquired Immunodeficiency Syndrome	10.8%
186	AIDS related complex	10.8%
187	Opportunistic Infections	10.7%
188	Murine Acquired Immunodeficiency Syndrome	10.7%
189	Hepatitis C	10.5%
190	Hepatitis, Viral, Animal	10.3%
191	Pneumonia, Viral	10.3%
192	Skin Diseases, Infectious	10.2%
193	Burkitt Lymphoma	10.1%
194	Exanthema	10.1%
195	Mucocutaneous Lymph Node Syndrome	10.1%
196	Drug Eruptions	10%
197	Hemorrhagic Fever, American	10%
198	Lassa Fever	10%
199	Lipodystrophy	10%
200	Smallpox	10%
201	Livedo Reticularis	10%
202	Malignant Atrophic Papulosis	10%
203	Lichen Planus	9.9%
204	Melanosis	9.9%
205	Chloasma	9.9%
206	Pityriasis Rosea	9.9%
207	Pityriasis Rubra Pilaris	9.9%
208	Vitiligo	9.9%
209	Lichen Nitidus	9.9%
210	Polyarteritis Nodosa	9.9%
211	Takayasu Arteritis	9.9%
212	Simian Acquired Immunodeficiency Syndrome	9.6%
213	Hepatitis A	9.5%
214	Candidiasis, Chronic Mucocutaneous	9.5%
215	Cutaneous Candidiasis	9.5%
216	Erysipelas	9.5%
217	Staphylococcal Skin Infections	9.5%
218	Erythrasma	9.4%
219	HIV-Associated Lipodystrophy Syndrome	9.2%
220	Chronic Fatigue Syndrome	9.1%
221	Sexually Transmitted Diseases	9.1%
222	Nail-Patella Syndrome	8.9%
223	Hemorrhagic Fever with Renal Syndrome	8.8%
224	Porphyrias, Hepatic	8.8%
225	Orthomyxoviridae Infections	8.8%
226	Picornaviridae Infections	8.8%
227	Reoviridae Infections	8.8%
228	Retroviridae Infections	8.8%
229	Leishmaniasis, Cutaneous	8.5%
230	Fusariosis	8.4%
231	Alopecia	8.4%
232	Sweating, Gustatory	8.4%
233	Androgenetic Alopecia	8.4%
234	Auriculotemporal Syndrome	8.4%
235	Varicose Ulcer	8.3%
236	Breast Neoplasms, Male	8.3%
237	Triple Negative Breast Neoplasms	8.3%
238	Galactorrhea	8.2%
239	Hepatitis B, Chronic	8.2%
240	Acanthosis Nigricans	7.9%
241	Alopecia Areata	7.9%
242	Lentigo	7.9%
243	Infectious Mononucleosis	7.9%
244	HIV Infections	7.7%
245	Blastomycosis	7.6%
246	Collagen Diseases	7.4%
247	Mixed Connective Tissue Disease	7.4%
248	Mucinoses	7.4%
249	Staphylococcal Scalded Skin Syndrome	7.3%
250	Angioedema	7.1%
251	AIDS-Related Opportunistic Infections	7.1%
252	Acute Generalized Exanthematous Pustulosis	7%
253	Rhinoscleroma	7%
254	Lichen Planus, Oral	6.7%
255	Furunculosis	6.6%
256	furuncle	6.6%
257	Hepatitis C, Chronic	6.6%
258	Herpangina	6.6%
259	CREST Syndrome	6.5%
260	Impetigo	6.5%
261	Cartilage Diseases	6.4%
262	Rheumatism	6.4%
263	Chondromalacia	6.4%
264	Superinfection	6.3%
265	carbuncle	6.3%
266	Herpes Zoster Oticus	6.3%
267	Giant Cell Arteritis	6.3%
268	Temporal Arteritis	6.3%
269	Lupus Erythematosus, Systemic	6.2%
270	Overlap syndrome	6.2%
271	Serum Sickness	6.2%
272	Variegate Porphyria	6.2%
273	Acute intermittent porphyria	6.2%
274	Porphyria Cutanea Tarda	6.2%
275	Carcinoma, Lobular	6.2%
276	Arthritis, Psoriatic	6.1%
277	HIV Seropositivity	6.1%
278	Enterovirus Infections	6%
279	Flavivirus Infections	6%
280	Paramyxoviridae Infections	6%
281	Cardiovirus Infections	6%
282	Rhabdoviridae Infections	6%
283	Herpesviridae Infections	5.4%
284	Dupuytren Contracture	5.2%
285	Foot-and-Mouth Disease	5.2%
286	Common Cold	5.1%
287	Influenza	5.1%
288	Catarrh	5.1%
289	Angioedemas, Hereditary	5%
290	Diabetic Foot	4.9%
291	Hereditary Angioedema Type III	4.9%
292	Hereditary Angioedema Types I and II	4.9%
293	Menkes Kinky Hair Syndrome	4.9%
294	HIV Wasting Syndrome	4.8%
295	AIDS Dementia Complex	4.8%
296	AIDS-Associated Nephropathy	4.8%
297	Scleromyxedema	4.7%
298	Coxsackievirus Infections	4.6%
299	Rubella	4.6%
300	Coronavirus Infections	4.6%
301	Nipah Virus Infection	4.6%
302	Hydrophobia	4.6%
303	Cellulitis	4.6%
304	Peutz-Jeghers Syndrome	4.4%
305	Measles	4%
306	Pleurodynia, Epidemic	4%
307	Respiratory Syncytial Virus Infections	4%
308	Mesenteric Panniculitis	3.9%
309	Panniculitis, Peritoneal	3.9%
310	Tietze's Syndrome	3.9%
311	Orbital Cellulitis	3.9%
312	Myxoid cyst	3.9%
313	Porcine Reproductive and Respiratory Syndrome	3.9%
314	Myxedema	3.9%
315	HTLV-I Infections	3.9%
316	Noonan Syndrome	3.7%
317	Vesicular Stomatitis	3.4%
318	Osteochondritis	3.4%
319	Polymyalgia Rheumatica	3.4%
320	Marfan Syndrome	3.4%
321	Osteogenesis Imperfecta	3.3%
322	Gastroenteritis, Transmissible, of Swine	3.3%
323	Severe Acute Respiratory Syndrome	3.3%
324	Keloid	3.3%
325	Homocystinuria	3.3%
326	Mumps	3.3%
327	Rheumatoid Arthritis	3%
328	Juvenile arthritis	3%
329	Poliomyelitis	2.9%
330	Lupus Nephritis	2.9%
331	Laryngomalacia	2.7%
332	Pectus carinatum	2.6%
333	Rheumatoid Nodule	2.4%
334	Felty Syndrome	2.1%
335	Bronchomalacia	2.1%
336	Tracheomalacia	2.1%
337	Rheumatoid Vasculitis	1.8%
338	Mucopolysaccharidosis III	1.8%
339	Sicca Syndrome	1.7%
340	Sjogren's Syndrome	1.7%
341	Lupus Vasculitis, Central Nervous System	1.5%
342	Mucopolysaccharidosis II	1.3%

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