MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Vitiligo

(UMLS:C0042900)

Definition:: A disorder consisting of areas of macular depigmentation, commonly on extensor aspects of extremities, on the face or neck, and in skin folds. Age of onset is often in young adulthood and the condition tends to progress gradually with lesions enlarging and extending until a quiescent state is reached.
UMLS ID:: C0042900
MeSH ID:: D014820

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.440.895

Synonym(s)

Vitiligo

Blotchy loss of skin color

Hypopigmentation of skin

VITILIGO

vitiligo

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Methylphenidate	FAERS: 26		US FAERS
2	tofacitinib	FAERS: 13		US FAERS
3	Imiquimod	FAERS: 10		US FAERS
4	Imatinib Mesylate	FAERS: 8		US FAERS
5	Omeprazole	FAERS: 7		US FAERS
6	Tacrolimus	FAERS: 7	19547993	CTD US FAERS
7	Alendronate	FAERS: 6		US FAERS
8	Finasteride	FAERS: 6		US FAERS
9	Isotretinoin	FAERS: 6		US FAERS
10	Amoxicillin-Potassium Clavulanate Combination	FAERS: 5		US FAERS
11	Norgestrel	FAERS: 5		US FAERS
12	Omeprazole	FAERS: 5		US FAERS
13	Varenicline	FAERS: 5		US FAERS
14	apremilast	FAERS: 5		US FAERS
15	Bisoprolol	FAERS: 4		US FAERS
16	Dimethyl Fumarate	FAERS: 4		US FAERS
17	Terbinafine	FAERS: 4		US FAERS
18	ledipasvir, sofosbuvir drug combination	FAERS: 4		US FAERS
19	Capecitabine	FAERS: 3		US FAERS
20	Ibuprofen	FAERS: 3		US FAERS
21	Simvastatin	FAERS: 3		US FAERS
22	Sulfasalazine	FAERS: 3		US FAERS
23	Vemurafenib	FAERS: 3		US FAERS
24	pimecrolimus	FAERS: 3	19547993	CTD US FAERS
25	rofecoxib	FAERS: 3		US FAERS
26	Amlodipine	FAERS: 2		US FAERS
27	Atomoxetine Hydrochloride	FAERS: 2		US FAERS
28	Chloramphenicol	FAERS: 2		US FAERS
29	Erlotinib Hydrochloride	FAERS: 2		US FAERS
30	Fingolimod Hydrochloride	FAERS: 2		US FAERS
31	Hydroxyurea	FAERS: 2		US FAERS
32	Imatinib Mesylate	FAERS: 2		US FAERS
33	Levetiracetam	FAERS: 2		US FAERS
34	Mesalamine	FAERS: 2		US FAERS
35	Thyroxine	FAERS: 2		US FAERS
36	Valproic Acid	FAERS: 2		US FAERS
37	montelukast	FAERS: 2		US FAERS
38	palbociclib	FAERS: 2		US FAERS
39	teriflunomide	FAERS: 2		US FAERS
40	AN2728	FAERS: 1		US FAERS
41	Amoxicillin and clavulanic acid	FAERS: 1		US FAERS
42	Azelaic acid	FAERS: 1		SIDER US FAERS
43	Benicar hct	FAERS: 1		US FAERS
44	Betamethasone Valerate	FAERS: 1		US FAERS
45	Cetirizine	FAERS: 1		US FAERS
46	Chloroquine	FAERS: 1		US FAERS
47	Ciprofloxacin	FAERS: 1		US FAERS
48	Clonazepam	FAERS: 1		US FAERS
49	Desoximetasone	FAERS: 1		US FAERS
50	Fentanyl	FAERS: 1		US FAERS
51	Flutamide	FAERS: 1		US FAERS
52	Glyxambi	FAERS: 1		US FAERS
53	Hydrochlorothiazide	FAERS: 1		US FAERS
54	Insulin Detemir	FAERS: 1		US FAERS
55	Latanoprost	FAERS: 1		US FAERS
56	Lenalidomide	FAERS: 1		US FAERS
57	Lovastatin	FAERS: 1		US FAERS
58	Mebendazole	FAERS: 1		US FAERS
59	Metformin	FAERS: 1		US FAERS
60	Methimazole	FAERS: 1		US FAERS
61	Methylphenidate	FAERS: 1		US FAERS
62	Minocycline	FAERS: 1		US FAERS
63	Nevirapine	FAERS: 1		US FAERS
64	Niacin	FAERS: 1		US FAERS
65	NuvaRing	FAERS: 1		US FAERS
66	Ortho Evra	FAERS: 1		US FAERS
67	Oxcarbazepine	FAERS: 1		SIDER US FAERS
68	Prednisone	FAERS: 1		US FAERS
69	Qlaira	FAERS: 1		US FAERS
70	Restasis	FAERS: 1		US FAERS
71	Rivaroxaban	FAERS: 1		US FAERS
72	Rosuvastatin Calcium	FAERS: 1		US FAERS
73	Sertraline	FAERS: 1		US FAERS
74	Thyroxine	FAERS: 1		US FAERS
75	Tretinoin	FAERS: 1	16761959	CTD US FAERS
76	Warfarin	FAERS: 1		US FAERS
77	anagrelide	FAERS: 1		US FAERS
78	betamethasone-17,21-dipropionate	FAERS: 1		US FAERS
79	etonogestrel	FAERS: 1		US FAERS
80	gemcitabine	FAERS: 1		US FAERS
81	haloperidol decanoate	FAERS: 1		US FAERS
82	linaclotide	FAERS: 1		US FAERS
83	pirfenidone	FAERS: 1		US FAERS
84	rotigotine	FAERS: 1		US FAERS
85	sofosbuvir-velpatasvir drug combination	FAERS: 1		US FAERS
86	telmisartan, hydrochlorothiazide drug combination	FAERS: 1		US FAERS
87	Clobetasol		9762827	CTD
88	Methoxsalen		16259964 28552422	CTD
89	Paclitaxel			SIDER
90	Tolcapone		10573327	CTD
91	Trioxsalen		16259964	CTD
92	butylphen		31256213	CTD
93	hydroquinone		31256213	CTD
94	monobenzone		16761959	CTD
95	rhododendrol		31256213	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Hyperpigmentation	34.4%
2	Breast Diseases	25.4%
3	Dermatitis	25.4%
4	Exanthema	25.4%
5	Facial Dermatoses	25.4%
6	Hair Diseases	25.4%
7	Hand Dermatoses	25.4%
8	keratoacanthoma	25.4%
9	Keratosis	25.4%
10	Nail Diseases	25.4%
11	Photosensitivity Disorders	25.4%
12	Prurigo	25.4%
13	Pyoderma	25.4%
14	Rosacea	25.4%
15	Sebaceous Gland Diseases	25.4%
16	Skin Diseases, Vesiculobullous	25.4%
17	Skin Ulcer	25.4%
18	Sweat Gland Diseases	25.4%
19	Skin Diseases, Papulosquamous	25.4%
20	Skin Diseases, Vascular	25.4%
21	Acneiform Eruptions	25.4%
22	Ocular Rosacea	25.4%
23	Subcorneal pustular dermatosis	25.4%
24	Erythematotelangiectatic Rosacea	25.4%
25	Papulopustular Rosacea	25.4%
26	Chronic Actinic Dermatitis	25.4%
27	Argyria	23.1%
28	Lupus Erythematosus, Cutaneous	23%
29	Panniculitis	23%
30	Systemic Scleroderma	23%
31	Morphea	23%
32	Melanosis	22.6%
33	Chloasma	22.6%
34	Pyoderma Gangrenosum	22.3%
35	Urticaria Pigmentosa	21.8%
36	Acne Vulgaris	19.8%
37	Contact Dermatitis	19.8%
38	Eczema	19.8%
39	Erythema Multiforme	19.8%
40	Intertrigo	19.8%
41	Neurodermatitis	19.8%
42	Rhinophyma	19.8%
43	Perioral Dermatitis	19.8%
44	Acne	19.8%
45	Foot Diseases	18.1%
46	Xeroderma Pigmentosum	17.8%
47	Skin Abnormalities	17.2%
48	Skin Diseases, Infectious	17.2%
49	Skin Neoplasms	17.2%
50	Lipomatosis	16.9%
51	Pruritus	16.9%
52	Erythema	16.9%
53	Necrolytic Migratory Erythema	16.9%
54	Cutaneous Fistula	16.9%
55	Nephrogenic Fibrosing Dermopathy	16.9%
56	Nephrogenic Systemic Fibrosis	16.9%
57	Acanthosis Nigricans	16.8%
58	Lentigo	16.8%
59	Connective Tissue Diseases	16.4%
60	Foot Ulcer	16.3%
61	Albinism	16.1%
62	Dermatitis Herpetiformis	15.1%
63	Dermatitis, Atopic	14.9%
64	Epidermolysis Bullosa	14.9%
65	Acrodermatitis	14.9%
66	Sebaceous Gland Neoplasms	14.9%
67	Porokeratosis	14.9%
68	Gianotti-Crosti Syndrome	14.9%
69	Keratoderma, Palmoplantar	14.9%
70	Anhidrosis	14.8%
71	Cholesteatoma	14.8%
72	Pressure Ulcer	14.8%
73	Folliculitis	14.8%
74	Foot Dermatoses	14.8%
75	Gynecomastia	14.8%
76	Hypertrichosis	14.8%
77	Hypohidrosis	14.8%
78	Hypotrichosis	14.8%
79	Leg Ulcer	14.8%
80	Miliaria	14.8%
81	Parakeratosis	14.8%
82	Parapsoriasis	14.8%
83	Pityriasis	14.8%
84	Psoriasis	14.8%
85	Sweet Syndrome	14.8%
86	Hidradenitis	14.8%
87	Onycholysis	14.8%
88	Miliaria Rubra	14.8%
89	Lichenoid Eruptions	14.8%
90	Chloracne	14.8%
91	Dermatitis, Phototoxic	14.5%
92	Pityriasis Lichenoides et Varioliformis Acuta	14.5%
93	Pityriasis Lichenoides	14.5%
94	Phototoxicity	14.5%
95	Dermatomyositis	13.4%
96	Lupus Erythematosus, Discoid	13.2%
97	Scleroderma, Limited	13.2%
98	Necrobiosis Lipoidica Diabeticorum	13.2%
99	Panniculitis, Lupus Erythematosus	13.1%
100	Dermatitis, Irritant	12.9%
101	Acne Conglobata	12.9%
102	Mastocytosis	12.5%
103	Xeroderma	12.1%
104	Cutis Laxa	11.8%
105	Dermatitis, Photoallergic	11.6%
106	Erythema Induratum	10.3%
107	Dermatitis, Occupational	10.3%
108	Acantholysis	10.1%
109	Breast Cyst	10.1%
110	Actinic keratosis	10.1%
111	Pemphigoid, Benign Mucous Membrane	10.1%
112	Pemphigus	10.1%
113	Piedra	10.1%
114	Sunburn	10.1%
115	Erythema Infectiosum	10%
116	Ectodermal Dysplasia	9.9%
117	Aplasia Cutis Congenita	9.9%
118	Exanthema Subitum	9.9%
119	Hirsutism	9.9%
120	Lactation Disorder	9.9%
121	Mastitis	9.9%
122	Urticaria	9.9%
123	Adiposis Dolorosa	9.8%
124	Pruritus Vulvae	9.8%
125	Dermatitis, Allergic Contact	9.8%
126	Erythema Nodosum	9.7%
127	Mastocytoma	9.7%
128	Pruritus Ani	9.7%
129	Lichen Planus	9.7%
130	Papillon-Lefevre Disease	9.7%
131	Pityriasis Rosea	9.7%
132	Pityriasis Rubra Pilaris	9.7%
133	Lichen Nitidus	9.7%
134	Pseudoxanthoma Elasticum	9.6%
135	Diaper Rash	9.6%
136	Granuloma Annulare	9%
137	Tinea Capitis	8.7%
138	Onychomycosis	8.7%
139	Collagen Diseases	8.5%
140	Mixed Connective Tissue Disease	8.5%
141	Mucinoses	8.5%
142	Toxic Epidermal Necrolysis	8.3%
143	Stevens-Johnson Syndrome	8.3%
144	Ecthyma	8.2%
145	Dermatomycoses	7.6%
146	Mucocutaneous Lymph Node Syndrome	7.6%
147	Skin Diseases, Bacterial	7.6%
148	Drug Eruptions	7.4%
149	Lipodystrophy	7.4%
150	Livedo Reticularis	7.4%
151	Malignant Atrophic Papulosis	7.4%
152	Polyarteritis Nodosa	7.3%
153	Takayasu Arteritis	7.3%
154	Alopecia Areata	7.2%
155	Behcet Syndrome	7.1%
156	Hyperkeratosis, Epidermolytic	6.9%
157	Ichthyosis, X-Linked	6.9%
158	Sjogren-Larsson Syndrome	6.8%
159	Alopecia	6.7%
160	Sweating, Gustatory	6.7%
161	Androgenetic Alopecia	6.7%
162	Auriculotemporal Syndrome	6.7%
163	Lice Infestations	6.5%
164	Varicose Ulcer	6.5%
165	Hidradenitis Suppurativa	6.5%
166	Breast Neoplasms, Male	6.5%
167	Triple Negative Breast Neoplasms	6.5%
168	Galactorrhea	6.5%
169	Nail-Patella Syndrome	6.1%
170	Erythema Chronicum Migrans	6.1%
171	Porphyrias, Hepatic	6%
172	Cartilage Diseases	6%
173	Rheumatism	6%
174	Chondromalacia	6%
175	Peutz-Jeghers Syndrome	5.8%
176	Lupus Erythematosus, Systemic	5.7%
177	Overlap syndrome	5.7%
178	Tinea Pedis	5.6%
179	Larva Migrans	5%
180	Leishmaniasis	5%
181	Molluscum Contagiosum	5%
182	Lichen Planus, Oral	5%
183	Angioedema	5%
184	Onchocerciasis	4.9%
185	Scleromyxedema	4.9%
186	Chromoblastomycosis	4.9%
187	Dermatophytosis	4.9%
188	Sporotrichosis	4.9%
189	Tinea	4.9%
190	Tinea Versicolor	4.9%
191	Trichophytosis	4.9%
192	Hyalohyphomycosis	4.9%
193	Mycetoma	4.9%
194	Acute Generalized Exanthematous Pustulosis	4.8%
195	Dupuytren Contracture	4.1%
196	Warts	4.1%
197	Candidiasis, Chronic Mucocutaneous	3.9%
198	Cutaneous Candidiasis	3.9%
199	Erysipelas	3.9%
200	Serum Sickness	3.9%
201	Staphylococcal Skin Infections	3.9%
202	Variegate Porphyria	3.9%
203	Acute intermittent porphyria	3.9%
204	Porphyria Cutanea Tarda	3.9%
205	Erythrasma	3.9%
206	Carcinoma, Lobular	3.9%
207	Arthritis, Psoriatic	3.9%
208	CREST Syndrome	3.7%
209	Giant Cell Arteritis	3.7%
210	Temporal Arteritis	3.7%
211	Leishmaniasis, Cutaneous	3.6%
212	Eczema Herpeticum	3.6%
213	Fusariosis	3.6%
214	Mesenteric Panniculitis	3.4%
215	Panniculitis, Peritoneal	3.4%
216	Tietze's Syndrome	3.4%
217	Orbital Cellulitis	3.4%
218	Myxoid cyst	3.4%
219	Cellulitis	3.3%
220	Myxedema	3.3%
221	Hereditary Angioedema Type III	3%
222	Hereditary Angioedema Types I and II	3%
223	Angioedemas, Hereditary	3%
224	Epidermodysplasia Verruciformis	2.9%
225	Herpes Labialis	2.9%
226	Diabetic Foot	2.9%
227	Staphylococcal Scalded Skin Syndrome	2.9%
228	Blastomycosis	2.8%
229	HIV-Associated Lipodystrophy Syndrome	2.8%
230	Menkes Kinky Hair Syndrome	2.6%
231	Osteochondritis	2.6%
232	Polymyalgia Rheumatica	2.6%
233	Rhinoscleroma	2.5%
234	Osteogenesis Imperfecta	2.5%
235	Condylomata Acuminata	2.5%
236	Furunculosis	2.4%
237	Keloid	2.4%
238	furuncle	2.4%
239	Impetigo	2.4%
240	carbuncle	2.4%
241	Noonan Syndrome	2.4%
242	Marfan Syndrome	2.1%
243	Rheumatoid Arthritis	2%
244	Juvenile arthritis	2%
245	Homocystinuria	2%
246	Lupus Nephritis	1.9%
247	Laryngomalacia	1.7%
248	Pectus carinatum	1.7%
249	Rheumatoid Nodule	1.6%
250	Felty Syndrome	1.3%
251	Bronchomalacia	1.3%
252	Tracheomalacia	1.3%
253	Rheumatoid Vasculitis	1.1%
254	Mucopolysaccharidosis III	1.1%
255	Sicca Syndrome	0.9%
256	Sjogren's Syndrome	0.9%
257	Lupus Vasculitis, Central Nervous System	0.8%
258	Mucopolysaccharidosis II	0.7%

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