MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Pheochromocytoma

(UMLS:C0031511)

Definition:: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
UMLS ID:: C0031511
MeSH ID:: D010673

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.650.700.725|C04.557.580.625.650.700.725

Synonym(s)

Pheochromocytoma

Chromaffin paraganglioma

Chromaffin tumor

Chromaffin tumors

Chromaffin tumour

Chromaffinoma

PHAEOCHROMOCYTOMA

PHEOCHROMOCYTOMA

Phaeochromocytoma NOS

10.

Phaeochromocytoma, NOS

11.

Pheochromocytoma NOS

12.

Pheochromocytoma syndrome

13.

Pheochromocytoma, NOS

Associated Drug(s)

	Name	Reference(s)	Data Source
1	C.I. Acid Red 114	12621513	CTD
2	CVD protocol	8152400 12657240 15032012	CTD
3	Canagliflozin	View details 25130857 25289773 25398756 28916336	CTD
4	Clomipramine	9315999	CTD
5	Deoxyglucose	20026095	CTD
6	Epinephrine	2217678 5919361	CTD
7	Fluoxetine	8094789	CTD
8	Imipramine	759417 8161395	CTD
9	Labetalol	View details 14627 990158 1268685 6151891	CTD
10	Metanephrine	5919361 22569243	CTD
11	N-methylepinephrine	2217678	CTD
12	Nifedipine	8228696	CTD
13	Phenoxybenzamine	9564401 15166586	CTD
14	Prazosin	7114650 8484524 9431876	CTD
15	Reserpine	15837122	CTD
16	Selegiline	8094789	CTD
17	Valproic Acid	1729766	CTD
18	Vanilmandelic Acid	832022 5919361	CTD
19	Vitamin D	10496673	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	melanoma	41.2%
2	Neoplasms, Neuroepithelial	37.6%
3	Gliomatosis cerebri	37.6%
4	Adenoma, Acidophil	37.1%
5	Neurilemmoma	37%
6	Craniopharyngioma	35.9%
7	Neuroectodermal Tumor, Melanotic	35.9%
8	Carcinoid Tumor	35.1%
9	leukemia	27.9%
10	Neoplasms, Glandular and Epithelial	27.9%
11	Hutchinson's Melanotic Freckle	26.3%
12	Melanoma, Amelanotic	26.3%
13	Chordoma	24.1%
14	Teratoma	24.1%
15	Germinoma	24.1%
16	Teratocarcinoma	24.1%
17	Malignant Carcinoid Syndrome	23.3%
18	Melanoma, Experimental	23%
19	Ganglioneuroma	21.9%
20	Glioma	21.9%
21	Malignant Glioma	21.9%
22	Histiocytic Disorders, Malignant	21%
23	Trophoblastic Neoplasms	20.5%
24	Meningioma	20.2%
25	Hamartoma	18.9%
26	Neoplasms, Hormone-Dependent	18.9%
27	Neoplasms, Multiple Primary	18.9%
28	Paraneoplastic Syndromes	18.9%
29	Precancerous Conditions	18.9%
30	Neoplasms, Second Primary	18.9%
31	Medulloblastoma	17.8%
32	Dermoid Cyst	17.1%
33	Carcinosarcoma	16.9%
34	Hemangiosarcoma	16.9%
35	lymphangiosarcoma	16.9%
36	Lymphoma	16.8%
37	Carcinoid Heart Disease	14.8%
38	Composite Lymphoma	14.6%
39	Adenoma	14.4%
40	Ameloblastoma	14.4%
41	Angiokeratoma	14.4%
42	Carcinoma	14.4%
43	Hemangioma	14.4%
44	hemangiopericytoma	14.4%
45	Lymphangioma	14.4%
46	Mesenchymoma	14.4%
47	Nevus	14.4%
48	Hepatoblastoma	14.4%
49	Mixed Tumor, Mullerian	14.4%
50	Angiofibroma	14.4%
51	Sarcoma	14.4%
52	Epithelioma	14.4%
53	Leukemia, Experimental	14.4%
54	Cyst	14.3%
55	Neoplastic Processes	14.3%
56	Neoplastic Syndromes, Hereditary	14.3%
57	Pregnancy Complications, Neoplastic	14.3%
58	Astrocytoma	14.2%
59	Ependymoma	14.2%
60	oligodendroglioma	14.2%
61	Ganglioglioma	14.2%
62	gliosarcoma	14.2%
63	Anaplastic astrocytoma	14.2%
64	Anaplastic Oligodendroglioma	14.2%
65	Neoplasms, Experimental	14%
66	Neoplasms, Germ Cell and Embryonal	13.9%
67	Germ Cell Cancer	13.9%
68	Leukemia, Plasma Cell	13.5%
69	Retinoblastoma	13.4%
70	Carcinoma 256, Walker	13.3%
71	Dysgerminoma	13.2%
72	Neuroma	13.2%
73	Seminoma	13.2%
74	Carcinoma, Ehrlich Tumor	13.1%
75	Carcinoma, Lewis Lung	13.1%
76	Acoustic Neuroma	12.6%
77	Leukemia, Radiation-Induced	12.2%
78	Basal cell carcinoma	12%
79	Carcinoma, Papillary	12%
80	Squamous cell carcinoma	12%
81	Chondrosarcoma	12%
82	Cystadenoma	12%
83	leiomyosarcoma	12%
84	liposarcoma	12%
85	Mesothelioma	12%
86	synovial sarcoma	12%
87	Angiomyolipoma	12%
88	Clear Cell Sarcoma of Soft Tissue	12%
89	Alveolar Soft Part Sarcoma	12%
90	Sarcoma, Myeloid	12%
91	Carcinoma, Basal Cell	12%
92	Choriocarcinoma	11.5%
93	Neoplasms, Radiation-Induced	11.3%
94	Plasmacytoma	10.9%
95	Neuroectodermal Tumors	10.9%
96	Malignant histiocytosis	10.8%
97	Histiocytic sarcoma	10.8%
98	Sarcoma, Experimental	10.4%
99	Glioblastoma	10.4%
100	Neuroblastoma	10.4%
101	Glioblastoma Multiforme	10.4%
102	Multiple Endocrine Neoplasia	10.4%
103	Thymoma	10.4%
104	Leukemia L1210	9.6%
105	Leukemia P388	9.6%
106	Acanthoma	9.6%
107	Endometrial Stromal Sarcoma	9.5%
108	Cystadenocarcinoma	9.5%
109	Fibrosarcoma	9.5%
110	Osteosarcoma	9.5%
111	Mucoepidermoid Carcinoma	9.5%
112	Abdominal Neoplasms	9.3%
113	Erythroplasia	9.3%
114	Follicular cyst	9.3%
115	Head and Neck Neoplasms	9.3%
116	Mucocele	9.3%
117	Pilonidal Cyst	9.3%
118	Soft Tissue Neoplasms	9.3%
119	Thoracic Neoplasms	9.3%
120	Thyroglossal Cyst	9.3%
121	Synovial Cyst	9.3%
122	Aberrant Crypt Foci	9.3%
123	Carcinoma, Lobular	8.8%
124	Paraneoplastic Encephalomyelitis	8.7%
125	Hodgkin Disease	8.7%
126	Lymphoma, Non-Hodgkin	8.7%
127	Mammary Neoplasms, Experimental	8.5%
128	Ganglioneuroblastoma	8.5%
129	Adenofibroma	8.3%
130	Fibroadenoma	8.3%
131	Malignant Fibrous Histiocytoma	8.3%
132	Vipoma	8.1%
133	Lymphangioleiomyomatosis	8%
134	neurofibroma	8%
135	Adenocarcinoma	7.9%
136	Carcinoma in Situ	7.9%
137	Carcinoma, Transitional Cell	7.9%
138	Phyllodes Tumor	7.9%
139	Hemangioendothelioma	7.9%
140	Lipoma	7.9%
141	Myoma	7.9%
142	Myxoma	7.9%
143	Papilloma	7.9%
144	Pseudomyxoma Peritonei	7.9%
145	Papillomatosis	7.9%
146	Angiolipoma	7.9%
147	Myelolipoma	7.9%
148	Neoplasms, Bone Tissue	7.9%
149	Neoplasms, Fibrous Tissue	7.9%
150	Smooth Muscle Tumor	7.9%
151	Adenomatosis, Pulmonary	7.9%
152	Adenomatous Polyps	7.9%
153	Carcinoma, Large Cell	7.9%
154	Carcinoma, Small Cell	7.9%
155	Desmoplastic Small Round Cell Tumor	7.9%
156	Chondroma	7.9%
157	Enchondroma	7.9%
158	Tuberous Sclerosis	7.8%
159	Nephroblastoma	7.6%
160	Digestive System Neoplasms	7.4%
161	Endocrine Gland Neoplasms	7.4%
162	Eye Neoplasms	7.4%
163	Nervous System Neoplasms	7.4%
164	Primary amyloidosis	7.3%
165	Sarcoma 180	7.2%
166	Bowen's Disease	7.1%
167	Rhabdomyosarcoma	7.1%
168	Giant Cell Tumor of Bone	7.1%
169	Bone neoplasms	7.1%
170	Leukoplakia	7.1%
171	Lymphocele	7.1%
172	Pancreatic Cyst	7.1%
173	Skin Neoplasms	7.1%
174	Hematologic Neoplasms	7.1%
175	Barrett Esophagus	7%
176	Breast Cyst	7%
177	Actinic keratosis	7%
178	Mediastinal Cyst	7%
179	Neoplasm Invasiveness	7%
180	Neoplasm Metastasis	7%
181	Neoplasm Recurrence, Local	7%
182	Parovarian Cyst	7%
183	Pericardial Cyst	7%
184	Splenic Neoplasms	7%
185	Thymic Cyst	7%
186	Carcinogenesis	7%
187	Myxoid cyst	7%
188	Metastasis	7%
189	Lymphomatoid Granulomatosis	7%
190	Neurofibrosarcoma	6.8%
191	Optic Nerve Glioma	6.6%
192	Hydatidiform Mole	6.3%
193	Mesoblastic Nephroma	6%
194	Leukemia, Myelomonocytic, Chronic	6%
195	Neuroendocrine Tumors	6%
196	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	6%
197	Dermatofibrosarcoma	5.9%
198	Dermatofibrosarcoma Protuberans	5.9%
199	Basal Cell Nevus Syndrome	5.6%
200	Corpus Luteum Cyst	5.6%
201	Ovarian Cysts	5.6%
202	Waldenstrom Macroglobulinemia	5.5%
203	Multiple Myeloma	5.5%
204	Hepatocellular Adenoma	5.4%
205	Multiple Endocrine Neoplasia Type 1	5.3%
206	Liver Neoplasms, Experimental	5.2%
207	Parathyroid Neoplasms	5%
208	Peritoneal Neoplasms	5%
209	Thyroid Neoplasm	5%
210	Thyroid carcinoma	5%
211	Mastocytosis	4.9%
212	Sturge-Weber Syndrome	4.9%
213	Gastrointestinal Stromal Tumors	4.9%
214	Hemangioma, Cavernous	4.8%
215	Retroperitoneal Neoplasms	4.8%
216	Leukemia, T-Cell	4.8%
217	Leukemia, B-Cell	4.8%
218	Lymphoma, Follicular	4.8%
219	T-Cell Lymphoma	4.8%
220	Mantle cell lymphoma	4.8%
221	Adenoid Cystic Carcinoma	4.7%
222	fibroma	4.7%
223	Fibromatosis	4.7%
224	Osteoblastoma	4.7%
225	Osteoma	4.7%
226	Rhabdomyoma	4.7%
227	Chondromatosis	4.7%
228	Adenocarcinoma, Clear Cell	4.7%
229	Cholangiocarcinoma	4.7%
230	Cervical Intraepithelial Neoplasia	4.7%
231	Hemangioblastoma	4.7%
232	Lymphoma, Extranodal NK-T-Cell	4.7%
233	Choledochal Cyst	4.7%
234	Alveolar rhabdomyosarcoma	4.7%
235	Peutz-Jeghers Syndrome	4.6%
236	Prolactinoma	4.6%
237	Growth Hormone-Secreting Pituitary Adenoma	4.6%
238	Carcinoma, Pancreatic Ductal	4.5%
239	Pancreatic Neoplasm	4.3%
240	Adenomatous Polyposis Coli	4.1%
241	granulosa cell tumor	4%
242	Carcinoma, Ovarian Epithelial	4%
243	Tracheal Neoplasms	3.9%
244	Leukoplakia, Oral	3.8%
245	Paraneoplastic Cerebellar Degeneration	3.8%
246	Mouth Neoplasms	3.7%
247	Central Nervous System Neoplasms	3.7%
248	Vascular Neoplasms	3.7%
249	Thymus Neoplasms	3.7%
250	Genital Neoplasms, Female	3.6%
251	Pancreatic Pseudocyst	3.6%
252	Lymphatic Metastasis	3.6%
253	Neoplasms, Unknown Primary	3.6%
254	Leukemic Infiltration	3.6%
255	Breast Neoplasms, Male	3.6%
256	Neoplasm Micrometastasis	3.6%
257	Triple Negative Breast Neoplasms	3.6%
258	Mastocytoma	3.6%
259	Mastocytosis, Systemic	3.6%
260	Leukemia, Myeloid, Chronic-Phase	3.6%
261	Paraganglioma	3.6%
262	Esophageal Neoplasms	3.3%
263	Limbic Encephalitis	3.2%
264	Fibromatosis, Aggressive	3.1%
265	Fibromatosis, Abdominal	3.1%
266	Klatskin Tumor	3.1%
267	Nasopharyngeal carcinoma	3%
268	Adrenal Gland Neoplasms	3%
269	Gastrointestinal Neoplasms	3%
270	Genital Neoplasms, Male	3%
271	Liver neoplasms	3%
272	Uveal Neoplasms	3%
273	insulinoma	3%
274	Urologic Neoplasms	3%
275	Denys-Drash Syndrome	3%
276	Sebaceous Gland Neoplasms	2.9%
277	Spinal Neoplasms	2.9%
278	Bone Marrow Neoplasms	2.9%
279	Lambert-Eaton Myasthenic Syndrome	2.9%
280	Testicular Neoplasms	2.9%
281	Polycystic Ovary Syndrome	2.9%
282	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	2.8%
283	Leukemia, Large Granular Lymphocytic	2.8%
284	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	2.8%
285	Lymphoma, T-Cell, Cutaneous	2.8%
286	Lymphoma, AIDS-Related	2.8%
287	Enteropathy-Associated T-Cell Lymphoma	2.8%
288	Primary Effusion Lymphoma	2.8%
289	Xeroderma Pigmentosum	2.8%
290	Adrenocortical carcinoma	2.7%
291	Thyroid Nodule	2.7%
292	Opsoclonus-Myoclonus Syndrome	2.6%
293	Leydig Cell Tumor	2.5%
294	Gastrinoma	2.4%
295	Glucagonoma	2.4%
296	Renal Cell Carcinoma	2.4%
297	Papillary Renal Cell Carcinoma	2.4%
298	Pheochromocytoma	2.4%
299	Myelitis, Transverse	2.3%
300	Carcinoma, Endometrioid	2.2%
301	ovarian neoplasm	2.1%
302	Burkitt Lymphoma	2.1%
303	Meningeal Neoplasms	2%
304	Dupuytren Contracture	2%
305	Urticaria Pigmentosa	1.9%
306	Mycosis Fungoides	1.9%
307	Lymphomatoid Papulosis	1.9%
308	Plasmablastic lymphoma	1.9%
309	Nose Neoplasms	1.9%
310	Pituitary Adenoma	1.7%
311	Pituitary Neoplasms	1.7%
312	Ear Neoplasms	1.7%
313	Eyelid Neoplasms	1.7%
314	Lung Neoplasms	1.7%
315	Pleural Neoplasms	1.7%
316	Zollinger-Ellison syndrome	1.6%
317	Cell Transformation, Viral	1.6%
318	Brain Neoplasms	1.6%
319	Salivary Gland Neoplasms	1.6%
320	Spinal Cord Neoplasms	1.6%
321	Tongue Neoplasms	1.6%
322	Palatal Neoplasms	1.6%
323	Uterine Neoplasms	1.6%
324	Vaginal Neoplasms	1.6%
325	Vulvar Neoplasms	1.6%
326	Uterine Cancer	1.6%
327	Fallopian Tube Neoplasms	1.6%
328	Pharyngeal Neoplasms	1.4%
329	Sezary Syndrome	1.4%
330	Central Nervous System Cysts	1.4%
331	Bile Duct Neoplasms	1.4%
332	gallbladder neoplasm	1.4%
333	Intestinal Neoplasms	1.4%
334	Penile Neoplasms	1.4%
335	Prostatic Neoplasms	1.4%
336	Stomach Neoplasms	1.4%
337	Polycythemia Vera	1.3%
338	Laryngeal neoplasm	1.2%
339	Meningeal Carcinomatosis	1.2%
340	Bladder Neoplasm	1.2%
341	Kidney Neoplasm	1.2%
342	Ureteral Neoplasms	1.2%
343	Urethral Neoplasms	1.2%
344	Bronchial Neoplasms	1%
345	Multiple Pulmonary Nodules	1%
346	Supratentorial Neoplasms	1%
347	Endometrial Neoplasms	0.9%
348	Hypopharyngeal Neoplasms	0.8%
349	Pleural Effusion, Malignant	0.8%
350	Hypopharyngeal Cancer	0.8%
351	Parotid Neoplasms	0.8%
352	Prostatic Neoplasms, Castration-Resistant	0.8%
353	Nelson Syndrome	0.8%
354	Cecal Neoplasms	0.7%
355	Duodenal Neoplasms	0.7%
356	Brain Stem Neoplasms	0.6%
357	Nasopharyngeal Neoplasms	0.6%
358	Colorectal Neoplasms	0.6%
359	Paranasal Sinus Neoplasms	0.5%
360	Tonsillar Neoplasms	0.5%
361	Cerebellar Neoplasms	0.5%
362	Choroid Plexus Papilloma	0.5%
363	Radicular Cyst	0.5%
364	Appendiceal Neoplasms	0.5%
365	Colonic Neoplasms	0.5%
366	Rectal Neoplasms	0.5%
367	Maxillary Sinus Neoplasms	0.4%
368	Anus Neoplasms	0.3%
369	Sigmoid Neoplasms	0.3%

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