MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Leishmaniasis, Cutaneous

(UMLS:C0023283)

Definition:: An endemic disease that is characterized by the development of single or multiple localized lesions on exposed areas of skin that typically ulcerate. The disease has been divided into Old and New World forms. Old World leishmaniasis is separated into three distinct types according to epidemiology and clinical manifestations and is caused by species of the L. tropica and L. aethiopica complexes as well as by species of the L. major genus. New World leishmaniasis, also called American leishmaniasis, occurs in South and Central America and is caused by species of the L. mexicana or L. braziliensis complexes.
UMLS ID:: C0023283
MeSH ID:: D016773

Classification 1:

Name:

Parasitic Diseases
MeSH Tree Number(s):: C03.752.300.500.400|C03.858.560.400

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.838.775.560.400

Synonym(s)

Leishmaniasis, Cutaneous

Cutaneous Leishmaniasis

Cutaneous leishmaniasis

Leishmaniasis, cutaneous

cutaneous leishmaniasis

cutaneous; leishmaniasis

leishmaniasis cutaneous

leishmaniasis; cutaneous

leishmaniasis; skin

10.

skin; leishmaniasis

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Allopurinol	9314461 12207774	CTD
2	Antimony	8889330 11475954 19141829	CTD
3	Antimony Sodium Gluconate	View details 1311351 1314873 1322070 1323630 1329273 2160914 2166429 7570843 7682386 7724530 8407083 9234779 9299828 9314461 9499605 9770149 10233236 10542306 10617787 10647737 10786029 10886148 11528583 12032913 14512915 15234329 15259478 15610669 15678803 17278657 19744259 20438389	CTD
4	Erythromycin Ethylsuccinate	View details 1287915 7570843 8889330 10219319	CTD
5	Gentamicins	10219319	CTD
6	Indomethacin	10320625 11703811 12228301	CTD
7	Itraconazole	11528583 14988693	CTD
8	Ketoconazole	View details 1311351 2166429 8838939 8889330 19744259	CTD
9	Meglumine Antimoniate	View details 1322070 2260171 2405727 9579209 10233236 10647737 10940114 10960810 12048519 12207774 15237267 15357081 15678803 15716050 15895170 16425717 16863518 17089782 19082196 19822700 22954418	CTD
10	Meglumine	19248655 19503979	CTD
11	Omeprazole	19248655	CTD
12	Pentamidine	View details 8889330 10617787 11806628 12453009	CTD
13	Pentoxifylline	16863518	CTD
14	Sodium Chloride	9499605	CTD
15	WR279396	10219319 20038619	CTD
16	Zinc Sulfate	15237267	CTD
17	liposomal amphotericin B	14988693 19141829 19952859	CTD
18	miltefosine	18256415 19141829	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Larva Migrans	28.9%
2	Onchocerciasis	26.7%
3	Leishmaniasis, Visceral	26.7%
4	Lice Infestations	24.4%
5	Trypanosomiasis	20.4%
6	Protozoan Infections, Animal	18.1%
7	Giardiasis	17.8%
8	Amebiasis	17.4%
9	Coccidiosis	17.4%
10	Malaria	17.4%
11	Acanthamoeba Infection	17.4%
12	Trichomonas Infections	17.4%
13	Ciliophora Infections	17.4%
14	Balamuthia Infection	17.4%
15	Helminthiasis	16.3%
16	Cryptosporidiosis	16.2%
17	Babesiosis	15.5%
18	African Trypanosomiasis	13.8%
19	Chagas Disease	13.8%
20	Parasitic Diseases, Animal	13.5%
21	Liver Diseases, Parasitic	13.1%
22	Intestinal Diseases, Parasitic	13%
23	Pregnancy Complications, Parasitic	13%
24	Parasitemia	12.8%
25	Helminthiasis, Animal	12.5%
26	Pyoderma Gangrenosum	12.3%
27	Mite Infestations	12.2%
28	Myiasis	12.2%
29	Tick Infestations	12.2%
30	Lupus Erythematosus, Cutaneous	12.1%
31	Panniculitis	12.1%
32	Systemic Scleroderma	12.1%
33	Morphea	12.1%
34	Acanthamoeba Keratitis	11.4%
35	Opportunistic Infections	11.3%
36	Breast Diseases	11.2%
37	Dermatitis	11.2%
38	Exanthema	11.2%
39	Facial Dermatoses	11.2%
40	Hair Diseases	11.2%
41	Hand Dermatoses	11.2%
42	keratoacanthoma	11.2%
43	Keratosis	11.2%
44	Nail Diseases	11.2%
45	Photosensitivity Disorders	11.2%
46	Prurigo	11.2%
47	Pyoderma	11.2%
48	Rosacea	11.2%
49	Sebaceous Gland Diseases	11.2%
50	Skin Diseases, Vesiculobullous	11.2%
51	Skin Ulcer	11.2%
52	Sweat Gland Diseases	11.2%
53	Skin Diseases, Papulosquamous	11.2%
54	Skin Diseases, Vascular	11.2%
55	Acneiform Eruptions	11.2%
56	Ocular Rosacea	11.2%
57	Subcorneal pustular dermatosis	11.2%
58	Erythematotelangiectatic Rosacea	11.2%
59	Papulopustular Rosacea	11.2%
60	Chronic Actinic Dermatitis	11.2%
61	Malaria, Cerebral	10.9%
62	Entamoebiasis	10.6%
63	Malaria, Falciparum	10.6%
64	Malaria, Vivax	10.6%
65	Toxoplasmosis	10.6%
66	Isosporiasis	10.6%
67	Fascioliasis	10%
68	Liver Abscess, Amebic	9.9%
69	Acne Vulgaris	9.8%
70	Contact Dermatitis	9.8%
71	Eczema	9.8%
72	Erythema Multiforme	9.8%
73	Intertrigo	9.8%
74	Neurodermatitis	9.8%
75	Rhinophyma	9.8%
76	Perioral Dermatitis	9.8%
77	Acne	9.8%
78	Dermatomycoses	9.7%
79	Skin Diseases, Bacterial	9.7%
80	Foot Diseases	9.3%
81	Dermatitis, Atopic	9.3%
82	Epidermolysis Bullosa	9.3%
83	Cestode Infections	9.1%
84	Nematode infections	9.1%
85	Trematode Infections	9.1%
86	Skin Abnormalities	9.1%
87	Skin Neoplasms	9.1%
88	Pigmentation Disorders	9.1%
89	Xeroderma Pigmentosum	9.1%
90	Lipomatosis	9%
91	Pruritus	9%
92	Erythema	9%
93	Necrolytic Migratory Erythema	9%
94	Cutaneous Fistula	9%
95	Nephrogenic Fibrosing Dermopathy	9%
96	Nephrogenic Systemic Fibrosis	9%
97	Hypodermyiasis	8.9%
98	Echinococcosis, Hepatic	8.8%
99	Protozoan Infections	8.6%
100	Dermatomyositis	8.5%
101	Erythema Infectiosum	8.5%
102	Exanthema Subitum	8.5%
103	Chagas Cardiomyopathy	8.4%
104	Trichomonas Vaginitis	8.4%
105	Toxocariasis	8.4%
106	Dermatitis Herpetiformis	8.3%
107	Acrodermatitis	8.2%
108	Sebaceous Gland Neoplasms	8.2%
109	Porokeratosis	8.2%
110	Gianotti-Crosti Syndrome	8.2%
111	Keratoderma, Palmoplantar	8.2%
112	Dirofilariasis	8.2%
113	Erythema Induratum	7.9%
114	Foot Ulcer	7.8%
115	Necrobiosis Lipoidica Diabeticorum	7.7%
116	Panniculitis, Lupus Erythematosus	7.5%
117	Mastocytosis	7.4%
118	Strongyle Infections, Equine	7.4%
119	Ecthyma	7.3%
120	Connective Tissue Diseases	7.3%
121	Blackwater Fever	7.3%
122	Dermatitis, Phototoxic	7.3%
123	Pityriasis Lichenoides et Varioliformis Acuta	7.3%
124	Pityriasis Lichenoides	7.3%
125	Phototoxicity	7.3%
126	Xeroderma	7.1%
127	Mycetoma	6.8%
128	Tinea Capitis	6.7%
129	Onychomycosis	6.7%
130	Cutis Laxa	6.6%
131	Lupus Erythematosus, Discoid	6.6%
132	Scleroderma, Limited	6.6%
133	Urticaria Pigmentosa	6.5%
134	Pseudoxanthoma Elasticum	6.5%
135	Dermatitis, Photoallergic	6.2%
136	Ectodermal Dysplasia	6.2%
137	Aplasia Cutis Congenita	6.2%
138	Superinfection	6.2%
139	Anhidrosis	6.1%
140	Cholesteatoma	6.1%
141	Pressure Ulcer	6.1%
142	Folliculitis	6.1%
143	Foot Dermatoses	6.1%
144	Gynecomastia	6.1%
145	Hypertrichosis	6.1%
146	Hypohidrosis	6.1%
147	Hypotrichosis	6.1%
148	Leg Ulcer	6.1%
149	Miliaria	6.1%
150	Parakeratosis	6.1%
151	Parapsoriasis	6.1%
152	Pityriasis	6.1%
153	Psoriasis	6.1%
154	Sweet Syndrome	6.1%
155	Hidradenitis	6.1%
156	Onycholysis	6.1%
157	Miliaria Rubra	6.1%
158	Hyperpigmentation	6.1%
159	Lichenoid Eruptions	6.1%
160	Chloracne	6.1%
161	Hidradenitis Suppurativa	6.1%
162	Neurocysticercosis	5.9%
163	Erythema Chronicum Migrans	5.8%
164	Dermatitis, Irritant	5.8%
165	Acne Conglobata	5.8%
166	Molluscum Contagiosum	5.8%
167	Diphyllobothriasis	5.7%
168	Echinococcosis	5.7%
169	Hymenolepiasis	5.7%
170	Opisthorchiasis	5.7%
171	Schistosomiasis	5.7%
172	Secernentea Infections	5.7%
173	Chromoblastomycosis	5.7%
174	Dermatophytosis	5.7%
175	Sporotrichosis	5.7%
176	Tinea	5.7%
177	Tinea Versicolor	5.7%
178	Trichophytosis	5.7%
179	Hyalohyphomycosis	5.7%
180	Erythema Nodosum	5.6%
181	Toxoplasmosis, Cerebral	5.2%
182	Dermatitis, Occupational	5%
183	Warts	5%
184	Acantholysis	5%
185	Breast Cyst	5%
186	Actinic keratosis	5%
187	Pemphigoid, Benign Mucous Membrane	5%
188	Pemphigus	5%
189	Piedra	5%
190	Sunburn	5%
191	Leishmaniasis	5%
192	Argyria	4.9%
193	Hirsutism	4.9%
194	Lactation Disorder	4.9%
195	Mastitis	4.9%
196	Toxoplasmosis, Congenital	4.9%
197	Urticaria	4.9%
198	Granuloma Annulare	4.9%
199	Candidiasis, Chronic Mucocutaneous	4.9%
200	Cutaneous Candidiasis	4.9%
201	Adiposis Dolorosa	4.9%
202	Pruritus Vulvae	4.9%
203	Dermatitis, Allergic Contact	4.9%
204	Erysipelas	4.9%
205	Staphylococcal Skin Infections	4.9%
206	Mastocytoma	4.9%
207	Pruritus Ani	4.9%
208	Toxic Epidermal Necrolysis	4.9%
209	Stevens-Johnson Syndrome	4.9%
210	Erythrasma	4.9%
211	Papillon-Lefevre Disease	4.9%
212	Tinea Pedis	4.6%
213	AIDS-Related Opportunistic Infections	4.6%
214	Ichthyosis, X-Linked	4.5%
215	Sjogren-Larsson Syndrome	4.5%
216	Behcet Syndrome	4.4%
217	Mucocutaneous Lymph Node Syndrome	4.2%
218	Drug Eruptions	4.1%
219	Lipodystrophy	4.1%
220	Livedo Reticularis	4.1%
221	Malignant Atrophic Papulosis	4.1%
222	Polyarteritis Nodosa	4.1%
223	Takayasu Arteritis	4.1%
224	Cysticercosis	4%
225	Schistosomiasis japonica	4%
226	Schistosomiasis mansoni	4%
227	Sparganosis	4%
228	Ascaridida Infections	4%
229	Oxyurida Infections	4%
230	Albinism	4%
231	Diaper Rash	3.9%
232	Blastomycosis	3.8%
233	Eczema Herpeticum	3.8%
234	Fusariosis	3.8%
235	Hyperkeratosis, Epidermolytic	3.7%
236	Collagen Diseases	3.7%
237	Mixed Connective Tissue Disease	3.7%
238	Mucinoses	3.7%
239	Lichen Planus	3.6%
240	Melanosis	3.6%
241	Chloasma	3.6%
242	Pityriasis Rosea	3.6%
243	Pityriasis Rubra Pilaris	3.6%
244	Vitiligo	3.6%
245	Lichen Nitidus	3.6%
246	Nail-Patella Syndrome	3.6%
247	Porphyrias, Hepatic	3.6%
248	Rhinoscleroma	3.5%
249	Epidermodysplasia Verruciformis	3.3%
250	Herpes Labialis	3.3%
251	Leishmaniasis, Cutaneous	3.2%
252	Ascariasis	3.2%
253	Filariasis	3.2%
254	Gnathostomiasis	3.2%
255	Hookworm Infections	3.2%
256	Oxyuriasis	3.2%
257	Strongyloidiasis	3.2%
258	Trichinellosis	3.2%
259	Trichostrongyloidiasis	3.2%
260	Staphylococcal Scalded Skin Syndrome	3.2%
261	Cartilage Diseases	3.1%
262	Rheumatism	3.1%
263	Chondromalacia	3.1%
264	Lupus Erythematosus, Systemic	3%
265	Overlap syndrome	3%
266	Alopecia	3%
267	Sweating, Gustatory	3%
268	Androgenetic Alopecia	3%
269	Auriculotemporal Syndrome	3%
270	Varicose Ulcer	2.9%
271	Breast Neoplasms, Male	2.9%
272	Triple Negative Breast Neoplasms	2.9%
273	Galactorrhea	2.9%
274	Condylomata Acuminata	2.9%
275	Furunculosis	2.8%
276	furuncle	2.8%
277	Loiasis	2.8%
278	Enterobiasis	2.8%
279	Impetigo	2.8%
280	Dupuytren Contracture	2.5%
281	Angioedema	2.5%
282	Giant Cell Arteritis	2.4%
283	Temporal Arteritis	2.4%
284	Acute Generalized Exanthematous Pustulosis	2.4%
285	Acanthosis Nigricans	2.4%
286	Alopecia Areata	2.4%
287	Lentigo	2.4%
288	carbuncle	2.4%
289	CREST Syndrome	2.2%
290	Cellulitis	2.1%
291	Serum Sickness	2.1%
292	Variegate Porphyria	2.1%
293	Acute intermittent porphyria	2.1%
294	Porphyria Cutanea Tarda	2.1%
295	Carcinoma, Lobular	2.1%
296	Arthritis, Psoriatic	2.1%
297	Scleromyxedema	2%
298	Lichen Planus, Oral	2%
299	Menkes Kinky Hair Syndrome	1.9%
300	Mesenteric Panniculitis	1.7%
301	Panniculitis, Peritoneal	1.7%
302	Tietze's Syndrome	1.7%
303	Orbital Cellulitis	1.7%
304	Myxoid cyst	1.7%
305	Noonan Syndrome	1.7%
306	Myxedema	1.6%
307	HIV-Associated Lipodystrophy Syndrome	1.6%
308	Marfan Syndrome	1.5%
309	Homocystinuria	1.5%
310	Angioedemas, Hereditary	1.4%
311	Osteochondritis	1.4%
312	Polymyalgia Rheumatica	1.4%
313	Diabetic Foot	1.4%
314	Osteogenesis Imperfecta	1.4%
315	Keloid	1.4%
316	Hereditary Angioedema Type III	1.2%
317	Hereditary Angioedema Types I and II	1.2%
318	Rheumatoid Arthritis	1.2%
319	Juvenile arthritis	1.2%
320	Lupus Nephritis	1.2%
321	Laryngomalacia	1.1%
322	Peutz-Jeghers Syndrome	1.1%
323	Pectus carinatum	1%
324	Rheumatoid Nodule	0.8%
325	Felty Syndrome	0.7%
326	Bronchomalacia	0.7%
327	Tracheomalacia	0.7%
328	Rheumatoid Vasculitis	0.6%
329	Mucopolysaccharidosis III	0.6%
330	Lupus Vasculitis, Central Nervous System	0.6%
331	Sicca Syndrome	0.5%
332	Sjogren's Syndrome	0.5%
333	Mucopolysaccharidosis II	0.4%

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