MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Giant Cell Tumor of Bone

(UMLS:C0206638)

Definition:: A bone tumor composed of cellular spindle-cell stroma containing scattered multinucleated giant cells resembling osteoclasts. The tumors range from benign to frankly malignant lesions. The tumor occurs most frequently in an end of a long tubular bone in young adults. (From Dorland, 27th ed; Stedman, 25th ed)
UMLS ID:: C0206638
MeSH ID:: D018212

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.450.565.380.380|C04.557.450.565.575.420

Synonym(s)

Giant Cell Tumor of Bone

Benign Bone Giant Cell Tumor

Bone giant cell tumour

Bone giant cell tumour benign

GIANT CELL TUMOR OF BONE

GIANT CELL TUMOR, BENIGN

GTCT - Giant cell tumor of bone

Giant Cell Tumor of the Bone

Giant cell tumor of bone

10.

Giant cell tumor of bone NOS

11.

Giant cell tumor of bone, NOS

12.

Giant cell tumour of bone

13.

Giant cell tumour of bone NOS

14.

Giant cell tumour of bone, NOS

15.

OSTEOCLASTOMA

16.

Osteoclastoma

17.

Osteoclastoma, Benign

18.

Osteoclastoma, NOS

Associated Drug(s)

	Name	Reference(s)	Data Source
1	Alendronate	15037971	CTD
2	Pamidronate	15037971 15346059	CTD
3	Zoledronic Acid	15037971 15346059	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Osteosarcoma	53.4%
2	Chondrosarcoma	52.8%
3	synovial sarcoma	52.8%
4	Clear Cell Sarcoma of Soft Tissue	52.8%
5	Osteoblastoma	48.7%
6	Osteoma	48.7%
7	Myxoma	47.9%
8	Neoplasms, Fibrous Tissue	47.9%
9	Chondroma	47.9%
10	Enchondroma	47.9%
11	Fibrosarcoma	40.6%
12	Sarcoma	37.6%
13	Malignant Fibrous Histiocytoma	34.6%
14	leiomyosarcoma	33.6%
15	liposarcoma	33.6%
16	Angiomyolipoma	33.6%
17	Alveolar Soft Part Sarcoma	33.6%
18	fibroma	31.7%
19	Fibromatosis	31.7%
20	Chondromatosis	31.7%
21	leukemia	29.7%
22	Neoplasms, Germ Cell and Embryonal	29.7%
23	Neoplasms, Glandular and Epithelial	29.7%
24	Germ Cell Cancer	29.7%
25	Mastocytosis	29.6%
26	Gastrointestinal Stromal Tumors	29.2%
27	Carcinosarcoma	29%
28	Hemangiosarcoma	29%
29	lymphangiosarcoma	29%
30	Dermatofibrosarcoma	28.9%
31	Dermatofibrosarcoma Protuberans	28.9%
32	Adenofibroma	25%
33	Fibroadenoma	25%
34	Neuroectodermal Tumors	24.4%
35	Mastocytoma	24.1%
36	Sarcoma, Myeloid	24%
37	Neoplasms, Bone Tissue	23.9%
38	Mastocytosis, Systemic	23.9%
39	Giant Cell Tumor of Bone	23.8%
40	Fibromatosis, Aggressive	23.7%
41	Fibromatosis, Abdominal	23.7%
42	Phyllodes Tumor	22.3%
43	Lipoma	22.3%
44	Myoma	22.3%
45	Angiolipoma	22.3%
46	Myelolipoma	22.3%
47	Smooth Muscle Tumor	22.3%
48	Desmoplastic Small Round Cell Tumor	22.3%
49	Histiocytic Disorders, Malignant	22.3%
50	Rhabdomyosarcoma	22.2%
51	Neoplasms, Neuroepithelial	21.3%
52	Gliomatosis cerebri	21.3%
53	Carcinoma 256, Walker	20.8%
54	Sarcoma, Experimental	19.6%
55	Hamartoma	19.5%
56	Neoplasms, Hormone-Dependent	19.5%
57	Neoplasms, Multiple Primary	19.5%
58	Paraneoplastic Syndromes	19.5%
59	Precancerous Conditions	19.5%
60	Neoplasms, Second Primary	19.5%
61	Neurofibrosarcoma	19.2%
62	Lymphoma	17.9%
63	melanoma	17.3%
64	Meningioma	17.3%
65	Alveolar rhabdomyosarcoma	16.6%
66	Composite Lymphoma	16.2%
67	Adenoma	16.1%
68	Ameloblastoma	16.1%
69	Angiokeratoma	16.1%
70	Carcinoma	16.1%
71	Chordoma	16.1%
72	Hemangioma	16.1%
73	hemangiopericytoma	16.1%
74	Lymphangioma	16.1%
75	Mesenchymoma	16.1%
76	Nevus	16.1%
77	Teratoma	16.1%
78	Hepatoblastoma	16.1%
79	Mixed Tumor, Mullerian	16.1%
80	Germinoma	16.1%
81	Teratocarcinoma	16.1%
82	Angiofibroma	16.1%
83	Epithelioma	16.1%
84	Lymphangioleiomyomatosis	16%
85	Trophoblastic Neoplasms	15.9%
86	Leukemia, Experimental	15.8%
87	Leukemia, Plasma Cell	15.5%
88	Endometrial Stromal Sarcoma	15.4%
89	Sarcoma 180	15.3%
90	Rhabdomyoma	14.8%
91	Cyst	14.8%
92	Neoplastic Processes	14.8%
93	Neoplastic Syndromes, Hereditary	14.8%
94	Pregnancy Complications, Neoplastic	14.8%
95	Carcinoma, Ehrlich Tumor	14.8%
96	Dermoid Cyst	14.8%
97	Carcinoma, Lewis Lung	14.8%
98	Dupuytren Contracture	14.7%
99	Neoplasms, Experimental	14.5%
100	Urticaria Pigmentosa	14.4%
101	Basal cell carcinoma	14.4%
102	Carcinoma, Papillary	14.4%
103	Squamous cell carcinoma	14.4%
104	Craniopharyngioma	14.4%
105	Cystadenoma	14.4%
106	Mesothelioma	14.4%
107	Neuroectodermal Tumor, Melanotic	14.4%
108	Neuroendocrine Tumors	14.4%
109	Carcinoma, Basal Cell	14.4%
110	Adenoma, Acidophil	13.4%
111	Ganglioneuroma	13.4%
112	Glioma	13.4%
113	Malignant Glioma	13.4%
114	Leukemia, Radiation-Induced	13.3%
115	Melanoma, Experimental	12.5%
116	Plasmacytoma	12.2%
117	Malignant histiocytosis	12.1%
118	Histiocytic sarcoma	12.1%
119	Cystadenocarcinoma	12%
120	Mucoepidermoid Carcinoma	12%
121	Medulloblastoma	11.9%
122	Thymoma	11.7%
123	Neoplasms, Radiation-Induced	11.6%
124	Carcinoid Tumor	11.4%
125	Neurilemmoma	11.4%
126	Hutchinson's Melanotic Freckle	11.4%
127	Melanoma, Amelanotic	11.4%
128	Leukemia L1210	11.3%
129	Leukemia P388	11.3%
130	Acanthoma	11.3%
131	Multiple Endocrine Neoplasia	11.1%
132	Choriocarcinoma	10.7%
133	Carcinoma, Lobular	10.7%
134	Abdominal Neoplasms	9.9%
135	Erythroplasia	9.9%
136	Follicular cyst	9.9%
137	Head and Neck Neoplasms	9.9%
138	Mucocele	9.9%
139	Pilonidal Cyst	9.9%
140	Soft Tissue Neoplasms	9.9%
141	Thoracic Neoplasms	9.9%
142	Thyroglossal Cyst	9.9%
143	Synovial Cyst	9.9%
144	Aberrant Crypt Foci	9.9%
145	Hodgkin Disease	9.7%
146	Lymphoma, Non-Hodgkin	9.7%
147	Adenocarcinoma	9.6%
148	Carcinoma in Situ	9.6%
149	Carcinoma, Transitional Cell	9.6%
150	Dysgerminoma	9.6%
151	Hemangioendothelioma	9.6%
152	Neuroma	9.6%
153	Papilloma	9.6%
154	Pseudomyxoma Peritonei	9.6%
155	Seminoma	9.6%
156	Papillomatosis	9.6%
157	Adenomatosis, Pulmonary	9.6%
158	Adenomatous Polyps	9.6%
159	Carcinoma, Large Cell	9.6%
160	Carcinoma, Small Cell	9.6%
161	Bowen's Disease	9.5%
162	Paraganglioma	9.5%
163	Astrocytoma	9.5%
164	Ependymoma	9.5%
165	oligodendroglioma	9.5%
166	Ganglioglioma	9.5%
167	gliosarcoma	9.5%
168	Anaplastic astrocytoma	9.5%
169	Anaplastic Oligodendroglioma	9.5%
170	Paraneoplastic Encephalomyelitis	9.4%
171	Mammary Neoplasms, Experimental	9.2%
172	Retinoblastoma	8.7%
173	Malignant Carcinoid Syndrome	8.5%
174	Nephroblastoma	8.5%
175	Tuberous Sclerosis	8.2%
176	Primary amyloidosis	8.2%
177	Lymphomatoid Granulomatosis	8.1%
178	Digestive System Neoplasms	7.8%
179	Endocrine Gland Neoplasms	7.8%
180	Eye Neoplasms	7.8%
181	Nervous System Neoplasms	7.8%
182	Glioblastoma	7.6%
183	Neuroblastoma	7.6%
184	Glioblastoma Multiforme	7.6%
185	Bone neoplasms	7.6%
186	Leukoplakia	7.6%
187	Lymphocele	7.6%
188	Pancreatic Cyst	7.6%
189	Skin Neoplasms	7.6%
190	Hematologic Neoplasms	7.6%
191	Barrett Esophagus	7.4%
192	Breast Cyst	7.4%
193	Actinic keratosis	7.4%
194	Mediastinal Cyst	7.4%
195	Neoplasm Invasiveness	7.4%
196	Neoplasm Metastasis	7.4%
197	Neoplasm Recurrence, Local	7.4%
198	Parovarian Cyst	7.4%
199	Pericardial Cyst	7.4%
200	Splenic Neoplasms	7.4%
201	Thymic Cyst	7.4%
202	Carcinogenesis	7.4%
203	Myxoid cyst	7.4%
204	Metastasis	7.4%
205	Leukemia, Myelomonocytic, Chronic	7.2%
206	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	7.2%
207	Pheochromocytoma	7.1%
208	Basal Cell Nevus Syndrome	6.8%
209	Mesoblastic Nephroma	6.8%
210	Ganglioneuroblastoma	6.6%
211	Hepatocellular Adenoma	6.5%
212	Adenoid Cystic Carcinoma	6.3%
213	Adenocarcinoma, Clear Cell	6.3%
214	Cholangiocarcinoma	6.3%
215	Cervical Intraepithelial Neoplasia	6.3%
216	Hemangioblastoma	6.3%
217	Lymphoma, Extranodal NK-T-Cell	6.3%
218	Waldenstrom Macroglobulinemia	6.1%
219	Multiple Myeloma	6.1%
220	Multiple Endocrine Neoplasia Type 1	6%
221	Carcinoid Heart Disease	6%
222	Carcinoma, Pancreatic Ductal	5.9%
223	Sturge-Weber Syndrome	5.9%
224	Corpus Luteum Cyst	5.9%
225	Ovarian Cysts	5.9%
226	Hemangioma, Cavernous	5.8%
227	Leukemia, T-Cell	5.8%
228	Leukemia, B-Cell	5.8%
229	neurofibroma	5.8%
230	Hydatidiform Mole	5.7%
231	Lymphoma, Follicular	5.7%
232	T-Cell Lymphoma	5.7%
233	Mantle cell lymphoma	5.7%
234	Liver Neoplasms, Experimental	5.6%
235	Parathyroid Neoplasms	5.6%
236	Peritoneal Neoplasms	5.6%
237	Thyroid Neoplasm	5.6%
238	Thyroid carcinoma	5.6%
239	Prolactinoma	5.5%
240	Growth Hormone-Secreting Pituitary Adenoma	5.5%
241	Acoustic Neuroma	5.4%
242	Retroperitoneal Neoplasms	5.4%
243	Choledochal Cyst	5%
244	Optic Nerve Glioma	4.9%
245	Peutz-Jeghers Syndrome	4.9%
246	Adenomatous Polyposis Coli	4.8%
247	Pancreatic Neoplasm	4.8%
248	granulosa cell tumor	4.8%
249	Carcinoma, Ovarian Epithelial	4.8%
250	Leukemia, Myeloid, Chronic-Phase	4.8%
251	Klatskin Tumor	4.7%
252	Vipoma	4.6%
253	Tracheal Neoplasms	4.4%
254	Leukoplakia, Oral	4.3%
255	Paraneoplastic Cerebellar Degeneration	4.3%
256	Mouth Neoplasms	4.1%
257	Central Nervous System Neoplasms	4.1%
258	Vascular Neoplasms	4.1%
259	Thymus Neoplasms	4.1%
260	Genital Neoplasms, Female	4.1%
261	Pancreatic Pseudocyst	4.1%
262	Lymphatic Metastasis	4%
263	Neoplasms, Unknown Primary	4%
264	Leukemic Infiltration	4%
265	Breast Neoplasms, Male	4%
266	Neoplasm Micrometastasis	4%
267	Triple Negative Breast Neoplasms	4%
268	insulinoma	4%
269	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
270	Leukemia, Large Granular Lymphocytic	3.8%
271	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	3.8%
272	Lymphoma, T-Cell, Cutaneous	3.8%
273	Lymphoma, AIDS-Related	3.8%
274	Enteropathy-Associated T-Cell Lymphoma	3.8%
275	Primary Effusion Lymphoma	3.8%
276	Nasopharyngeal carcinoma	3.7%
277	Esophageal Neoplasms	3.7%
278	Limbic Encephalitis	3.7%
279	Adrenocortical carcinoma	3.7%
280	Denys-Drash Syndrome	3.5%
281	Gastrinoma	3.4%
282	Glucagonoma	3.4%
283	Adrenal Gland Neoplasms	3.4%
284	Gastrointestinal Neoplasms	3.4%
285	Genital Neoplasms, Male	3.4%
286	Liver neoplasms	3.4%
287	Uveal Neoplasms	3.4%
288	Leydig Cell Tumor	3.4%
289	Urologic Neoplasms	3.3%
290	Lambert-Eaton Myasthenic Syndrome	3.3%
291	Testicular Neoplasms	3.3%
292	Sebaceous Gland Neoplasms	3.3%
293	Spinal Neoplasms	3.3%
294	Bone Marrow Neoplasms	3.3%
295	Thyroid Nodule	3.2%
296	Polycystic Ovary Syndrome	3.2%
297	Renal Cell Carcinoma	3.2%
298	Papillary Renal Cell Carcinoma	3.2%
299	Xeroderma Pigmentosum	3%
300	Carcinoma, Endometrioid	3%
301	Opsoclonus-Myoclonus Syndrome	2.9%
302	Mycosis Fungoides	2.8%
303	Lymphomatoid Papulosis	2.8%
304	Plasmablastic lymphoma	2.8%
305	Burkitt Lymphoma	2.7%
306	Myelitis, Transverse	2.6%
307	Meningeal Neoplasms	2.4%
308	ovarian neoplasm	2.3%
309	Nose Neoplasms	2.2%
310	Sezary Syndrome	2.1%
311	Pituitary Adenoma	2%
312	Pituitary Neoplasms	2%
313	Palatal Neoplasms	2%
314	Ear Neoplasms	2%
315	Eyelid Neoplasms	2%
316	Lung Neoplasms	2%
317	Pleural Neoplasms	2%
318	Cell Transformation, Viral	2%
319	Brain Neoplasms	1.9%
320	Salivary Gland Neoplasms	1.9%
321	Spinal Cord Neoplasms	1.9%
322	Tongue Neoplasms	1.9%
323	Uterine Neoplasms	1.9%
324	Vaginal Neoplasms	1.9%
325	Vulvar Neoplasms	1.9%
326	Uterine Cancer	1.9%
327	Fallopian Tube Neoplasms	1.9%
328	Zollinger-Ellison syndrome	1.8%
329	Pharyngeal Neoplasms	1.7%
330	Central Nervous System Cysts	1.6%
331	Bile Duct Neoplasms	1.6%
332	gallbladder neoplasm	1.6%
333	Intestinal Neoplasms	1.6%
334	Penile Neoplasms	1.6%
335	Prostatic Neoplasms	1.6%
336	Stomach Neoplasms	1.6%
337	Polycythemia Vera	1.6%
338	Meningeal Carcinomatosis	1.6%
339	Laryngeal neoplasm	1.5%
340	Bladder Neoplasm	1.4%
341	Kidney Neoplasm	1.4%
342	Ureteral Neoplasms	1.4%
343	Urethral Neoplasms	1.4%
344	Bronchial Neoplasms	1.3%
345	Multiple Pulmonary Nodules	1.3%
346	Supratentorial Neoplasms	1.3%
347	Endometrial Neoplasms	1.3%
348	Hypopharyngeal Neoplasms	1.1%
349	Pleural Effusion, Malignant	1.1%
350	Hypopharyngeal Cancer	1.1%
351	Parotid Neoplasms	1.1%
352	Prostatic Neoplasms, Castration-Resistant	1.1%
353	Nelson Syndrome	1.1%
354	Brain Stem Neoplasms	1%
355	Cecal Neoplasms	0.9%
356	Duodenal Neoplasms	0.9%
357	Nasopharyngeal Neoplasms	0.8%
358	Colorectal Neoplasms	0.8%
359	Tonsillar Neoplasms	0.8%
360	Cerebellar Neoplasms	0.8%
361	Choroid Plexus Papilloma	0.8%
362	Paranasal Sinus Neoplasms	0.7%
363	Radicular Cyst	0.7%
364	Appendiceal Neoplasms	0.7%
365	Colonic Neoplasms	0.7%
366	Rectal Neoplasms	0.7%
367	Maxillary Sinus Neoplasms	0.5%
368	Anus Neoplasms	0.5%
369	Sigmoid Neoplasms	0.5%

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