MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Argyria

(UMLS:C0003782)

Definition:: A permanent ashen-gray discoloration of the skin, conjunctiva, and internal organs resulting from long-continued use of silver salts. (Dorland, 27th ed)
UMLS ID:: C0003782
MeSH ID:: D001129

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.166

Classification 2:

Name:

Chemically-Induced Disorders
MeSH Tree Number(s):: C25.723.522.313

Synonym(s)

Argyria

ARGYRIA

Argyrosis

Deposition of silver

Silver poisoning

Silver poisoning syndrome

argyria

argyrosis

poisoning by silver

10.

silver poisoning

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Dimethyl Fumarate	FAERS: 1		US FAERS
2	Sulfadiazine	FAERS: 1		US FAERS
3	Agarol	Canada Vigilance: 1		Canada Vigilance
4	Dermazin		1352005	CTD
5	Silver		16531870 27624343	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Cadmium poisoning	31.1%
2	Lead Poisoning	31.1%
3	Mercury Poisoning	31.1%
4	Hyperpigmentation	31.1%
5	Urticaria Pigmentosa	24.2%
6	Pyoderma Gangrenosum	24%
7	Manganese Poisoning	23.3%
8	Melanosis	23.1%
9	Chloasma	23.1%
10	Vitiligo	23.1%
11	Xeroderma Pigmentosum	21.5%
12	Lupus Erythematosus, Cutaneous	20.7%
13	Panniculitis	20.7%
14	Systemic Scleroderma	20.7%
15	Morphea	20.7%
16	Breast Diseases	20.5%
17	Dermatitis	20.5%
18	Exanthema	20.5%
19	Facial Dermatoses	20.5%
20	Fluoride Poisoning	20.5%
21	Food Poisoning	20.5%
22	Gas Poisoning	20.5%
23	Hair Diseases	20.5%
24	Hand Dermatoses	20.5%
25	keratoacanthoma	20.5%
26	Keratosis	20.5%
27	Mycotoxicosis	20.5%
28	Nail Diseases	20.5%
29	Photosensitivity Disorders	20.5%
30	Plant Poisoning	20.5%
31	Prurigo	20.5%
32	Pyoderma	20.5%
33	Rosacea	20.5%
34	Sebaceous Gland Diseases	20.5%
35	Skin Diseases, Vesiculobullous	20.5%
36	Skin Ulcer	20.5%
37	Sweat Gland Diseases	20.5%
38	Skin Diseases, Papulosquamous	20.5%
39	Skin Diseases, Vascular	20.5%
40	Acneiform Eruptions	20.5%
41	Ocular Rosacea	20.5%
42	Subcorneal pustular dermatosis	20.5%
43	Organophosphate poisoning	20.5%
44	Erythematotelangiectatic Rosacea	20.5%
45	Papulopustular Rosacea	20.5%
46	Chronic Actinic Dermatitis	20.5%
47	Acne Vulgaris	20%
48	Contact Dermatitis	20%
49	Eczema	20%
50	Erythema Multiforme	20%
51	Intertrigo	20%
52	Mushroom Poisoning	20%
53	Neurodermatitis	20%
54	Rhinophyma	20%
55	Perioral Dermatitis	20%
56	Acne	20%
57	Acanthosis Nigricans	19.1%
58	Lentigo	19.1%
59	Dermatitis, Phototoxic	17.6%
60	Pityriasis Lichenoides et Varioliformis Acuta	17.6%
61	Pityriasis Lichenoides	17.6%
62	Phototoxicity	17.6%
63	Foot Ulcer	17.4%
64	Mercury Poisoning, Nervous System	17.4%
65	Lead Poisoning, Nervous System	17.4%
66	Dermatitis, Atopic	17.1%
67	Epidermolysis Bullosa	17.1%
68	Chemical and Drug Induced Liver Injury	16.7%
69	Dermatitis Herpetiformis	16.2%
70	Bites and Stings	16.1%
71	Foot Diseases	16.1%
72	Neurotoxicity Syndromes	16.1%
73	Acrodermatitis	16%
74	Sebaceous Gland Neoplasms	16%
75	Porokeratosis	16%
76	Gianotti-Crosti Syndrome	16%
77	Keratoderma, Palmoplantar	16%
78	Skin Abnormalities	15.5%
79	Skin Diseases, Infectious	15.5%
80	Skin Neoplasms	15.5%
81	Panniculitis, Lupus Erythematosus	15.4%
82	Lipomatosis	15.3%
83	Pruritus	15.3%
84	Erythema	15.3%
85	Water Intoxication	15.3%
86	Necrolytic Migratory Erythema	15.3%
87	Arsenic Poisoning	15.3%
88	Cutaneous Fistula	15.3%
89	Nephrogenic Fibrosing Dermopathy	15.3%
90	Nephrogenic Systemic Fibrosis	15.3%
91	Necrobiosis Lipoidica Diabeticorum	14.9%
92	Dermatitis, Irritant	14.8%
93	Acne Conglobata	14.8%
94	Dermatitis, Photoallergic	14.7%
95	Lead Poisoning, Nervous System, Childhood	14.3%
96	Lead Poisoning, Nervous System, Adult	14.3%
97	Psychoses, Substance-Induced	13.8%
98	Xeroderma	13.5%
99	Dermatomyositis	13.4%
100	Anhidrosis	13.3%
101	Carbon Monoxide Poisoning	13.3%
102	Cholesteatoma	13.3%
103	Ciguatera Poisoning	13.3%
104	Pressure Ulcer	13.3%
105	Ergotism	13.3%
106	Folliculitis	13.3%
107	Foot Dermatoses	13.3%
108	Gynecomastia	13.3%
109	Hypertrichosis	13.3%
110	Hypohidrosis	13.3%
111	Hypotrichosis	13.3%
112	Leg Ulcer	13.3%
113	Lupus Erythematosus, Discoid	13.3%
114	Miliaria	13.3%
115	Parakeratosis	13.3%
116	Parapsoriasis	13.3%
117	Pityriasis	13.3%
118	Psoriasis	13.3%
119	Sweet Syndrome	13.3%
120	Hidradenitis	13.3%
121	Onycholysis	13.3%
122	Miliaria Rubra	13.3%
123	Lichenoid Eruptions	13.3%
124	Chloracne	13.3%
125	Scleroderma, Limited	13.3%
126	Shellfish Poisoning	13.3%
127	Erythema Nodosum	13.1%
128	Erythema Induratum	12.9%
129	Dermatitis, Occupational	12.3%
130	Toxic Epidermal Necrolysis	12.2%
131	Stevens-Johnson Syndrome	12.2%
132	Diaper Rash	12.2%
133	Albinism	12.2%
134	Cutis Laxa	12.2%
135	Mastocytosis	12.1%
136	Connective Tissue Diseases	11.9%
137	Drug toxicity	11.9%
138	Dermatitis, Allergic Contact	11.8%
139	Papillon-Lefevre Disease	11.8%
140	Erythema Infectiosum	11.7%
141	Exanthema Subitum	11.7%
142	Acrodynia	11.5%
143	Ectodermal Dysplasia	11.4%
144	Aplasia Cutis Congenita	11.4%
145	Pseudoxanthoma Elasticum	11.2%
146	Drug Eruptions	10.7%
147	Chemical and Drug Induced Liver Injury, Chronic	10.7%
148	Tinea Capitis	10.6%
149	Onychomycosis	10.6%
150	Acantholysis	10.2%
151	Breast Cyst	10.2%
152	Insect Bites and Stings	10.2%
153	Actinic keratosis	10.2%
154	Pemphigoid, Benign Mucous Membrane	10.2%
155	Pemphigus	10.2%
156	Piedra	10.2%
157	Sunburn	10.2%
158	Alcohol-Induced Disorders, Nervous System	10.1%
159	Hirsutism	10%
160	Lactation Disorder	10%
161	Mastitis	10%
162	Urticaria	10%
163	Granuloma Annulare	9.9%
164	Adiposis Dolorosa	9.9%
165	Pruritus Vulvae	9.9%
166	Lichen Planus	9.9%
167	Pityriasis Rosea	9.9%
168	Pityriasis Rubra Pilaris	9.9%
169	Lichen Nitidus	9.9%
170	Mastocytoma	9.9%
171	Pruritus Ani	9.9%
172	Salmonella food poisoning	9.9%
173	Ecthyma	9.9%
174	Hyperkeratosis, Epidermolytic	9.7%
175	Drug abuse	9.3%
176	Substance Dependence	9.3%
177	Substance-Related Disorders	9.3%
178	Drug Dependence	9.3%
179	Ichthyosis, X-Linked	9%
180	Sjogren-Larsson Syndrome	8.9%
181	Behcet Syndrome	8.7%
182	Peutz-Jeghers Syndrome	8.7%
183	Akathisia, Drug-Induced	8.7%
184	Hidradenitis Suppurativa	8.5%
185	Psychoses, Alcoholic	8.2%
186	Alopecia Areata	8.2%
187	Tick Paralysis	8.2%
188	Dermatomycoses	8.1%
189	Mucocutaneous Lymph Node Syndrome	8.1%
190	Skin Diseases, Bacterial	8.1%
191	Neuroleptic Malignant Syndrome	8.1%
192	Lipodystrophy	8%
193	Livedo Reticularis	8%
194	Malignant Atrophic Papulosis	8%
195	Polyarteritis Nodosa	7.9%
196	Takayasu Arteritis	7.9%
197	Acute Generalized Exanthematous Pustulosis	7.8%
198	Tinea Pedis	7.6%
199	Erythema Chronicum Migrans	7.6%
200	Alopecia	7.6%
201	Dyskinesia, Drug-Induced	7.6%
202	Sweating, Gustatory	7.6%
203	Androgenetic Alopecia	7.6%
204	Auriculotemporal Syndrome	7.6%
205	Lice Infestations	7.4%
206	Varicose Ulcer	7.4%
207	Breast Neoplasms, Male	7.4%
208	Triple Negative Breast Neoplasms	7.4%
209	Galactorrhea	7.4%
210	Collagen Diseases	6.8%
211	Mixed Connective Tissue Disease	6.8%
212	Nail-Patella Syndrome	6.8%
213	Anticholinergic Syndrome	6.8%
214	Mucinoses	6.8%
215	Serotonin Syndrome	6.8%
216	Propofol Infusion Syndrome	6.8%
217	Porphyrias, Hepatic	6.7%
218	Botulism	6.7%
219	MPTP Poisoning	6.6%
220	Serum Sickness	6.6%
221	Mycetoma	6.5%
222	Alcohol Withdrawal Delirium	6.4%
223	Alcohol Withdrawal Seizures	6.4%
224	Lichen Planus, Oral	6.3%
225	Larva Migrans	6%
226	Leishmaniasis	6%
227	Molluscum Contagiosum	6%
228	Angioedema	6%
229	Onchocerciasis	6%
230	Chromoblastomycosis	5.9%
231	Dermatophytosis	5.9%
232	Sporotrichosis	5.9%
233	Tinea	5.9%
234	Tinea Versicolor	5.9%
235	Trichophytosis	5.9%
236	Hyalohyphomycosis	5.9%
237	Cartilage Diseases	5.4%
238	Rheumatism	5.4%
239	Chondromalacia	5.4%
240	Lupus Erythematosus, Systemic	5.2%
241	Marijuana Abuse	5.2%
242	Opioid-Related Disorders	5.2%
243	Nicotine Dependence	5.2%
244	Opioid abuse	5.2%
245	Phencyclidine Abuse	5.2%
246	Substance Abuse, Intravenous	5.2%
247	Substance Withdrawal Syndrome	5.2%
248	Tobacco Use Disorder	5.2%
249	Alcohol-Related Disorders	5.2%
250	Amphetamine-Related Disorders	5.2%
251	Cocaine-Related Disorders	5.2%
252	Overlap syndrome	5.2%
253	Metabolic Side Effects of Drugs and Substances	5.2%
254	Injection Site Reaction	5.1%
255	Infusion site reaction	5.1%
256	Warts	5.1%
257	Drug Overdose	5%
258	Candidiasis, Chronic Mucocutaneous	4.9%
259	Cutaneous Candidiasis	4.9%
260	Erysipelas	4.9%
261	Leishmaniasis, Cutaneous	4.9%
262	Staphylococcal Skin Infections	4.9%
263	Variegate Porphyria	4.9%
264	Acute intermittent porphyria	4.9%
265	Porphyria Cutanea Tarda	4.9%
266	Eczema Herpeticum	4.9%
267	Erythrasma	4.9%
268	Carcinoma, Lobular	4.9%
269	CREST Syndrome	4.9%
270	Arthritis, Psoriatic	4.9%
271	Fusariosis	4.9%
272	Alcohol-Induced Disorders	4.4%
273	Scleromyxedema	4.4%
274	Hereditary Angioedema Type III	4.4%
275	Hereditary Angioedema Types I and II	4.4%
276	Giant Cell Arteritis	4.4%
277	Temporal Arteritis	4.4%
278	Neonatal Abstinence Syndrome	4.2%
279	Angioedemas, Hereditary	4.1%
280	Epidermodysplasia Verruciformis	4.1%
281	Herpes Labialis	4.1%
282	Diabetic Foot	4.1%
283	Staphylococcal Scalded Skin Syndrome	4%
284	Dupuytren Contracture	4%
285	Blastomycosis	3.7%
286	HIV-Associated Lipodystrophy Syndrome	3.7%
287	carbuncle	3.6%
288	Condylomata Acuminata	3.5%
289	Furunculosis	3.5%
290	furuncle	3.5%
291	Impetigo	3.5%
292	Cardiotoxicity	3.4%
293	Mesenteric Panniculitis	3.4%
294	Panniculitis, Peritoneal	3.4%
295	Tietze's Syndrome	3.4%
296	Orbital Cellulitis	3.4%
297	Myxoid cyst	3.4%
298	Rhinoscleroma	3.4%
299	Cellulitis	3.4%
300	Alcohol Use Disorder	3.3%
301	Alcoholic Intoxication	3.3%
302	Heroin Dependence	3.3%
303	Morphine Dependence	3.3%
304	Myxedema	3.3%
305	Alcohol abuse	3.3%
306	Menkes Kinky Hair Syndrome	3.2%
307	Osteochondritis	2.7%
308	Polymyalgia Rheumatica	2.7%
309	Osteogenesis Imperfecta	2.7%
310	Binge Drinking	2.6%
311	Keloid	2.6%
312	Noonan Syndrome	2.5%
313	Cardiomyopathy, Alcoholic	2.5%
314	Pancreatitis, Alcoholic	2.5%
315	Rheumatoid Arthritis	2.3%
316	Juvenile arthritis	2.3%
317	Marfan Syndrome	2.2%
318	Lupus Nephritis	2.2%
319	Homocystinuria	2.2%
320	Fetal Alcohol Spectrum Disorders	2%
321	Rheumatoid Nodule	2%
322	Laryngomalacia	2%
323	Pectus carinatum	1.9%
324	Asthma, Aspirin-Induced	1.9%
325	Wernicke Encephalopathy	1.9%
326	Fatty Liver, Alcoholic	1.7%
327	Hepatitis, Alcoholic	1.7%
328	Liver Cirrhosis, Alcoholic	1.7%
329	Felty Syndrome	1.6%
330	Bronchomalacia	1.6%
331	Tracheomalacia	1.6%
332	Rheumatoid Vasculitis	1.4%
333	Mucopolysaccharidosis III	1.4%
334	Sicca Syndrome	1.2%
335	Sjogren's Syndrome	1.2%
336	Lupus Vasculitis, Central Nervous System	1%
337	Mucopolysaccharidosis II	1%

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