MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

carbuncle

(UMLS:C0007078)

Definition:: An infection of cutaneous and subcutaneous tissue that consists of a cluster of boils. Commonly, the causative agent is STAPHYLOCOCCUS AUREUS. Carbuncles produce fever, leukocytosis, extreme pain, and prostration.
UMLS ID:: C0007078
MeSH ID:: D002270

Classification 1:

Name:

Bacterial Infections and Mycoses
MeSH Tree Number(s):: C01.252.410.868.820.270.200|C01.252.825.770.270.200|C01.539.800.720.770.270.200

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.838.765.770.270.200

Synonym(s)

carbuncle

CARBUNCLE

Carbuncle

Carbuncle of skin and subcutaneous tissue, NOS

carbuncles

nos carbuncle

Associated Drug(s)

	Name	Number of Reports	Data Source
1	NuvaRing	FAERS: 6	US FAERS
2	Afatinib	FAERS: 2	US FAERS
3	Dimethyl Fumarate	FAERS: 2	US FAERS
4	Olanzapine	FAERS: 2	US FAERS
5	Quetiapine Fumarate	FAERS: 2	US FAERS
6	rofecoxib	FAERS: 2	US FAERS
7	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 1	US FAERS
8	Aripiprazole	FAERS: 1	US FAERS
9	Budesonide	FAERS: 1	OFFSIDES US FAERS
10	Clozapine	FAERS: 1	US FAERS
11	Orlistat	FAERS: 1	US FAERS
12	Ruxolitinib phosphate	FAERS: 1	US FAERS
13	Teriparatide	FAERS: 1	US FAERS
14	Testosterone	FAERS: 1	US FAERS
15	Tiotropium Bromide	FAERS: 1	US FAERS
16	Triamcinolone Acetonide	FAERS: 1	US FAERS
17	Valsartan	FAERS: 1	US FAERS
18	empagliflozin	FAERS: 1	US FAERS
19	pazopanib	FAERS: 1	US FAERS
20	testosterone 17 beta-cypionate	FAERS: 1	US FAERS
21	tofacitinib	FAERS: 1 Canada Vigilance: 1	Canada Vigilance US FAERS
22	Azathioprine		OFFSIDES
23	Benzoyl Peroxide		OFFSIDES
24	Cimetidine		OFFSIDES
25	Citalopram		SIDER
26	Doxycycline		OFFSIDES
27	Erythromycin		OFFSIDES
28	Fluconazole		OFFSIDES
29	Fluphenazine		OFFSIDES
30	Fosinopril		OFFSIDES
31	Gatifloxacin		OFFSIDES
32	Ibandronic Acid		OFFSIDES
33	Methyltestosterone		OFFSIDES
34	Minocycline		OFFSIDES
35	Mycophenolic Acid		OFFSIDES
36	Nabumetone		OFFSIDES
37	Ofloxacin		OFFSIDES
38	Pioglitazone		OFFSIDES
39	Primidone		OFFSIDES
40	Ribavirin		OFFSIDES
41	Sumatriptan		OFFSIDES
42	Terbinafine		OFFSIDES
43	Tetracycline		OFFSIDES
44	Tretinoin		OFFSIDES
45	Zalcitabine		SIDER
46	clindamycin phosphate		OFFSIDES
47	cyclobenzaprine		OFFSIDES
48	fexofenadine		OFFSIDES
49	isosorbide-5-mononitrate		OFFSIDES
50	valdecoxib		OFFSIDES
51	zolmitriptan		OFFSIDES

Similar ADE(s)

	Name	Semantic Similarity
1	Impetigo	41.4%
2	Staphylococcal Scalded Skin Syndrome	40.7%
3	Erysipelas	32.5%
4	Ecthyma	31.5%
5	Erythrasma	30.3%
6	Mycetoma	30.1%
7	Hidradenitis Suppurativa	29.3%
8	Erythema Chronicum Migrans	26.7%
9	Dermatomycoses	22.9%
10	Rhinoscleroma	21.8%
11	Central Nervous System Bacterial Infections	20.4%
12	Gram-Negative Bacterial Infections	19.7%
13	Bacteremia	19.4%
14	Borrelia Infections	17.7%
15	Leptospirosis	17.7%
16	Erythema Induratum	17.6%
17	Bacterial Endocarditis	17.3%
18	Mycoses	16.6%
19	Bacterial Vaginosis	16.4%
20	Actinomycetales Infections	16.3%
21	Clostridium Infections	16.3%
22	Listeriosis	16.3%
23	Streptococcal Infections	16.3%
24	Bacillaceae Infections	16.3%
25	Clostridium difficile infection	16.3%
26	Cellulitis	14.8%
27	Pneumonia, Bacterial	14.2%
28	Erysipelothrix infection	14.1%
29	Central Nervous System Infection	14%
30	Pelvic Infection	13.9%
31	Wound Infection	13.9%
32	Soft Tissue Infection	13.9%
33	Community-Acquired Infections	13.9%
34	Candidiasis, Chronic Mucocutaneous	13.8%
35	Cutaneous Candidiasis	13.8%
36	Syphilis	13.5%
37	Subacute Bacterial Endocarditis	13.4%
38	Lyme Disease	13%
39	Relapsing Fever	13%
40	Ulcerative stomatitis	12.6%
41	Chromoblastomycosis	12.5%
42	Dermatophytosis	12.5%
43	Sporotrichosis	12.5%
44	Tinea	12.5%
45	Tinea Versicolor	12.5%
46	Trichophytosis	12.5%
47	Hyalohyphomycosis	12.5%
48	Lyme Neuroborreliosis	12.2%
49	Eye Infection	12%
50	Respiratory Tract Infections	12%
51	Bone Diseases, Infectious	11.8%
52	Pregnancy Complications, Infectious	11.8%
53	Arthritis, Infectious	11.6%
54	Suppuration	11.6%
55	Cross Infection	11.6%
56	Septicemia	11.6%
57	Sepsis	11.6%
58	Chlamydia Infections	11.6%
59	Gonorrhea	11.6%
60	Gram-Positive Bacterial Infections	11.5%
61	Neurosyphilis	11.4%
62	Infection	11.1%
63	Blastomycosis	11.1%
64	Piedra	10.7%
65	Opportunistic Infections	10.6%
66	Bordetella Infections	10.5%
67	Brucellosis	10.5%
68	Campylobacter infection	10.5%
69	Enterobacteriaceae Infections	10.5%
70	Pseudomonas Infections	10.5%
71	Q Fever	10.5%
72	Vibrio Infections	10.5%
73	Helicobacter Infections	10.5%
74	Neisseriaceae Infections	10.5%
75	Burkholderia Infections	10.5%
76	Flavobacteriaceae Infections	10.5%
77	Moraxellaceae Infections	10.5%
78	Burkholderia cepacia Infection	10.5%
79	Skin Diseases, Bacterial	10.1%
80	Urinary tract infection	10.1%
81	Human Ehrlichiosis	10.1%
82	Pertussis	9.7%
83	Meningitis, Listeria	9.6%
84	Hordeolum	9.4%
85	Pyoderma Gangrenosum	9.3%
86	Lupus Erythematosus, Cutaneous	9.3%
87	Panniculitis	9.3%
88	Systemic Scleroderma	9.3%
89	Morphea	9.3%
90	Bacterial conjunctivitis	9.3%
91	Actinomycosis	9.2%
92	Corynebacterium Infections	9.2%
93	Gas Gangrene	9.2%
94	Mycobacterium Infections	9.2%
95	Nocardia Infections	9.2%
96	Pneumococcal Infections	9.2%
97	Scarlet Fever	9.2%
98	Tetanus	9.2%
99	Pulmonary Nocardiosis	9.2%
100	Tinea Capitis	9.2%
101	Onychomycosis	9.2%
102	Sexually Transmitted Diseases	9.1%
103	Human anaplasmosis	8.9%
104	Fungemia	8.5%
105	Aspergillosis	8.4%
106	Candidiasis	8.4%
107	Coccidioidomycosis	8.4%
108	Histoplasmosis	8.4%
109	Paracoccidioidomycosis	8.4%
110	Zygomycosis	8.4%
111	Phaeohyphomycosis	8.4%
112	Pneumocystis Infections	8.4%
113	Breast Diseases	8.2%
114	Dermatitis	8.2%
115	Exanthema	8.2%
116	Facial Dermatoses	8.2%
117	Hair Diseases	8.2%
118	Hand Dermatoses	8.2%
119	keratoacanthoma	8.2%
120	Keratosis	8.2%
121	Nail Diseases	8.2%
122	Photosensitivity Disorders	8.2%
123	Prurigo	8.2%
124	Pyoderma	8.2%
125	Rosacea	8.2%
126	Sebaceous Gland Diseases	8.2%
127	Skin Diseases, Vesiculobullous	8.2%
128	Skin Ulcer	8.2%
129	Sweat Gland Diseases	8.2%
130	Skin Diseases, Papulosquamous	8.2%
131	Skin Diseases, Vascular	8.2%
132	Acneiform Eruptions	8.2%
133	Ocular Rosacea	8.2%
134	Subcorneal pustular dermatosis	8.2%
135	Erythematotelangiectatic Rosacea	8.2%
136	Papulopustular Rosacea	8.2%
137	Chronic Actinic Dermatitis	8.2%
138	Endotoxemia	8.2%
139	Japanese Spotted Fever	8.2%
140	Joint Tuberculosis	8.1%
141	Tuberculosis, Osteoarticular	8.1%
142	Bone Tuberculosis	8.1%
143	Brain Abscess	7.9%
144	Meningitis, Bacterial	7.6%
145	Xeroderma Pigmentosum	7.4%
146	Fusariosis	7.4%
147	Meningitis, Pneumococcal	7.3%
148	Dermatitis, Atopic	7.3%
149	Epidermolysis Bullosa	7.3%
150	Acne Vulgaris	7.2%
151	Contact Dermatitis	7.2%
152	Eczema	7.2%
153	Erythema Multiforme	7.2%
154	Intertrigo	7.2%
155	Neurodermatitis	7.2%
156	Rhinophyma	7.2%
157	Perioral Dermatitis	7.2%
158	Acne	7.2%
159	Foot Diseases	7.1%
160	Otomycosis	7.1%
161	Tinea Pedis	7.1%
162	Central Nervous System Fungal Infections	7%
163	Staphylococcal Skin Infections	7%
164	Skin Abnormalities	7%
165	Skin Neoplasms	7%
166	Pigmentation Disorders	7%
167	Dermatomyositis	6.9%
168	Lipomatosis	6.9%
169	Pruritus	6.9%
170	Erythema	6.9%
171	Necrolytic Migratory Erythema	6.9%
172	Cutaneous Fistula	6.9%
173	Nephrogenic Fibrosing Dermopathy	6.9%
174	Nephrogenic Systemic Fibrosis	6.9%
175	Lymphogranuloma Venereum	6.9%
176	Rheumatic Fever	6.7%
177	Enterocolitis, Pseudomembranous	6.6%
178	pseudomembranous colitis	6.6%
179	Candidemia	6.5%
180	Neuroaspergillosis	6.4%
181	Erythema Infectiosum	6.3%
182	Dermatitis Herpetiformis	6.3%
183	Exanthema Subitum	6.3%
184	Ophthalmia Neonatorum	6.3%
185	Trachoma	6.3%
186	Panophthalmitis	6.2%
187	Acrodermatitis	6.2%
188	Sebaceous Gland Neoplasms	6.2%
189	Porokeratosis	6.2%
190	Gianotti-Crosti Syndrome	6.2%
191	Keratoderma, Palmoplantar	6.2%
192	Endophthalmitis	6.2%
193	Peritonitis	6.2%
194	Staphylococcal Infections	6.2%
195	Lung Diseases, Fungal	6.2%
196	Osteomyelitis	6.2%
197	Periostitis	6.2%
198	Surgical Wound Infection	6.2%
199	Meningitis, Haemophilus	6.2%
200	Abscess	6.1%
201	Adnexitis	6.1%
202	Empyema	6.1%
203	Pelvic Inflammatory Disease	6.1%
204	Acinetobacter Infections	6%
205	Bacteroides Infections	6%
206	Cholera	6%
207	Escherichia coli Infections	6%
208	Haemophilus Infections	6%
209	Klebsiella Infections	6%
210	Meningococcal Infections	6%
211	Mycoplasma Infections	6%
212	Pasteurella Infections	6%
213	Proteus Infections	6%
214	Rickettsia Infections	6%
215	Salmonella infections	6%
216	Scrub Typhus	6%
217	Serratia Infections	6%
218	Ureaplasma Infections	6%
219	Necrobiosis Lipoidica Diabeticorum	6%
220	Mastocytosis	5.9%
221	Botulism	5.9%
222	Diphtheria	5.7%
223	Leprosy	5.7%
224	Mycobacterium Infections, Nontuberculous	5.7%
225	Tuberculosis	5.7%
226	Mycobacterium abscessus Infection	5.7%
227	Panniculitis, Lupus Erythematosus	5.6%
228	Foot Ulcer	5.6%
229	Xeroderma	5.5%
230	Syphilis, Congenital	5.5%
231	Bacterial Infections	5.5%
232	Connective Tissue Diseases	5.5%
233	Superinfection	5.4%
234	Rocky Mountain Spotted Fever	5.4%
235	Corneal Ulcer	5.4%
236	Puerperal Infection	5.3%
237	Spondylitis	5.3%
238	Pseudoxanthoma Elasticum	5.3%
239	Appendicitis	5.3%
240	Bacteriuria	5.3%
241	Pyuria	5.3%
242	Pyomyositis	5.3%
243	Endotoxic shock	5.2%
244	Septic Shock	5.2%
245	Toxic Shock Syndrome	5.2%
246	Cutis Laxa	5.1%
247	Dermatitis, Phototoxic	5.1%
248	Pityriasis Lichenoides et Varioliformis Acuta	5.1%
249	Pityriasis Lichenoides	5.1%
250	Phototoxicity	5.1%
251	Tuberculosis, Meningeal	5.1%
252	Invasive Pulmonary Aspergillosis	5%
253	Ectodermal Dysplasia	4.9%
254	Aplasia Cutis Congenita	4.9%
255	Rheumatic Heart Disease	4.8%
256	Lupus Erythematosus, Discoid	4.8%
257	Scleroderma, Limited	4.8%
258	Skin Diseases, Infectious	4.8%
259	Urticaria Pigmentosa	4.8%
260	Lice Infestations	4.7%
261	Arthritis, Reactive	4.6%
262	Tuberculosis, Spinal	4.5%
263	Dermatitis, Photoallergic	4.5%
264	Mucormycosis	4.5%
265	Meningitis, Cryptococcal	4.4%
266	Dysentery, Bacillary	4.3%
267	Anhidrosis	4.3%
268	Cholesteatoma	4.3%
269	Pressure Ulcer	4.3%
270	Folliculitis	4.3%
271	Foot Dermatoses	4.3%
272	Gynecomastia	4.3%
273	Hypertrichosis	4.3%
274	Hypohidrosis	4.3%
275	Hypotrichosis	4.3%
276	Leg Ulcer	4.3%
277	Miliaria	4.3%
278	Parakeratosis	4.3%
279	Parapsoriasis	4.3%
280	Pityriasis	4.3%
281	Psoriasis	4.3%
282	Sweet Syndrome	4.3%
283	Hidradenitis	4.3%
284	Onycholysis	4.3%
285	Miliaria Rubra	4.3%
286	Hyperpigmentation	4.3%
287	Lichenoid Eruptions	4.3%
288	Chloracne	4.3%
289	Erythema Nodosum	4.2%
290	AIDS-Related Opportunistic Infections	4.2%
291	Psoas Abscess	4.1%
292	Abdominal Abscess	4.1%
293	Larva Migrans	4.1%
294	Leishmaniasis	4.1%
295	Molluscum Contagiosum	4.1%
296	Onchocerciasis	4%
297	Dermatitis, Irritant	4%
298	Acne Conglobata	4%
299	Mycobacterium avium-intracellulare Infection	3.9%
300	Lymph Node Tuberculosis	3.9%
301	Tuberculosis, Miliary	3.9%
302	Tuberculosis, Multidrug-Resistant	3.9%
303	Leprosy, Multibacillary	3.9%
304	Latent Tuberculosis	3.9%
305	Psittacosis	3.8%
306	Paratyphoid Fever	3.8%
307	Plague	3.8%
308	Typhoid Fever	3.8%
309	TYPHUS	3.8%
310	Yersinia pseudotuberculosis Infections	3.8%
311	Bubonic Plague	3.8%
312	Oral candidiasis	3.8%
313	Pulmonary Aspergillosis	3.7%
314	Bronchopulmonary Aspergillosis	3.7%
315	Furunculosis	3.7%
316	furuncle	3.7%
317	Granuloma Annulare	3.7%
318	Acantholysis	3.7%
319	Breast Cyst	3.7%
320	Actinic keratosis	3.7%
321	Pemphigoid, Benign Mucous Membrane	3.7%
322	Pemphigus	3.7%
323	Sunburn	3.7%
324	Argyria	3.6%
325	Hirsutism	3.6%
326	Lactation Disorder	3.6%
327	Mastitis	3.6%
328	Urticaria	3.6%
329	Toxic Epidermal Necrolysis	3.6%
330	Stevens-Johnson Syndrome	3.6%
331	Adiposis Dolorosa	3.6%
332	Pruritus Vulvae	3.6%
333	Warts	3.6%
334	Mastocytoma	3.6%
335	Pruritus Ani	3.6%
336	Ichthyosis, X-Linked	3.5%
337	Sjogren-Larsson Syndrome	3.5%
338	Dermatitis, Occupational	3.5%
339	Diverticulitis	3.4%
340	Dermatitis, Allergic Contact	3.4%
341	Behcet Syndrome	3.4%
342	Papillon-Lefevre Disease	3.4%
343	Tuberculosis, Gastrointestinal	3.4%
344	Tuberculosis, Central Nervous System	3.3%
345	Salmonella Infections, Animal	3.3%
346	Meningitis, Fungal	3.2%
347	Toxoplasmosis, Cerebral	3.2%
348	Salmonella food poisoning	3.2%
349	Candidiasis, Vulvovaginal	3.2%
350	Mucocutaneous Lymph Node Syndrome	3.1%
351	Drug Eruptions	3.1%
352	Lipodystrophy	3.1%
353	Livedo Reticularis	3.1%
354	Malignant Atrophic Papulosis	3.1%
355	Albinism	3.1%
356	Polyarteritis Nodosa	3.1%
357	Takayasu Arteritis	3.1%
358	Borderline leprosy	3.1%
359	Leprosy, Lepromatous	3.1%
360	Tuberculoid leprosy	3.1%
361	Extensively Drug-Resistant Tuberculosis	3.1%
362	Lung Abscess	3%
363	Diverticulum	3%
364	Diverticulosis	3%
365	Discitis	3%
366	Mastoiditis	3%
367	Petrositis	3%
368	Tuberculosis, Pulmonary	2.9%
369	Nail-Patella Syndrome	2.8%
370	carbuncle	2.8%
371	Porphyrias, Hepatic	2.8%
372	Collagen Diseases	2.7%
373	Mixed Connective Tissue Disease	2.7%
374	Mucinoses	2.7%
375	Hyperkeratosis, Epidermolytic	2.6%
376	Retropharyngeal Abscess	2.6%
377	Epidural Abscess	2.6%
378	Peritonsillar Abscess	2.6%
379	Waterhouse-Friderichsen Syndrome	2.5%
380	Leishmaniasis, Cutaneous	2.4%
381	Eczema Herpeticum	2.4%
382	Cartilage Diseases	2.4%
383	Rheumatism	2.4%
384	Chondromalacia	2.4%
385	Lichen Planus	2.4%
386	Melanosis	2.4%
387	Chloasma	2.4%
388	Pityriasis Rosea	2.4%
389	Pityriasis Rubra Pilaris	2.4%
390	Vitiligo	2.4%
391	Lichen Nitidus	2.4%
392	Diaper Rash	2.4%
393	Lupus Erythematosus, Systemic	2.3%
394	Overlap syndrome	2.3%
395	Liver Abscess	2.1%
396	Epidermodysplasia Verruciformis	2.1%
397	Herpes Labialis	2.1%
398	Alopecia	2%
399	Sweating, Gustatory	2%
400	Androgenetic Alopecia	2%
401	Auriculotemporal Syndrome	2%
402	Varicose Ulcer	2%
403	Breast Neoplasms, Male	2%
404	Triple Negative Breast Neoplasms	2%
405	Galactorrhea	2%
406	Giant Cell Arteritis	2%
407	Temporal Arteritis	2%
408	Dupuytren Contracture	2%
409	Lemierre Syndrome	1.9%
410	Condylomata Acuminata	1.9%
411	Tuberculosis, Renal	1.8%
412	Angioedema	1.7%
413	Acute Generalized Exanthematous Pustulosis	1.7%
414	CREST Syndrome	1.6%
415	Menkes Kinky Hair Syndrome	1.5%
416	Serum Sickness	1.5%
417	Variegate Porphyria	1.5%
418	Acute intermittent porphyria	1.5%
419	Porphyria Cutanea Tarda	1.5%
420	Carcinoma, Lobular	1.5%
421	Arthritis, Psoriatic	1.5%
422	Aspergillosis, Allergic Bronchopulmonary	1.4%
423	Scleromyxedema	1.4%
424	Acanthosis Nigricans	1.4%
425	Alopecia Areata	1.4%
426	Lentigo	1.4%
427	Noonan Syndrome	1.4%
428	Marfan Syndrome	1.3%
429	Homocystinuria	1.2%
430	Mesenteric Panniculitis	1.2%
431	Panniculitis, Peritoneal	1.2%
432	Tietze's Syndrome	1.2%
433	Orbital Cellulitis	1.2%
434	Myxoid cyst	1.2%
435	Lichen Planus, Oral	1.2%
436	Myxedema	1.2%
437	HIV-Associated Lipodystrophy Syndrome	1.2%
438	Osteochondritis	1.1%
439	Polymyalgia Rheumatica	1.1%
440	Osteogenesis Imperfecta	1%
441	Keloid	1%
442	Liver Abscess, Amebic	1%
443	Rheumatoid Arthritis	0.9%
444	Juvenile arthritis	0.9%
445	Angioedemas, Hereditary	0.9%
446	Lupus Nephritis	0.9%
447	Diabetic Foot	0.9%
448	Laryngomalacia	0.8%
449	Pectus carinatum	0.8%
450	Hereditary Angioedema Type III	0.7%
451	Hereditary Angioedema Types I and II	0.7%
452	Peutz-Jeghers Syndrome	0.6%
453	Rheumatoid Nodule	0.6%
454	Felty Syndrome	0.5%
455	Bronchomalacia	0.5%
456	Tracheomalacia	0.5%
457	Lupus Vasculitis, Central Nervous System	0.5%
458	Rheumatoid Vasculitis	0.4%
459	Mucopolysaccharidosis III	0.4%
460	Sicca Syndrome	0.4%
461	Sjogren's Syndrome	0.4%
462	Mucopolysaccharidosis II	0.3%

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