MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Klatskin Tumor

(UMLS:C0206702)

Definition:: Cholangiocarcinoma arising near or at the confluence of the right and left hepatic ducts (COMMON HEPATIC DUCT). These tumors are generally small, sharply localized, and seldom metastasizing.
UMLS ID:: C0206702
MeSH ID:: D018285

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.470.200.025.450.500

Synonym(s)

Klatskin Tumor

Hilar CC

Hilar Cholangiocarcinoma

Klatskin

Klatskin tumor

Klatskin tumor (bile duct bifurcation)

Klatskin's tumor

Klatskin's tumor morphology

Klatskin's tumour

10.

Klatskin; tumor

11.

Klatzkin tumor

12.

klatskin tumor

13.

klatskin tumors

14.

klatskin's tumor

15.

klatskin's tumour

16.

klatskins tumor

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Azathioprine		8414164	CTD
2	Methotrexate		1849410	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Adenoid Cystic Carcinoma	36.8%
2	Adenocarcinoma, Clear Cell	36.8%
3	Cystadenocarcinoma	34%
4	Mucoepidermoid Carcinoma	34%
5	Carcinoma in Situ	29.9%
6	Carcinoma, Transitional Cell	29.9%
7	Carcinoma, Large Cell	29.9%
8	Carcinoma, Small Cell	29.9%
9	Basal cell carcinoma	29.3%
10	Carcinoma, Papillary	29.3%
11	Squamous cell carcinoma	29.3%
12	Carcinoma, Basal Cell	29.3%
13	Adenoma	25.5%
14	Carcinoma, Ehrlich Tumor	25.3%
15	Carcinoma, Lewis Lung	25.3%
16	Carcinoma, Lobular	22.1%
17	Carcinoid Tumor	22%
18	leukemia	21.3%
19	Neoplasms, Germ Cell and Embryonal	21.3%
20	Germ Cell Cancer	21.3%
21	Choriocarcinoma	18.8%
22	Neoplasms, Neuroepithelial	18.8%
23	Gliomatosis cerebri	18.8%
24	Cystadenoma	18.7%
25	Mesothelioma	18.7%
26	Cervical Intraepithelial Neoplasia	17.8%
27	Bowen's Disease	17.4%
28	Hamartoma	14.8%
29	Neoplasms, Hormone-Dependent	14.8%
30	Neoplasms, Multiple Primary	14.8%
31	Paraneoplastic Syndromes	14.8%
32	Precancerous Conditions	14.8%
33	Neoplasms, Second Primary	14.8%
34	Neuroectodermal Tumors	14.7%
35	Malignant Carcinoid Syndrome	14.6%
36	Histiocytic Disorders, Malignant	14.2%
37	Papilloma	13.9%
38	Pseudomyxoma Peritonei	13.9%
39	Papillomatosis	13.9%
40	Adenomatosis, Pulmonary	13.9%
41	Adenomatous Polyps	13.9%
42	Adrenocortical carcinoma	12.8%
43	Acanthoma	11.9%
44	Carcinosarcoma	11.3%
45	Hemangiosarcoma	11.3%
46	lymphangiosarcoma	11.3%
47	Ameloblastoma	10.9%
48	Angiokeratoma	10.9%
49	Chordoma	10.9%
50	Hemangioma	10.9%
51	hemangiopericytoma	10.9%
52	Lymphangioma	10.9%
53	Mesenchymoma	10.9%
54	Nevus	10.9%
55	Teratoma	10.9%
56	Hepatoblastoma	10.9%
57	Mixed Tumor, Mullerian	10.9%
58	Germinoma	10.9%
59	Teratocarcinoma	10.9%
60	Angiofibroma	10.9%
61	Sarcoma	10.9%
62	Renal Cell Carcinoma	10.9%
63	Papillary Renal Cell Carcinoma	10.9%
64	Adenofibroma	10.8%
65	Fibroadenoma	10.8%
66	Carcinoma, Endometrioid	10.7%
67	Lymphoma	10.6%
68	Adenoma, Acidophil	10.5%
69	Ganglioneuroma	10.5%
70	Glioma	10.5%
71	Malignant Glioma	10.5%
72	Cyst	9.9%
73	Neoplastic Processes	9.9%
74	Neoplastic Syndromes, Hereditary	9.9%
75	Pregnancy Complications, Neoplastic	9.9%
76	Neoplasms, Experimental	9.6%
77	Carcinoma, Pancreatic Ductal	9.4%
78	Meningioma	9.2%
79	Trophoblastic Neoplasms	9.2%
80	Carcinoma, Ovarian Epithelial	9.2%
81	Leukemia, Experimental	9.1%
82	melanoma	9%
83	Carcinoid Heart Disease	8.9%
84	Dermoid Cyst	8.8%
85	Composite Lymphoma	8.8%
86	Leukemia, Plasma Cell	8.5%
87	Carcinoma 256, Walker	8.4%
88	Chondrosarcoma	8%
89	Craniopharyngioma	8%
90	leiomyosarcoma	8%
91	liposarcoma	8%
92	synovial sarcoma	8%
93	Neuroectodermal Tumor, Melanotic	8%
94	Angiomyolipoma	8%
95	Clear Cell Sarcoma of Soft Tissue	8%
96	Alveolar Soft Part Sarcoma	8%
97	Neuroendocrine Tumors	8%
98	Sarcoma, Myeloid	8%
99	Gastrinoma	7.7%
100	Glucagonoma	7.7%
101	Nasopharyngeal carcinoma	7.7%
102	Medulloblastoma	7.4%
103	Leukemia, Radiation-Induced	7.4%
104	Vipoma	7.4%
105	Plasmacytoma	7.4%
106	Malignant histiocytosis	7.3%
107	Histiocytic sarcoma	7.3%
108	Neoplasms, Radiation-Induced	7.2%
109	Abdominal Neoplasms	7.1%
110	Erythroplasia	7.1%
111	Follicular cyst	7.1%
112	Head and Neck Neoplasms	7.1%
113	Mucocele	7.1%
114	Pilonidal Cyst	7.1%
115	Soft Tissue Neoplasms	7.1%
116	Thoracic Neoplasms	7.1%
117	Thyroglossal Cyst	7.1%
118	Synovial Cyst	7.1%
119	Aberrant Crypt Foci	7.1%
120	Basal Cell Nevus Syndrome	7%
121	Sarcoma, Experimental	6.6%
122	Thymoma	6.5%
123	Astrocytoma	6.5%
124	Ependymoma	6.5%
125	oligodendroglioma	6.5%
126	Ganglioglioma	6.5%
127	gliosarcoma	6.5%
128	Anaplastic astrocytoma	6.5%
129	Anaplastic Oligodendroglioma	6.5%
130	Hepatocellular Adenoma	6.5%
131	Leukemia L1210	6.5%
132	Leukemia P388	6.5%
133	Fibrosarcoma	6.4%
134	Osteosarcoma	6.4%
135	Multiple Endocrine Neoplasia	6.1%
136	Phyllodes Tumor	6%
137	Dysgerminoma	6%
138	Hemangioendothelioma	6%
139	Lipoma	6%
140	Myoma	6%
141	Myxoma	6%
142	Neuroma	6%
143	Seminoma	6%
144	Angiolipoma	6%
145	Myelolipoma	6%
146	Neoplasms, Bone Tissue	6%
147	Neoplasms, Fibrous Tissue	6%
148	Smooth Muscle Tumor	6%
149	Desmoplastic Small Round Cell Tumor	6%
150	Chondroma	6%
151	Enchondroma	6%
152	Melanoma, Experimental	5.9%
153	Retinoblastoma	5.9%
154	Endometrial Stromal Sarcoma	5.7%
155	Malignant Fibrous Histiocytoma	5.6%
156	Paraneoplastic Encephalomyelitis	5.5%
157	Hodgkin Disease	5.5%
158	Lymphoma, Non-Hodgkin	5.5%
159	Prolactinoma	5.4%
160	Growth Hormone-Secreting Pituitary Adenoma	5.4%
161	Mammary Neoplasms, Experimental	5.4%
162	Neurilemmoma	5.3%
163	Hutchinson's Melanotic Freckle	5.3%
164	Melanoma, Amelanotic	5.3%
165	Digestive System Neoplasms	5.1%
166	Endocrine Gland Neoplasms	5.1%
167	Eye Neoplasms	5.1%
168	Nervous System Neoplasms	5.1%
169	Bone neoplasms	4.8%
170	Leukoplakia	4.8%
171	Lymphocele	4.8%
172	Pancreatic Cyst	4.8%
173	Skin Neoplasms	4.8%
174	Hematologic Neoplasms	4.8%
175	Sarcoma 180	4.8%
176	Lymphangioleiomyomatosis	4.8%
177	Paraganglioma	4.7%
178	Rhabdomyosarcoma	4.7%
179	Giant Cell Tumor of Bone	4.7%
180	Barrett Esophagus	4.7%
181	Breast Cyst	4.7%
182	Actinic keratosis	4.7%
183	Mediastinal Cyst	4.7%
184	Neoplasm Invasiveness	4.7%
185	Neoplasm Metastasis	4.7%
186	Neoplasm Recurrence, Local	4.7%
187	Parovarian Cyst	4.7%
188	Pericardial Cyst	4.7%
189	Splenic Neoplasms	4.7%
190	Thymic Cyst	4.7%
191	Carcinogenesis	4.7%
192	Myxoid cyst	4.7%
193	Metastasis	4.7%
194	Glioblastoma	4.5%
195	Neuroblastoma	4.5%
196	Glioblastoma Multiforme	4.5%
197	Primary amyloidosis	4.4%
198	Tuberous Sclerosis	4.3%
199	Nephroblastoma	4.3%
200	Lymphomatoid Granulomatosis	4.2%
201	Leukemia, Myelomonocytic, Chronic	4%
202	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	4%
203	Dermatofibrosarcoma	3.9%
204	Dermatofibrosarcoma Protuberans	3.9%
205	Retroperitoneal Neoplasms	3.6%
206	fibroma	3.6%
207	Fibromatosis	3.6%
208	Osteoblastoma	3.6%
209	Osteoma	3.6%
210	Rhabdomyoma	3.6%
211	Chondromatosis	3.6%
212	Hemangioblastoma	3.6%
213	Lymphoma, Extranodal NK-T-Cell	3.6%
214	Ganglioneuroblastoma	3.5%
215	Corpus Luteum Cyst	3.5%
216	Ovarian Cysts	3.5%
217	Mesoblastic Nephroma	3.4%
218	Adenomatous Polyposis Coli	3.2%
219	Neurofibrosarcoma	3.2%
220	Waldenstrom Macroglobulinemia	3.2%
221	Multiple Myeloma	3.2%
222	Pheochromocytoma	3.1%
223	Alveolar rhabdomyosarcoma	3.1%
224	Multiple Endocrine Neoplasia Type 1	3.1%
225	Mastocytosis	3.1%
226	Sturge-Weber Syndrome	3.1%
227	insulinoma	3.1%
228	Gastrointestinal Stromal Tumors	3.1%
229	Parathyroid Neoplasms	3%
230	Peritoneal Neoplasms	3%
231	Thyroid Neoplasm	3%
232	Thyroid carcinoma	3%
233	Hemangioma, Cavernous	3%
234	Liver Neoplasms, Experimental	3%
235	Leukemia, T-Cell	3%
236	Leukemia, B-Cell	3%
237	neurofibroma	3%
238	Lymphoma, Follicular	3%
239	T-Cell Lymphoma	3%
240	Mantle cell lymphoma	3%
241	Choledochal Cyst	2.9%
242	Peutz-Jeghers Syndrome	2.8%
243	Hydatidiform Mole	2.8%
244	Optic Nerve Glioma	2.8%
245	Pancreatic Neoplasm	2.6%
246	Mouth Neoplasms	2.5%
247	Central Nervous System Neoplasms	2.5%
248	Vascular Neoplasms	2.5%
249	Thymus Neoplasms	2.5%
250	Genital Neoplasms, Female	2.5%
251	Pancreatic Pseudocyst	2.5%
252	Lymphatic Metastasis	2.4%
253	Neoplasms, Unknown Primary	2.4%
254	Leukemic Infiltration	2.4%
255	Breast Neoplasms, Male	2.4%
256	Neoplasm Micrometastasis	2.4%
257	Triple Negative Breast Neoplasms	2.4%
258	Mastocytoma	2.4%
259	Mastocytosis, Systemic	2.4%
260	Leukemia, Myeloid, Chronic-Phase	2.4%
261	Fibromatosis, Aggressive	2.4%
262	Fibromatosis, Abdominal	2.4%
263	Tracheal Neoplasms	2.4%
264	granulosa cell tumor	2.3%
265	Leukoplakia, Oral	2.3%
266	Paraneoplastic Cerebellar Degeneration	2.3%
267	Acoustic Neuroma	2.1%
268	Esophageal Neoplasms	1.9%
269	Adrenal Gland Neoplasms	1.9%
270	Gastrointestinal Neoplasms	1.9%
271	Genital Neoplasms, Male	1.9%
272	Liver neoplasms	1.9%
273	Uveal Neoplasms	1.9%
274	Limbic Encephalitis	1.9%
275	Urologic Neoplasms	1.9%
276	Sebaceous Gland Neoplasms	1.8%
277	Spinal Neoplasms	1.8%
278	Bone Marrow Neoplasms	1.8%
279	Polycystic Ovary Syndrome	1.8%
280	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
281	Leukemia, Large Granular Lymphocytic	1.8%
282	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	1.8%
283	Lymphoma, T-Cell, Cutaneous	1.8%
284	Lymphoma, AIDS-Related	1.8%
285	Enteropathy-Associated T-Cell Lymphoma	1.8%
286	Primary Effusion Lymphoma	1.8%
287	Lambert-Eaton Myasthenic Syndrome	1.7%
288	Testicular Neoplasms	1.7%
289	Thyroid Nodule	1.6%
290	Denys-Drash Syndrome	1.6%
291	Xeroderma Pigmentosum	1.6%
292	Opsoclonus-Myoclonus Syndrome	1.4%
293	Leydig Cell Tumor	1.4%
294	Meningeal Neoplasms	1.3%
295	Myelitis, Transverse	1.3%
296	Dupuytren Contracture	1.2%
297	ovarian neoplasm	1.2%
298	Urticaria Pigmentosa	1.2%
299	Burkitt Lymphoma	1.2%
300	Mycosis Fungoides	1.2%
301	Lymphomatoid Papulosis	1.2%
302	Plasmablastic lymphoma	1.2%
303	Nose Neoplasms	1.1%
304	Ear Neoplasms	1.1%
305	Eyelid Neoplasms	1.1%
306	Lung Neoplasms	1.1%
307	Pleural Neoplasms	1.1%
308	Cell Transformation, Viral	1%
309	Brain Neoplasms	1%
310	Salivary Gland Neoplasms	1%
311	Spinal Cord Neoplasms	1%
312	Tongue Neoplasms	1%
313	Uterine Neoplasms	1%
314	Vaginal Neoplasms	1%
315	Vulvar Neoplasms	1%
316	Uterine Cancer	1%
317	Fallopian Tube Neoplasms	1%
318	Pituitary Adenoma	1%
319	Pituitary Neoplasms	1%
320	Palatal Neoplasms	0.9%
321	Zollinger-Ellison syndrome	0.9%
322	Pharyngeal Neoplasms	0.9%
323	Central Nervous System Cysts	0.8%
324	Bile Duct Neoplasms	0.8%
325	gallbladder neoplasm	0.8%
326	Intestinal Neoplasms	0.8%
327	Penile Neoplasms	0.8%
328	Prostatic Neoplasms	0.8%
329	Stomach Neoplasms	0.8%
330	Polycythemia Vera	0.8%
331	Sezary Syndrome	0.8%
332	Meningeal Carcinomatosis	0.8%
333	Laryngeal neoplasm	0.7%
334	Bladder Neoplasm	0.7%
335	Kidney Neoplasm	0.7%
336	Ureteral Neoplasms	0.7%
337	Urethral Neoplasms	0.7%
338	Bronchial Neoplasms	0.6%
339	Multiple Pulmonary Nodules	0.6%
340	Supratentorial Neoplasms	0.6%
341	Endometrial Neoplasms	0.6%
342	Hypopharyngeal Neoplasms	0.5%
343	Pleural Effusion, Malignant	0.5%
344	Hypopharyngeal Cancer	0.5%
345	Parotid Neoplasms	0.5%
346	Prostatic Neoplasms, Castration-Resistant	0.5%
347	Nelson Syndrome	0.5%
348	Cecal Neoplasms	0.4%
349	Duodenal Neoplasms	0.4%
350	Brain Stem Neoplasms	0.4%
351	Nasopharyngeal Neoplasms	0.4%
352	Colorectal Neoplasms	0.3%
353	Tonsillar Neoplasms	0.3%
354	Cerebellar Neoplasms	0.3%
355	Paranasal Sinus Neoplasms	0.3%
356	Choroid Plexus Papilloma	0.3%
357	Radicular Cyst	0.3%
358	Appendiceal Neoplasms	0.3%
359	Colonic Neoplasms	0.3%
360	Rectal Neoplasms	0.3%
361	Maxillary Sinus Neoplasms	0.2%
362	Anus Neoplasms	0.2%
363	Sigmoid Neoplasms	0.2%

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