MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Epidermodysplasia Verruciformis

(UMLS:C0014522)

Definition:: An autosomal recessive trait with impaired cell-mediated immunity. About 15 human papillomaviruses are implicated in associated infection, four of which lead to skin neoplasms. The disease begins in childhood with red papules and later spreads over the body as gray or yellow scales.
UMLS ID:: C0014522
MeSH ID:: D004819

Classification 1:

Name:

Virus Diseases
MeSH Tree Number(s):: C02.256.650.810.345|C02.825.810.260|C02.928.914.345

Classification 2:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.838.790.810.260

Synonym(s)

Epidermodysplasia Verruciformis

Epidermodysplasia verruciformis

Epidermodysplasia verruciformis of Lewandowsky-Lutz

Lewandowsky-Lutz Dysplasia

Lewandowsky-Lutz disease

epidermodysplasia verruciformis

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Cyclosporine	FAERS: 3	US FAERS
2	Carboplatin	FAERS: 1	US FAERS
3	Tacrolimus	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Condylomata Acuminata	53.8%
2	Molluscum Contagiosum	32.4%
3	Erythema Infectiosum	31.5%
4	Exanthema Subitum	29.3%
5	Epstein-Barr Virus Infections	25.5%
6	Eczema Herpeticum	21.4%
7	Arbovirus Infections	19.8%
8	Murine Acquired Immunodeficiency Syndrome	19.2%
9	Herpes Labialis	18.8%
10	Rift Valley Fever	18.7%
11	Herpesviridae Infections	17.9%
12	Polyomavirus Infections	17.9%
13	Dengue Fever	17%
14	Yellow Fever	17%
15	Hepatitis, Viral, Human	16.4%
16	Viremia	16.3%
17	Hepatitis E	16.2%
18	Hepatitis B	16.1%
19	Leukoencephalopathy, Progressive Multifocal	15.8%
20	Hemorrhagic Fever, Crimean	15.5%
21	Phlebotomus Fever	15.5%
22	Subacute Sclerosing Panencephalitis	15.1%
23	Opportunistic Infections	14.6%
24	Pseudorabies	14.4%
25	Hepatitis, Viral, Animal	14.1%
26	Pneumonia, Viral	14%
27	Zika Virus Infection	13.8%
28	West Nile Fever	13.2%
29	Hepatitis C	13.2%
30	Acquired Immunodeficiency Syndrome	13%
31	AIDS related complex	13%
32	Warts	12.5%
33	Herpes Zoster Ophthalmicus	12.5%
34	Chronic Fatigue Syndrome	12.5%
35	Sexually Transmitted Diseases	12.5%
36	Hemorrhagic Fever, American	12.1%
37	Lassa Fever	12.1%
38	Keratitis, Herpetic	12%
39	Cytomegalovirus Retinitis	12%
40	Simian Acquired Immunodeficiency Syndrome	11.8%
41	Hepatitis A	11.8%
42	Orthomyxoviridae Infections	11.3%
43	Picornaviridae Infections	11.3%
44	Reoviridae Infections	11.3%
45	Retroviridae Infections	11.3%
46	Cytomegalovirus Infections	11.1%
47	Smallpox	11.1%
48	Varicella Zoster Virus Infection	11.1%
49	Burkitt Lymphoma	11.1%
50	Pyoderma Gangrenosum	10.6%
51	Hemorrhagic Fever with Renal Syndrome	10.4%
52	Lupus Erythematosus, Cutaneous	10.1%
53	Panniculitis	10.1%
54	Systemic Scleroderma	10.1%
55	Morphea	10.1%
56	Genital Herpes	9.5%
57	Hepatitis B, Chronic	9.3%
58	HIV Infections	9%
59	Breast Diseases	9%
60	Dermatitis	9%
61	Exanthema	9%
62	Facial Dermatoses	9%
63	Hair Diseases	9%
64	Hand Dermatoses	9%
65	keratoacanthoma	9%
66	Keratosis	9%
67	Nail Diseases	9%
68	Photosensitivity Disorders	9%
69	Prurigo	9%
70	Pyoderma	9%
71	Rosacea	9%
72	Sebaceous Gland Diseases	9%
73	Skin Diseases, Vesiculobullous	9%
74	Skin Ulcer	9%
75	Sweat Gland Diseases	9%
76	Skin Diseases, Papulosquamous	9%
77	Skin Diseases, Vascular	9%
78	Acneiform Eruptions	9%
79	Ocular Rosacea	9%
80	Subcorneal pustular dermatosis	9%
81	Erythematotelangiectatic Rosacea	9%
82	Papulopustular Rosacea	9%
83	Chronic Actinic Dermatitis	9%
84	AIDS-Related Opportunistic Infections	8.7%
85	Xeroderma Pigmentosum	8.3%
86	Dermatomycoses	8.3%
87	Skin Diseases, Bacterial	8.3%
88	Dermatitis, Atopic	8.3%
89	Epidermolysis Bullosa	8.3%
90	Acne Vulgaris	8.2%
91	Contact Dermatitis	8.2%
92	Eczema	8.2%
93	Erythema Multiforme	8.2%
94	Intertrigo	8.2%
95	Neurodermatitis	8.2%
96	Rhinophyma	8.2%
97	Perioral Dermatitis	8.2%
98	Acne	8.2%
99	Epidermodysplasia Verruciformis	8.2%
100	Superinfection	8.2%
101	Chickenpox	7.8%
102	Foot Diseases	7.7%
103	Hepatitis C, Chronic	7.7%
104	Skin Abnormalities	7.6%
105	Skin Neoplasms	7.6%
106	Pigmentation Disorders	7.6%
107	Lipomatosis	7.5%
108	Pruritus	7.5%
109	Erythema	7.5%
110	Necrolytic Migratory Erythema	7.5%
111	Cutaneous Fistula	7.5%
112	Nephrogenic Fibrosing Dermopathy	7.5%
113	Nephrogenic Systemic Fibrosis	7.5%
114	Dermatomyositis	7.5%
115	Erythema Induratum	7.2%
116	Enterovirus Infections	7.2%
117	Flavivirus Infections	7.2%
118	Paramyxoviridae Infections	7.2%
119	Cardiovirus Infections	7.2%
120	Rhabdoviridae Infections	7.2%
121	Dermatitis Herpetiformis	7.1%
122	Bell Palsy	7.1%
123	Acrodermatitis	7.1%
124	Sebaceous Gland Neoplasms	7.1%
125	Porokeratosis	7.1%
126	Gianotti-Crosti Syndrome	7.1%
127	Keratoderma, Palmoplantar	7.1%
128	Herpangina	7%
129	Necrobiosis Lipoidica Diabeticorum	6.8%
130	HIV Seropositivity	6.7%
131	Panniculitis, Lupus Erythematosus	6.5%
132	Foot Ulcer	6.5%
133	Ecthyma	6.5%
134	Mastocytosis	6.4%
135	Dermatitis, Phototoxic	6.3%
136	Pityriasis Lichenoides et Varioliformis Acuta	6.3%
137	Pityriasis Lichenoides	6.3%
138	Phototoxicity	6.3%
139	Xeroderma	6.2%
140	Foot-and-Mouth Disease	6.2%
141	Mycetoma	6.2%
142	HIV-Associated Lipodystrophy Syndrome	6.2%
143	Common Cold	6.1%
144	Influenza	6.1%
145	Catarrh	6.1%
146	Pseudoxanthoma Elasticum	5.9%
147	Tinea Capitis	5.9%
148	Onychomycosis	5.9%
149	Connective Tissue Diseases	5.8%
150	Lice Infestations	5.7%
151	Cutis Laxa	5.7%
152	Urticaria Pigmentosa	5.6%
153	Ectodermal Dysplasia	5.5%
154	Aplasia Cutis Congenita	5.5%
155	Lupus Erythematosus, Discoid	5.5%
156	Scleroderma, Limited	5.5%
157	Dermatitis, Photoallergic	5.5%
158	Hidradenitis Suppurativa	5.4%
159	Erythema Chronicum Migrans	5.3%
160	HIV Wasting Syndrome	5.3%
161	AIDS Dementia Complex	5.3%
162	AIDS-Associated Nephropathy	5.3%
163	Coxsackievirus Infections	5.2%
164	Rubella	5.2%
165	Coronavirus Infections	5.2%
166	Nipah Virus Infection	5.2%
167	Hydrophobia	5.2%
168	Larva Migrans	5%
169	Leishmaniasis	5%
170	Infectious Mononucleosis	4.9%
171	Onchocerciasis	4.9%
172	Anhidrosis	4.9%
173	Cholesteatoma	4.9%
174	Pressure Ulcer	4.9%
175	Folliculitis	4.9%
176	Foot Dermatoses	4.9%
177	Gynecomastia	4.9%
178	Hypertrichosis	4.9%
179	Hypohidrosis	4.9%
180	Hypotrichosis	4.9%
181	Leg Ulcer	4.9%
182	Miliaria	4.9%
183	Parakeratosis	4.9%
184	Parapsoriasis	4.9%
185	Pityriasis	4.9%
186	Psoriasis	4.9%
187	Sweet Syndrome	4.9%
188	Hidradenitis	4.9%
189	Onycholysis	4.9%
190	Miliaria Rubra	4.9%
191	Hyperpigmentation	4.9%
192	Lichenoid Eruptions	4.9%
193	Chloracne	4.9%
194	Chromoblastomycosis	4.9%
195	Dermatophytosis	4.9%
196	Sporotrichosis	4.9%
197	Tinea	4.9%
198	Tinea Versicolor	4.9%
199	Trichophytosis	4.9%
200	Hyalohyphomycosis	4.9%
201	Erythema Nodosum	4.9%
202	Dermatitis, Irritant	4.9%
203	Acne Conglobata	4.9%
204	Porcine Reproductive and Respiratory Syndrome	4.4%
205	Toxic Epidermal Necrolysis	4.4%
206	Stevens-Johnson Syndrome	4.4%
207	HTLV-I Infections	4.4%
208	Dermatitis, Occupational	4.3%
209	Candidiasis, Chronic Mucocutaneous	4.3%
210	Cutaneous Candidiasis	4.3%
211	Erysipelas	4.3%
212	Staphylococcal Skin Infections	4.3%
213	Erythrasma	4.3%
214	Measles	4.2%
215	Pleurodynia, Epidemic	4.2%
216	Respiratory Syncytial Virus Infections	4.2%
217	Granuloma Annulare	4.2%
218	Dermatitis, Allergic Contact	4.2%
219	Papillon-Lefevre Disease	4.2%
220	Acantholysis	4.2%
221	Breast Cyst	4.2%
222	Actinic keratosis	4.2%
223	Pemphigoid, Benign Mucous Membrane	4.2%
224	Pemphigus	4.2%
225	Piedra	4.2%
226	Sunburn	4.2%
227	Ichthyosis, X-Linked	4.2%
228	Sjogren-Larsson Syndrome	4.1%
229	Tinea Pedis	4.1%
230	Argyria	4.1%
231	Hirsutism	4.1%
232	Lactation Disorder	4.1%
233	Mastitis	4.1%
234	Urticaria	4.1%
235	Adiposis Dolorosa	4.1%
236	Pruritus Vulvae	4.1%
237	Mastocytoma	4.1%
238	Pruritus Ani	4.1%
239	Behcet Syndrome	4%
240	Herpes Zoster Oticus	3.9%
241	Vesicular Stomatitis	3.9%
242	Albinism	3.6%
243	Gastroenteritis, Transmissible, of Swine	3.6%
244	Severe Acute Respiratory Syndrome	3.6%
245	Mucocutaneous Lymph Node Syndrome	3.6%
246	Drug Eruptions	3.5%
247	Lipodystrophy	3.5%
248	Livedo Reticularis	3.5%
249	Malignant Atrophic Papulosis	3.5%
250	Mumps	3.5%
251	Polyarteritis Nodosa	3.5%
252	Takayasu Arteritis	3.5%
253	Blastomycosis	3.4%
254	Hyperkeratosis, Epidermolytic	3.4%
255	Poliomyelitis	3.3%
256	Leishmaniasis, Cutaneous	3.3%
257	Diaper Rash	3.2%
258	Fusariosis	3.2%
259	Rhinoscleroma	3.2%
260	Nail-Patella Syndrome	3.1%
261	Porphyrias, Hepatic	3.1%
262	Collagen Diseases	3%
263	Mixed Connective Tissue Disease	3%
264	Mucinoses	3%
265	Lichen Planus	2.9%
266	Melanosis	2.9%
267	Chloasma	2.9%
268	Pityriasis Rosea	2.9%
269	Pityriasis Rubra Pilaris	2.9%
270	Vitiligo	2.9%
271	Lichen Nitidus	2.9%
272	Staphylococcal Scalded Skin Syndrome	2.8%
273	Cartilage Diseases	2.6%
274	Rheumatism	2.6%
275	Chondromalacia	2.6%
276	Furunculosis	2.5%
277	furuncle	2.5%
278	Lupus Erythematosus, Systemic	2.5%
279	Overlap syndrome	2.5%
280	Impetigo	2.5%
281	Alopecia	2.5%
282	Sweating, Gustatory	2.5%
283	Androgenetic Alopecia	2.5%
284	Auriculotemporal Syndrome	2.5%
285	Varicose Ulcer	2.5%
286	Breast Neoplasms, Male	2.5%
287	Triple Negative Breast Neoplasms	2.5%
288	Galactorrhea	2.4%
289	Giant Cell Arteritis	2.2%
290	Temporal Arteritis	2.2%
291	Dupuytren Contracture	2.1%
292	Angioedema	2.1%
293	carbuncle	2.1%
294	Acute Generalized Exanthematous Pustulosis	2.1%
295	Acanthosis Nigricans	1.9%
296	Alopecia Areata	1.9%
297	Lentigo	1.9%
298	CREST Syndrome	1.9%
299	Cellulitis	1.9%
300	Serum Sickness	1.8%
301	Variegate Porphyria	1.8%
302	Acute intermittent porphyria	1.8%
303	Porphyria Cutanea Tarda	1.8%
304	Carcinoma, Lobular	1.8%
305	Arthritis, Psoriatic	1.8%
306	Menkes Kinky Hair Syndrome	1.7%
307	Lichen Planus, Oral	1.6%
308	Scleromyxedema	1.6%
309	Noonan Syndrome	1.5%
310	Mesenteric Panniculitis	1.4%
311	Panniculitis, Peritoneal	1.4%
312	Tietze's Syndrome	1.4%
313	Orbital Cellulitis	1.4%
314	Myxoid cyst	1.4%
315	Myxedema	1.4%
316	Marfan Syndrome	1.4%
317	Homocystinuria	1.3%
318	Angioedemas, Hereditary	1.2%
319	Diabetic Foot	1.2%
320	Osteochondritis	1.2%
321	Polymyalgia Rheumatica	1.2%
322	Osteogenesis Imperfecta	1.2%
323	Keloid	1.2%
324	Rheumatoid Arthritis	1%
325	Juvenile arthritis	1%
326	Hereditary Angioedema Type III	1%
327	Hereditary Angioedema Types I and II	1%
328	Lupus Nephritis	1%
329	Laryngomalacia	0.9%
330	Pectus carinatum	0.9%
331	Peutz-Jeghers Syndrome	0.9%
332	Rheumatoid Nodule	0.7%
333	Felty Syndrome	0.6%
334	Bronchomalacia	0.6%
335	Tracheomalacia	0.6%
336	Rheumatoid Vasculitis	0.5%
337	Lupus Vasculitis, Central Nervous System	0.5%
338	Mucopolysaccharidosis III	0.5%
339	Sicca Syndrome	0.5%
340	Sjogren's Syndrome	0.5%
341	Mucopolysaccharidosis II	0.4%

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