MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Granuloma Annulare

(UMLS:C0085074)

Definition:: Benign granulomatous disease of unknown etiology characterized by a ring of localized or disseminated papules or nodules on the skin and palisading histiocytes surrounding necrobiotic tissue resulting from altered collagen structures.
UMLS ID:: C0085074
MeSH ID:: D016460

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.300.200.495.380|C17.800.550.380

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.550.382.375

Synonym(s)

Granuloma Annulare

GA - Granuloma annulare

GRANULOMA ANNULARE

Granuloma annulare

annulare granuloma

annulare; granuloma

granuloma annulare

granuloma; annulare

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Levetiracetam	FAERS: 17		US FAERS
2	Topiramate	FAERS: 11		US FAERS
3	Teriparatide	FAERS: 7		US FAERS
4	Dimethyl Fumarate	FAERS: 4		US FAERS
5	rofecoxib	FAERS: 4		US FAERS
6	Allopurinol	FAERS: 3		US FAERS
7	Cyclosporine	FAERS: 3		US FAERS
8	Valsartan	FAERS: 3		US FAERS
9	apremilast	FAERS: 3		US FAERS
10	teriflunomide	FAERS: 3		US FAERS
11	2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol	FAERS: 2		US FAERS
12	Dasatinib	FAERS: 2		US FAERS
13	Isotretinoin	FAERS: 2		US FAERS
14	Pregabalin	FAERS: 2		US FAERS
15	Sertraline	FAERS: 2		US FAERS
16	Tamoxifen	FAERS: 2		US FAERS
17	Tolbutamide	FAERS: 2		US FAERS
18	tofacitinib	FAERS: 2		US FAERS
19	Alendronate	FAERS: 1		US FAERS
20	Amiodarone	FAERS: 1		US FAERS
21	Atorvastatin	FAERS: 1		US FAERS
22	Azithromycin	FAERS: 1		US FAERS
23	BMS201038	FAERS: 1		US FAERS
24	Benicar hct	FAERS: 1		US FAERS
25	CID 129626832	FAERS: 1		US FAERS
26	Ciprofloxacin	FAERS: 1		US FAERS
27	Dabigatran	FAERS: 1		US FAERS
28	Duloxetine Hydrochloride	FAERS: 1		US FAERS
29	Esomeprazole	FAERS: 1		US FAERS
30	Fingolimod Hydrochloride	FAERS: 1		US FAERS
31	Fluorouracil	FAERS: 1		US FAERS
32	Hydroxychloroquine	FAERS: 1		US FAERS
33	Latanoprost	FAERS: 1		US FAERS
34	Metformin	FAERS: 1		US FAERS
35	Methotrexate	FAERS: 1		US FAERS
36	Methylphenidate	FAERS: 1		US FAERS
37	Metoprolol	FAERS: 1		US FAERS
38	Minocycline	FAERS: 1		US FAERS
39	Polidocanol	FAERS: 1		US FAERS
40	Rivaroxaban	FAERS: 1		US FAERS
41	Thyroxine	FAERS: 1		US FAERS
42	Thyroxine	FAERS: 1		US FAERS
43	Zoledronic Acid	FAERS: 1		US FAERS
44	apixaban	FAERS: 1		US FAERS
45	candesartan cilexetil	FAERS: 1		US FAERS
46	insulin glulisine	FAERS: 1		US FAERS
47	ledipasvir, sofosbuvir drug combination	FAERS: 1		US FAERS
48	olaparib	FAERS: 1		US FAERS
49	Clorazepate Dipotassium			OFFSIDES
50	Dapsone		15999287	CTD OFFSIDES
51	Ibandronic Acid			OFFSIDES
52	Leflunomide			OFFSIDES
53	Mitoxantrone			OFFSIDES
54	Opipramol			OFFSIDES
55	Ribavirin			OFFSIDES
56	darifenacin			SIDER

Similar ADE(s)

	Name	Semantic Similarity
1	Necrobiosis Lipoidica Diabeticorum	37.3%
2	Lupus Erythematosus, Cutaneous	29.9%
3	Panniculitis	29.9%
4	Systemic Scleroderma	29.9%
5	Morphea	29.9%
6	Pigmentation Disorders	27.9%
7	Pyoderma Gangrenosum	24.9%
8	Nephrogenic Fibrosing Dermopathy	23.5%
9	Nephrogenic Systemic Fibrosis	23.5%
10	Granuloma, Plasma Cell	23.1%
11	Pyogenic granuloma	23.1%
12	Panniculitis, Lupus Erythematosus	22.5%
13	Acantholysis	22.1%
14	Dermatomyositis	21%
15	Cutis Laxa	20.1%
16	Acne Vulgaris	19.9%
17	Contact Dermatitis	19.9%
18	Eczema	19.9%
19	Erythema Multiforme	19.9%
20	Intertrigo	19.9%
21	Neurodermatitis	19.9%
22	Rhinophyma	19.9%
23	Perioral Dermatitis	19.9%
24	Acne	19.9%
25	Breast Diseases	19.3%
26	Dermatitis	19.3%
27	Exanthema	19.3%
28	Facial Dermatoses	19.3%
29	Hair Diseases	19.3%
30	Hand Dermatoses	19.3%
31	keratoacanthoma	19.3%
32	Keratosis	19.3%
33	Nail Diseases	19.3%
34	Photosensitivity Disorders	19.3%
35	Prurigo	19.3%
36	Pyoderma	19.3%
37	Rosacea	19.3%
38	Sebaceous Gland Diseases	19.3%
39	Skin Diseases, Vesiculobullous	19.3%
40	Skin Ulcer	19.3%
41	Sweat Gland Diseases	19.3%
42	Skin Diseases, Papulosquamous	19.3%
43	Skin Diseases, Vascular	19.3%
44	Acneiform Eruptions	19.3%
45	Ocular Rosacea	19.3%
46	Subcorneal pustular dermatosis	19.3%
47	Erythematotelangiectatic Rosacea	19.3%
48	Papulopustular Rosacea	19.3%
49	Chronic Actinic Dermatitis	19.3%
50	Granuloma, Respiratory Tract	19.3%
51	Dermatitis, Atopic	18.7%
52	Epidermolysis Bullosa	18.7%
53	Keloid	18.6%
54	Granuloma, Foreign-Body	18.5%
55	Lupus Erythematosus, Discoid	18.5%
56	Scleroderma, Limited	18.5%
57	Xeroderma Pigmentosum	18.2%
58	Pruritus	18.1%
59	Erythema	18.1%
60	Necrolytic Migratory Erythema	18.1%
61	Cutaneous Fistula	18.1%
62	Dermatitis, Phototoxic	17.9%
63	Pityriasis Lichenoides et Varioliformis Acuta	17.9%
64	Pityriasis Lichenoides	17.9%
65	Phototoxicity	17.9%
66	Mixed Connective Tissue Disease	17.6%
67	Mucinoses	17.6%
68	Foot Ulcer	17.1%
69	Pseudoxanthoma Elasticum	17%
70	Erythema Induratum	16.9%
71	Dermatitis Herpetiformis	16.8%
72	Acrodermatitis	16.6%
73	Sebaceous Gland Neoplasms	16.6%
74	Porokeratosis	16.6%
75	Gianotti-Crosti Syndrome	16.6%
76	Keratoderma, Palmoplantar	16.6%
77	Polydipsia	16.3%
78	Foot Diseases	16.1%
79	Infarction	15.9%
80	Postoperative Hemorrhage	15.9%
81	Shock, Hemorrhagic	15.9%
82	Systemic Inflammatory Response Syndrome	15.9%
83	Skin Abnormalities	15.6%
84	Skin Diseases, Infectious	15.6%
85	Skin Neoplasms	15.6%
86	Lipomatosis	15.4%
87	Dermatitis, Photoallergic	15.3%
88	Ascites	15.1%
89	Fibrosis	15.1%
90	Gliosis	15.1%
91	Growth Disorders	15.1%
92	Hemorrhage	15.1%
93	Hyperbilirubinemia	15.1%
94	Hyperplasia	15.1%
95	Hypomenorrhea	15.1%
96	Inflammation	15.1%
97	Intraoperative Complications	15.1%
98	Ischemia	15.1%
99	Lithiasis	15.1%
100	Malacoplakia	15.1%
101	Menstruation Disturbances	15.1%
102	Metaplasia	15.1%
103	Nerve Degeneration	15.1%
104	Ochronosis	15.1%
105	Polymenorrhea	15.1%
106	Postoperative Complications	15.1%
107	Sclerosis	15.1%
108	Shock	15.1%
109	Ulcer	15.1%
110	Hyperammonemia	15.1%
111	Hyperamylasemia	15.1%
112	Teratogenesis	15.1%
113	Cardiac Death	15.1%
114	Hypovolemia	15.1%
115	Hyperuricemia	15.1%
116	Leukoaraiosis	15.1%
117	Dysbacteriosis	15.1%
118	Delayed Graft Function	15.1%
119	Cirrhosis	15.1%
120	Neointima	15.1%
121	Dysbiosis	15.1%
122	Cartilage Diseases	14.7%
123	Rheumatism	14.7%
124	Chondromalacia	14.7%
125	Dermatitis, Irritant	14.4%
126	Acne Conglobata	14.4%
127	Xeroderma	14.4%
128	Cellulitis	14.3%
129	Lupus Erythematosus, Systemic	14.3%
130	Overlap syndrome	14.3%
131	Urticaria Pigmentosa	14.1%
132	Osteogenesis Imperfecta	13.9%
133	Vascular Remodeling	13.7%
134	Giant Cell Epulis	13.5%
135	Mastocytosis	12.8%
136	Extravasation of Diagnostic and Therapeutic Materials	12.6%
137	Neoplastic Processes	12.6%
138	Hirsutism	12.6%
139	Ectodermal Dysplasia	12.4%
140	Aplasia Cutis Congenita	12.4%
141	Dermatitis, Occupational	12.4%
142	Anhidrosis	12.4%
143	Cholesteatoma	12.4%
144	Pressure Ulcer	12.4%
145	Folliculitis	12.4%
146	Foot Dermatoses	12.4%
147	Gynecomastia	12.4%
148	Hypertrichosis	12.4%
149	Hypohidrosis	12.4%
150	Hypotrichosis	12.4%
151	Leg Ulcer	12.4%
152	Miliaria	12.4%
153	Parakeratosis	12.4%
154	Parapsoriasis	12.4%
155	Pityriasis	12.4%
156	Psoriasis	12.4%
157	Sweet Syndrome	12.4%
158	Hidradenitis	12.4%
159	Onycholysis	12.4%
160	Miliaria Rubra	12.4%
161	Hyperpigmentation	12.4%
162	Lichenoid Eruptions	12.4%
163	Chloracne	12.4%
164	Erythema Infectiosum	12.4%
165	Exanthema Subitum	12.3%
166	Necrosis	12.2%
167	Granulomatosis, Orofacial	12.2%
168	Respiratory Aspiration	12.2%
169	Erythema Nodosum	12.1%
170	Chromosome Aberrations	12.1%
171	Dehydration	12.1%
172	Leukocytosis	12.1%
173	Pleocytosis	12.1%
174	Dermatitis, Allergic Contact	12%
175	Toxic Epidermal Necrolysis	12%
176	Papillon-Lefevre Disease	12%
177	Stevens-Johnson Syndrome	12%
178	Sudden infant death syndrome	11.8%
179	Diaper Rash	11.7%
180	Dupuytren Contracture	11.6%
181	Eosinophilic Granuloma	11.6%
182	Menorrhagia	11.4%
183	Chromosomal Instability	11.4%
184	Alopecia	11.3%
185	Androgenetic Alopecia	11.3%
186	Tinea Capitis	11.2%
187	Onychomycosis	11.2%
188	Scleromyxedema	10.7%
189	Ecthyma	10.7%
190	Incisional hernia	10.6%
191	jaundice	10.6%
192	Livedo Reticularis	10.5%
193	Hyperkeratosis, Epidermolytic	10.4%
194	Genomic Instability	10.4%
195	Ichthyosis, X-Linked	10.1%
196	Muscle Weakness	10.1%
197	Breast Cyst	10.1%
198	Actinic keratosis	10.1%
199	Pemphigoid, Benign Mucous Membrane	10.1%
200	Pemphigus	10.1%
201	Piedra	10.1%
202	Sunburn	10.1%
203	Sjogren-Larsson Syndrome	10.1%
204	Argyria	9.9%
205	Lactation Disorder	9.9%
206	Mastitis	9.9%
207	Urticaria	9.9%
208	Acute Disease	9.9%
209	Acute-Phase Reaction	9.9%
210	Amenorrhea	9.9%
211	Chronic disease	9.9%
212	Critical Illness	9.9%
213	Sudden death	9.9%
214	Fat necrosis	9.9%
215	Gangrene	9.9%
216	Graft Occlusion, Vascular	9.9%
217	Hematoma	9.9%
218	Iatrogenic Disease	9.9%
219	Multiple Organ Failure	9.9%
220	Oligomenorrhea	9.9%
221	Premenstrual syndrome	9.9%
222	Recurrence	9.9%
223	Retrograde Degeneration	9.9%
224	Retroperitoneal fibrosis	9.9%
225	Serositis	9.9%
226	Subcutaneous Emphysema	9.9%
227	Surgical Wound Dehiscence	9.9%
228	Syndrome	9.9%
229	Wallerian Degeneration	9.9%
230	Exsanguination	9.9%
231	Azotemia	9.9%
232	Disease Progression	9.9%
233	Seroma	9.9%
234	Premenstrual Tension	9.9%
235	Delayed Emergence from Anesthesia	9.9%
236	Infant Death	9.9%
237	Anastomotic Leak	9.9%
238	Intraoperative Awareness	9.9%
239	Adiposis Dolorosa	9.9%
240	Pain, Postoperative	9.9%
241	Pruritus Vulvae	9.9%
242	Mastocytoma	9.8%
243	Pruritus Ani	9.8%
244	Postoperative Nausea and Vomiting	9.8%
245	Behcet Syndrome	9.6%
246	Dysmenorrhea	9.5%
247	Failed Back Surgery Syndrome	9.5%
248	Tinea Pedis	9.3%
249	Eye Hemorrhage	9.1%
250	Lichen Planus	9%
251	Melanosis	9%
252	Chloasma	9%
253	Pityriasis Rosea	9%
254	Pityriasis Rubra Pilaris	9%
255	Vitiligo	9%
256	Hidradenitis Suppurativa	9%
257	Lichen Nitidus	9%
258	Endotoxic shock	9%
259	Septic Shock	9%
260	Toxic Shock Syndrome	9%
261	Hemoptysis	8.9%
262	Granuloma, Laryngeal	8.9%
263	Ecchymosis	8.8%
264	Petechiae	8.8%
265	Purpura	8.8%
266	Cardiotoxicity	8.7%
267	Mesenteric Panniculitis	8.7%
268	Panniculitis, Peritoneal	8.7%
269	Tietze's Syndrome	8.7%
270	Orbital Cellulitis	8.7%
271	Myxoid cyst	8.7%
272	Connective Tissue Diseases	8.7%
273	Signs and Symptoms	8.7%
274	Pathological Conditions, Anatomical	8.7%
275	Albinism	8.6%
276	Myxedema	8.6%
277	Erythema Chronicum Migrans	8.5%
278	Chromosome Fragility	8.4%
279	Dermatomycoses	8.4%
280	Mucocutaneous Lymph Node Syndrome	8.4%
281	Skin Diseases, Bacterial	8.4%
282	Drug Eruptions	8.3%
283	Lipodystrophy	8.3%
284	Malignant Atrophic Papulosis	8.3%
285	Asphyxia	8.3%
286	Shock, Traumatic	8.3%
287	Polyarteritis Nodosa	8.2%
288	Takayasu Arteritis	8.2%
289	Disease susceptibility	8.1%
290	Fetal Death	8.1%
291	Foreign-Body Reaction	8.1%
292	Gastrointestinal Hemorrhage	8.1%
293	Hemarthrosis	8.1%
294	Hemoperitoneum	8.1%
295	Hemothorax	8.1%
296	Neoplasm Invasiveness	8.1%
297	Neoplasm Metastasis	8.1%
298	Neoplasm Recurrence, Local	8.1%
299	Postpericardiotomy Syndrome	8.1%
300	Prosthesis Failure	8.1%
301	Reperfusion Injury	8.1%
302	Injection Site Reaction	8.1%
303	Retrobulbar Hemorrhage	8.1%
304	Aseptic Necrosis of Bone	8.1%
305	Peritoneal Fibrosis	8.1%
306	Carcinogenesis	8.1%
307	Neurogenic Inflammation	8.1%
308	Perinatal death	8.1%
309	Infusion site reaction	8.1%
310	Corneal Endothelial Cell Loss	8.1%
311	Encapsulating Peritoneal Sclerosis	8.1%
312	Vasoplegia	8.1%
313	Suppuration	8.1%
314	Metastasis	8.1%
315	Sinus Arrhythmia	7.9%
316	Atrial Fibrillation	7.9%
317	Atrial Flutter	7.9%
318	Dental Pulp Necrosis	7.9%
319	Mediastinal Emphysema	7.9%
320	Surgical Wound Infection	7.9%
321	Ventricular Fibrillation	7.9%
322	Ventricular Flutter	7.9%
323	Parasystole	7.9%
324	Paroxysmal atrial fibrillation	7.9%
325	Facies	7.9%
326	Bradycardia	7.9%
327	Embryo Loss	7.9%
328	Afferent Loop Syndrome	7.9%
329	Sex Chromosome Aberrations	7.9%
330	Short Bowel Syndrome	7.9%
331	Uterine hemorrhage	7.9%
332	No-Reflow Phenomenon	7.9%
333	Jaundice, Obstructive	7.8%
334	Noonan Syndrome	7.7%
335	Epistaxis	7.7%
336	Tissue Adhesions	7.4%
337	Hematoma, Epidural, Spinal	7.4%
338	Acanthosis Nigricans	7.3%
339	Alopecia Areata	7.3%
340	Lentigo	7.3%
341	Osteochondritis	7.3%
342	Polymyalgia Rheumatica	7.3%
343	Sweating, Gustatory	7.3%
344	Auriculotemporal Syndrome	7.3%
345	Sick Sinus Syndrome	7.3%
346	Trisomy	7.3%
347	Nail-Patella Syndrome	7.2%
348	Lice Infestations	7.2%
349	Varicose Ulcer	7.2%
350	Breast Neoplasms, Male	7.2%
351	Triple Negative Breast Neoplasms	7.2%
352	CREST Syndrome	7.2%
353	Galactorrhea	7.2%
354	Mycetoma	7.2%
355	Porphyrias, Hepatic	7.2%
356	Marfan Syndrome	7%
357	Drowning	6.9%
358	Homocystinuria	6.9%
359	Fetal Growth Retardation	6.7%
360	DNA Degradation, Necrotic	6.7%
361	Aneuploidy	6.7%
362	Polyploidy	6.7%
363	Microsatellite Instability	6.7%
364	Heart Block	6.6%
365	Tachycardia	6.6%
366	Tachyarrhythmia	6.6%
367	Cicatrix	6.6%
368	Hematuria	6.6%
369	Chromosome Breakage	6.6%
370	Brain Death	6.6%
371	Hematemesis	6.6%
372	Shock, Cardiogenic	6.6%
373	Purpura Fulminans	6.5%
374	Hematoma, Subdural	6.5%
375	Hematoma, Epidural, Cranial	6.5%
376	Rheumatoid Arthritis	6.3%
377	Juvenile arthritis	6.3%
378	Hematoma, Subdural, Spinal	6.1%
379	Larva Migrans	6.1%
380	Leishmaniasis	6.1%
381	Molluscum Contagiosum	6.1%
382	Angioedema	6.1%
383	Lupus Nephritis	6.1%
384	Onchocerciasis	6.1%
385	Chromoblastomycosis	6%
386	Dermatophytosis	6%
387	Sporotrichosis	6%
388	Tinea	6%
389	Tinea Versicolor	6%
390	Trichophytosis	6%
391	Hyalohyphomycosis	6%
392	Cross Infection	6%
393	Hyphema	6%
394	Retinal Neovascularization	6%
395	Septicemia	6%
396	Vitreous Hemorrhage	6%
397	Sepsis	6%
398	Lichen Planus, Oral	6%
399	Acute Generalized Exanthematous Pustulosis	6%
400	Abscess	5.9%
401	Empyema	5.9%
402	Femur Head Necrosis	5.9%
403	Fetal Resorption	5.9%
404	Lymphatic Metastasis	5.9%
405	Neoplasms, Unknown Primary	5.9%
406	Peptic Ulcer Hemorrhage	5.9%
407	Sudden Cardiac Death	5.9%
408	Leukemic Infiltration	5.9%
409	Premenstrual Dysphoric Disorder	5.9%
410	Choroidal Neovascularization	5.9%
411	Primary Graft Dysfunction	5.9%
412	Neoplasm Micrometastasis	5.9%
413	Dumping Syndrome	5.9%
414	Cicatrix, Hypertrophic	5.9%
415	Sinus Arrest, Cardiac	5.9%
416	Metrorrhagia	5.9%
417	Phantom pain	5.7%
418	Phantom Limb Pain	5.7%
419	Long QT Syndrome	5.7%
420	Micronuclei, Chromosome-Defective	5.6%
421	Laryngomalacia	5.5%
422	Pectus carinatum	5.5%
423	Hematoma, Subdural, Intracranial	5.3%
424	Hematoma, Subdural, Chronic	5.3%
425	Hematoma, Subdural, Acute	5.3%
426	Warts	5.3%
427	Candidiasis, Chronic Mucocutaneous	5.2%
428	Cutaneous Candidiasis	5.2%
429	Erysipelas	5.1%
430	Serum Sickness	5.1%
431	Staphylococcal Skin Infections	5.1%
432	Variegate Porphyria	5.1%
433	Acute intermittent porphyria	5.1%
434	Porphyria Cutanea Tarda	5.1%
435	Erythrasma	5.1%
436	Carcinoma, Lobular	5.1%
437	Viremia	5.1%
438	Parasitemia	5.1%
439	Arthritis, Psoriatic	5.1%
440	Retinal Hemorrhage	5.1%
441	Asthenia	5%
442	Body Temperature Changes	5%
443	Calculi	5%
444	Collagen Diseases	5%
445	Cyanosis	5%
446	Edema	5%
447	Failure to Thrive	5%
448	Fatigue	5%
449	Feminization	5%
450	Fetal Distress	5%
451	Hernia	5%
452	Hypertrophy	5%
453	Motion Sickness	5%
454	Nails, Malformed	5%
455	polyps	5%
456	Rupture, Spontaneous	5%
457	Signs and Symptoms, Digestive	5%
458	Signs and Symptoms, Respiratory	5%
459	Skin Manifestations	5%
460	Chills	5%
461	Lassitude	5%
462	Enterocele	5%
463	Atheroma	5%
464	Pseudophakia	5%
465	Urological Manifestations	5%
466	Stenosis	5%
467	Facial asymmetry	5%
468	Mobility Limitation	5%
469	Somnolence	5%
470	Plaque, Amyloid	5%
471	Plaque, Atherosclerotic	5%
472	Subacute Combined Degeneration	5%
473	Thrombocytopenic purpura	5%
474	Choroid Hemorrhage	5%
475	Melena	5%
476	Postpartum Hemorrhage	4.9%
477	Gingival Hemorrhage	4.9%
478	Rheumatoid Nodule	4.9%
479	Leishmaniasis, Cutaneous	4.9%
480	Monosomy	4.9%
481	Tetraploidy	4.9%
482	Stillbirth	4.9%
483	Eczema Herpeticum	4.9%
484	Purpura, Hyperglobulinemic	4.9%
485	Giant Cell Arteritis	4.9%
486	Temporal Arteritis	4.9%
487	Adams-Stokes Syndrome	4.9%
488	Atrioventricular Block	4.9%
489	Bundle-Branch Block	4.9%
490	Atrial Premature Complexes	4.9%
491	Sinoatrial Block	4.9%
492	Tachycardia, Paroxysmal	4.9%
493	Supraventricular tachycardia	4.9%
494	Tachycardia, Ventricular	4.9%
495	Tachycardia, Reciprocating	4.9%
496	Subarachnoid Hemorrhage	4.9%
497	Cerebral Hemorrhage	4.9%
498	Fusariosis	4.9%
499	Abdominal Pain	4.6%
500	Kernicterus	4.4%
501	Hereditary Angioedema Type III	4.3%
502	Hereditary Angioedema Types I and II	4.3%
503	Angioedemas, Hereditary	4.2%
504	Renal Colic	4.2%
505	Felty Syndrome	4.2%
506	Bronchomalacia	4.2%
507	Tracheomalacia	4.2%
508	Epidermodysplasia Verruciformis	4.2%
509	Herpes Labialis	4.2%
510	Cyst	4.2%
511	Eye Manifestations	4.2%
512	Neurologic Manifestations	4.2%
513	Diabetic Foot	4.2%
514	Romano-Ward Syndrome	4.2%
515	Staphylococcal Scalded Skin Syndrome	4.2%
516	Bacteremia	4.2%
517	Cell Transformation, Viral	4.1%
518	Fungemia	4.1%
519	Leukoplakia	4.1%
520	Cardiac Output, High	4.1%
521	Myocardial Stunning	4.1%
522	Reticulocytosis	4.1%
523	Low Cardiac Output Syndrome	4.1%
524	Airway Remodeling	4.1%
525	Purpura, Thrombotic Thrombocytopenic	4%
526	Tachycardia, Atrioventricular Nodal Reentry	4%
527	Tachycardia, Ectopic Atrial	4%
528	Tachycardia, Ectopic Junctional	4%
529	Sinus Tachycardia	4%
530	Torsades de Pointes	4%
531	Accelerated Idioventricular Rhythm	4%
532	Blastomycosis	4%
533	Ventricular Remodeling	4%
534	Intermittent Claudication	4%
535	HIV-Associated Lipodystrophy Syndrome	4%
536	Eye pain	3.9%
537	Muscular Atrophy	3.8%
538	Peutz-Jeghers Syndrome	3.8%
539	Menkes Kinky Hair Syndrome	3.7%
540	Myocardial Reperfusion Injury	3.7%
541	Condylomata Acuminata	3.7%
542	Rheumatoid Vasculitis	3.7%
543	Rhinoscleroma	3.7%
544	Furunculosis	3.7%
545	furuncle	3.7%
546	carbuncle	3.7%
547	Endotoxemia	3.7%
548	Impetigo	3.6%
549	Mucopolysaccharidosis III	3.6%
550	Abdomen, Acute	3.6%
551	Hypergammaglobulinemia	3.4%
552	Diverticulum	3.3%
553	Diverticulosis	3.3%
554	Anorexia	3.3%
555	Anoxia	3.3%
556	Constipation	3.3%
557	Diarrhea	3.3%
558	Dyspepsia	3.3%
559	Eructation	3.3%
560	Fever	3.3%
561	Flatulence	3.3%
562	Flushing	3.3%
563	Halitosis	3.3%
564	Heartburn	3.3%
565	Diaphragmatic Hernia	3.3%
566	Hiccough	3.3%
567	Hypercalciuria	3.3%
568	Hypercapnia	3.3%
569	Hyperphagia	3.3%
570	Intestinal Polyps	3.3%
571	Nausea	3.3%
572	Pallor	3.3%
573	Psychophysiologic Disorders	3.3%
574	Splenomegaly	3.3%
575	Vomiting	3.3%
576	Hypocapnia	3.3%
577	Dyschezia	3.3%
578	Hypoxia	3.3%
579	Hyperoxia	3.3%
580	Lower Urinary Tract Symptoms	3.3%
581	Hypoxemia	3.3%
582	Urinoma	3.3%
583	Autoimmune thrombocytopenia	3.3%
584	Immune thrombocytopenic purpura	3.3%
585	Granuloma Annulare	3.3%
586	Sicca Syndrome	3.3%
587	Sjogren's Syndrome	3.3%
588	Waterhouse-Friderichsen Syndrome	3.2%
589	Philadelphia Chromosome	3.2%
590	Lupus Vasculitis, Central Nervous System	3%
591	Sarcopenia	3%
592	Respiratory Tract Fistula	2.8%
593	Candidemia	2.7%
594	Apnea	2.7%
595	Cheyne-Stokes Respiration	2.7%
596	Decerebrate State	2.7%
597	Dyspnea	2.7%
598	Cardiomegaly	2.7%
599	Hemiparesis	2.7%
600	Hepatomegaly	2.7%
601	Hyperventilation	2.7%
602	Meningism	2.7%
603	Mouth Breathing	2.7%
604	Paresis	2.7%
605	Parovarian Cyst	2.7%
606	Seizures	2.7%
607	Sensation Disorders	2.7%
608	Sneezing	2.7%
609	Spermatocele	2.7%
610	Oral Fistula	2.7%
611	Complex partial seizures	2.7%
612	Tachypnea	2.7%
613	Monoparesis	2.7%
614	Gait Disorders, Neurologic	2.7%
615	Neuromuscular Manifestations	2.7%
616	Cardiac Hypertrophy	2.7%
617	Basal Ganglia Hemorrhage	2.7%
618	Edema, Cardiac	2.6%
619	Mental Fatigue	2.6%
620	Orthostatic intolerance	2.6%
621	Hypoventilation	2.6%
622	Mucopolysaccharidosis II	2.6%
623	Vaginal Fistula	2.6%
624	Rectocele	2.6%
625	Body Weight Changes	2.6%
626	Hoarseness	2.6%
627	Gait Ataxia	2.6%
628	Body Weight	2.5%
629	Back Pain	2.5%
630	Bulimia	2.5%
631	Neck Pain	2.5%
632	Chest Pain	2.5%
633	Colonic Polyps	2.5%
634	Dizziness	2.5%
635	Dysuria	2.5%
636	Facial Pain	2.5%
637	Fever of Unknown Origin	2.5%
638	Flank Pain	2.5%
639	Headache	2.5%
640	Nocturia	2.5%
641	Pain, Intractable	2.5%
642	Pelvic Pain	2.5%
643	Snoring	2.5%
644	Chronic pain	2.5%
645	Lightheadedness	2.5%
646	Pain, Referred	2.5%
647	Prostatism	2.5%
648	Throbbing Headache	2.5%
649	Labor Pain	2.5%
650	Cancer Pain	2.5%
651	Nociceptive Pain	2.5%
652	Putaminal Hemorrhage	2.4%
653	Sleep Wake Disorders	2.4%
654	Pupil Disorders	2.3%
655	Neurobehavioral Manifestations	2.3%
656	Nasal Polyps	2.3%
657	Akathisia	2.2%
658	Restlessness	2.2%
659	Psychomotor Agitation	2.2%
660	Pleural Rub	2.2%
661	Rales	2.2%
662	Respiratory Sounds	2.2%
663	Rhonchi	2.2%
664	Stridor	2.2%
665	Wheezing	2.2%
666	Asterixis	2.2%
667	Ballismus	2.2%
668	Vertigo	2.2%
669	Vesicovaginal Fistula	2.2%
670	Pain	2.2%
671	Ache	2.2%
672	Meningocele	2.2%
673	Oliguria	2.2%
674	Polyuria	2.2%
675	Proteinuria	2.2%
676	Urinary Calculi	2.2%
677	Encephalocele	2.2%
678	Underweight	2.2%
679	Overweight	2.2%
680	Gait Apraxia	2.1%
681	Emaciation	2%
682	Low Back Pain	2%
683	Visceral Pain	2%
684	Biliary Fistula	2%
685	Gastric Fistula	2%
686	Congenital diaphragmatic hernia	2%
687	Morning Sickness	2%
688	Anosmia	2%
689	Ataxia	2%
690	Athetosis	2%
691	Catalepsy	2%
692	Dental Fistula	2%
693	Dystonia	2%
694	Hemiplegia	2%
695	Locked-In Syndrome	2%
696	Muscle Hypertonia	2%
697	Muscle hypotonia	2%
698	Myoclonus	2%
699	Myotonia	2%
700	Neuralgia	2%
701	Oroantral Fistula	2%
702	Paraplegia	2%
703	Pseudobulbar Palsy	2%
704	Quadriplegia	2%
705	Spasm	2%
706	Spastic Paraplegia	2%
707	Status Epilepticus	2%
708	Taste Disorders	2%
709	Tremor	2%
710	Monoplegia	2%
711	Hypokinesia	2%
712	Left Ventricular Hypertrophy	2%
713	Gastroparesis	2%
714	Right Ventricular Hypertrophy	2%
715	Paraparesis	2%
716	Bradykinesia	2%
717	Waxy flexibility	2%
718	Action Tremor	2%
719	Resting Tremor	2%
720	Dysosmia	2%
721	Quadriparesis	2%
722	Olfaction Disorders	2%
723	Myokymia	2%
724	Somatosensory Disorders	2%
725	Neuropathic pain	2%
726	Hyperkinesia	2%
727	Intention tremor	2%
728	Rectal Prolapse	2%
729	Uterine Prolapse	2%
730	Vaginal Prolapse	2%
731	Voice Disorders	2%
732	Weight Gain	2%
733	Voice Disturbance	2%
734	Gagging	1.9%
735	Leukoplakia, Oral	1.9%
736	Cachexia	1.8%
737	Alexia	1.8%
738	Dyslexia	1.8%
739	Alice in Wonderland Syndrome	1.8%
740	Vision Disorders	1.7%
741	Metamorphopsia	1.7%
742	Visual Impairment	1.7%
743	Bronchial Fistula	1.7%
744	Metatarsalgia	1.7%
745	Pancreatic Fistula	1.7%
746	Anisocoria	1.7%
747	Confusion	1.7%
748	Facial paralysis	1.7%
749	Intestinal Fistula	1.7%
750	Lethargy	1.7%
751	Memory Disorders	1.7%
752	Muscle Cramp	1.7%
753	Perceptual Disorders	1.7%
754	Psychomotor Disorders	1.7%
755	Tonic Pupil	1.7%
756	Anhedonia	1.7%
757	Disorientation	1.7%
758	Gastroschisis	1.7%
759	Enterocutaneous Fistula	1.7%
760	Fetal Hypoxia	1.7%
761	Facial Paresis	1.7%
762	Memory Loss	1.7%
763	Hemisensory Neglect	1.7%
764	Dysacusis	1.7%
765	Umbilical hernia	1.7%
766	Toothache	1.7%
767	Jet Lag Syndrome	1.7%
768	Reflex, Abnormal	1.7%
769	Hyporeflexia	1.7%
770	Hyperreflexia	1.7%
771	Dyspnea, Paroxysmal	1.6%
772	Mastodynia	1.6%
773	Respiratory Paralysis	1.6%
774	Salivary Gland Fistula	1.6%
775	Chorea	1.6%
776	Cystocele	1.6%
777	Hyperemesis Gravidarum	1.6%
778	Tetany	1.6%
779	Urinary Incontinence	1.6%
780	Breakthrough Pain	1.6%
781	Dysgeusia	1.6%
782	Formication	1.6%
783	Hyperalgesia	1.6%
784	Hyperesthesia	1.6%
785	Hypesthesia	1.6%
786	Language Disorders	1.6%
787	Numbness	1.6%
788	Paresthesia	1.6%
789	Paraparesis, Spastic	1.6%
790	Trismus	1.6%
791	Epilepsia Partialis Continua	1.6%
792	Hypogeusia	1.6%
793	Brown-Sequard Syndrome	1.6%
794	Lockjaw	1.6%
795	Allodynia	1.6%
796	Ageusia	1.6%
797	Albuminuria	1.6%
798	Hemoglobinuria	1.6%
799	Birth Weight	1.6%
800	Agraphia	1.5%
801	Anomia	1.5%
802	Cluttering	1.5%
803	Language Development Disorders	1.5%
804	Speech Disorders	1.5%
805	Syncope	1.5%
806	Stupor	1.5%
807	Dysgraphia	1.5%
808	Presyncope	1.5%
809	Dyslalia	1.5%
810	Consciousness Disorders	1.4%
811	Mental Retardation	1.4%
812	Depressed Level of Consciousness	1.4%
813	Mental deficiency	1.4%
814	Intellectual Disability	1.4%
815	Catatonia	1.4%
816	Musculoskeletal Pain	1.4%
817	Ophthalmoplegia	1.4%
818	External Ophthalmoplegia	1.4%
819	Aphonia	1.4%
820	Arthralgia	1.4%
821	Sleep Deprivation	1.4%
822	Polyarthralgia	1.4%
823	Dysphonia	1.4%
824	Cerebrospinal Fluid Otorrhea	1.4%
825	Cerebrospinal Fluid Rhinorrhea	1.4%
826	Obesity	1.4%
827	Diplopia	1.4%
828	Muscle Rigidity	1.4%
829	Muscle Spasticity	1.4%
830	Scotoma	1.4%
831	Photophobia	1.4%
832	Cogwheel Rigidity	1.4%
833	Hemifacial Spasm	1.4%
834	Amaurosis	1.4%
835	Blindness	1.4%
836	Nuchal Rigidity	1.4%
837	Aphasia	1.4%
838	Articulation Disorders	1.4%
839	Echolalia	1.4%
840	Stuttering	1.4%
841	Dysphasia	1.4%
842	Angina Pectoris	1.4%
843	Agnosia	1.4%
844	Apraxias	1.4%
845	Hallucinations	1.4%
846	Hemianopsia	1.4%
847	Hyperacusis	1.4%
848	Tinnitus	1.4%
849	Visual Agnosia	1.4%
850	Anosognosia	1.4%
851	Wernicke-Korsakoff Syndrome	1.4%
852	Phonophobia	1.4%
853	Hearing Loss	1.4%
854	Cerebellar Ataxia	1.4%
855	Torticollis	1.4%
856	Sciatica	1.4%
857	Urge Incontinence	1.4%
858	Tardive Dyskinesia	1.4%
859	Dysarthria	1.3%
860	Hydrops Fetalis	1.3%
861	Fetal Weight	1.3%
862	Vocal Cord Paralysis	1.3%
863	Urinary Bladder Fistula	1.2%
864	Amaurosis Fugax	1.2%
865	Blindness, Cortical	1.2%
866	Dyscalculia	1.2%
867	Angina, Unstable	1.2%
868	Deafness	1.2%
869	Hearing Loss, Sudden	1.2%
870	Gerstmann Syndrome	1.2%
871	Hearing Loss, Bilateral	1.2%
872	Hearing Loss, High-Frequency	1.2%
873	Hearing Loss, Mixed Conductive-Sensorineural	1.2%
874	Prosopagnosia	1.2%
875	Apraxia, Ideomotor	1.2%
876	Persistent Vegetative State	1.2%
877	Charles Bonnet Syndrome	1.2%
878	Hearing Loss, Unilateral	1.2%
879	Complete Hearing Loss	1.2%
880	Alien Hand Syndrome	1.2%
881	Deaf Mutism	1.2%
882	Amblyopia	1.2%
883	Amnesia	1.2%
884	Delirium	1.2%
885	Horner Syndrome	1.2%
886	Dissociative Amnesia	1.2%
887	Color blindness	1.2%
888	Global Amnesia	1.2%
889	Rectal Fistula	1.2%
890	Anal Fistula	1.2%
891	Mutism	1.2%
892	Selective Mutism	1.2%
893	Shoulder Pain	1.2%
894	Pediatric Obesity	1.2%
895	Angina Pectoris, Variant	1.1%
896	Alexia, Pure	1.1%
897	Dyskinesia, Drug-Induced	1.1%
898	Alcohol Withdrawal Seizures	1.1%
899	Arteriovenous fistula	1.1%
900	Akathisia, Drug-Induced	1%
901	Retrograde amnesia	1%
902	Amnesia, Anterograde	1%
903	Myalgia	1%
904	Kidney Calculi	1%
905	Ureteral Calculi	1%
906	Amnesia, Transient Global	0.9%
907	Auditory Perceptual Disorders	0.9%
908	Ophthalmoplegic Migraine	0.8%
909	Progressive supranuclear palsy	0.8%
910	Kearns-Sayre syndrome	0.6%

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