MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Necrolytic Migratory Erythema

(UMLS:C0221243)

Definition:: Recurrent cutaneous manifestation of GLUCAGONOMA characterized by necrolytic polycyclic migratory lesions with scaling borders. It is associated with elevated secretion of GLUCAGON by the tumor. Other conditions with elevated serum glucagon levels such as HEPATIC CIRRHOSIS may also result in similar skin lesions, which are referred to as pseudoglucagonoma syndrome.
UMLS ID:: C0221243
MeSH ID:: D058568

Classification 1:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.551

Classification 2:

Name:

Pathological Conditions, Signs and Symptoms
MeSH Tree Number(s):: C23.888.885.468

Synonym(s)

Necrolytic Migratory Erythema

Necrolytic migratory erythema

necrolytic migratory erythema

Associated Drug(s)

	Name	Number of Reports	Data Source
1	Everolimus	FAERS: 1	US FAERS
2	GlucaGen	FAERS: 1	US FAERS
3	Octreotide	FAERS: 1	US FAERS

Similar ADE(s)

	Name	Semantic Similarity
1	Pruritus	44.8%
2	Erythema	44.8%
3	Pyoderma Gangrenosum	36.5%
4	Flushing	31.8%
5	Pallor	31.8%
6	Livedo Reticularis	31.1%
7	Acne Vulgaris	30.5%
8	Contact Dermatitis	30.5%
9	Eczema	30.5%
10	Erythema Multiforme	30.5%
11	Intertrigo	30.5%
12	Neurodermatitis	30.5%
13	Rhinophyma	30.5%
14	Perioral Dermatitis	30.5%
15	Acne	30.5%
16	Dermatitis, Phototoxic	29.8%
17	Pityriasis Lichenoides et Varioliformis Acuta	29.8%
18	Pityriasis Lichenoides	29.8%
19	Phototoxicity	29.8%
20	Lupus Erythematosus, Cutaneous	28.1%
21	Panniculitis	28.1%
22	Systemic Scleroderma	28.1%
23	Morphea	28.1%
24	Breast Diseases	27.9%
25	Dermatitis	27.9%
26	Exanthema	27.9%
27	Facial Dermatoses	27.9%
28	Hair Diseases	27.9%
29	Hand Dermatoses	27.9%
30	keratoacanthoma	27.9%
31	Keratosis	27.9%
32	Nail Diseases	27.9%
33	Photosensitivity Disorders	27.9%
34	Prurigo	27.9%
35	Pyoderma	27.9%
36	Rosacea	27.9%
37	Sebaceous Gland Diseases	27.9%
38	Skin Diseases, Vesiculobullous	27.9%
39	Skin Ulcer	27.9%
40	Sweat Gland Diseases	27.9%
41	Skin Diseases, Papulosquamous	27.9%
42	Skin Diseases, Vascular	27.9%
43	Acneiform Eruptions	27.9%
44	Ocular Rosacea	27.9%
45	Subcorneal pustular dermatosis	27.9%
46	Erythematotelangiectatic Rosacea	27.9%
47	Papulopustular Rosacea	27.9%
48	Chronic Actinic Dermatitis	27.9%
49	Foot Ulcer	27.7%
50	jaundice	27.1%
51	Pigmentation Disorders	26.3%
52	Dermatitis, Atopic	26%
53	Epidermolysis Bullosa	26%
54	Hirsutism	25.4%
55	Dermatitis, Irritant	25%
56	Acne Conglobata	25%
57	Dermatitis, Photoallergic	24.7%
58	Dermatitis Herpetiformis	24.7%
59	Panniculitis, Lupus Erythematosus	24.4%
60	Acrodermatitis	24.3%
61	Sebaceous Gland Neoplasms	24.3%
62	Xeroderma Pigmentosum	24.3%
63	Porokeratosis	24.3%
64	Gianotti-Crosti Syndrome	24.3%
65	Keratoderma, Palmoplantar	24.3%
66	Cutaneous Fistula	24.1%
67	Nephrogenic Fibrosing Dermopathy	24.1%
68	Nephrogenic Systemic Fibrosis	24.1%
69	Tinea Pedis	23.1%
70	Necrobiosis Lipoidica Diabeticorum	22.9%
71	Diaper Rash	22.3%
72	Urticaria Pigmentosa	21.9%
73	Foot Diseases	21.8%
74	Ecchymosis	21.6%
75	Petechiae	21.6%
76	Purpura	21.6%
77	Skin Abnormalities	21.1%
78	Skin Diseases, Infectious	21.1%
79	Skin Neoplasms	21.1%
80	Polydipsia	21.1%
81	Asthenia	20.9%
82	Body Temperature Changes	20.9%
83	Cyanosis	20.9%
84	Edema	20.9%
85	Failure to Thrive	20.9%
86	Fatigue	20.9%
87	Feminization	20.9%
88	Fetal Distress	20.9%
89	Motion Sickness	20.9%
90	Signs and Symptoms, Digestive	20.9%
91	Signs and Symptoms, Respiratory	20.9%
92	Chills	20.9%
93	Lassitude	20.9%
94	Pseudophakia	20.9%
95	Urological Manifestations	20.9%
96	Mobility Limitation	20.9%
97	Somnolence	20.9%
98	Dermatitis, Occupational	20.8%
99	Acantholysis	20.7%
100	Lipomatosis	20.7%
101	Anhidrosis	20.5%
102	Cholesteatoma	20.5%
103	Pressure Ulcer	20.5%
104	Folliculitis	20.5%
105	Foot Dermatoses	20.5%
106	Gynecomastia	20.5%
107	Hypertrichosis	20.5%
108	Hypohidrosis	20.5%
109	Hypotrichosis	20.5%
110	Leg Ulcer	20.5%
111	Miliaria	20.5%
112	Parakeratosis	20.5%
113	Parapsoriasis	20.5%
114	Pityriasis	20.5%
115	Psoriasis	20.5%
116	Xeroderma	20.5%
117	Sweet Syndrome	20.5%
118	Hidradenitis	20.5%
119	Onycholysis	20.5%
120	Miliaria Rubra	20.5%
121	Hyperpigmentation	20.5%
122	Lichenoid Eruptions	20.5%
123	Chloracne	20.5%
124	Lupus Erythematosus, Discoid	20.3%
125	Scleroderma, Limited	20.3%
126	Erythema Induratum	20.3%
127	Jaundice, Obstructive	20%
128	Dermatitis, Allergic Contact	20%
129	Papillon-Lefevre Disease	19.9%
130	Erythema Infectiosum	18.6%
131	Exanthema Subitum	18.5%
132	Toxic Epidermal Necrolysis	18.5%
133	Stevens-Johnson Syndrome	18.5%
134	Erythema Nodosum	18.2%
135	Dermatomyositis	18.1%
136	Granuloma Annulare	18.1%
137	Alopecia	17.9%
138	Androgenetic Alopecia	17.9%
139	Cutis Laxa	17.8%
140	Abdominal Pain	17.6%
141	Ectodermal Dysplasia	17.3%
142	Tinea Capitis	17.3%
143	Onychomycosis	17.3%
144	Aplasia Cutis Congenita	17.3%
145	Hyperkeratosis, Epidermolytic	17.1%
146	Lichen Planus	16.9%
147	Melanosis	16.9%
148	Chloasma	16.9%
149	Pityriasis Rosea	16.9%
150	Pityriasis Rubra Pilaris	16.9%
151	Vitiligo	16.9%
152	Lichen Nitidus	16.9%
153	Pseudoxanthoma Elasticum	16.5%
154	Eye Manifestations	16.4%
155	Neurologic Manifestations	16.4%
156	Mastocytosis	16.3%
157	Purpura Fulminans	15.9%
158	Cardiac Output, High	15.8%
159	Myocardial Stunning	15.8%
160	Reticulocytosis	15.8%
161	Low Cardiac Output Syndrome	15.8%
162	Ecthyma	15.6%
163	Breast Cyst	15.5%
164	Actinic keratosis	15.5%
165	Pemphigoid, Benign Mucous Membrane	15.5%
166	Pemphigus	15.5%
167	Piedra	15.5%
168	Sunburn	15.5%
169	Intermittent Claudication	15.4%
170	Argyria	15.3%
171	Lactation Disorder	15.3%
172	Mastitis	15.3%
173	Urticaria	15.3%
174	Adiposis Dolorosa	15.1%
175	Pruritus Vulvae	15.1%
176	Acanthosis Nigricans	15.1%
177	Alopecia Areata	15.1%
178	Lentigo	15.1%
179	Renal Colic	15.1%
180	Mastocytoma	15.1%
181	Pruritus Ani	15.1%
182	Postoperative Nausea and Vomiting	14.7%
183	Connective Tissue Diseases	14.6%
184	Ichthyosis, X-Linked	14.4%
185	Sjogren-Larsson Syndrome	14.3%
186	Eye pain	14.3%
187	Hidradenitis Suppurativa	14.2%
188	Behcet Syndrome	13.8%
189	Abdomen, Acute	13.7%
190	Anorexia	13.6%
191	Anoxia	13.6%
192	Constipation	13.6%
193	Diarrhea	13.6%
194	Dyspepsia	13.6%
195	Eructation	13.6%
196	Fever	13.6%
197	Flatulence	13.6%
198	Halitosis	13.6%
199	Heartburn	13.6%
200	Hiccough	13.6%
201	Hypercalciuria	13.6%
202	Hypercapnia	13.6%
203	Hyperphagia	13.6%
204	Nausea	13.6%
205	Psychophysiologic Disorders	13.6%
206	Vomiting	13.6%
207	Hypocapnia	13.6%
208	Dyschezia	13.6%
209	Hypoxia	13.6%
210	Hyperoxia	13.6%
211	Lower Urinary Tract Symptoms	13.6%
212	Hypoxemia	13.6%
213	Urinoma	13.6%
214	Sweating, Gustatory	12.8%
215	Auriculotemporal Syndrome	12.8%
216	Lice Infestations	12.6%
217	Varicose Ulcer	12.6%
218	Breast Neoplasms, Male	12.6%
219	Triple Negative Breast Neoplasms	12.6%
220	Hypergammaglobulinemia	12.5%
221	Galactorrhea	12.5%
222	Dermatomycoses	12.3%
223	Mucocutaneous Lymph Node Syndrome	12.3%
224	Skin Diseases, Bacterial	12.3%
225	Albinism	12.3%
226	Pathological Conditions, Anatomical	12.2%
227	Drug Eruptions	12.2%
228	Lipodystrophy	12.2%
229	Malignant Atrophic Papulosis	12.2%
230	Erythema Chronicum Migrans	12%
231	Polyarteritis Nodosa	12%
232	Takayasu Arteritis	12%
233	Thrombocytopenic purpura	11.6%
234	Lichen Planus, Oral	11.5%
235	Purpura, Hyperglobulinemic	11.3%
236	Eye Hemorrhage	11.3%
237	Mycetoma	11%
238	Hemoptysis	11%
239	Pain, Postoperative	10.9%
240	Apnea	10.3%
241	Cheyne-Stokes Respiration	10.3%
242	Decerebrate State	10.3%
243	Dyspnea	10.3%
244	Hemiparesis	10.3%
245	Hyperventilation	10.3%
246	Meningism	10.3%
247	Mouth Breathing	10.3%
248	Nail-Patella Syndrome	10.3%
249	Paresis	10.3%
250	Seizures	10.3%
251	Sensation Disorders	10.3%
252	Sneezing	10.3%
253	Complex partial seizures	10.3%
254	Tachypnea	10.3%
255	Monoparesis	10.3%
256	Gait Disorders, Neurologic	10.3%
257	Neuromuscular Manifestations	10.3%
258	Porphyrias, Hepatic	10.2%
259	Larva Migrans	10.2%
260	Leishmaniasis	10.2%
261	Molluscum Contagiosum	10.2%
262	Edema, Cardiac	10.2%
263	Mental Fatigue	10.2%
264	Orthostatic intolerance	10.2%
265	Hypoventilation	10.2%
266	Angioedema	10.1%
267	Back Pain	10.1%
268	Bulimia	10.1%
269	Neck Pain	10.1%
270	Chest Pain	10.1%
271	Dizziness	10.1%
272	Dysuria	10.1%
273	Facial Pain	10.1%
274	Fever of Unknown Origin	10.1%
275	Flank Pain	10.1%
276	Headache	10.1%
277	Nocturia	10.1%
278	Pain, Intractable	10.1%
279	Pelvic Pain	10.1%
280	Snoring	10.1%
281	Chronic pain	10.1%
282	Lightheadedness	10.1%
283	Pain, Referred	10.1%
284	Prostatism	10.1%
285	Throbbing Headache	10.1%
286	Labor Pain	10.1%
287	Cancer Pain	10.1%
288	Nociceptive Pain	10.1%
289	Onchocerciasis	10.1%
290	Body Weight Changes	10%
291	Chromoblastomycosis	10%
292	Dermatophytosis	10%
293	Sporotrichosis	10%
294	Tinea	10%
295	Tinea Versicolor	10%
296	Trichophytosis	10%
297	Hyalohyphomycosis	10%
298	Acute Generalized Exanthematous Pustulosis	9.9%
299	Dysmenorrhea	9.6%
300	Failed Back Surgery Syndrome	9.6%
301	Purpura, Thrombotic Thrombocytopenic	9.3%
302	Collagen Diseases	9.3%
303	Mixed Connective Tissue Disease	9.3%
304	Mucinoses	9.3%
305	Epistaxis	9.2%
306	Gait Ataxia	9.1%
307	Leishmaniasis, Cutaneous	9%
308	Eczema Herpeticum	9%
309	Fusariosis	8.9%
310	Hoarseness	8.9%
311	Sleep Wake Disorders	8.8%
312	Muscular Atrophy	8.7%
313	Pupil Disorders	8.6%
314	Muscle Weakness	8.6%
315	Neurobehavioral Manifestations	8.6%
316	Warts	8.6%
317	Body Weight	8.5%
318	Phantom pain	8.5%
319	Vascular Remodeling	8.5%
320	Phantom Limb Pain	8.5%
321	Emaciation	8.4%
322	Low Back Pain	8.4%
323	Visceral Pain	8.4%
324	Hereditary Angioedema Type III	8.4%
325	Hereditary Angioedema Types I and II	8.4%
326	Candidiasis, Chronic Mucocutaneous	8.3%
327	Cutaneous Candidiasis	8.3%
328	Erysipelas	8.3%
329	Serum Sickness	8.3%
330	Staphylococcal Skin Infections	8.3%
331	Variegate Porphyria	8.3%
332	Acute intermittent porphyria	8.3%
333	Porphyria Cutanea Tarda	8.3%
334	Erythrasma	8.3%
335	Carcinoma, Lobular	8.3%
336	Arthritis, Psoriatic	8.2%
337	Pleural Rub	8.2%
338	Rales	8.2%
339	Respiratory Sounds	8.2%
340	Rhonchi	8.2%
341	Stridor	8.2%
342	Wheezing	8.2%
343	Asterixis	8.2%
344	Ballismus	8.2%
345	CREST Syndrome	8.2%
346	Vertigo	8.2%
347	Pain	8.1%
348	Ache	8.1%
349	Oliguria	8.1%
350	Polyuria	8.1%
351	Proteinuria	8.1%
352	Hematemesis	8%
353	Underweight	7.9%
354	Overweight	7.9%
355	Akathisia	7.8%
356	Restlessness	7.8%
357	Psychomotor Agitation	7.8%
358	Morning Sickness	7.7%
359	Anosmia	7.6%
360	Ataxia	7.6%
361	Athetosis	7.6%
362	Catalepsy	7.6%
363	Dystonia	7.6%
364	Hemiplegia	7.6%
365	Locked-In Syndrome	7.6%
366	Muscle Hypertonia	7.6%
367	Muscle hypotonia	7.6%
368	Myoclonus	7.6%
369	Myotonia	7.6%
370	Neuralgia	7.6%
371	Paraplegia	7.6%
372	Pseudobulbar Palsy	7.6%
373	Quadriplegia	7.6%
374	Spasm	7.6%
375	Spastic Paraplegia	7.6%
376	Status Epilepticus	7.6%
377	Taste Disorders	7.6%
378	Tremor	7.6%
379	Monoplegia	7.6%
380	Hypokinesia	7.6%
381	Gastroparesis	7.6%
382	Paraparesis	7.6%
383	Bradykinesia	7.6%
384	Waxy flexibility	7.6%
385	Action Tremor	7.6%
386	Resting Tremor	7.6%
387	Dysosmia	7.6%
388	Quadriparesis	7.6%
389	Olfaction Disorders	7.6%
390	Myokymia	7.6%
391	Somatosensory Disorders	7.6%
392	Neuropathic pain	7.6%
393	Hyperkinesia	7.6%
394	Intention tremor	7.6%
395	Angioedemas, Hereditary	7.5%
396	Cachexia	7.5%
397	Epidermodysplasia Verruciformis	7.5%
398	Herpes Labialis	7.5%
399	Weight Gain	7.5%
400	Diabetic Foot	7.4%
401	Autoimmune thrombocytopenia	7.4%
402	Immune thrombocytopenic purpura	7.4%
403	Gait Apraxia	7.4%
404	Staphylococcal Scalded Skin Syndrome	7.4%
405	Cartilage Diseases	7.3%
406	Rheumatism	7.3%
407	Chondromalacia	7.3%
408	Peutz-Jeghers Syndrome	7.1%
409	Waterhouse-Friderichsen Syndrome	7.1%
410	Lupus Erythematosus, Systemic	7%
411	Overlap syndrome	7%
412	Ascites	7%
413	Calculi	7%
414	Fibrosis	7%
415	Gliosis	7%
416	Growth Disorders	7%
417	Hemorrhage	7%
418	Hernia	7%
419	Hyperbilirubinemia	7%
420	Hyperplasia	7%
421	Hypertrophy	7%
422	Hypomenorrhea	7%
423	Inflammation	7%
424	Intraoperative Complications	7%
425	Ischemia	7%
426	Lithiasis	7%
427	Malacoplakia	7%
428	Menstruation Disturbances	7%
429	Metaplasia	7%
430	Nails, Malformed	7%
431	Nerve Degeneration	7%
432	Ochronosis	7%
433	Polymenorrhea	7%
434	polyps	7%
435	Postoperative Complications	7%
436	Rupture, Spontaneous	7%
437	Sclerosis	7%
438	Shock	7%
439	Ulcer	7%
440	Voice Disorders	7%
441	Enterocele	7%
442	Hyperammonemia	7%
443	Hyperamylasemia	7%
444	Teratogenesis	7%
445	Atheroma	7%
446	Cardiac Death	7%
447	Hypovolemia	7%
448	Hyperuricemia	7%
449	Leukoaraiosis	7%
450	Stenosis	7%
451	Facial asymmetry	7%
452	Voice Disturbance	7%
453	Dysbacteriosis	7%
454	Delayed Graft Function	7%
455	Cirrhosis	7%
456	Plaque, Amyloid	7%
457	Plaque, Atherosclerotic	7%
458	Neointima	7%
459	Dysbiosis	7%
460	Sarcopenia	6.9%
461	carbuncle	6.9%
462	Gagging	6.8%
463	Scleromyxedema	6.8%
464	Infarction	6.8%
465	Postoperative Hemorrhage	6.8%
466	Shock, Hemorrhagic	6.8%
467	Systemic Inflammatory Response Syndrome	6.8%
468	Incisional hernia	6.8%
469	Giant Cell Arteritis	6.6%
470	Temporal Arteritis	6.6%
471	Condylomata Acuminata	6.4%
472	Furunculosis	6.4%
473	Toothache	6.4%
474	furuncle	6.4%
475	Alexia	6.3%
476	Impetigo	6.3%
477	Vision Disorders	6.3%
478	Metamorphopsia	6.3%
479	Dyslexia	6.3%
480	Visual Impairment	6.3%
481	Hyperemesis Gravidarum	6.3%
482	Blastomycosis	6.2%
483	Dysgeusia	6.2%
484	Formication	6.2%
485	Hyperalgesia	6.2%
486	Hyperesthesia	6.2%
487	Hypesthesia	6.2%
488	Language Disorders	6.2%
489	Numbness	6.2%
490	Paresthesia	6.2%
491	Paraparesis, Spastic	6.2%
492	Trismus	6.2%
493	Epilepsia Partialis Continua	6.2%
494	Hypogeusia	6.2%
495	Brown-Sequard Syndrome	6.2%
496	Lockjaw	6.2%
497	Allodynia	6.2%
498	Ageusia	6.2%
499	Cellulitis	6.2%
500	Metatarsalgia	6.2%
501	HIV-Associated Lipodystrophy Syndrome	6.2%
502	Alice in Wonderland Syndrome	6.1%
503	Anisocoria	6.1%
504	Confusion	6.1%
505	Facial paralysis	6.1%
506	Lethargy	6.1%
507	Memory Disorders	6.1%
508	Muscle Cramp	6.1%
509	Perceptual Disorders	6.1%
510	Psychomotor Disorders	6.1%
511	Tonic Pupil	6.1%
512	Anhedonia	6.1%
513	Disorientation	6.1%
514	Fetal Hypoxia	6.1%
515	Facial Paresis	6.1%
516	Memory Loss	6.1%
517	Hemisensory Neglect	6.1%
518	Dysacusis	6.1%
519	Dyspnea, Paroxysmal	6%
520	Mastodynia	6%
521	Respiratory Paralysis	6%
522	Chorea	6%
523	Keloid	6%
524	Tetany	6%
525	Urinary Incontinence	6%
526	Breakthrough Pain	6%
527	Albuminuria	5.9%
528	Hemoglobinuria	5.9%
529	Jet Lag Syndrome	5.8%
530	Reflex, Abnormal	5.7%
531	Hyporeflexia	5.7%
532	Hyperreflexia	5.7%
533	Rhinoscleroma	5.6%
534	Birth Weight	5.6%
535	Agraphia	5.6%
536	Anomia	5.6%
537	Cluttering	5.6%
538	Language Development Disorders	5.6%
539	Speech Disorders	5.6%
540	Syncope	5.6%
541	Stupor	5.6%
542	Dysgraphia	5.6%
543	Presyncope	5.6%
544	Dyslalia	5.6%
545	Cyst	5.5%
546	Extravasation of Diagnostic and Therapeutic Materials	5.5%
547	Neoplastic Processes	5.5%
548	Dupuytren Contracture	5.4%
549	Leukoplakia	5.3%
550	Necrosis	5.3%
551	Granulomatosis, Orofacial	5.3%
552	Respiratory Aspiration	5.3%
553	Airway Remodeling	5.3%
554	Aphasia	5.2%
555	Articulation Disorders	5.2%
556	Echolalia	5.2%
557	Stuttering	5.2%
558	Dysphasia	5.2%
559	Chromosome Aberrations	5.2%
560	Dehydration	5.2%
561	Granuloma	5.2%
562	Leukocytosis	5.2%
563	Mesenteric Panniculitis	5.2%
564	Panniculitis, Peritoneal	5.2%
565	Tietze's Syndrome	5.2%
566	Orbital Cellulitis	5.2%
567	Pleocytosis	5.2%
568	Ventricular Remodeling	5.2%
569	Myxoid cyst	5.2%
570	Consciousness Disorders	5.1%
571	Mental Retardation	5.1%
572	Depressed Level of Consciousness	5.1%
573	Mental deficiency	5.1%
574	Intellectual Disability	5.1%
575	Catatonia	5.1%
576	Musculoskeletal Pain	5.1%
577	Myxedema	5.1%
578	Ophthalmoplegia	5.1%
579	External Ophthalmoplegia	5.1%
580	Dysarthria	5.1%
581	Diplopia	5.1%
582	Muscle Rigidity	5.1%
583	Muscle Spasticity	5.1%
584	Scotoma	5.1%
585	Photophobia	5.1%
586	Cogwheel Rigidity	5.1%
587	Hemifacial Spasm	5.1%
588	Amaurosis	5.1%
589	Blindness	5.1%
590	Nuchal Rigidity	5.1%
591	Aphonia	5%
592	Arthralgia	5%
593	Sleep Deprivation	5%
594	Polyarthralgia	5%
595	Dysphonia	5%
596	Angina Pectoris	5%
597	Sudden infant death syndrome	5%
598	Agnosia	5%
599	Apraxias	5%
600	Hallucinations	5%
601	Hemianopsia	5%
602	Hyperacusis	5%
603	Tinnitus	5%
604	Visual Agnosia	5%
605	Anosognosia	5%
606	Wernicke-Korsakoff Syndrome	5%
607	Phonophobia	5%
608	Hearing Loss	5%
609	Cerebrospinal Fluid Otorrhea	5%
610	Cerebrospinal Fluid Rhinorrhea	5%
611	Cerebellar Ataxia	5%
612	Torticollis	5%
613	Sciatica	4.9%
614	Urge Incontinence	4.9%
615	Tardive Dyskinesia	4.9%
616	Obesity	4.9%
617	Menkes Kinky Hair Syndrome	4.9%
618	Menorrhagia	4.7%
619	Acute Disease	4.5%
620	Acute-Phase Reaction	4.5%
621	Amenorrhea	4.5%
622	Chronic disease	4.5%
623	Critical Illness	4.5%
624	Sudden death	4.5%
625	Fat necrosis	4.5%
626	Gangrene	4.5%
627	Graft Occlusion, Vascular	4.5%
628	Granuloma, Plasma Cell	4.5%
629	Hematoma	4.5%
630	Diaphragmatic Hernia	4.5%
631	Iatrogenic Disease	4.5%
632	Intestinal Polyps	4.5%
633	Multiple Organ Failure	4.5%
634	Oligomenorrhea	4.5%
635	Premenstrual syndrome	4.5%
636	Recurrence	4.5%
637	Retrograde Degeneration	4.5%
638	Retroperitoneal fibrosis	4.5%
639	Serositis	4.5%
640	Splenomegaly	4.5%
641	Subcutaneous Emphysema	4.5%
642	Surgical Wound Dehiscence	4.5%
643	Syndrome	4.5%
644	Wallerian Degeneration	4.5%
645	Pyogenic granuloma	4.5%
646	Exsanguination	4.5%
647	Disease Progression	4.5%
648	Seroma	4.5%
649	Premenstrual Tension	4.5%
650	Delayed Emergence from Anesthesia	4.5%
651	Infant Death	4.5%
652	Anastomotic Leak	4.5%
653	Intraoperative Awareness	4.5%
654	Chromosomal Instability	4.5%
655	Amaurosis Fugax	4.5%
656	Blindness, Cortical	4.5%
657	Dyscalculia	4.5%
658	Angina, Unstable	4.4%
659	Hydrops Fetalis	4.4%
660	Deafness	4.4%
661	Hearing Loss, Sudden	4.4%
662	Gerstmann Syndrome	4.4%
663	Hearing Loss, Bilateral	4.4%
664	Hearing Loss, High-Frequency	4.4%
665	Hearing Loss, Mixed Conductive-Sensorineural	4.4%
666	Prosopagnosia	4.4%
667	Apraxia, Ideomotor	4.4%
668	Persistent Vegetative State	4.4%
669	Charles Bonnet Syndrome	4.4%
670	Hearing Loss, Unilateral	4.4%
671	Complete Hearing Loss	4.4%
672	Alien Hand Syndrome	4.4%
673	Deaf Mutism	4.4%
674	Vocal Cord Paralysis	4.4%
675	Fetal Weight	4.4%
676	Genomic Instability	4.3%
677	Mutism	4.3%
678	Selective Mutism	4.3%
679	Amblyopia	4.2%
680	Amnesia	4.2%
681	Delirium	4.2%
682	Horner Syndrome	4.2%
683	Dissociative Amnesia	4.2%
684	Color blindness	4.2%
685	Global Amnesia	4.2%
686	Angina Pectoris, Variant	4.2%
687	Osteochondritis	4.2%
688	Polymyalgia Rheumatica	4.2%
689	Shoulder Pain	4.1%
690	Osteogenesis Imperfecta	4.1%
691	Alexia, Pure	4.1%
692	Pediatric Obesity	4.1%
693	Diverticulum	4.1%
694	Diverticulosis	4.1%
695	Azotemia	4%
696	Dyskinesia, Drug-Induced	3.8%
697	Alcohol Withdrawal Seizures	3.7%
698	Retrograde amnesia	3.7%
699	Amnesia, Anterograde	3.7%
700	Endotoxic shock	3.7%
701	Septic Shock	3.7%
702	Toxic Shock Syndrome	3.7%
703	Akathisia, Drug-Induced	3.6%
704	Myalgia	3.6%
705	Asphyxia	3.6%
706	Granuloma, Respiratory Tract	3.6%
707	Shock, Traumatic	3.6%
708	Respiratory Tract Fistula	3.6%
709	Cardiotoxicity	3.5%
710	Rheumatoid Arthritis	3.4%
711	Disease susceptibility	3.4%
712	Fetal Death	3.4%
713	Foreign-Body Reaction	3.4%
714	Gastrointestinal Hemorrhage	3.4%
715	Cardiomegaly	3.4%
716	Hemarthrosis	3.4%
717	Hemoperitoneum	3.4%
718	Hemothorax	3.4%
719	Hepatomegaly	3.4%
720	Neoplasm Invasiveness	3.4%
721	Neoplasm Metastasis	3.4%
722	Neoplasm Recurrence, Local	3.4%
723	Parovarian Cyst	3.4%
724	Postpericardiotomy Syndrome	3.4%
725	Prosthesis Failure	3.4%
726	Reperfusion Injury	3.4%
727	Spermatocele	3.4%
728	Oral Fistula	3.4%
729	Injection Site Reaction	3.4%
730	Retrobulbar Hemorrhage	3.4%
731	Aseptic Necrosis of Bone	3.4%
732	Peritoneal Fibrosis	3.4%
733	Carcinogenesis	3.4%
734	Neurogenic Inflammation	3.4%
735	Perinatal death	3.4%
736	Infusion site reaction	3.4%
737	Cardiac Hypertrophy	3.4%
738	Corneal Endothelial Cell Loss	3.4%
739	Encapsulating Peritoneal Sclerosis	3.4%
740	Vasoplegia	3.4%
741	Suppuration	3.4%
742	Juvenile arthritis	3.4%
743	Metastasis	3.4%
744	Sinus Arrhythmia	3.4%
745	Atrial Fibrillation	3.4%
746	Atrial Flutter	3.4%
747	Dental Pulp Necrosis	3.4%
748	Granuloma, Foreign-Body	3.4%
749	Mediastinal Emphysema	3.4%
750	Surgical Wound Infection	3.4%
751	Ventricular Fibrillation	3.4%
752	Ventricular Flutter	3.4%
753	Parasystole	3.4%
754	Paroxysmal atrial fibrillation	3.4%
755	Facies	3.4%
756	Bradycardia	3.4%
757	Embryo Loss	3.4%
758	Tissue Adhesions	3.4%
759	Colonic Polyps	3.4%
760	Hematoma, Epidural, Spinal	3.4%
761	Afferent Loop Syndrome	3.4%
762	Noonan Syndrome	3.4%
763	Sex Chromosome Aberrations	3.4%
764	Short Bowel Syndrome	3.4%
765	Uterine hemorrhage	3.4%
766	Vaginal Fistula	3.4%
767	Rectocele	3.4%
768	No-Reflow Phenomenon	3.4%
769	Rheumatoid Nodule	3.3%
770	Lupus Nephritis	3.3%
771	Chromosome Fragility	3.3%
772	Amnesia, Transient Global	3.2%
773	Auditory Perceptual Disorders	3.1%
774	Marfan Syndrome	3%
775	Laryngomalacia	3%
776	Pectus carinatum	2.9%
777	Homocystinuria	2.9%
778	Drowning	2.8%
779	Sick Sinus Syndrome	2.8%
780	Trisomy	2.8%
781	Hematoma, Subdural, Spinal	2.8%
782	Ophthalmoplegic Migraine	2.8%
783	Felty Syndrome	2.8%
784	Nasal Polyps	2.8%
785	Bronchomalacia	2.8%
786	Tracheomalacia	2.8%
787	Progressive supranuclear palsy	2.8%
788	Fetal Growth Retardation	2.7%
789	DNA Degradation, Necrotic	2.7%
790	Aneuploidy	2.7%
791	Polyploidy	2.7%
792	Microsatellite Instability	2.7%
793	Heart Block	2.7%
794	Tachycardia	2.7%
795	Tachyarrhythmia	2.7%
796	Cicatrix	2.7%
797	Hematuria	2.7%
798	Meningocele	2.7%
799	Urinary Calculi	2.7%
800	Chromosome Breakage	2.7%
801	Encephalocele	2.7%
802	Brain Death	2.7%
803	Shock, Cardiogenic	2.7%
804	Biliary Fistula	2.6%
805	Cross Infection	2.6%
806	Gastric Fistula	2.6%
807	Hyphema	2.6%
808	Retinal Neovascularization	2.6%
809	Septicemia	2.6%
810	Vitreous Hemorrhage	2.6%
811	Congenital diaphragmatic hernia	2.6%
812	Sepsis	2.6%
813	Vesicovaginal Fistula	2.6%
814	Abscess	2.5%
815	Dental Fistula	2.5%
816	Empyema	2.5%
817	Femur Head Necrosis	2.5%
818	Fetal Resorption	2.5%
819	Lymphatic Metastasis	2.5%
820	Neoplasms, Unknown Primary	2.5%
821	Oroantral Fistula	2.5%
822	Peptic Ulcer Hemorrhage	2.5%
823	Sudden Cardiac Death	2.5%
824	Left Ventricular Hypertrophy	2.5%
825	Leukemic Infiltration	2.5%
826	Right Ventricular Hypertrophy	2.5%
827	Premenstrual Dysphoric Disorder	2.5%
828	Choroidal Neovascularization	2.5%
829	Primary Graft Dysfunction	2.5%
830	Neoplasm Micrometastasis	2.5%
831	Dumping Syndrome	2.5%
832	Rectal Prolapse	2.5%
833	Uterine Prolapse	2.5%
834	Cicatrix, Hypertrophic	2.5%
835	Vaginal Prolapse	2.5%
836	Sinus Arrest, Cardiac	2.5%
837	Metrorrhagia	2.5%
838	Hematoma, Subdural	2.4%
839	Hematoma, Epidural, Cranial	2.4%
840	Rheumatoid Vasculitis	2.4%
841	Mucopolysaccharidosis III	2.3%
842	Giant Cell Epulis	2.3%
843	Leukoplakia, Oral	2.2%
844	Long QT Syndrome	2.2%
845	Viremia	2.2%
846	Parasitemia	2.2%
847	Micronuclei, Chromosome-Defective	2.2%
848	Umbilical hernia	2.1%
849	Sicca Syndrome	2.1%
850	Sjogren's Syndrome	2.1%
851	Bronchial Fistula	2.1%
852	Pancreatic Fistula	2.1%
853	Retinal Hemorrhage	2.1%
854	Choroid Hemorrhage	2%
855	Intestinal Fistula	2%
856	Melena	2%
857	Gastroschisis	2%
858	Enterocutaneous Fistula	2%
859	Hematoma, Subdural, Intracranial	2%
860	Hematoma, Subdural, Chronic	2%
861	Hematoma, Subdural, Acute	2%
862	Postpartum Hemorrhage	2%
863	Salivary Gland Fistula	2%
864	Cystocele	2%
865	Gingival Hemorrhage	2%
866	Monosomy	2%
867	Tetraploidy	2%
868	Stillbirth	2%
869	Adams-Stokes Syndrome	2%
870	Atrioventricular Block	2%
871	Bundle-Branch Block	2%
872	Atrial Premature Complexes	2%
873	Sinoatrial Block	2%
874	Tachycardia, Paroxysmal	2%
875	Supraventricular tachycardia	2%
876	Tachycardia, Ventricular	2%
877	Tachycardia, Reciprocating	2%
878	Subarachnoid Hemorrhage	2%
879	Cerebral Hemorrhage	2%
880	Subacute Combined Degeneration	1.9%
881	Eosinophilic Granuloma	1.9%
882	Kearns-Sayre syndrome	1.8%
883	Bacteremia	1.7%
884	Kernicterus	1.7%
885	Cell Transformation, Viral	1.7%
886	Fungemia	1.7%
887	Romano-Ward Syndrome	1.6%
888	Tachycardia, Atrioventricular Nodal Reentry	1.6%
889	Tachycardia, Ectopic Atrial	1.6%
890	Tachycardia, Ectopic Junctional	1.6%
891	Sinus Tachycardia	1.6%
892	Torsades de Pointes	1.6%
893	Accelerated Idioventricular Rhythm	1.6%
894	Mucopolysaccharidosis II	1.6%
895	Lupus Vasculitis, Central Nervous System	1.5%
896	Endotoxemia	1.5%
897	Granuloma, Laryngeal	1.5%
898	Myocardial Reperfusion Injury	1.4%
899	Urinary Bladder Fistula	1.4%
900	Rectal Fistula	1.4%
901	Anal Fistula	1.4%
902	Arteriovenous fistula	1.2%
903	Philadelphia Chromosome	1.2%
904	Kidney Calculi	1.1%
905	Ureteral Calculi	1.1%
906	Candidemia	1.1%
907	Basal Ganglia Hemorrhage	1%
908	Putaminal Hemorrhage	0.9%

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