MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Acanthosis Nigricans

(UMLS:C0000889)

Definition:: A circumscribed melanosis consisting of a brown-pigmented, velvety verrucosity or fine papillomatosis appearing in the axillae and other body folds. It occurs in association with endocrine disorders, underlying malignancy, administration of certain drugs, or as in inherited disorder.
UMLS ID:: C0000889
MeSH ID:: D000052

Classification:

Name:

Skin and Connective Tissue Diseases
MeSH Tree Number(s):: C17.800.621.430.530.100

Synonym(s)

Acanthosis Nigricans

ACANTHOSIS NIGRICANS

AN - Acanthosis nigricans

Acanthosis nigricans

Darkened and thickened skin

KERATOSIS NIGRICANS

Keratosis nigricans

acanthosis nigricans

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Atazanavir Sulfate	FAERS: 3		US FAERS
2	Exenatide	FAERS: 3		US FAERS
3	Dexamethasone	FAERS: 2		US FAERS
4	Isotretinoin	FAERS: 2		US FAERS
5	Methylprednisolone	FAERS: 2		US FAERS
6	Niacin	FAERS: 2		SIDER US FAERS
7	Olanzapine	FAERS: 2		US FAERS
8	Carbamazepine	FAERS: 1		US FAERS
9	Glatiramer Acetate	FAERS: 1		US FAERS
10	Insulin Glargine	FAERS: 1		US FAERS
11	Leuprolide	FAERS: 1		US FAERS
12	Liraglutide	FAERS: 1		US FAERS
13	Metformin	FAERS: 1		US FAERS
14	Norgestrel	FAERS: 1		US FAERS
15	NuvaRing	FAERS: 1		US FAERS
16	Ondansetron	FAERS: 1		US FAERS
17	Quetiapine Fumarate	FAERS: 1		US FAERS
18	Telmisartan	FAERS: 1		US FAERS
19	Tramadol	FAERS: 1		US FAERS
20	anagrelide	FAERS: 1		US FAERS
21	prednisolone acetate		11004305	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Lentigo	49.2%
2	Breast Diseases	22.7%
3	Dermatitis	22.7%
4	Exanthema	22.7%
5	Facial Dermatoses	22.7%
6	Hair Diseases	22.7%
7	Hand Dermatoses	22.7%
8	keratoacanthoma	22.7%
9	Keratosis	22.7%
10	Nail Diseases	22.7%
11	Photosensitivity Disorders	22.7%
12	Prurigo	22.7%
13	Pyoderma	22.7%
14	Rosacea	22.7%
15	Sebaceous Gland Diseases	22.7%
16	Skin Diseases, Vesiculobullous	22.7%
17	Skin Ulcer	22.7%
18	Sweat Gland Diseases	22.7%
19	Skin Diseases, Papulosquamous	22.7%
20	Skin Diseases, Vascular	22.7%
21	Acneiform Eruptions	22.7%
22	Ocular Rosacea	22.7%
23	Subcorneal pustular dermatosis	22.7%
24	Erythematotelangiectatic Rosacea	22.7%
25	Papulopustular Rosacea	22.7%
26	Chronic Actinic Dermatitis	22.7%
27	Lupus Erythematosus, Cutaneous	20.6%
28	Panniculitis	20.6%
29	Systemic Scleroderma	20.6%
30	Morphea	20.6%
31	Argyria	19.1%
32	Pyoderma Gangrenosum	18.5%
33	Urticaria Pigmentosa	17.7%
34	Vitiligo	16.8%
35	Acne Vulgaris	16.4%
36	Contact Dermatitis	16.4%
37	Eczema	16.4%
38	Erythema Multiforme	16.4%
39	Intertrigo	16.4%
40	Neurodermatitis	16.4%
41	Rhinophyma	16.4%
42	Perioral Dermatitis	16.4%
43	Acne	16.4%
44	Foot Diseases	16.2%
45	Skin Abnormalities	15.4%
46	Skin Diseases, Infectious	15.4%
47	Skin Neoplasms	15.4%
48	Connective Tissue Diseases	15.3%
49	Peutz-Jeghers Syndrome	15.3%
50	Lipomatosis	15.1%
51	Pruritus	15.1%
52	Erythema	15.1%
53	Necrolytic Migratory Erythema	15.1%
54	Cutaneous Fistula	15.1%
55	Nephrogenic Fibrosing Dermopathy	15.1%
56	Nephrogenic Systemic Fibrosis	15.1%
57	Xeroderma Pigmentosum	14.8%
58	Foot Ulcer	13%
59	Dermatitis Herpetiformis	12.6%
60	Dermatitis, Atopic	12.4%
61	Epidermolysis Bullosa	12.4%
62	Acrodermatitis	12.3%
63	Sebaceous Gland Neoplasms	12.3%
64	Porokeratosis	12.3%
65	Gianotti-Crosti Syndrome	12.3%
66	Keratoderma, Palmoplantar	12.3%
67	Anhidrosis	12.2%
68	Cholesteatoma	12.2%
69	Pressure Ulcer	12.2%
70	Folliculitis	12.2%
71	Foot Dermatoses	12.2%
72	Gynecomastia	12.2%
73	Hypertrichosis	12.2%
74	Hypohidrosis	12.2%
75	Hypotrichosis	12.2%
76	Leg Ulcer	12.2%
77	Miliaria	12.2%
78	Parakeratosis	12.2%
79	Parapsoriasis	12.2%
80	Pityriasis	12.2%
81	Psoriasis	12.2%
82	Sweet Syndrome	12.2%
83	Hidradenitis	12.2%
84	Onycholysis	12.2%
85	Miliaria Rubra	12.2%
86	Lichenoid Eruptions	12.2%
87	Chloracne	12.2%
88	Dermatomyositis	12%
89	Mastocytosis	11.2%
90	Lupus Erythematosus, Discoid	10.9%
91	Scleroderma, Limited	10.9%
92	Dermatitis, Phototoxic	10.8%
93	Pityriasis Lichenoides et Varioliformis Acuta	10.8%
94	Pityriasis Lichenoides	10.8%
95	Phototoxicity	10.8%
96	Necrobiosis Lipoidica Diabeticorum	10.8%
97	Panniculitis, Lupus Erythematosus	10.4%
98	Cutis Laxa	10%
99	Xeroderma	10%
100	Dermatitis, Irritant	9.6%
101	Acne Conglobata	9.6%
102	Dermatitis, Photoallergic	8.7%
103	Acantholysis	8.4%
104	Breast Cyst	8.4%
105	Actinic keratosis	8.4%
106	Pemphigoid, Benign Mucous Membrane	8.4%
107	Pemphigus	8.4%
108	Piedra	8.4%
109	Sunburn	8.4%
110	Erythema Induratum	8.3%
111	Ectodermal Dysplasia	8.3%
112	Aplasia Cutis Congenita	8.3%
113	Hirsutism	8.2%
114	Lactation Disorder	8.2%
115	Mastitis	8.2%
116	Urticaria	8.2%
117	Adiposis Dolorosa	8.1%
118	Pruritus Vulvae	8.1%
119	Pseudoxanthoma Elasticum	8.1%
120	Mastocytoma	8.1%
121	Pruritus Ani	8.1%
122	Erythema Infectiosum	8%
123	Exanthema Subitum	7.9%
124	Erythema Nodosum	7.8%
125	Dermatitis, Occupational	7.7%
126	Collagen Diseases	7.6%
127	Mixed Connective Tissue Disease	7.6%
128	Mucinoses	7.6%
129	Albinism	7.4%
130	Granuloma Annulare	7.3%
131	Dermatitis, Allergic Contact	7.3%
132	Papillon-Lefevre Disease	7.2%
133	Lichen Planus	7.2%
134	Pityriasis Rosea	7.2%
135	Pityriasis Rubra Pilaris	7.2%
136	Lichen Nitidus	7.2%
137	Tinea Capitis	6.8%
138	Onychomycosis	6.8%
139	Ecthyma	6.5%
140	Diaper Rash	6.3%
141	Dermatomycoses	6.3%
142	Mucocutaneous Lymph Node Syndrome	6.3%
143	Skin Diseases, Bacterial	6.3%
144	Toxic Epidermal Necrolysis	6.2%
145	Stevens-Johnson Syndrome	6.2%
146	Drug Eruptions	6.2%
147	Lipodystrophy	6.2%
148	Livedo Reticularis	6.2%
149	Malignant Atrophic Papulosis	6.2%
150	Polyarteritis Nodosa	6.1%
151	Takayasu Arteritis	6.1%
152	Behcet Syndrome	5.7%
153	Cartilage Diseases	5.4%
154	Rheumatism	5.4%
155	Chondromalacia	5.4%
156	Ichthyosis, X-Linked	5.4%
157	Sjogren-Larsson Syndrome	5.3%
158	Lupus Erythematosus, Systemic	5.1%
159	Overlap syndrome	5.1%
160	Nail-Patella Syndrome	5.1%
161	Porphyrias, Hepatic	5%
162	Alopecia	5%
163	Sweating, Gustatory	5%
164	Androgenetic Alopecia	5%
165	Auriculotemporal Syndrome	5%
166	Hidradenitis Suppurativa	4.9%
167	Lice Infestations	4.9%
168	Varicose Ulcer	4.9%
169	Breast Neoplasms, Male	4.9%
170	Triple Negative Breast Neoplasms	4.9%
171	Erythema Chronicum Migrans	4.8%
172	Galactorrhea	4.8%
173	Hyperkeratosis, Epidermolytic	4.8%
174	Alopecia Areata	4.8%
175	Scleromyxedema	4.1%
176	Tinea Pedis	4%
177	Larva Migrans	3.7%
178	Leishmaniasis	3.7%
179	Molluscum Contagiosum	3.7%
180	Dupuytren Contracture	3.7%
181	Angioedema	3.7%
182	Onchocerciasis	3.7%
183	Chromoblastomycosis	3.6%
184	Dermatophytosis	3.6%
185	Mycetoma	3.6%
186	Sporotrichosis	3.6%
187	Tinea	3.6%
188	Tinea Versicolor	3.6%
189	Trichophytosis	3.6%
190	Hyalohyphomycosis	3.6%
191	Acute Generalized Exanthematous Pustulosis	3.6%
192	Lichen Planus, Oral	3.3%
193	Giant Cell Arteritis	3%
194	Temporal Arteritis	3%
195	Warts	3%
196	Cellulitis	3%
197	Candidiasis, Chronic Mucocutaneous	2.9%
198	Cutaneous Candidiasis	2.9%
199	Erysipelas	2.9%
200	Serum Sickness	2.9%
201	Staphylococcal Skin Infections	2.9%
202	Variegate Porphyria	2.9%
203	Acute intermittent porphyria	2.9%
204	Porphyria Cutanea Tarda	2.9%
205	Erythrasma	2.9%
206	Carcinoma, Lobular	2.9%
207	Arthritis, Psoriatic	2.9%
208	Mesenteric Panniculitis	2.8%
209	Panniculitis, Peritoneal	2.8%
210	Tietze's Syndrome	2.8%
211	Orbital Cellulitis	2.8%
212	Myxoid cyst	2.8%
213	CREST Syndrome	2.8%
214	Myxedema	2.7%
215	Leishmaniasis, Cutaneous	2.4%
216	Eczema Herpeticum	2.4%
217	Fusariosis	2.4%
218	Menkes Kinky Hair Syndrome	2.2%
219	Noonan Syndrome	2.1%
220	Osteochondritis	2.1%
221	Polymyalgia Rheumatica	2.1%
222	Blastomycosis	2.1%
223	Osteogenesis Imperfecta	2.1%
224	HIV-Associated Lipodystrophy Syndrome	2.1%
225	Keloid	2%
226	Angioedemas, Hereditary	2%
227	Epidermodysplasia Verruciformis	1.9%
228	Herpes Labialis	1.9%
229	Diabetic Foot	1.9%
230	Staphylococcal Scalded Skin Syndrome	1.9%
231	Marfan Syndrome	1.9%
232	Rhinoscleroma	1.9%
233	Homocystinuria	1.8%
234	Hereditary Angioedema Type III	1.8%
235	Hereditary Angioedema Types I and II	1.8%
236	Rheumatoid Arthritis	1.7%
237	Juvenile arthritis	1.7%
238	Condylomata Acuminata	1.6%
239	Furunculosis	1.6%
240	furuncle	1.6%
241	Lupus Nephritis	1.6%
242	Impetigo	1.6%
243	Laryngomalacia	1.4%
244	carbuncle	1.4%
245	Pectus carinatum	1.4%
246	Rheumatoid Nodule	1.2%
247	Felty Syndrome	1%
248	Bronchomalacia	1%
249	Tracheomalacia	1%
250	Rheumatoid Vasculitis	0.8%
251	Mucopolysaccharidosis III	0.8%
252	Sicca Syndrome	0.7%
253	Sjogren's Syndrome	0.7%
254	Lupus Vasculitis, Central Nervous System	0.7%
255	Mucopolysaccharidosis II	0.5%

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