MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Hutchinson's Melanotic Freckle

(UMLS:C0149722)

Definition:: A cellular subtype of malignant melanoma. It is a pigmented lesion composed of melanocytes occurring on sun-exposed skin, usually the face and neck. The melanocytes are commonly multinucleated with a "starburst" appearance. It is considered by many to be the in situ phase of lentigo maligna melanoma.
UMLS ID:: C0149722
MeSH ID:: D018327

Classification:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.465.625.650.510.385|C04.557.580.625.650.510.385|C04.557.665.510.385

Synonym(s)

Hutchinson's Melanotic Freckle

Hutchinson melanotic freckle

Hutchinson's melanotic freckle

Hutchinson's melanotic freckle NOS

Hutchinson's melanotic freckle, NOS

Hutchinsons melanotic freckle

LENTIGO MALIGNA

LM - Lentigo maligna

Lentigo Maligna

10.

Lentigo maligna

11.

hutchinson's melanotic freckle

12.

lentigo maligna

13.

lentigo malignant

14.

melanotic freckle

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	Azelaic acid		8635147	CTD
2	Imiquimod		16302556	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	Melanoma, Amelanotic	58.7%
2	Melanoma, Experimental	50.2%
3	Neoplasms, Neuroepithelial	42.6%
4	Gliomatosis cerebri	42.6%
5	Adenoma, Acidophil	39%
6	Neurilemmoma	38.1%
7	Paraganglioma	38.1%
8	Carcinoid Tumor	36.5%
9	Craniopharyngioma	36.4%
10	Neuroectodermal Tumor, Melanotic	36.4%
11	leukemia	33.1%
12	Neoplasms, Glandular and Epithelial	33.1%
13	Nevus	27.7%
14	Histiocytic Disorders, Malignant	26.6%
15	Meningioma	26.3%
16	Pheochromocytoma	26.3%
17	Ganglioneuroma	26.3%
18	Glioma	26.3%
19	Malignant Glioma	26.3%
20	Malignant Carcinoid Syndrome	25.4%
21	Chordoma	25.3%
22	Teratoma	25.3%
23	Germinoma	25.3%
24	Teratocarcinoma	25.3%
25	Trophoblastic Neoplasms	24.7%
26	Medulloblastoma	24.3%
27	Carcinosarcoma	23.2%
28	Hemangiosarcoma	23.2%
29	lymphangiosarcoma	23.2%
30	Neoplasms, Germ Cell and Embryonal	22.7%
31	Germ Cell Cancer	22.7%
32	Lymphoma	22.2%
33	Hamartoma	21.5%
34	Neoplasms, Hormone-Dependent	21.5%
35	Neoplasms, Multiple Primary	21.5%
36	Paraneoplastic Syndromes	21.5%
37	Precancerous Conditions	21.5%
38	Neoplasms, Second Primary	21.5%
39	Dermoid Cyst	20.8%
40	Composite Lymphoma	20.8%
41	Neuroectodermal Tumors	20.4%
42	Leukemia, Experimental	19.6%
43	Carcinoma 256, Walker	19.5%
44	Leukemia, Plasma Cell	19.3%
45	Astrocytoma	18.2%
46	Ependymoma	18.2%
47	oligodendroglioma	18.2%
48	Ganglioglioma	18.2%
49	gliosarcoma	18.2%
50	Anaplastic astrocytoma	18.2%
51	Anaplastic Oligodendroglioma	18.2%
52	Adenoma	18.1%
53	Ameloblastoma	18.1%
54	Angiokeratoma	18.1%
55	Carcinoma	18.1%
56	Hemangioma	18.1%
57	hemangiopericytoma	18.1%
58	Lymphangioma	18.1%
59	Mesenchymoma	18.1%
60	Hepatoblastoma	18.1%
61	Mixed Tumor, Mullerian	18.1%
62	Angiofibroma	18.1%
63	Sarcoma	18.1%
64	Epithelioma	18.1%
65	Carcinoma, Ehrlich Tumor	17.6%
66	Carcinoma, Lewis Lung	17.6%
67	Retinoblastoma	17.6%
68	Cyst	17.4%
69	Neoplastic Processes	17.4%
70	Neoplastic Syndromes, Hereditary	17.4%
71	Pregnancy Complications, Neoplastic	17.4%
72	Carcinoid Heart Disease	17.4%
73	Basal cell carcinoma	17.3%
74	Carcinoma, Papillary	17.3%
75	Squamous cell carcinoma	17.3%
76	Chondrosarcoma	17.3%
77	Cystadenoma	17.3%
78	leiomyosarcoma	17.3%
79	liposarcoma	17.3%
80	Mesothelioma	17.3%
81	synovial sarcoma	17.3%
82	Angiomyolipoma	17.3%
83	Clear Cell Sarcoma of Soft Tissue	17.3%
84	Alveolar Soft Part Sarcoma	17.3%
85	Sarcoma, Myeloid	17.3%
86	Carcinoma, Basal Cell	17.3%
87	Neoplasms, Experimental	17.2%
88	Leukemia, Radiation-Induced	17%
89	Choriocarcinoma	16.1%
90	Acoustic Neuroma	15.6%
91	Dysgerminoma	14.7%
92	Neuroma	14.7%
93	Seminoma	14.7%
94	Sarcoma, Experimental	14.6%
95	Plasmacytoma	14.6%
96	Thymoma	14.6%
97	Malignant histiocytosis	14.5%
98	Histiocytic sarcoma	14.5%
99	Multiple Endocrine Neoplasia	14.5%
100	melanoma	14.4%
101	Neoplasms, Radiation-Induced	14.4%
102	Endometrial Stromal Sarcoma	14.3%
103	Cystadenocarcinoma	14.3%
104	Fibrosarcoma	14.3%
105	Osteosarcoma	14.3%
106	Mucoepidermoid Carcinoma	14.3%
107	Glioblastoma	14.2%
108	Neuroblastoma	14.2%
109	Glioblastoma Multiforme	14.2%
110	Carcinoma, Lobular	13.8%
111	Leukemia L1210	13.5%
112	Leukemia P388	13.5%
113	Acanthoma	13.5%
114	Adenofibroma	12.9%
115	Fibroadenoma	12.9%
116	Malignant Fibrous Histiocytoma	12.9%
117	Neuroendocrine Tumors	12.5%
118	Lymphangioleiomyomatosis	12.4%
119	Ganglioneuroblastoma	12.2%
120	Hodgkin Disease	12.1%
121	Lymphoma, Non-Hodgkin	12.1%
122	Paraneoplastic Encephalomyelitis	11.6%
123	Nephroblastoma	11.5%
124	Mammary Neoplasms, Experimental	11.4%
125	Bowen's Disease	11.4%
126	Rhabdomyosarcoma	11.4%
127	Giant Cell Tumor of Bone	11.4%
128	Tuberous Sclerosis	11.3%
129	Abdominal Neoplasms	11%
130	Erythroplasia	11%
131	Follicular cyst	11%
132	Head and Neck Neoplasms	11%
133	Mucocele	11%
134	Pilonidal Cyst	11%
135	Soft Tissue Neoplasms	11%
136	Thoracic Neoplasms	11%
137	Thyroglossal Cyst	11%
138	Synovial Cyst	11%
139	Aberrant Crypt Foci	11%
140	Neurofibrosarcoma	11%
141	Adenocarcinoma	10.8%
142	Carcinoma in Situ	10.8%
143	Carcinoma, Transitional Cell	10.8%
144	Phyllodes Tumor	10.8%
145	Hemangioendothelioma	10.8%
146	Lipoma	10.8%
147	Myoma	10.8%
148	Myxoma	10.8%
149	Papilloma	10.8%
150	Pseudomyxoma Peritonei	10.8%
151	Papillomatosis	10.8%
152	Angiolipoma	10.8%
153	Myelolipoma	10.8%
154	Neoplasms, Bone Tissue	10.8%
155	Neoplasms, Fibrous Tissue	10.8%
156	Smooth Muscle Tumor	10.8%
157	Adenomatosis, Pulmonary	10.8%
158	Adenomatous Polyps	10.8%
159	Carcinoma, Large Cell	10.8%
160	Carcinoma, Small Cell	10.8%
161	Desmoplastic Small Round Cell Tumor	10.8%
162	Chondroma	10.8%
163	Enchondroma	10.8%
164	Vipoma	10.7%
165	Sarcoma 180	10.6%
166	Primary amyloidosis	10.4%
167	Lymphomatoid Granulomatosis	10.3%
168	Dermatofibrosarcoma	10%
169	Dermatofibrosarcoma Protuberans	10%
170	neurofibroma	9.8%
171	Optic Nerve Glioma	9.8%
172	Hutchinson's Melanotic Freckle	9.5%
173	Basal Cell Nevus Syndrome	9.3%
174	Digestive System Neoplasms	9.2%
175	Endocrine Gland Neoplasms	9.2%
176	Eye Neoplasms	9.2%
177	Nervous System Neoplasms	9.2%
178	Mesoblastic Nephroma	9.1%
179	Bone neoplasms	9%
180	Leukoplakia	9%
181	Lymphocele	9%
182	Pancreatic Cyst	9%
183	Skin Neoplasms	9%
184	Hematologic Neoplasms	9%
185	Barrett Esophagus	8.9%
186	Breast Cyst	8.9%
187	Actinic keratosis	8.9%
188	Mediastinal Cyst	8.9%
189	Neoplasm Invasiveness	8.9%
190	Neoplasm Metastasis	8.9%
191	Neoplasm Recurrence, Local	8.9%
192	Parovarian Cyst	8.9%
193	Pericardial Cyst	8.9%
194	Splenic Neoplasms	8.9%
195	Thymic Cyst	8.9%
196	Carcinogenesis	8.9%
197	Myxoid cyst	8.9%
198	Metastasis	8.9%
199	Hydatidiform Mole	8.8%
200	Leukemia, Myelomonocytic, Chronic	8.6%
201	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	8.6%
202	Alveolar rhabdomyosarcoma	8.5%
203	Hepatocellular Adenoma	8.3%
204	Waldenstrom Macroglobulinemia	8.1%
205	Multiple Myeloma	8.1%
206	Carcinoma, Pancreatic Ductal	8%
207	Multiple Endocrine Neoplasia Type 1	7.9%
208	Liver Neoplasms, Experimental	7.4%
209	Mastocytosis	7.4%
210	Sturge-Weber Syndrome	7.4%
211	Corpus Luteum Cyst	7.3%
212	Ovarian Cysts	7.3%
213	Gastrointestinal Stromal Tumors	7.3%
214	Prolactinoma	7.3%
215	Growth Hormone-Secreting Pituitary Adenoma	7.3%
216	Hemangioma, Cavernous	7.2%
217	Leukemia, T-Cell	7.2%
218	Leukemia, B-Cell	7.2%
219	Lymphoma, Follicular	7.2%
220	T-Cell Lymphoma	7.2%
221	Mantle cell lymphoma	7.2%
222	Adenoid Cystic Carcinoma	7.1%
223	fibroma	7.1%
224	Fibromatosis	7.1%
225	Osteoblastoma	7.1%
226	Osteoma	7.1%
227	Rhabdomyoma	7.1%
228	Chondromatosis	7.1%
229	Adenocarcinoma, Clear Cell	7.1%
230	Cholangiocarcinoma	7.1%
231	Cervical Intraepithelial Neoplasia	7.1%
232	Hemangioblastoma	7.1%
233	Lymphoma, Extranodal NK-T-Cell	7.1%
234	Parathyroid Neoplasms	7.1%
235	Peritoneal Neoplasms	7.1%
236	Thyroid Neoplasm	7.1%
237	Thyroid carcinoma	7.1%
238	Adenomatous Polyposis Coli	6.6%
239	Choledochal Cyst	6.4%
240	granulosa cell tumor	6.4%
241	Carcinoma, Ovarian Epithelial	6.4%
242	Pancreatic Neoplasm	6.3%
243	Peutz-Jeghers Syndrome	6.3%
244	Retroperitoneal Neoplasms	6%
245	Mastocytoma	5.8%
246	Mastocytosis, Systemic	5.7%
247	Leukemia, Myeloid, Chronic-Phase	5.7%
248	Tracheal Neoplasms	5.7%
249	Leukoplakia, Oral	5.6%
250	Paraneoplastic Cerebellar Degeneration	5.5%
251	Fibromatosis, Aggressive	5.3%
252	Fibromatosis, Abdominal	5.3%
253	Klatskin Tumor	5.3%
254	insulinoma	5.3%
255	Nasopharyngeal carcinoma	5%
256	Denys-Drash Syndrome	4.9%
257	Mouth Neoplasms	4.9%
258	Central Nervous System Neoplasms	4.9%
259	Vascular Neoplasms	4.9%
260	Thymus Neoplasms	4.9%
261	Esophageal Neoplasms	4.9%
262	Genital Neoplasms, Female	4.9%
263	Pancreatic Pseudocyst	4.9%
264	Limbic Encephalitis	4.8%
265	Lymphatic Metastasis	4.8%
266	Neoplasms, Unknown Primary	4.8%
267	Leukemic Infiltration	4.8%
268	Breast Neoplasms, Male	4.8%
269	Neoplasm Micrometastasis	4.8%
270	Triple Negative Breast Neoplasms	4.8%
271	Adrenocortical carcinoma	4.8%
272	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
273	Leukemia, Large Granular Lymphocytic	4.8%
274	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	4.8%
275	Lymphoma, T-Cell, Cutaneous	4.7%
276	Lymphoma, AIDS-Related	4.7%
277	Enteropathy-Associated T-Cell Lymphoma	4.7%
278	Primary Effusion Lymphoma	4.7%
279	Leydig Cell Tumor	4.5%
280	Gastrinoma	4.5%
281	Glucagonoma	4.5%
282	Lambert-Eaton Myasthenic Syndrome	4.4%
283	Testicular Neoplasms	4.4%
284	Renal Cell Carcinoma	4.2%
285	Papillary Renal Cell Carcinoma	4.2%
286	Thyroid Nodule	4.2%
287	Adrenal Gland Neoplasms	4.2%
288	Gastrointestinal Neoplasms	4.2%
289	Genital Neoplasms, Male	4.2%
290	Liver neoplasms	4.2%
291	Uveal Neoplasms	4.2%
292	Urologic Neoplasms	4.1%
293	Sebaceous Gland Neoplasms	4.1%
294	Spinal Neoplasms	4.1%
295	Bone Marrow Neoplasms	4.1%
296	Xeroderma Pigmentosum	4.1%
297	Polycystic Ovary Syndrome	4%
298	Carcinoma, Endometrioid	4%
299	Opsoclonus-Myoclonus Syndrome	3.9%
300	Dupuytren Contracture	3.7%
301	Urticaria Pigmentosa	3.6%
302	Burkitt Lymphoma	3.6%
303	Mycosis Fungoides	3.6%
304	Lymphomatoid Papulosis	3.6%
305	Plasmablastic lymphoma	3.6%
306	Myelitis, Transverse	3.5%
307	ovarian neoplasm	3.1%
308	Nose Neoplasms	3%
309	Meningeal Neoplasms	2.9%
310	Pituitary Adenoma	2.8%
311	Pituitary Neoplasms	2.8%
312	Sezary Syndrome	2.7%
313	Palatal Neoplasms	2.7%
314	Ear Neoplasms	2.5%
315	Eyelid Neoplasms	2.5%
316	Lung Neoplasms	2.5%
317	Pleural Neoplasms	2.5%
318	Zollinger-Ellison syndrome	2.4%
319	Cell Transformation, Viral	2.4%
320	Brain Neoplasms	2.4%
321	Salivary Gland Neoplasms	2.4%
322	Spinal Cord Neoplasms	2.4%
323	Tongue Neoplasms	2.4%
324	Uterine Neoplasms	2.4%
325	Vaginal Neoplasms	2.4%
326	Vulvar Neoplasms	2.4%
327	Uterine Cancer	2.4%
328	Fallopian Tube Neoplasms	2.4%
329	Pharyngeal Neoplasms	2.1%
330	Central Nervous System Cysts	2.1%
331	Bile Duct Neoplasms	2.1%
332	gallbladder neoplasm	2.1%
333	Intestinal Neoplasms	2.1%
334	Penile Neoplasms	2.1%
335	Prostatic Neoplasms	2.1%
336	Stomach Neoplasms	2.1%
337	Polycythemia Vera	2.1%
338	Meningeal Carcinomatosis	1.9%
339	Laryngeal neoplasm	1.9%
340	Bladder Neoplasm	1.8%
341	Kidney Neoplasm	1.8%
342	Ureteral Neoplasms	1.8%
343	Urethral Neoplasms	1.8%
344	Bronchial Neoplasms	1.6%
345	Multiple Pulmonary Nodules	1.6%
346	Supratentorial Neoplasms	1.6%
347	Endometrial Neoplasms	1.6%
348	Hypopharyngeal Neoplasms	1.4%
349	Pleural Effusion, Malignant	1.4%
350	Hypopharyngeal Cancer	1.4%
351	Parotid Neoplasms	1.4%
352	Prostatic Neoplasms, Castration-Resistant	1.4%
353	Nelson Syndrome	1.4%
354	Cecal Neoplasms	1.2%
355	Duodenal Neoplasms	1.2%
356	Brain Stem Neoplasms	1.2%
357	Nasopharyngeal Neoplasms	1.1%
358	Colorectal Neoplasms	1.1%
359	Tonsillar Neoplasms	1%
360	Cerebellar Neoplasms	1%
361	Choroid Plexus Papilloma	1%
362	Paranasal Sinus Neoplasms	1%
363	Radicular Cyst	0.9%
364	Appendiceal Neoplasms	0.9%
365	Colonic Neoplasms	0.9%
366	Rectal Neoplasms	0.9%
367	Maxillary Sinus Neoplasms	0.7%
368	Anus Neoplasms	0.7%
369	Sigmoid Neoplasms	0.7%

Page last updated at 2020-05-25 10:01:57 (Asia/Shanghai) | You are visitor No. 120234