MetaADEDB: ADE

MetaADEDB 2.0 @ LMMD

Histiocytic sarcoma

(UMLS:C0334663)

Definition:: Malignant neoplasms composed of MACROPHAGES or DENDRITIC CELLS. Most histiocytic sarcomas present as localized tumor masses without a leukemic phase. Though the biological behavior of these neoplasms resemble lymphomas, their cell lineage is histiocytic not lymphoid.
UMLS ID:: C0334663
MeSH ID:: D054747

Classification 1:

Name:

Neoplasms
MeSH Tree Number(s):: C04.557.227.380

Classification 2:

Name:

Hemic and Lymphatic Diseases
MeSH Tree Number(s):: C15.604.250.390.380

Synonym(s)

Histiocytic sarcoma

Histiocytic Sarcoma

Histiocytic sarcoma (clinical)

SARCOMA, HISTIOCYTIC, MALIGNANT

True Histiocytic Lymphoma

True histiocytic lymphoma

True histiocytic lymphoma (clinical)

histiocytic lymphoma

histiocytic sarcoma

10.

histiocytic; lymphoma, true

11.

lymphoma; histiocytic, true

12.

lymphoma; true histiocytic

Associated Drug(s)

	Name	Number of Reports	Reference(s)	Data Source
1	trametinib	FAERS: 2		US FAERS
2	Lenalidomide	FAERS: 1		US FAERS
3	Methotrexate	FAERS: 1		US FAERS
4	PCI 32765	FAERS: 1		US FAERS
5	Thalidomide		17408102	CTD
6	Zidovudine		10558926	CTD

Similar ADE(s)

	Name	Semantic Similarity
1	leukemia	20.2%
2	Neoplasms, Germ Cell and Embryonal	20.2%
3	Neoplasms, Glandular and Epithelial	20.2%
4	Germ Cell Cancer	20.2%
5	Neuroectodermal Tumors	19.8%
6	Neoplasms, Neuroepithelial	19.6%
7	Gliomatosis cerebri	19.6%
8	Lymphoma	18.1%
9	Lymphocele	17.9%
10	melanoma	17.5%
11	Histiocytosis, Langerhans-Cell	17.4%
12	Carcinosarcoma	17.2%
13	Hemangiosarcoma	17.2%
14	lymphangiosarcoma	17.2%
15	Adenitis	16.9%
16	Lymphadenitis	16.9%
17	Lymphangitis	16.9%
18	Lymphedema	16.9%
19	Splenic Diseases	16.9%
20	Thymus Hyperplasia	16.9%
21	Pseudolymphoma	16.9%
22	Lymphadenopathy	16.9%
23	Medulloblastoma	16.7%
24	Composite Lymphoma	16.4%
25	Thymus Neoplasms	16%
26	Thymoma	15.8%
27	Adenoma, Acidophil	15.5%
28	Ganglioneuroma	15.5%
29	Glioma	15.5%
30	Malignant Glioma	15.5%
31	Lymphohistiocytosis, Hemophagocytic	15.2%
32	Erdheim-Chester Disease	15.2%
33	Carcinoma 256, Walker	14.9%
34	Basal cell carcinoma	14.6%
35	Carcinoma, Papillary	14.6%
36	Squamous cell carcinoma	14.6%
37	Chondrosarcoma	14.6%
38	Craniopharyngioma	14.6%
39	Cystadenoma	14.6%
40	leiomyosarcoma	14.6%
41	liposarcoma	14.6%
42	Mesothelioma	14.6%
43	synovial sarcoma	14.6%
44	Neuroectodermal Tumor, Melanotic	14.6%
45	Angiomyolipoma	14.6%
46	Clear Cell Sarcoma of Soft Tissue	14.6%
47	Alveolar Soft Part Sarcoma	14.6%
48	Neuroendocrine Tumors	14.6%
49	Sarcoma, Myeloid	14.6%
50	Carcinoma, Basal Cell	14.6%
51	Carcinoid Tumor	14.5%
52	Neurilemmoma	14.5%
53	Hutchinson's Melanotic Freckle	14.5%
54	Melanoma, Amelanotic	14.5%
55	Meningioma	14.4%
56	Leukemia, Plasma Cell	13.7%
57	Astrocytoma	13.5%
58	Ependymoma	13.5%
59	oligodendroglioma	13.5%
60	Ganglioglioma	13.5%
61	gliosarcoma	13.5%
62	Anaplastic astrocytoma	13.5%
63	Anaplastic Oligodendroglioma	13.5%
64	Cystadenocarcinoma	13.4%
65	Fibrosarcoma	13.4%
66	Osteosarcoma	13.4%
67	Mucoepidermoid Carcinoma	13.4%
68	Melanoma, Experimental	13.3%
69	Adenoma	13.2%
70	Ameloblastoma	13.2%
71	Angiokeratoma	13.2%
72	Carcinoma	13.2%
73	Chordoma	13.2%
74	Hemangioma	13.2%
75	hemangiopericytoma	13.2%
76	Lymphangioma	13.2%
77	Mesenchymoma	13.2%
78	Nevus	13.2%
79	Teratoma	13.2%
80	Hepatoblastoma	13.2%
81	Mixed Tumor, Mullerian	13.2%
82	Germinoma	13.2%
83	Teratocarcinoma	13.2%
84	Angiofibroma	13.2%
85	Sarcoma	13.2%
86	Epithelioma	13.2%
87	Lymphangioleiomyomatosis	13%
88	Malignant Carcinoid Syndrome	13%
89	Lymphoproliferative Disorders	12.8%
90	Lymphatic Abnormalities	12.8%
91	Adenofibroma	12.7%
92	Fibroadenoma	12.7%
93	Malignant Fibrous Histiocytoma	12.7%
94	Splenic Neoplasms	12.6%
95	Carcinoma, Ehrlich Tumor	12.5%
96	Dermoid Cyst	12.5%
97	Carcinoma, Lewis Lung	12.5%
98	Glioblastoma	12.5%
99	Neuroblastoma	12.5%
100	Glioblastoma Multiforme	12.5%
101	Bowen's Disease	12.1%
102	Paraganglioma	12.1%
103	Rhabdomyosarcoma	12.1%
104	Giant Cell Tumor of Bone	12.1%
105	Trophoblastic Neoplasms	12.1%
106	Leukemia, Experimental	12%
107	Ganglioneuroblastoma	12%
108	Lymphangiectasis, Intestinal	11.9%
109	Hamartoma	11.8%
110	Hodgkin Disease	11.8%
111	Lymphoma, Non-Hodgkin	11.8%
112	Neoplasms, Hormone-Dependent	11.8%
113	Neoplasms, Multiple Primary	11.8%
114	Paraneoplastic Syndromes	11.8%
115	Precancerous Conditions	11.8%
116	Neoplasms, Second Primary	11.8%
117	Dermatofibrosarcoma	11.5%
118	Dermatofibrosarcoma Protuberans	11.5%
119	Choriocarcinoma	11.1%
120	Carcinoma, Lobular	11.1%
121	Pheochromocytoma	10.8%
122	Alveolar rhabdomyosarcoma	10.8%
123	Leukemia L1210	10.7%
124	Leukemia P388	10.7%
125	Acanthoma	10.7%
126	Endometrial Stromal Sarcoma	10.5%
127	Carcinoid Heart Disease	10.4%
128	Waldenstrom Macroglobulinemia	10.3%
129	Leukemia, Radiation-Induced	10.1%
130	Mucocutaneous Lymph Node Syndrome	10.1%
131	Sarcoma, Experimental	9.9%
132	Neurofibrosarcoma	9.9%
133	Plasmacytoma	9.9%
134	Elephantiasis	9.9%
135	Hypersplenism	9.9%
136	Sarcoidosis	9.9%
137	Elephantiasis Nostras Verrucosa	9.9%
138	Retinoblastoma	9.9%
139	Adenocarcinoma	9.8%
140	Carcinoma in Situ	9.8%
141	Carcinoma, Transitional Cell	9.8%
142	Phyllodes Tumor	9.8%
143	Dysgerminoma	9.8%
144	Hemangioendothelioma	9.8%
145	Lipoma	9.8%
146	Myoma	9.8%
147	Myxoma	9.8%
148	Neuroma	9.8%
149	Papilloma	9.8%
150	Pseudomyxoma Peritonei	9.8%
151	Seminoma	9.8%
152	Papillomatosis	9.8%
153	Angiolipoma	9.8%
154	Myelolipoma	9.8%
155	Neoplasms, Bone Tissue	9.8%
156	Neoplasms, Fibrous Tissue	9.8%
157	Smooth Muscle Tumor	9.8%
158	Adenomatosis, Pulmonary	9.8%
159	Adenomatous Polyps	9.8%
160	Carcinoma, Large Cell	9.8%
161	Carcinoma, Small Cell	9.8%
162	Desmoplastic Small Round Cell Tumor	9.8%
163	Chondroma	9.8%
164	Enchondroma	9.8%
165	Leukemia, T-Cell	9.7%
166	Leukemia, B-Cell	9.7%
167	Hematologic Neoplasms	9.4%
168	Sarcoma 180	9.4%
169	Lymphomatoid Granulomatosis	9.4%
170	Leukemia, Myelomonocytic, Chronic	8.9%
171	Leukemia, Myeloid, Chronic, Atypical, BCR-ABL Negative	8.9%
172	Cyst	8.8%
173	Neoplastic Processes	8.8%
174	Neoplastic Syndromes, Hereditary	8.8%
175	Pregnancy Complications, Neoplastic	8.8%
176	Sezary Syndrome	8.8%
177	Lymphoma, Follicular	8.7%
178	T-Cell Lymphoma	8.7%
179	Mantle cell lymphoma	8.7%
180	Neoplasms, Experimental	8.7%
181	Adenoid Cystic Carcinoma	8.1%
182	fibroma	8.1%
183	Fibromatosis	8.1%
184	Osteoblastoma	8.1%
185	Osteoma	8.1%
186	Rhabdomyoma	8.1%
187	Chondromatosis	8.1%
188	Adenocarcinoma, Clear Cell	8.1%
189	Cholangiocarcinoma	8.1%
190	Cervical Intraepithelial Neoplasia	8.1%
191	Hemangioblastoma	8.1%
192	Lymphoma, Extranodal NK-T-Cell	8.1%
193	Agammaglobulinemia	8.1%
194	Multiple Endocrine Neoplasia	7.8%
195	Precursor B-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
196	Leukemia, Large Granular Lymphocytic	7.7%
197	Precursor T-Cell Lymphoblastic Leukemia-Lymphoma	7.7%
198	Acoustic Neuroma	7.6%
199	Granuloma	7.6%
200	Splenic Infarction	7.6%
201	Eosinophilic Granuloma	7.5%
202	Tumor Lysis Syndrome	7.4%
203	Carcinoma, Pancreatic Ductal	7.3%
204	Fibromatosis, Aggressive	7.3%
205	Fibromatosis, Abdominal	7.3%
206	Klatskin Tumor	7.3%
207	Leukemia, Myeloid, Chronic-Phase	7.3%
208	Heavy Chain Disease	7.2%
209	Lymphoma, T-Cell, Cutaneous	7.2%
210	Lymphoma, AIDS-Related	7.2%
211	Enteropathy-Associated T-Cell Lymphoma	7.2%
212	Primary Effusion Lymphoma	7.2%
213	Hemangioma, Cavernous	7.2%
214	Basal Cell Nevus Syndrome	7%
215	Neoplasms, Radiation-Induced	6.9%
216	Optic Nerve Glioma	6.9%
217	Paraneoplastic Encephalomyelitis	6.8%
218	Hydatidiform Mole	6.8%
219	Abdominal Neoplasms	6.7%
220	Erythroplasia	6.7%
221	Follicular cyst	6.7%
222	Head and Neck Neoplasms	6.7%
223	Mucocele	6.7%
224	Pilonidal Cyst	6.7%
225	Soft Tissue Neoplasms	6.7%
226	Thoracic Neoplasms	6.7%
227	Thyroglossal Cyst	6.7%
228	Synovial Cyst	6.7%
229	Aberrant Crypt Foci	6.7%
230	Nephroblastoma	6.7%
231	Mammary Neoplasms, Experimental	6.7%
232	Bone Marrow Neoplasms	6.6%
233	Vipoma	6.6%
234	Infectious Mononucleosis	6.6%
235	Primary amyloidosis	6.6%
236	Multiple Myeloma	6.6%
237	Hepatocellular Adenoma	6.6%
238	Mycosis Fungoides	6.5%
239	Lymphomatoid Papulosis	6.5%
240	Plasmablastic lymphoma	6.5%
241	Mastocytoma	6.1%
242	Splenic Rupture	6.1%
243	Mastocytosis, Systemic	6.1%
244	Mastocytosis	6%
245	Sturge-Weber Syndrome	6%
246	Disseminated Intravascular Coagulation	6%
247	Protein S Deficiency	6%
248	Gastrointestinal Stromal Tumors	5.9%
249	Mesoblastic Nephroma	5.9%
250	neurofibroma	5.8%
251	Anemia	5.6%
252	Blood Coagulation Disorders	5.6%
253	Blood Platelet Disorders	5.6%
254	Bone Marrow Diseases	5.6%
255	Hemorrhagic Disorders	5.6%
256	Leukocyte Disorders	5.6%
257	Methemoglobinemia	5.6%
258	Pancytopenia	5.6%
259	Polycythemia	5.6%
260	Sulfhemoglobinemia	5.6%
261	Thrombophilia	5.6%
262	Erythrocytosis	5.6%
263	Prolactinoma	5.6%
264	Growth Hormone-Secreting Pituitary Adenoma	5.6%
265	Tuberous Sclerosis	5.5%
266	Digestive System Neoplasms	5.3%
267	Endocrine Gland Neoplasms	5.3%
268	Eye Neoplasms	5.3%
269	Nervous System Neoplasms	5.3%
270	Burkitt Lymphoma	5.2%
271	Thrombocythemia, Essential	5.2%
272	Multiple Endocrine Neoplasia Type 1	5.2%
273	Bone neoplasms	5.1%
274	Leukoplakia	5.1%
275	Pancreatic Cyst	5.1%
276	Skin Neoplasms	5.1%
277	Autoimmune Lymphoproliferative Syndrome	5.1%
278	Barrett Esophagus	5%
279	Breast Cyst	5%
280	Actinic keratosis	5%
281	Mediastinal Cyst	5%
282	Neoplasm Invasiveness	5%
283	Neoplasm Metastasis	5%
284	Neoplasm Recurrence, Local	5%
285	Parovarian Cyst	5%
286	Pericardial Cyst	5%
287	Thymic Cyst	5%
288	Carcinogenesis	5%
289	Myxoid cyst	5%
290	Metastasis	5%
291	insulinoma	5%
292	Sarcoidosis, Pulmonary	4.9%
293	Polycythemia Vera	4.9%
294	granulosa cell tumor	4.9%
295	Carcinoma, Ovarian Epithelial	4.9%
296	Gastrinoma	4.7%
297	Glucagonoma	4.7%
298	Adenomatous Polyposis Coli	4.6%
299	Adrenocortical carcinoma	4.6%
300	Parathyroid Neoplasms	4.5%
301	Peritoneal Neoplasms	4.5%
302	Thyroid Neoplasm	4.5%
303	Thyroid carcinoma	4.5%
304	Dupuytren Contracture	4.5%
305	Transfusion Reaction	4.4%
306	Hypotensive Transfusion Reaction	4.4%
307	Retroperitoneal Neoplasms	4.4%
308	Thrombasthenia	4.4%
309	Antithrombin III Deficiency	4.4%
310	Protein C Deficiency	4.4%
311	Urticaria Pigmentosa	4.4%
312	Leydig Cell Tumor	4.4%
313	Pregnancy Complications, Hematologic	4.3%
314	Liver Neoplasms, Experimental	4.3%
315	Thrombocytosis	4.1%
316	Nasopharyngeal carcinoma	4%
317	Renal Cell Carcinoma	4%
318	Papillary Renal Cell Carcinoma	4%
319	Corpus Luteum Cyst	4%
320	Ovarian Cysts	4%
321	Splenosis	3.9%
322	Vitamin K Deficiency	3.9%
323	Tracheal Neoplasms	3.9%
324	Pancreatic Neoplasm	3.9%
325	Carcinoma, Endometrioid	3.9%
326	Leukoplakia, Oral	3.8%
327	Afibrinogenemia	3.8%
328	Factor VII Deficiency	3.8%
329	Factor X Deficiency	3.8%
330	Factor XII Deficiency	3.8%
331	Hemophilia A	3.8%
332	Paraneoplastic Cerebellar Degeneration	3.8%
333	Activated Protein C Resistance	3.8%
334	Factor II deficiency	3.8%
335	Factor VIII Deficiency	3.8%
336	Factor V deficiency	3.8%
337	Factor XI Deficiency	3.8%
338	Hypoprothrombinemias	3.8%
339	Denys-Drash Syndrome	3.5%
340	Choledochal Cyst	3.4%
341	Mouth Neoplasms	3.4%
342	Central Nervous System Neoplasms	3.4%
343	Vascular Neoplasms	3.4%
344	Genital Neoplasms, Female	3.3%
345	Pancreatic Pseudocyst	3.3%
346	Esophageal Neoplasms	3.3%
347	Peutz-Jeghers Syndrome	3.3%
348	Anemia, Hemolytic	3.3%
349	Anemia, Macrocytic	3.3%
350	Eosinophilia	3.3%
351	Hypoproteinemia	3.3%
352	Leukopenia	3.3%
353	Thrombocytopenia	3.3%
354	Leukostasis	3.3%
355	MYELODYSPLASTIC SYNDROME	3.3%
356	Lymphatic Metastasis	3.3%
357	Neoplasms, Unknown Primary	3.3%
358	Thyroid Nodule	3.3%
359	Leukemic Infiltration	3.3%
360	Breast Neoplasms, Male	3.3%
361	Neoplasm Micrometastasis	3.3%
362	Triple Negative Breast Neoplasms	3.3%
363	Limbic Encephalitis	3.3%
364	Hemoglobinuria, Paroxysmal	3.3%
365	Leukemoid Reaction	3.3%
366	Lambert-Eaton Myasthenic Syndrome	2.9%
367	Testicular Neoplasms	2.9%
368	Niemann-Pick Disease, Type C	2.8%
369	Adrenal Gland Neoplasms	2.7%
370	Gastrointestinal Neoplasms	2.7%
371	Genital Neoplasms, Male	2.7%
372	Liver neoplasms	2.7%
373	Uveal Neoplasms	2.7%
374	Anemia, Diamond-Blackfan	2.7%
375	Urologic Neoplasms	2.7%
376	Wiskott-Aldrich Syndrome	2.7%
377	Sebaceous Gland Neoplasms	2.6%
378	Spinal Neoplasms	2.6%
379	Purpura, Thrombotic Thrombocytopenic	2.6%
380	Polycystic Ovary Syndrome	2.6%
381	Opsoclonus-Myoclonus Syndrome	2.6%
382	Anemia, Neonatal	2.5%
383	Leukocytosis	2.5%
384	Paraproteinemias	2.5%
385	Pelger-Huet Anomaly	2.5%
386	Pleocytosis	2.5%
387	Anemia, Sickle Cell	2.5%
388	Thalassemia	2.5%
389	Meningeal Neoplasms	2.5%
390	Myelitis, Transverse	2.3%
391	Nose Neoplasms	2.3%
392	Palatal Neoplasms	2.2%
393	Cryoglobulinemia	2.2%
394	Monoclonal Gammopathy of Undetermined Significance	2.2%
395	Primary Myelofibrosis	2.2%
396	Agranulocytosis	2.2%
397	Anemia, Megaloblastic	2.2%
398	Lymphocytosis	2.2%
399	Myelofibrosis	2.2%
400	Myeloid Metaplasia	2.2%
401	Hypoalbuminemia	2.2%
402	Hypereosinophilic syndrome	2.2%
403	bone marrow fibrosis	2.2%
404	Thrombotic Microangiopathies	2.2%
405	Autoimmune thrombocytopenia	2.1%
406	Immune thrombocytopenic purpura	2.1%
407	Hypergammaglobulinemia	2%
408	Ear Neoplasms	2%
409	Eyelid Neoplasms	2%
410	Lung Neoplasms	2%
411	Pleural Neoplasms	2%
412	Meningeal Carcinomatosis	2%
413	Xeroderma Pigmentosum	2%
414	Pituitary Adenoma	2%
415	Pituitary Neoplasms	2%
416	Transfusion-Related Acute Lung Injury	2%
417	Ecchymosis	2%
418	Petechiae	2%
419	Purpura	2%
420	Cell Transformation, Viral	2%
421	Brain Neoplasms	2%
422	Salivary Gland Neoplasms	2%
423	Spinal Cord Neoplasms	2%
424	Tongue Neoplasms	2%
425	Uterine Neoplasms	1.9%
426	Vaginal Neoplasms	1.9%
427	Vulvar Neoplasms	1.9%
428	Uterine Cancer	1.9%
429	Fallopian Tube Neoplasms	1.9%
430	ovarian neoplasm	1.9%
431	Hemolytic-Uremic Syndrome	1.9%
432	Purpura, Hyperglobulinemic	1.9%
433	Sickle Cell Trait	1.7%
434	Pharyngeal Neoplasms	1.7%
435	Thrombocytopenic purpura	1.7%
436	Lymphopenia	1.7%
437	Central Nervous System Cysts	1.7%
438	Bronchial Neoplasms	1.7%
439	Bile Duct Neoplasms	1.6%
440	gallbladder neoplasm	1.6%
441	Hydrops Fetalis	1.6%
442	Intestinal Neoplasms	1.6%
443	Penile Neoplasms	1.6%
444	Prostatic Neoplasms	1.6%
445	Stomach Neoplasms	1.6%
446	Multiple Pulmonary Nodules	1.6%
447	Job Syndrome	1.6%
448	Fanconi Anemia	1.6%
449	Neutropenia	1.6%
450	Supratentorial Neoplasms	1.6%
451	Endometrial Neoplasms	1.6%
452	Laryngeal neoplasm	1.5%
453	Waterhouse-Friderichsen Syndrome	1.5%
454	Atypical Hemolytic Uremic Syndrome	1.5%
455	Zollinger-Ellison syndrome	1.5%
456	Brain Stem Neoplasms	1.4%
457	Bladder Neoplasm	1.4%
458	Kidney Neoplasm	1.4%
459	Ureteral Neoplasms	1.4%
460	Urethral Neoplasms	1.4%
461	Hypopharyngeal Neoplasms	1.4%
462	Pleural Effusion, Malignant	1.4%
463	Hypopharyngeal Cancer	1.4%
464	Choroid Plexus Papilloma	1.4%
465	Parotid Neoplasms	1.3%
466	Febrile Neutropenia	1.3%
467	Prostatic Neoplasms, Castration-Resistant	1.3%
468	Acute Chest Syndrome	1.3%
469	Nelson Syndrome	1.3%
470	Eosinophilia-Myalgia Syndrome	1.3%
471	Chronic granulomatous disease	1.3%
472	Shwartzman Phenomenon	1.3%
473	Scurvy	1.3%
474	Purpura Fulminans	1.3%
475	Kernicterus	1.3%
476	Pulmonary Eosinophilia	1.2%
477	Eosinophilic Pneumonia	1.2%
478	Tonsillar Neoplasms	1.2%
479	Anemia, Pernicious	1.2%
480	Cerebellar Neoplasms	1.2%
481	Cecal Neoplasms	1.2%
482	Duodenal Neoplasms	1.2%
483	POEMS Syndrome	1.1%
484	Radicular Cyst	1%
485	Nasopharyngeal Neoplasms	1%
486	Appendiceal Neoplasms	1%
487	Colonic Neoplasms	1%
488	Rectal Neoplasms	1%
489	Colorectal Neoplasms	1%
490	Paranasal Sinus Neoplasms	0.9%
491	Anus Neoplasms	0.8%
492	Sigmoid Neoplasms	0.8%
493	Maxillary Sinus Neoplasms	0.8%
494	Pseudoxanthoma Elasticum	0.7%

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